Fluid-phase endocytosis (pinocytosis) kinetics were studied inDictyostelium discoideum amoebae from the axenic strain Ax-2 that exhibits high rates of fluid-phase endocytosis when cultured in liquid nutrient media. Fluorescein-labelled dextran (FITC-dextran) was used as a marker in continuous uptake- and in pulse-chase exocytosis experiments. In the latter case, efflux of the marker was monitored on cells loaded for short periods of time and resuspended in marker-free medium. A multicompartmental model was developed which describes satisfactorily fluid-phase endocytosis kinetics. In particular, it accounts (...) correctly for the extended latency period before exocytosis in pulse-chase experiments and it suggests the existence of some sorts of maturation stages in the pathway. (shrink)

La mécanique quantique est l'un des domaines de la physique les plus surprenants et controversés. Depuis le début, elle a suscité les plus vifs débats quant à sa signification et à son lien avec le réel. L'atomisme, la lumière ou les théories relativistes ont aussi défrayé la chronique, mais rien ne semble devoir arrêter les polémiques qui entourent l'interprétation des phénomènes quantiques. De Heisenberg à Schrödinger en passant par la fameuse controverse entre Einstein et Niels Bohr, Jean-Pierre Pharabod et (...) class='Hi'>Gérard Klein n'omettent aucune péripétie de cette saga de la physique quantique qui mène aujourd'hui à l'affirmation pour le moins surprenante de la "non-localité" de la nature. C'est un nouveau défi à nos modes de pensée ordinaires. (shrink)

In What the Body Commands, Colin Klein proposes and defends a novel theory of pain. Klein argues that pains are imperative; they are sensations with a content, and that content is a command to protect the injured part of the body. He terms this view "imperativism about pain," and argues that imperativism can account for two puzzling features of pain: its strong motivating power and its uninformative nature. Klein argues that the biological purpose of pain is homeostatic; (...) like hunger and thirst, pain helps solve a challenge to bodily integrity. It does so by motivating you to act in ways that help the body recover. If you obey pain's command, you get better. He develops his account to handle a variety of pain phenomena and applies it to solve a number of historically puzzling cases. Klein's intent is to defend the imperativist view in a pure form -- without requiring pain to represent facts about the world.Klein presents a model of imperative content showing that intrinsically motivating sensations are best understood as imperatives, and argues that pain belongs to this class. He considers the distinction between pain and suffering; explains how pain motivates; addresses variations among pains; and offers an imperativist account of maladaptive pains, pains that don't appear to hurt, masochism, and why pain feels bad. (shrink)

Important study focuses on the revival and assimilation of ancient Greek mathematics in the 13th–16th centuries, via Arabic science, and the 16th-century development of symbolic algebra. This brought about the crucial change in the concept of number that made possible modern science — in which the symbolic "form" of a mathematical statement is completely inseparable from its "content" of physical meaning. Includes a translation of Vieta's Introduction to the Analytical Art. 1968 edition. Bibliography.

_The first comprehensive one-volume collection of St.Thomas More’s writing__ “[A] tremendous scholarly undertaking.... Accessible and transparent to both scholars and the general audience.”—_Renaissance and Reformation__ In this book, Wegemer and Smith assemble More’s most important English and Latin works for the first time in a single volume. This volume reveals the breadth of More’s writing and includes a rich selection of illustrations and artwork. The book provides the most complete picture of More’s work available, serving as a major resource for (...) early modern scholars, teachers, students, and the general reader. (shrink)

We present a Kripke model for Girard's Linear Logic (without exponentials) in a conservative fashion where the logical functors beyond the basic lattice operations may be added one by one without recourse to such things as negation. You can either have some logical functors or not as you choose. Commutatively and associatively are isolated in such a way that the base Kripke model is a model for noncommutative, nonassociative Linear Logic. We also extend the logic by adding a coimplication operator, (...) similar to Curry's subtraction operator, which is resituated with Linear Logic's contensor product. And we can add contraction to get nondistributive Relevance Logic. The model rests heavily on Urquhart's representation of nondistributive lattices and also on Dunn's Gaggle Theory. Indeed, the paper may be viewed as an investigation into nondistributive Gaggle Theory restricted to binary operations. The valuations on the Kripke model are three valued: true, false, and indifferent. The lattice representation theorem of Urquhart has the nice feature of yielding Priestley's representation theorem for distributive lattices if the original lattice happens to be distributive. Hence the representation is consistent with Stone's representation of distributive and Boolean lattices, and our semantics is consistent with the Lemmon-Scott representation of modal algebras and the Routley-Meyer semantics for Relevance Logic. (shrink)

As Thomas Uebel has recently argued, some early logical positivists saw American pragmatism as a kindred form of scientific philosophy. They associated pragmatism with William James, whom they rightly saw as allied with Ernst Mach. But what apparently blocked sympathetic positivists from pursuing commonalities with American pragmatism was the concern that James advocated some form of psychologism, a view they thought could not do justice to the a priori. This paper argues that positivists were wrong to read James as offering (...) a psychologistic account of the a priori. They had encountered James by reading Pragmatism as translated by the unabashedly psychologistic Wilhelm Jerusalem. But in more technical works, James had actually developed a form of conventionalism that anticipated the so-called “relativized” a priori positivists themselves would independently develop. While positivists arrived at conventionalism largely through reflection on the exact sciences, though, James’s account of the a priori grew from his reflections on the biological evolution of cognition, particularly in the context of his Darwin-inspired critique of Herbert Spencer. (shrink)

[Note: Picture of Peirce available] Charles S. Peirce’s Philosophy of Signs Essays in Comparative Semiotics Gérard Deledalle Peirce’s semiotics and metaphysics compared to the thought of other leading philosophers. "This is essential reading for anyone who wants to find common ground between the best of American semiotics and better-known European theories. Deledalle has done more than anyone else to introduce Peirce to European audiences, and now he sends Peirce home with some new flare."—Nathan Houser, Director, Peirce Edition Project Charles (...) S. Peirce’s Philosophy of Signs examines Peirce’s philosophy and semiotic thought from a European perspective, comparing the American’s unique views with a wide variety of work by thinkers from the ancients to moderns. Parts I and II deal with the philosophical paradigms which are at the root of Peirce’s new theory of signs, pragmatic and social. The main concepts analyzed are those of "sign" and "semiosis" and their respective trichotomies; formally in the case of "sign," in time in the case of semiosis. Part III is devoted to comparing Peirce’s theory of semiotics as a form of logic to the work of other philosophers, including Bertrand Russell, Wittgenstein, Frege, Philodemus, Lady Welby, Saussure, Morris, Jakobson, and Marshall McLuhan. Part IV compares Peirce’s "scientific metaphysics" with European metaphysics. Gérard Deledalle holds the Doctorate in Philosophy from the Sorbonne. A research scholar at Columbia University and Attaché at the Centre National de la Recherche Scientifique, Paris, he has also been Professor of Philosophy and Head of the Philosophy Department of the universities of Tunis, Perpignan, and Libreville. In 1990 he received the Herbert W. Schneider Award "for distinguished contributions to the understanding and development of American philosophy. In 2001, he was appointed vice-president of the Charles S. Peirce Society. Contents Introduction—Peirce Compared: Directions for Use Part I—Semeiotic as Philosophy Peirce’s New Philosophical Paradigms Peirce’s Philosophy of Semeiotic Peirce’s First Pragmatic Papers The Postscriptum of 1893 Part II—Semeiotic as Semiotics Sign: Semiosis and Representamen—Semiosis and Time Sign: The Concept and Its Use—Reading as Translation Part III—Comparative Semiotics Semiotics and Logic: A Reply to Jerzy Pelc Semeiotic and Greek Logic: Peirce and Philodemus Semeiotic and Significs: Peirce and Lady Welby Semeiotic and Semiology: Peirce and Saussure Semeiotic and Semiotics: Peirce and Morris Semeiotic and Linguistics: Peirce and Jakobson Semeiotic and Communication: Peirce and McLuhan Semeiotic and Epistemology: Peirce, Frege, and Wittgenstein Part IV—Comparative Metaphysics Gnoseology—Perceiving and Knowing: Peirce, Wittgenstein, and Gestalttheorie Ontology—Transcendentals "of" or "without" Being: Peirce versus Aristotle and Thomas Aquinas Cosmology—Chaos and Chance within Order and Continuity: Peirce between Plato and Darwin Theology—The Reality of God: Peirce’s Triune God and the Church’s Trinity Conclusion—Peirce: A Lateral View. (shrink)

The paper investigates the way norms relate to and affect agents' intentions and actions. Current work in deontic logic dealing with agency mainly falls within two different groups: a variety of frameworks which adopt a purely external approach and represent agency in terms of possible outcomes of actions, and frameworks which instead endorse an internal approach and focus exclusively on the agents' intentions. The paper argues that neither of these models alone can produce a satisfactory analysis. An integrated model which (...) combines the internal and external approaches is therefore put forward. The model is dynamic and represents the change that accepting a goal norm triggers in an agent's intentions (especially the so-called "prior-intentions" and actions. (shrink)

This paper identifies the key assumptions underpinning current arrangements in vocational education and training (VET) in the UK. These assumptions, and the idea of vocational capability they denote, are rejected in favour of a more coherent conception—a conception centred not on the traditional dichotomy of ‘knowing how-knowing that’ but on what I refer to as the ‘constitutive understandings’ from which both practical and theoretical capabilities can be seen to derive. It is argued that an account of vocational capability in these (...) terms suggests a far richer conception of vocational preparation than current arrangements are able to admit. (shrink)

Utopia repeatedly sets forth the rhetorical strategy of using pleasant and healing words to “enter” or “flow” or “steal into” fortresses of hardened opinion and custom without arousing warlike passions to keep them out. An important part of this strategy is the creation of a character who denounces major instances and causes of injustice but who nonetheless supports war and other means of force at the expense of law in rectifying that injustice; another part of the strategy is the creation (...) of a character and a plot that embody the “indirect” rhetorical approach aimed primarily at long-term persuasion needed to improve laws and institutions. (shrink)

ABSTRACT An examination of the use of the word “laboratory” before the nineteenth century yields two striking results. First, “laboratory” referred almost exclusively to a room or house where chemical operations such as distillation, combustion, and dissolution were performed. Second, a “laboratory” was not exclusively a scientific institution but also an artisanal workplace. Drawing on the historical actors' use of “laboratory,” the essay first presents (some necessarily scattered) evidence for the actual correspondence between artisanal and scientific laboratories in the eighteenth (...) century. A particularly instructive case is the way the equipment of the laboratory of the Prussian Academy of Sciences was acquired. There was, in this case, a direct transfer of instruments, vessels, and materials from a pharmaceutical to an academic laboratory. The essay then argues that we ought to distinguish between two different experimental traditions in the early modern period: experimental philosophy and the laboratory tradition that meshed studies of nature with technological innovation. (shrink)

The emergence of economic inequality has often been linked to individual differences in mental or physical capacities. By means of an agent-based simulation this paper shows that neither of these is a necessary condition. Rather, inequality can arise from iterated interactions of fully rational agents. This bears consequences for our understanding of both inequality and rationality. In a setting of iterated bargaining games, we claim that expected utility maximizing agents perform suboptimally in comparison with other strategies. The reason for this (...) lies in complex feedback effects between an agents’ action and the quality of beliefs used to calculate expected utility. Consequentially, we argue that the standard notion of rationality as maximizing expected utility is insufficient, even for certain standard cases of economic interaction. (shrink)

As a philosopher of sport who takes a broadly neo-Aristotelian, virtue-ethical approach, Sabrina B. Little’s The Examined Run seems tailor-made for me. Little uses Aristotle, Plato, Aquinas, and ot...

For some thirty years, a handful of architects has been trying to call into question the primacy that the history of architecture has given to monumental buildings. The representatives of this trend want to get away from the short chronology, common since the Italian Renaissance, and react against the dominant international functionalism that has too little respect for the local cultural contexts. It is under the influence of this “vernacular” approach that the small traditional structure became as legitimate an object (...) of research as the well-known buildings. This approach, innovative and audacious as it was, broke with a Utopian vision of a large part of modern architecture. It led the architects concerned to turn toward non-European countries and to focus their attention on the connections between indigenous housing patterns and cultures. From this decentralization ethno-architecture was born by which we understand the study of preindustrial, “traditional” habitats and housing. Inspired by Panofsky, Eliade, and Lévi-Strauss and familiar with the social sciences, these researchers appropriated the conceptual tools of anthropology. They opened up important fields of research in Asia, Oceania, the Middle East, and Africa and reaped a rich harvest of ethnographic materials. It quickly became clear to them that the so-called “traditional” house developed, in imitation of palaces and temples, from the culture of a given population and that it was informed by the religious images of the inhabitants as much as by its most sacred buildings. (shrink)

For Dōgen, the Buddhist doctrine of “no self” ultimately presents the self as contextualized. The self is for him not an independent entity, but is intricately related to its environment, determined through the many beings around it. In a quite different philosophical setting, Spinoza developed similar ideas. While Dōgen challenged the specifics of a tradition that explicitly argues against the idea of an absolute self, Spinoza faced a more radical challenge: questioning an absolute, unchanging, and free self that the Western (...) tradition has mostly taken for granted. After an analysis of the ideas of the two thinkers, the essay presents some important implications for contemporary times. Our domination of the earth and one another is arguably rooted in the individualism Dōgen and Spinoza seek to overcome. The insight that we are contextualized is a first step toward re-determining ourselves as placed within a larger whole. (shrink)

El texto aquí traducido presenta una lectura de Sein und Zeit efectuada por Gérard Granel. En ella aborda la relación que allí se establece con la metafísica comparándola con las posiciones de Feuerbach y Husserl, también aborda la cuestión de la circularidad explicativa del libro de Heidegger exponiendo en qué modo su particular postura ante la metafísica implica necesariamente proceder con este método mostrativo a diferencia del método descriptivo ya situado ante lo que se muestra: La circularidad de los (...) conceptos no cae en una circularidad argumental porque, precisamente, permite hacer ver o llegar a mostrar aquello de que se trata y que, dado su carácter necesariamente fragmentario, no puede mantenerse simplemente a la presencia para proceder con el método descriptivo. Además, sostiene y muestra en qué modo en Ser y Tiempo ya está contenido el pensamiento posterior de Heidegger. (shrink)

Tous les ans, les anciens bûcherons Balâmi vivant à la périphérie de la vallée de Katmandou (Népal) donnent des représentations théâtrales très ritualisées à l’intention des habitants des agglomérations voisines, dont la petite ville de Pharping. Ces performances mettent en scène de vieilles histoires royales dont l’intrigue varie légèrement d’années en années. Elles sont ponctuées d’épisodes comiques. Les émotions qu’expriment les acteurs constituent un ressort essentiel du drame, notamment les larmes des princesses qui voient périr leur mari. Le jeu reste (...) extrêmement codifié et entouré de croyances religieuses. Ces pièces se terminent par des sacrifices d’animaux offerts aux divinités patronnes de la troupe. Issues du théâtre néwar classique de l’époque Malla ( xvii e - xviii e siècle particulièrement), elles témoignent de puissantes interactions entre traditions populaires et littérature plus savante. (shrink)