The prospect of using cell-based interventions to treat neurological conditions raises several important ethical and policy questions. In this target article, we focus on issues related to the unique constellation of traits that characterize CBIs targeted at the central nervous system. In particular, there is at least a theoretical prospect that these cells will alter the recipients' cognition, mood, and behavior—brain functions that are central to our concept of the self. The potential for such changes, although perhaps remote, is cause (...) for concern and careful ethical analysis. Both to enable better informed consent in the future and as an end in itself, we argue that early human trials of CBIs for neurological conditions must monitor subjects for changes in cognition, mood, and behavior; further, we recommend concrete steps for that monitoring. Such steps will help better characterize the potential risks and benefits of CBIs as they are tested and potentially used for treatment. (shrink)

The PEIRCE EDITION contains large sections of previously unpublished material in addition to selected published works. Each volume includes a brief historical and biographical introduction, extensive editorial and textual notes, and a full chronological list of all of Peirce’s writings, published and unpublished, during the period covered.

This collection of essays in moral philosophy has as its intended mark of distinction the fact that moral problems of the moment are the themes of the essays. The chapter headings indicate this contemporary concern: Abortion, Sex, Human Rights and Civil Disobedience, Criminal Punishment, Violence and Pacifism, War and Suicide and Death. There are essays by: Paul Ramsey, Philippa Foot, Jonathan Bennett, Thomas Nagel, Sara Ruddick, Richard Wassenstrom, [[sic]] John Rawls, R. M. Dworkin, William Kneale, H. L. A. Hart, J. (...) R. Lucas, Newton Carver, Jan Narveson, G. E. M. Anscombe, R. M. Hare, R. F. Holland, Mary Mothersill. One might well be inclined to agree with the editor's opposition to such philosophizing about morality which abstracts from the moral problems of one's own life. A purely theoretical approach to the study of morality would almost appear contradictory. However, it is necessary to express grave reservations about such a collection of essays as this. While the arguments of the essays are thoughtful and somewhat uncommon, the conclusions of the essays, as a rule, do not differ from "advanced" liberal opinions. In other words, the essays do not challenge students' opinions. The reading of these essays will but confirm the young in their prejudices. The problems the essays are concerned with are real problems; and it is a defect of the book that with the single exception of the chapter on Abortion no real opposing arguments are presented.--J. W. S. (shrink)

1 Evidence-based policy requires researchers to provide the answers to ecological questions that are of interest to policy makers. To find out what those questions are in the UK, representatives from 28 organizations involved in policy, together with scientists from 10 academic institutions, were asked to generate a list of questions from their organizations. 2 During a 2-day workshop the initial list of 1003 questions generated from consulting at least 654 policy makers and academics was used as a basis for (...) generating a short list of 100 questions of significant policy relevance. Short-listing was decided on the basis of the preferences of the representatives from the policy-led organizations. 3 The areas covered included most major issues of environmental concern in the UK, including agriculture, marine fisheries, climate change, ecosystem function and land management. 4 The most striking outcome was the preference for general questions rather than narrow ones. The reason is that policy is driven by broad issues rather than specific ones. In contrast, scientists are frequently best equipped to answer specific questions. This means that it may be necessary to extract the underpinning specific question before researchers can proceed. 5 Synthesis and applications. Greater communication between policy makers and scientists is required in order to ensure that applied ecologists are dealing with issues in a way that can feed into policy. It is particularly important that applied ecologists emphasize the generic value of their work wherever possible. (shrink)

This paper investigates the possibilities and problems of benchmarking Corporate Social Responsibility (CSR). After a methodological analysis of the advantages and problems of benchmarking, we develop a benchmark method that includes economic, social and environmental aspects as well as national and international aspects of CSR. The overall benchmark is based on a weighted average of these aspects. The weights are based on the opinions of companies and NGO's. Using different methods of weighting, we find that the outcome of the benchmark (...) is rather robust for a sample of more than 50 large Dutch companies. (shrink)