The “DNA is a program” metaphor is still widely used in Molecular Biology and its popularization. There are good historical reasons for the use of such a metaphor or theoretical model. Yet we argue that both the metaphor and the model are essentially inadequate also from the point of view of Physics and Computer Science. Relevant work has already been done, in Biology, criticizing the programming paradigm. We will refer to empirical evidence and theoretical writings in Biology, although our arguments (...) will be mostly based on a comparison with the use of differential methods (in Molecular Biology: a mutation or alike is observed or induced and its phenotypic consequences are observed) as applied in Computer Science and in Physics, where this fundamental tool for empirical investigation originated and acquired a well-justified status. In particular, as we will argue, the programming paradigm is not theoretically sound as a causal(as in Physics) or deductive(as in Programming) framework for relating the genome to the phenotype, in contrast to the physicalist and computational grounds that this paradigm claims to propose. (shrink)

We experience our own body through both touch and vision. We further see that others’ bodies are similar to our own body, but we have no direct experience of touch on others’ bodies. Therefore, relations between vision and touch are important for the sense of self and for mental representation of one’s own body. For example, seeing the hand improves tactile acuity on the hand, compared to seeing a non-hand object. While several studies have demonstrated this visual enhancement of touch (...) effect, its relation to the ‘bodily self’, or mental representation of one’s own body remains unclear. We examined whether VET is an effect of seeing a hand, or of seeing my hand, using the rubber hand illusion. In this illusion, a prosthetic hand which is brushed synchronously—but not asynchronously—with one’s own hand is felt to actually be one’s hand. Thus, we manipulated whether or not participants felt like they were looking directly at their hand, while holding the actual stimulus they viewed constant. Tactile acuity was measured by having participants judge the orientation of square-wave gratings. Two characteristic effects of VET were observed: cross-modal enhancement from seeing the hand was inversely related to overall tactile acuity, and participants near sensory threshold showed significant improvement following synchronous stroking, compared to asynchronous stroking or no stroking at all. These results demonstrate a clear functional relation between the bodily self and basic tactile perception. (shrink)

Saggio storico-pedagogico costruito su scritti editi e inediti di Elena Marano, pedagogista, filantropa, scrittrice vissuta tra la il XIX e il XX secolo ad Adrano (Ct). Ancorato alla pedagogia tradizionale, il suo pensiero trae alimento da ideologi del Risorgimento (Mazzini e Gioberti), si confronta con studiosi e intellettuali coevi, si apre a forme di rigenerazione didattico-educative i cui temi precorrono la contemporaneità: riposizionamento morale per contrastare emergenza educativa, istruzione diffusa per abbattere disagio sociale e analfabetismo, formazione delle bambine per favorire (...) cittadinanza femminile e inserimento delle donne nella società, relazionalità produttiva e funzione pedagogica del lavoro per conseguire «quella legalità che è attributo dello Stato». Diversi gli aspetti dell'educazione – morale, intellettuale, civile...– che, avviando corresponsabilità educativa tra docente e studente, scuola e famiglia, costituiscono strumento di interazione tra le discipline e l'unità di pensiero, necessaria diade per la deduzione del vero. (shrink)

How do we prove true but unprovable propositions? Gödel produced a statement whose undecidability derives from its ad hoc construction. Concrete or mathematical incompleteness results are interesting unprovable statements of formal arithmetic. We point out where exactly the unprovability lies in the ordinary ‘mathematical’ proofs of two interesting formally unprovable propositions, the Kruskal-Friedman theorem on trees and Girard's normalization theorem in type theory. Their validity is based on robust cognitive performances, which ground mathematics in our relation to space and time, (...) such as symmetries and order, or on the generality of Herbrand's notion of ‘prototype proof’. (shrink)

Very large databases are a major opportunity for science and data analytics is a remarkable new field of investigation in computer science. The effectiveness of these tools is used to support a “philosophy” against the scientific method as developed throughout history. According to this view, computer-discovered correlations should replace understanding and guide prediction and action. Consequently, there will be no need to give scientific meaning to phenomena, by proposing, say, causal relations, since regularities in very large databases are enough: “with (...) enough data, the numbers speak for themselves”. The “end of science” is proclaimed. Using classical results from ergodic theory, Ramsey theory and algorithmic information theory, we show that this “philosophy” is wrong. For example, we prove that very large databases have to contain arbitrary correlations. These correlations appear only due to the size, not the nature, of data. They can be found in “randomly” generated, large enough databases, which—as we will prove—implies that most correlations are spurious. Too much information tends to behave like very little information. The scientific method can be enriched by computer mining in immense databases, but not replaced by it. (shrink)

As systems based on opaque Artificial Intelligence (AI) continue to flourish in diverse real-world applications, understanding these black box models has become paramount. In response, Explainable AI (XAI) has emerged as a field of research with practical and ethical benefits across various domains. This paper not only highlights the advancements in XAI and its application in real-world scenarios but also addresses the ongoing challenges within XAI, emphasizing the need for broader perspectives and collaborative efforts. We bring together experts from diverse (...) fields to identify open problems, striving to synchronize research agendas and accelerate XAI in practical applications. By fostering collaborative discussion and interdisciplinary cooperation, we aim to propel XAI forward, contributing to its continued success. Our goal is to put forward a comprehensive proposal for advancing XAI. To achieve this goal, we present a manifesto of 27 open problems categorized into nine categories. These challenges encapsulate the complexities and nuances of XAI and offer a road map for future research. For each problem, we provide promising research directions in the hope of harnessing the collective intelligence of interested stakeholders. (shrink)

The dependence on history of both present and future dynamics of life is a common intuition in biology and in humanities. Historicity will be understood in terms of changes of the space of possibilities as well as by the role of diversity in life’s structural stability and of rare events in history formation. We hint to a rigorous analysis of “path dependence” in terms of invariants and invariance preserving transformations, as it may be found also in physics, while departing from (...) the physico-mathematical analyses. The idea is that the invariant traces of the past under organismal or ecosystemic transformations contribute to the understanding of present and future states of affairs. This yields a peculiar form of unpredictability in biology, at the core of novelty formation: the changes of observables and pertinent parameters may depend also on past events. In particular, in relation to the properties of synchronic measurement in physics, the relevance of diachronic measurement in biology is highlighted. This analysis may a fortiori apply to cognitive and historical human dynamics, while allowing to investigate some general properties of historicity in biology. (shrink)

This authored monograph introduces a genuinely theoretical approach to biology. Starting point is the investigation of empirical biological scaling including their variability, which is found in the literature, e.g. allometric relationships, fractals, etc. The book then analyzes two different aspects of biological time: first, a supplementary temporal dimension to accommodate proper biological rhythms; secondly, the concepts of protension and retention as a means of local organization of time in living organisms. Moreover, the book investigates the role of symmetry in biology, (...) in view of its ubiquitous importance in physics. In relation with the notion of extended critical transitions, the book proposes that organisms and their evolution can be characterized by continued symmetry changes, which accounts for the irreducibility of their historicity and variability. The authors also introduce the concept of anti-entropy as a measure for the potential of variability, being equally understood as alterations in symmetry. By this, the book provides a mathematical account of Gould's analysis of phenotypic complexity with respect to biological evolution. The target audience primarily comprises researchers interested in new theoretical approaches to biology, from physical, biological or philosophical backgrounds, but the book may also be beneficial for graduate students who want to enter this field. (shrink)

BIG DATA AND ARTIFICIAL INTELLIGENCE: A LOOK INTO THE FUTURE To say or write something innovative on the ongoing revolution in the fields of Big Data and Artificial Intelligence is very difficult. The advent of these two new technologies is in fact among the most relevant events in human history since in a little more than a decade it will likely lead to the creation of the First Artificial Intelligence of the Fourth level: i.e capable to think and create autonomously. (...) This is a strong statement but like it or not is also irrefutable and fully compatible with the current technological trends and with what is happening right now, in front of our eyes. For the time being, however, we are dealing just with a weak Artificial Intelligence deeply rooted in Big Data and Big Data Analytics. Even so, however, the epochal changes which are currently taking place in the social, economic, and political structure of our world, have no historical equivalent. In this essay, after a short introduction (for the nonprofessional) of Machine Learning and of the basics of the weak Artificial Intelligence, I will try to explain why Artificial Intelligence and Big Data inextricably connect to each other. I will also try to summarise some among the many positive and negative aspects of the problem. (shrink)

Digital technology has prompted philosophers to rethink some of the fundamental categories we use to make sense of the world and ourselves. Particularly, the concept of ‘identity’ and its reconfiguration in the digital age has sparked much debate in this regard. While many studies have addressed the impact of the digital on personal and social identities, the concept of ‘collective identity’ has been remarkably absent in such inquiries. In this article, I take the context of social movements as an entry (...) point to discuss the reconfiguration of collective identity in social media environments. I do so by introducing a narrative approach to collective identity. I argue that Twitter’s affordances invite new ways of constructing collective identities and imply a shifting relationship between the individual and the collective. (shrink)

Il brano del "Fedro" (269el-270c5) in cui è menzionato Ippocrate e il suo metodo è uno dei più controversi dell'opera platonica. Alcuni studiosi si sono serviti degli scolî antichi al dialogo, tramandati sotto il nome del neoplatonico Ermia (V sec. d. C.), per sostenere che il metodo in questione non implica un'indagine preliminare dell'universo. È tuttavia utile (oltreché finora intentato) ripercorrere quanto l'esegeta neoplatonico dice a proposito dell'intero brano in questione per constatare come egli, al contrario, ne fornisca un'interpretazione cosmologica, (...) sulla base della significazione tecnica di ἡ ὅλη ψυχή come "anima dell'universo". In ogni caso l'esegesi di Ermia risulta essere non una semplice parafrasi grammaticale del testo platonico, ma anche una sua riformulazione filosofica nei termini della dottrina neoplatonica, la quale è estremamente complessa anche nel caso dell'anima umana. (shrink)

Human mental workload is arguably the most invoked multidimensional construct in Human Factors and Ergonomics, getting momentum also in Neuroscience and Neuroergonomics. Uncertainties exist in its characterization, motivating the design and development of computational models, thus recently and actively receiving support from the discipline of Computer Science. However, its role in human performance prediction is assured. This work is aimed at providing a synthesis of the current state of the art in human mental workload assessment through considerations, definitions, measurement techniques (...) as well as applications, Findings suggest that, despite an increasing number of associated research works, a single, reliable and generally applicable framework for mental workload research does not yet appear fully established. One reason for this gap is the existence of a wide swath of operational definitions, built upon different theoretical assumptions which are rarely examined collectively. A second reason is that the three main classes of measures, which are self-report, task performance, and physiological indices, have been used in isolation or in pairs, but more rarely in conjunction all together. Multiple definitions complement each another and we propose a novel inclusive definition of mental workload to support the next generation of empirical-based research. Similarly, by comprehensively employing physiological, task-performance, and self-report measures, more robust assessments of mental workload can be achieved. (shrink)

Plasticity of body representation fundamentally underpins human tool use. Recent studies have demonstrated remarkably complex plasticity of body representation in humans, showing that such plasticity (1) occurs flexibly across multiple time scales and (2) involves multiple body representations responding differently to tool use. Such findings reveal remarkable sophistication of body plasticity in humans, suggesting that Vaesen may overestimate the similarity of such mechanisms in humans and non-human primates.

An images is build up of elements placed in a fix reciprocal positions. In this way an image is able to organize a block of space-time extracted from becoming and offered as a crystallized present, this notion imply Chronos notion of time. How would spatial co-ordinates work on the time line of Aîon , where present can’t exist? We are going to answer this question by analyzing Robert Smithson’s Monuments of Passaic.

Manufacturing and industry practices are undergoing an unprecedented revolution as a consequence of the convergence of emerging technologies such as artificial intelligence, robotics, cloud computing, virtual and augmented reality, among others. This fourth industrial revolution is similarly changing the practices and capabilities of operators in their industrial environments. This paper introduces and explores the notion of the Operator 4.0 as well as how this novel way of conceptualizing the human operator necessarily implicates human values in the technologies that constitute it. (...) The design approach known as value sensitive design (VSD) is used to explore how these Operator 4.0 technologies can be designed for human values. Expert elicitation surveys were used to determine the values of industry stakeholders and examples of how the VSD methodology can be adopted by engineers in order to design for these values is illustrated. The results provide preliminary adoption strategies that industrial teams can take to Operator 4.0 technology for human values. (shrink)