Although early‐life adversity has been associated with negative consequences during adulthood, growing evidence shows that such adversity can also lead to subsequent stress resilience and positive fitness outcomes. Telomere dynamics are relevant in this context because of the link with developmental conditions and longevity. However, few studies have assessed whether the effects of early‐life adversity on developmental telomere dynamics may relate to adult telomere dynamics. We propose that the potential links between early‐life adversity and adult telomere dynamics could be driven (...) by developmental constraints (the Constraint hypothesis), by the nature/severity of developmental adversity (the Resilience hypothesis), or by developmental‐mediated changes in individual life‐history strategies (the Pace of Life hypothesis). We discuss these non‐mutually exclusive hypotheses, explore future research directions, and propose specific studies to test these hypotheses. Our article aims to expand our understanding of the evolutionary role of developmental conditions on adult telomere dynamics, stress resilience and ageing. (shrink)

The complexity of the physiological phenotype currently prevents us from identifying an integrative measure to assess how the internal state and environmental conditions modify life‐history strategies. In this article, it is proposed that shorter telomeres should lead to a faster pace‐of‐life where investment in self‐maintenance is decreased as a means of saving energy for reproduction, but at the cost of somatic durability. Inversely, longer telomeres would favor an increased investment in soma maintenance and thus a longer reproductive lifespan (i.e., slower (...) pace‐of‐life). Under this hypothesis, telomere dynamics could be such an integrative mediator, which will assemble the information about oxidative stress levels, inflammation status and stress reactivity, and relate this information to the potential lifespan of the organism and its pace‐of‐life strategy. The signaling function of telomere dynamics can also reach over generations, a phenomenon in which the telomere lengths of gametes would provide a channel through which offspring would receive information about their environment early in their development, hence increasing the possibilities for developmental plasticity. -/- . (shrink)

The idea that deep brain stimulation (DBS) induces changes to personality, identity, agency, authenticity, autonomy and self (PIAAAS) is so deeply entrenched within neuroethics discourses that it has become an unchallenged narrative. In this article, we critically assess evidence about putative effects of DBS on PIAAAS. We conducted a literature review of more than 1535 articles to investigate the prevalence of scientific evidence regarding these potential DBS-induced changes. While we observed an increase in the number of publications in theoretical neuroethics (...) that mention putative DBS-induced changes to patients’ postoperative PIAAAS, we found a critical lack of primary empirical studies corroborating these claims. Our findings strongly suggest that the theoretical neuroethics debate on putative effects of DBS relies on very limited empirical evidence and is, instead, reliant on unsubstantiated speculative assumptions probablyin lieuof robust evidence. As such, this may reflect the likelihood of a speculative neuroethics bubble that may need to be deflated. Nevertheless, despite the low number of first-hand primary studies and large number of marginal and single case reports, potential postoperative DBS changes experienced by patients remain a critical ethical concern. We recommend further empirical research in order to enhance theoretical neuroethics work in the area. In particular, we call for the development of better instruments capable of capturing potential postoperative variations of PIAAAS. (shrink)

We argue that a fashionable interpretation of the theory of natural selection as a claim exclusively about populations is mistaken. The interpretation rests on adopting an analysis of fitness as a probabilistic propensity which cannot be substantiated, draws parallels with thermodynamics which are without foundations, and fails to do justice to the fundamental distinction between drift and selection. This distinction requires a notion of fitness as a pairwise comparison between individuals taken two at a time, and so vitiates the interpretation (...) of the theory as one about populations exclusively. (shrink)

Recent years have featured the existence of a variety of structuralisms, with an important partition between methodological versus philosophical structuralism. Inside philosophical structuralism, many trends can be identified, corresponding to various ontological stances. We argue here that another main partition has contributed to organize structuralism in the twentieth century, rooted in different technical and theoretical interests. This partition is largely transversal to the ones classically identified. Concretely, the paper will focus on possible differences between an arithmetical and logical notion of (...) structure that can be traced back to the writings of Bertrand Russell and Rudolf Carnap, and a mathematical notion of structure, exemplified in the works by Bourbaki. This coexistence gives rise to a fundamental ambiguity that affects contemporary structuralism. Philosophically, in one case the attention is rather centered on a foundational and reductionist perspective, as featured by the Whitehead-Russell Principia and the Carnapian project of the Aufbau: the scientific construction of the world around the idea of structure. In the other, the focus is on epistemological and dynamical issues, as exemplified by two key issues in Bourbaki’s treatise: understanding the architecture of mathematics, offering a tool-kit to mathematicians. These two distinct meanings still coexist inside contemporary scientific practices and lead to different theoretical interests, as we will show thanks to various recent examples. (shrink)

A view inherited from Max Weber states that purposive rational action, value rational action and affective action are three distinct types of social action that can compete, oppose, complement or substitute each other in social explanations. Contrary to this statement, I will defend the view that these do not constitute three different types of social actions, but that social actions always seem to concurrently involve rationality, normativity and affectivity. I show this by discussing the links between rational actions and consequentialism (...) and non-consequentialism, and by elaborating on certain major relationships between rationality, normativity and emotions. (shrink)

Mathematical continuity, in the technical sense, is a precisely definable mathematical notion which refers to certain properties of numbers and number sequences. The continuity of the physical world, on the other hand, is rather different from mathematical continuity, since it is a directly experienced attribute of nature and does not require, for being understood, any mathematical theory of properties of numbers.

O'Regan & Noë (O&N) argue that there is no need of internal, more or less picture-like, representation of the visual world in the brain. They propose a new approach in which vision is a mode of exploration of the world that is mediated by knowledge of sensorimotor contingencies. Data obtained in “change blindness” experiments support this assumption.

Sensory cues provided by compression garments can improve movement accuracy and potentially reduce inter-limb balance asymmetries and the associated risk of injury. The aim of this study was to analyze the effects of CG wearing on inter-limb balance asymmetries. The hypothesis was that CG would reduce inter-limb balance asymmetries, especially in subjects with high level of asymmetries. Twenty-five sportsmen were recruited. They had to stand as motionless as possible in a one-leg stance in two postural tasks, while wearing CG or (...) not. Asymmetry indexes were calculated from center of foot pressure parameters. The effects of CG wearing were analyzed according to participants’ baseline level of asymmetry with correlation analyses. A qualitative analysis was also performed after a dichotomization procedure to check for a specific influence of CG on the dominant and non-dominant leg. Inter-limb balance asymmetries were reduced with CG in participants with high levels of asymmetries at baseline. However, asymmetries were increased with CG in participants with low levels of asymmetries at baseline. The dominant leg was more affected by this negative effect. CG wearing could reduce inter-limb balance asymmetries and the related injury risk in subjects with high levels of inter-limb balance asymmetries at baseline. Nevertheless, CG should not be used in individuals with low baseline balance asymmetries since it can increase asymmetries in these subjects, likely by confusing and overloading the sensorimotor processing on the dominant leg. (shrink)

This paper examines the correspondence and contacts between Galileo and a number of French intellectuals. It demonstrates that exchanges between Galileo and those Frenchmen did much to stimulate an interest in new scientific ideas in France, especially in astronomy; for example, Galileo provided a number of good telescopic lenses that did much to establish observational astronomy in France. The Frenchmen for their part provided Galileo with considerable useful information. Several were very active in his support after the condemnation of 1633 (...) and in publishing his later works. The paper further demonstrates the extent of the network of intellectuals who corresponded with Galileo and each other across Europe in the early seventeenth century. (shrink)

Il ne suffit plus de s'interroger sur l'art littéraire mis au service de la composition des récits bibliques ; il faut poser aux textes eux-mêmes la question de la littérature, discerner l'effet de la littérature sur ce qu'on appelle la Bible. Car la littérature n'est pas un simple effet construit, mais d'abord, culturellement, un mode d'expression qui induit également une réception, une compréhension de ce qu'il exprime. L'exemple de l'appel d'Abraham et de la “ ligature d'Isaac ”, le rappel de (...) la création et la figure de Job ouvrent à cette dimension littéraire essentielle à la Bible qui ne se contente pas d'échanger ou de transmettre des expériences, mais se définit elle-même comme expérience ou épreuve adressée à ses lecteurs.It is no longer enough to question oneself about literary art put to the service of the composition of biblical narratives. One must put the question of literature to the texts themselves, discern the effect of literature on that which one calls the Bible. For literature is just no simply composed, but above all a cultural type of expression that calls for a reception, an understanding of that which it expresses. The examples of the call of Abraham, and the "binding of Isaac ", the recall of creation and the figure of job, give this a literary dimension that is essential to the Bible, which does not stop at exchanging or transmitting some experiences, but defines itself as experience or test addressed to its readers. (shrink)

We study the formation of a communication network under perfect foresight. We show the existence of a non-monotonic relationship between the cost of link formation and the total number of links created in stable networks. This result enhances a dilemma between stable and efficient networks.

In this paper I wish to reformulate in my own way some parts of Whitehead's theory of prehensions. This reformulation will deviate in various respects from Whitehead's own detailed views and terminology, but the main inspiration is from Whitehead.

L’évolution des concepts de corps et de processus d’animation dans le domaine de la robotique conduit aujourd’hui à définir le concept d’un noyau, ensemble d’algorithmes stables, indépendant des espaces corporels auxquels ils s’appliquent. Il devient alors possible d’étudier la manière dont certaines inscriptions corporelles, considérées comme des variables, structurent le comportement et, à plus long terme, le développement d’un robot. Cette démarche méthodologique peut mener à une approche originale du développement soulignant l’importance d’un corps variable aux frontières en continuelle redéfinition.In (...) the field of robotics, the evolution of the concepts of embodiment and animation processes lead to define the concept of a kernel consisting of a set of stable algorhythms, independent of the specific embodiment on which these algorhythms could be applied. Thus, it becomes possible to study experimentally how particular embodiments, considered as experimental variables, shape the robot’s behaviour and its longer-term developmental patterns. This methodological stance results into a new approach to children development stressing the importance of a continuously changing body. (shrink)

As alusões implícitas e as referências explícitas ao pensamento de Søren Kierkegaard pontuam toda a obra de Jacques Ellul. Com efeito, segundo o autor do artigo, sempre que trata de temas como a Bíblia, a fé, a esperança, o amor, a oração, a liberdade, a política, a técnica, a não-conformidade ao mundo, ou o sofrimento, Jacques Ellul recorre insistentemente a Kierkegaard em ordem a construir o seu próprio pensamento. Nesse sentido, o artigo pretende mostrar os modos de fidelidade, de retoma (...) e de reinterpretação de uma na outra obra de modo a, de algum modo, também poder esclarecer o significado da expressão "ser kierkegaardiano". /// Implicit allusions and explicit references to Søren Kierkegaard's thought punctuate the entire work of Jacques Ellul. Especially when dealing with topics like the Bible, faith, hope, love, prayer, freedom, politics, technology, nonconformity to the world, or suffering, Ellul calls frequently on Kierkegaard in order to build his own thought. The article shows the different modes of fidelity, resumption and reinterpretation of a work into the other, so that at the end it also clarifies what it means to be kierkegaardian. (shrink)

This is an important new book about human motivation, about the reasons people have for their actions. What is distinctively new about it is its focus on how people see or understand their situations, options, and prospects. By taking account of people's understandings, Professor Schick is able to expand the current theory of decision and action. The author provides a perspective on the topic by outlining its history. He defends his new theory against criticism, considers its formal structure, and shows (...) at length how it resolves many currently debated problems: the problems of conflict and weakness of will, Allais' problem, Kahneman and Tversky's problems, Newcomb's problem, and others. The book will be of special interest to philosophers, psychologists, and economists. (shrink)

Our intuitive assumption that only organisms are the real individuals in the natural world is at odds with developments in cell biology, ecology, genetics, evolutionary biology, and other fields. Although organisms have served for centuries as nature’s paradigmatic individuals, science suggests that organisms are only one of the many ways in which the natural world could be organized. When living beings work together—as in ant colonies, beehives, and bacteria-metazoan symbiosis—new collective individuals can emerge. In this book, leading scholars consider the (...) biological and philosophical implications of the emergence of these new collective individuals from associations of living beings. The topics they consider range from metaphysical issues to biological research on natural selection, sociobiology, and symbiosis. -/- The contributors investigate individuality and its relationship to evolution and the specific concept of organism; the tension between group evolution and individual adaptation; and the structure of collective individuals and the extent to which they can be defined by the same concept of individuality. These new perspectives on evolved individuality should trigger important revisions to both philosophical and biological conceptions of the individual. -/- Contributors: Frédéric Bouchard, Ellen Clarke, Jennifer Fewell, Andrew Gardner, Peter Godfrey-Smith, Charles J. Goodnight, Matt Haber, Andrew Hamilton, Philippe Huneman, Samir Okasha, Thomas Pradeu, Scott Turner, Minus van Baalen. (shrink)

In this book Frederic Schick develops his challenge to standard decision theory. He argues that talk of the beliefs and desires of an agent is not sufficient to explain choices. To account for a given choice we need to take into consideration how the agent understands the problem, how he sees in a selective way the options open to him. The author applies his new logic to a host of common human predicaments. Why do people in choice experiments act (...) so often against expectations? Why do people cooperate in situations where textbook logic predicts that they won't? What exactly is weakness of will? What are people reporting when they say their lives have no meaning for them? This book questions the foundations of technical and philosophical decision theory and will appeal to all those who work in that field, be they philosophers, economists and psychologists. (shrink)

This article discusses the concept of joint attention and the different skills underlying its development. Research in developmental psychology clearly states that the development of skills to understand, manipulate and coordinate attentional behavior plays a pivotal role for imitation, social cognition and the development of language. However, beside the fact that joint attention has recently received an increasing interest in the robotics community, existing models concentrate only on partial and isolated elements of these phenomena. In the line of Tomasello’s research, (...) we argue that joint attention is much more than simultaneous looking because it implies a shared intentional relation to the world. This requires skills for attention detection, attention manipulation, social coordination and, most importantly, intentional understanding. After defining joint attention and its challenges, the current state-of-the-art of robotic and computational models relevant for this issue is discussed in relation to a developmental timeline drawn from results in child studies. From this survey, we identify open issues and challenges that still need to be addressed to understand the development of the various aspects of joint attention and conclude with the potential contribution of robotic models. (shrink)

Ecological fitness has been suggested to provide a unifying definition of fitness. However, a metric for this notion of fitness was in most cases unavailable except by proxy with differential reproductive success. In this article, I show how differential persistence of lineages can be used as a way to assess ecological fitness. This view is inspired by a better understanding of the evolution of some clonal plants, colonial organisms, and ecosystems. Differential persistence shows the limitation of an ensemblist noncausal understanding (...) of evolution. Causal explanations are necessary to understand the evolution by natural selection of these biological systems. †To contact the author write to: Department of Philosophy, University of Montreal, P.O. Box 6128, Station Centre‐Ville, Montreal, Quebec, H3C 3J7 Canada; e‐mail: [email protected]. (shrink)

The goal of this article is to shed light on Deep Brain Stimulation (DBS) postoperative suicidality risk factors within Treatment Resistant Depression (TRD) patients, in particular by focusing on the ethical concern of enrolling patient with history of self-estrangement, suicide attempts and impulsive–aggressive inclinations. In order to illustrate these ethical issues we report and review a clinical case associated with postoperative feelings of self-estrangement, self-harm behaviours and suicide attempt leading to the removal of DBS devices. Could prospectively identifying and excluding (...) patients with suicidality risk factors from DBS experimental trials—such as history of self-estrangement, suicide attempts and impulsive–aggressive inclinations—lead to minimizing the risk of suicidality harm? (shrink)

Russian philosophy underwent many phases: Westernism, Slavophilism, nihilism, pre-revolutionary religious philosophy, and dialectical materialism or Soviet philosophy. At first sight, each one of these phases seems antithetical to the preceding one. Yet, they all appear to have in common a certain negative attitude towards the subjectivism of Kantianism and German Idealism. In contrast to the latter, Russian philosophy typically displays a tendency towards ontologism, which is generally defined as the view that there is such a thing as being in itself, (...) i.e., being independent of cognition, and that this being is to some extent knowable. We discern, in these otherwise diametrically opposed movements, an underlying ontologism that constitutes a common thread running in a straight line through the history of Russian philosophy. In this article, I provide an overview of Russian ontologism. (shrink)

Optogenetics is being optimistically presented in contemporary media for its unprecedented capacity to control cell behavior through the application of light to genetically modified target cells. As such, optogenetics holds obvious potential for application in a new generation of invasive medical devices by which to potentially provide treatment for neurological and psychiatric conditions such as Parkinson's disease, addiction, schizophrenia, autism and depression. Design of a first-in-human optogenetics experimental trial has already begun for the treatment of blindness. Optogenetics trials involve a (...) combination of highly invasive genetic and electronic interventions that results in irreversible and permanent modifications of an individual's nervous system. Given its novelty, its uncertain benefit to patients, and its unique risk profile of irreversible physiological alteration, optogenetics requires a reassessment of the ethical challenges for protecting human participants in clinical trials, particularly at formative stages of clinical evaluation. This study explores the evolving ethical issues surrounding optogenetics’ potential harm to participants within trial design, especially focusing on whether Phase 1 trials should incorporate efficacy as well as safety endpoints in ways that are fair and respectful to research trial participants. (shrink)

In this article, we explore the implications of a Rawlsian theory for intergenerational issues. First, we confront Rawls's way of locating his `just savings' principle in his Theory of Justice with an alternative way of doing so. We argue that both sides of his intergenerational principle, as they apply to the accumulation phase and the steady-state stage, can be dealt with on the bases, respectively, of the principle of equal liberty (and its priority) and of the difference principle. We then (...) proceed by focusing on the implications of applying maximin to his steady-state stage. One central claim is that, in principle, Rawlsians should consider not only generational dissavings, but also generational savings, as unfair. This principle suffers a series of exceptions on which we focus in the fourth section of the article. In some cases, growth can be maximin compatible. (shrink)

The phenomenological effects of deep brain stimulation (DBS) on the self of the patient remains poorly understood and under described in the literature, despite growing evidence that a significant number of patients experience postoperative neuropsychiatric changes. To address this lack of phenomenological evidence, we conducted in-depth, semistructured interviews with 17 patients with Parkinson's disease who had undergone DBS. Exploring the subjective character specific to patients' experience of being implanted gives empirical and conceptual understanding of the potential phenomenon of DBS-induced self-estrangement. (...) Our study concluded that (1) the more patients preoperatively felt alienated by their illness, the more they experienced postoperative self-estrangement, and (2) the notion of self-estrangement seems to exist in association with certain common qualitative characters, namely, loss of control, which reflects a deteriorative estrangement, and distorted perception of capacities, which reveals a restorative estrangement. These findings indicate that subjective self-reports help us to understand some aspects of the potential phenomenon of DBS-induced self-estrangement. (shrink)

Despite growing evidence that a significant number of patients living with Parkison’s disease experience neuropsychiatric changes following Deep Brain Stimulation treatment, the phenomenon remains poorly understood and largely unexplored in the literature. To shed new light on this phenomenon, we used qualitative methods grounded in phenomenology to conduct in-depth, semi-structured interviews with 17 patients living with Parkinson’s Disease who had undergone DBS. Our study found that patients appear to experience postoperative DBS-induced changes in the form of self-estrangement. Using the insights (...) from patients’ subjective perceptions of postoperative self-change provides a potent explanation of potential DBS-induced self-estrangement. (shrink)

Propose une hypothèse originale sur les sources de la pensée de Bergson et sa portée profonde, sur le mouvement de son oeuvre et la méthode qui s'impose pour la lire, sur la place de sa philosophie dans l'histoire.