New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division (...) and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology. (shrink)

Suggests an open system of psychological exploration to cut through accepted norms of morality, language, and politics.

Deleuze and Guattari differentiate between philosophy, science, and the arts - seeing each as a means of confronting chaos - and challenge the common view that philosophy is an extension of logic. The authors also discuss the similarities and distinctions between creative and philosophical writing. Fresh anecdotes from the history of philosophy illuminate this book, along with engaging discussions of composers, painters, writers, and architects.

For those not yet acquainted with the work of this philosopher, this book provides a point of entry to his complex theories. For those more familiar with Deleuze, this collection should be useful in broadening their understanding of this influential thinker's journey in search of knowledge.

Il faudrait que le dialogue se fasse, non pas entre des personnes, mais entre les lignes, entre des chapitres ou des parties de chapitre. Ce seraient les vrais personnages. Perdre la mémoire : il faudrait plutôt dresser des " blocs ", les faire flotter. Un bloc d'enfance n'est pas un souvenir d'enfant. Un bloc nous accompagne, est toujours anonyme et contemporain, et fonctionne dans le présent - Oublier l'histoire : la question des devenirs, et de leur géographie. Un devenir-révolutionnaire est (...) plus important que l'avenir ou le passé de la révolution. Un devenir-femme, un devenir-animal sont plus importants que la différence des sexes et des règnes - Ne pas " faire le point " : plutôt tracer des lignes. Les lignes n'ont pas d'origine, et poussent par le milieu. On ne fait jamais table rase, on est toujours au milieu de quelque chose, comme l'herbe. Plus on prend le monde là où il est, plus on a de chance de le changer... Se séparer de l'appareil d'Etat et de tout système qui le prend pour modèle ou veut le conquérir : la présence diffuse de machines de guerre irréductibles au modèle d'Etat, toute une histoire populaire qui n'a pas été recueillie, un nomadisme même immobile. Devenir ou re-devenir marxiste : aucune analyse n'est possible si elle ne porte aussi sur les mécanismes industriels et surtout financiers dans un champ social. Non pas suprême instance, mais lignes, et régimes de signes, qui s'enchaînent avec les autres, et dont les flottaisons s'agencent avec d'autres flux. (shrink)

Praised for its rare combination of scholarly rigor and imaginative interpretation, _Nietzsche and Philosophy_ has long been recognized as one of the most important analyses of Nietzsche. It is also one of the best introductions to Deleuze's thought, establishing many of his central philosophical positions. In _Nietzsche and Philosophy_, Deleuze identifies and explores three crucial concepts in Nietzschean thought-multiplicity, becoming, and affirmation-and clarifies Nietzsche's views regarding the will to power, eternal return, nihilism, and difference. For Deleuze, Nietzsche challenged conventional philosophical (...) ideas and provided a means of escape from Hegel's dialectical thinking, which had come to dominate French philosophy. He also offered a path toward a politics of difference. In this new edition, Michael Hardt's foreword examines the profound influence of Deleuze's provocative interpretations on the study of Nietzsche, which opened a whole new avenue in postwar thought. (shrink)

Considered one of the most important works of one of France's foremost philosophers, and long-awaited in English, "The Logic Of Sense" is an essay in literary and psychoanalytic theory, and philosophy, and helps to illuminate such works as "Anti-Oedipus".

This brilliant exposition of the critique of identity is a classic in contemporary philosophy and one of Deleuze's most important works. Of fundamental importance to literary critics and philosophers,Difference and Repetition develops two central concepts—pure difference and complex repetition&mdasha;and shows how the two concepts are related. While difference implies divergence and decentering, repetition is associated with displacement and disguising. Central in initiating the shift in French thought away from Hegel and Marx toward Nietzsche and Freud, _Difference and Repetition_ moves deftly (...) to establish a fundamental critique of Western metaphysics. (shrink)

A critical examination of the figure of Oedipus in psychoanalysis and Western culture as it relates to the history of society and capitalism.

ABSTRACTNegative emotion influences cognitive control, and more specifically conflict adaptation. However, discrepant results have often been reported in the literature. In this study, we broke down negative emotion into integral and incidental components using a modern motivation-based framework, and assessed whether the former could change conflict adaptation. In the first experiment, we manipulated the duration of the inter-trial-interval to assess the actual time-scale of this effect. Integral negative emotion was induced by using loss-related feedback contingent on task performance, and measured (...) at the subjective and physiological levels. Results showed that conflict-driven adaptive control was enhanced when integral negative emotion was elicited, compared to a control condition without changes in defensive motivation. Importantly, this effect was only found when a short, as opposed to long ITI was used, suggesting that it had a short time scale. In the second experiment, we controlled for effe... (shrink)

A criticism of the book "a la recherche du temps perdu".

Here, I lay the foundations of a high-level ontology of particulars whose structuring principles differ radically from the 'continuant' vs. 'occurrent' distinction traditionally adopted in applied ontology. These principles are derived from a new analysis of the ontology of “occurring” or “happening” entities. Firstly, my analysis integrates recent work on the ontology of processes, which brings them closer to objects in their mode of existence and persistence by assimilating them to continuant particulars. Secondly, my analysis distinguishes clearly between processes and (...) events, in order to make the latter abstract objects of thought (alongside propositions). Lastly, I open my ontological inventory to properties and facts, the existence of which is commonly admitted. By giving specific roles to these primitives, the framework allows one to account for static and dynamic aspects of the physical world and for the way that subjects conceive its history: facts account for the life of substances (physical objects and processes), whereas events enable cognitive subjects to account for the life story of substances. (shrink)

In this essay, we aim to help clarify the nature of so-called 'occurrences' by attributing distinct modes of existence and persistence to processes and events. In doing so, we break with the perdurantism claimed by DOLCE’s authors and we distance ourselves from mereological analyzes like those recently conducted by Guarino to distinguish between 'processes' and 'episodes'. In line with the works of Stout and Galton, we first bring closer (physical) processes and objects in their way of enduring by proposing for (...) processes a notion of dynamic presence (contrasting with a static presence for objects). Then, on the events side, we attribute to them the status of abstract entities by identifying them with objects of thought (by individual and collective subjects), and this allows us to distinguish for themselves between existence and occurrence. We therefore identify them with psychological (or even social) endurants, which may contingently occur. (shrink)

The following text is not just unpublished. There is something intimate, secret, confidential about it. It consists of a series of notes - classed from A to H - that Gilles Deleuze had entrusted to me in order that I give them to Michel Foucault. It was in 1977. Foucault had just published La Volonté de savoir, the introduction to a Histoire de la Sexualité which challenged the play of categories through which the struggles of sexual liberation reflected itself. (...) The reception of the book, poorly understood, was contemporary with a sort of crisis in Foucault, already wholly bent to the task of bringing out of himself, and converting himself to, what would become the problematic of L'usage de plaisirs and the Souci de soi. Gilles Deleuze, sensitive to what he perceives as a suffering in his friend, thus writes up these notes: therein he gives the account of his convergences and divergences with Foucault. It is not a matter of a critique, even less of a polemic, but of an invitation, entirely imbued with the sincerity of friendship, to take up again a dialogue which had been interrupted. (shrink)

Most models of response time (RT) in elementary cognitive tasks implicitly assume that the speed-accuracy trade-off is continuous: When payoffs or instructions gradually increase the level of speed stress, people are assumed to gradually sacrifice response accuracy in exchange for gradual increases in response speed. This trade-off presumably operates over the entire range from accurate but slow responding to fast but chance-level responding (i.e., guessing). In this article, we challenge the assumption of continuity and propose a phase transition model for (...) RTs and accuracy. Analogous to the fast guess model (Ollman, 1966), our model postulates two modes of processing: a guess mode and a stimulus-controlled mode. From catastrophe theory, we derive two important predictions that allow us to test our model against the fast guess model and against the popular class of sequential sampling models. The first prediction—hysteresis in the transitions between guessing and stimulus-controlled behavior—was confirmed in an experiment that gradually changed the reward for speed versus accuracy. The second prediction—bimodal RT distributions—was confirmed in an experiment that required participants to respond in a way that is intermediate between guessing and accurate responding. (shrink)

Le langage est, pour l'homme, a la fois outil et objet. Philosopher sur le langage, c'est donc s'interroger a la fois sur les formes et les limites de son pouvoir, st sur l'etrange nature de cette realite exterieure a nous et dont nous ne pouvons pourtant dissocier ce que nous appelons notre pensee. L'auteur, par inclination personnelle et non point par principe, choisit d'orienter son enquete selon le point de vue de la connaissance scientifique. Ainsi se propose-t-il d'abord de definir (...) le role que joue le langage dans la constitution de la science. Il est alors conduit a examiner les pseudo-langages que celle-ci se construit, et, en precisant la fonction du symbolisme dans la connaissance objective, il met en lumiere, dans ce domaine, le privilege et l'infirmite des langues naturelles. C'est alors cette notion de langue naturelle qui devient le theme de sa reflexion : le linguiste en veut faire l'objet d'une science. Comment determine-t-il cet objet, par quelles demarches parvient-il a sa connaissance, qu'est-ce enfin qu'une " science du langage "? Sur cette science, encore aujourd'hui peut-etre a l'etat naissant, le philosophe ne peut faire de pronostics. Du moins lui appartient-il, en dehors des querelles d'ecoles, de tenter de reconnaitre jusqu'ou l'on s'est avance dans la voie du savoir. (shrink)

Tous deux résistants, Cavaillès et Lautmann ont été fusillés par les Allemands.Ils étaient l’un et l’autre « philosophes des mathématiques », mais leur réflexion proprement philosophique porte sur les rapports des mathématiques et de la logique, et, plus généralement, sur la pensée formelle.À la notion lautmanienne de « dialectique » mathématique, s’oppose – ou du moins se juxtapose –, du côté de Cavaillès, l’idée de la nécessité interne d’une histoire des concepts.Both resisting during WWII, Cavaillès et Lautmann were shot by (...) the Germans.Both were « philosophers of maths » but their true philosophical thoughts deal with the relationships between mathematics and logics and, more specifically, with formal thought.To the Lautmanian reflection on mathematical « dialectics », Cavaillès opposes – or rather, juxtaposes – the idea of an internal necessity of a history of concepts. (shrink)

L’étude des troubles de la voix et de la parole est sortie du cadre de la recherche clinique. Par l’observation des dysfonctionnements, les chercheurs non cliniciens confrontent les résultats de leur recherche établis sur des corpus de parole « normale » à des situations de dysfonctionnement. Le défi est immense car le cadre « pathologique » induit une variation considérable dans ses manifestations de surface. Toute généralisation à une population clinique particulière nécessite l’observation d’un grand nombre de patients du fait (...) de la très forte variation interindividuelle. Il est donc important de capitaliser et mutualiser les enregistrements existants. Or pour être utilisables, ces enregistrements doivent répondre à de fortes exigences. Le maillon faible reste la normalisation et la structuration des données sur les locuteurs et leurs productions langagières. Concrètement, si les données sonores sont souvent accessibles, elles ne présentent au final aucun intérêt si les liens entre les enregistrements et les caractéristiques cliniques du locuteur sont rompus ou erronés. L’objectif de ce travail est de présenter différentes actions de terrain et de proposer des recommandations pour la structuration des données sonores, physiologiques et cliniques dans le cas de corpus de parole issue de patients atteints de troubles de la voix et de la parole. (shrink)

L’auteur a déjà introduit les concepts de “contenu formel” et “dualité” dans des publications antérieures, avec l’intention d’éclairer les problèmes suscités par la fécondité de la pensée formelle. Cet article a pour objectif d’établir leur relation et articulation. Le terme “dualité” est emprunté aux mathématiques. Il désigne une catégorie fondamentale de la pensée objective, dans la mesure où il est défini comme un principe de détermination réciproque pour n’importe quel système d’objets et le système d’opérations auquel il est nécessairement associé. (...) Son caractère fundamental en tant que catégorie tient essentiellement au fait d’être une condition transcendentale pour n’importe quelle espèce de pensée symbolique objective. Par le principe de dualité, on peut établir de façon générale la signification de l’opposition du contenu et de la forme, et celle de la détermination des contenus par de simples formes, indépendemment de leur origine empirique. La forme logique est alors définie comme le “degré zéro” d’une telle opposition. Des exemples de production de contenus formels dans les processus scientifiques sont examinés et considérés comme des preuves d’une dialectique interne des concepts, principalement dans le domaine des mathématiques. Dans la conclusion, nous proposons l’examen de deux questions : 1) Est-il approprié de concevoir un niveau de pensée formelle plus profond que celui de la Logique, et comment pourrions-nous y accéder? 2) Comment des contenus purement formels peuvent-ils produire des connaissances applicables au monde empirique ? Ce problème n’est qu’une nouvelle formulation de la vieille énigme de la déduction transcendentale.The author has introduced the concepts of “formal content” and “duality” in previous papers, with a view to shedding light on the problems posed by the fecundity of formal thought. The present work is an attempt to show their relationship and articulation. The term “duality” has been borrowed from mathematics. It designates a fundamental category of objective thinking, in so far as it is defined as a principle of reciprocal determination for every system of objects and the system of operations to which it is necessarily associated. The fundamental character of duality as a category essentially lies in its being a transcendental condition for every symbolic kind of objective thought. Through the principle of duality, one can give its more general meaning to the opposition of content to form, and to the determination of contents by mere forms, independent of empirical import. Logical form is then defined as the “zero degree” of such an opposition. Examples of the production of formal contents in scientific processes are examined, and considered as evidence of an internal dialectics of concepts, principally in the field of mathematics. In the conclusion, two questions are proposed: 1) Is it appropriate to conceive of a level of formal thought, deeper than the level of Logics, and how could we try to approach it? 2) How do pure formal contents come to generate knowledge applicable to the empirical world? This problem is, under new guise, the old transcendental deduction enigma. (shrink)

Le pli a toujours existé dans les arts, mais le propre du Baroque est de porter le pli à l'infini. Si la philosophie de Leibniz est baroque par excellence, c'est parce que tout se plie, se déplie, se replie. Sa thèse la plus célèbre est celle de l'âme comme " monade " sans porte ni fenêtre, qui tire d'un sombre fond toutes ses perceptions claires : elle ne peut se confondre que par analogie avec l'intérieur d'une chapelle baroque, de marbre (...) noir, où la lumière n'arrive que par des ouvertures imperceptibles à l'observateur du dedans : aussi l'âme est-elle pleine de plis obscurs. Pour découvrir un néo-Baroque moderne, il suffit de suivre l'histoire du pli infini dans tous les arts : " pli selon pli " avec la poésie de Mallarmé et le roman de Proust, mais aussi l'œuvre de Michaux, la musique de Boulez, la peinture de Hantaï. Et ce néoleibnizianisme n'a cessé d'inspirer la philosophie. (shrink)

The aim of the present article is to examine the paradox that while Bourdieu appears to be highly favorable to Marx, there is a radical disagreement between their two theoretical systems. In Bourdieu’s writing, comments favorable to Marx outweigh criticism by a ratio of 4,5 to 1. Marxists, in contrast, come in for ten times more criticism than support. Bourdieu’s approval of Marx in fact concerns only what are secondary aspects, while the few critiques he addresses delineate a structural opposition (...) between the two authors. Bourdieu rejects the theory of surplus value, the Marxist theory of exploitation, and the communist project. Among other things, he draws up a critique of Marx’s analyses of the State, legitimation, social classes. Explanation for the paradox is to be sought in the strategy deployed by Bourdieu in the field of the social sciences. (shrink)

The flames of Alexandria continue to rage. After twenty centuries, they still dazzle us, as though the Mouseion were the only massacred library. One would believe that Julius Caesar, Theophilus of Antioch and Omar (the three pyromaniacs, the pagan, the Christian and the Moslem) had had no predecessors or imitators. But the race of incendiaries is as numerous as the waves of the sea. It is monotonous, it is indestructible, it is equal to that of the ants. It was born (...) at the same time as the first Babylonian tablets. In 1988, it continues its work. All over the world and in all times, the incendiaries were there with their torches. They burned parchments, wood or clay tablets, leather manuscripts, papyrus or folios. The same warriors who profaned temples set fire to incunabula. The same ones who slaughtered the Aztecs threw their firebrands into the collection of codices. What is it, this unleashed fury of prince and priest, judge and soldier against these small monuments of clay or paper, against these sepulchres in which the dead say that they have lived and loved, suffered and hoped? (shrink)

Tratamos neste artigo de algumas questões concernentes aos aspectos do pensamento nas obras científicas e à relação entre ciência e filosofia.