Kidney transplantation is the most efficacious and cost-effective treatment for end-stage renal disease. However, the treatment’s accessibility is limited by a chronic shortage of transplantable kidneys, resulting in the death of numerous patients worldwide as they wait for a kidney to become available. Despite the implementation of various measures the disparity between supply and needs continues to grow. This paper begins with a look at the current treatment options, including various sources of transplantable kidneys, for end-stage renal disease. We propose, (...) in accordance with others, the introduction of compensated kidney donation as a means of addressing the current shortage. We briefly outline some of the advantages of this proposal, and then turn to examine several of the ethical arguments usually marshaled against it in a bid to demonstrate that this proposal indeed passes the ethics test. Using available data of public opinions on compensated donation, we illustrate that public support for such a program would be adequate enough that we can realistically eliminate the transplant waiting list if compensation is introduced. We urge a pragmatic approach going forward; altruism in living kidney donation is important, but altruism only is an unsuccessful doctrine. (shrink)

Hepatocellular carcinoma (HCC) presents a significant problem that necessitates a greater understanding of its underlying molecular complexity in order to improve diagnostics and therapies. Recent studies have shed light on the critical role that mitochondrial dysfunction plays in the development and course of HCC. Once thought to be primarily involved in the synthesis of cellular energy, mitochondria are now known to be key participants in the regulation of a variety of cellular functions that go beyond bioenergetics. The purpose of this (...) review is to elucidate the diagnostic and therapeutic implications of mitochondrial dysfunction in HCC by synthesising ideas from conventional and contemporary scientific literature. Within diagnostics, the discovery of mitochondrial biomarkers such as mutations in mitochondrial DNA and abnormalities in respiratory chain complex activities provides a state-of-the-art viewpoint for the timely identification and accurate description of HCC. In addition, non-invasive imaging methods that focus on mitochondrial function offer prospective means of improving clinical diagnostic accuracy. Moving on to treatment, a growing area of study investigates how mitochondria-targeted therapies might be used to treat HCC. Novel substances and repurposed medications with the potential to induce selective apoptosis in cancer cells, reduce oxidative stress, and restore mitochondrial homeostasis are highly promising. In the fight against hepatocellular carcinoma, an understanding of the complex interactions between mitochondrial dysfunction and HCC opens new diagnostic opportunities and paves the way for individualised treatment plans. (shrink)

The University of Michigan conference “Where Religion, Policy, and Bioethics Meet: An Interdisciplinary Conference on Islamic Bioethics and End-of-Life Care” in April 2011 addressed the issue of brain death as the prototype for a discourse that would reflect the emergence of Islamic bioethics as a formal field of study. In considering the issue of brain death, various Muslim legal experts have raised concerns over the lack of certainty in the scientific criteria as applied to the definition and diagnosis of brain (...) death by the medical community. In contrast, the medical community at large has not required absolute certainty in its process, but has sought to eliminate doubt through cumulative diagnostic modalities and supportive scientific evidence. This has recently become a principal model, with increased interest in data analysis and evidence-based medicine with the intent to analyze and ultimately improve outcomes. Islamic law has also long employed a systematic methodology with the goal of eliminating doubt from rulings regarding the question of certainty. While ample criticism of the scientific criteria of brain death (Harvard criteria) by traditional legal sources now exists, an analysis of the legal process in assessing brain death, geared toward informing the clinician’s perspective on the issue, is lacking. In this article, we explore the role of certainty in the diagnostic modalities used to establish diagnoses of brain death in current medical practice. We further examine the Islamic jurisprudential approach vis-à-vis the concept of certainty (yaqīn). Finally, we contrast the two at times divergent philosophies and consider what each perspective may contribute to the global discourse on brain death, understanding that the interdependence that exists between the theological, juridical, ethical, and medical/scientific fields necessitates an open discussion and active collaboration between all parties. We hope that this article serves to continue the discourse that was successfully begun by this initial interdisciplinary endeavor at the University of Michigan. (shrink)

This paper discusses how it is possible to find, in the Islamic tradition, a universal concept of “humanity”. It insists on the concept of “ummah” as a peculiar Muslim way to define a comprehensive humanity, and try to point out its internal limits. It shows the communal implication of this concept and the ways it can, or cannot, be considered as constitutive of a we-group concept that may eventually lead to conflict and violence. It brings to the attention of the (...) reader some historical examples, focusing, among others, on Mohammad Iqbal’s contribution. (shrink)

Pediatric dentists rely on access to hospital operating rooms for safe, effective, and humane delivery of dental care. The children who benefit most from dental treatment in a hospital operating room are those who are very young, have dental anxieties or phobias, are precommunicative or noncommunicative, need extensive or invasive dental treatments, or have special healthcare needs. Diminishing access to hospital operating rooms for pediatric dental treatment has become an escalating problem in contemporary times. Financial barriers, hospital costs, reimbursement rates, (...) health insurance policies and deductibles, out-of-network hospitals, socioeconomic factors, and the COVID-19 pandemic are prominent contributing factors. This problem in access to care has resulted in long waiting times for hospital operating rooms, deferral of medically necessary dental care, and pain and infection among this vulnerable patient population. Pediatric dentists have responded to the problem by utilizing alternative methods of care delivery, such as in-office deep sedation or in-office general anesthesia, and by implementing aggressive medical management of dental caries. However, the youngest of pediatric patients and children with special healthcare needs still remain at a disadvantage in receiving definitive dental treatment. This article aims to highlight the ethical challenges faced by pediatric dentists in contemporary practice in the face of limitations in hospital operating room access through four case scenarios. (shrink)

The investigation in political science and political sociology often has as objective to settle down the conditions that associate with the occurrence of some type of historical event as, for example, changes of political régime. In the cases in that the unit of time is discreet, the logistical reg..

This paper argues for continuity in purpose and specific results between some hand drawn nebulae, especially those ‘descriptive maps’ by John F. W. Herschel and E. P. Mason in the late 1830s, and the first photographs made of the nebulae in the 1880s. Using H. H. Turners’ explication in 1904 of the three great advantages of astrophotography, the paper concludes that to some extent Herschel’s and Mason’s hand-drawings of the nebulae were meant to achieve the same kinds of results. This (...) is surprising not only because such drawings were conceived and achieved over forty-years earlier, but also because the procedures used in the production of these pictorially and metrically rich images were those directly inspired by cartography, geodesy, and land-surveying. Such drawings provided the standard for what was depicted, expected and aimed at by way of successful representations of the nebulae; standards that seemed to have been used to judge the success of nebular photographs. Being conditions of expectation and possibility for later photography, these drawings were themselves made possible by such techniques of representation and measurement as isolines and triangulation, so fundamental to Imperial and ‘Humboltian science.’Keywords: Ebenezer Porter Mason; Cartography; Draughtsmanship; Observation; Scientific Representation; Philosophy of Scientific Practice. (shrink)

Todo autor tiene su favorito entre los libros que ha escrito. El mío es Confesiones de un médico. Así se refiere el médico y filósofo estadounidense Alfred Tauber a esta obra con ya 12 años de recorrido a sus espaldas que acaba de ser traducida al castellano por Antonio Casado. Un texto que da inicio a la andadura de la epistemología moral defendida por su autor y en el que, por lo tanto, se trazan las líneas maestras de esa propuesta (...) que ocupa un lugar esencial en la obra posterior de este referente de las humanidades médicas en Estados Unidos. Confesiones de un médico se constituye, de esta manera, en la obra de presentación de la filosofía rectora de Tauber y actúa al mismo tiempo como el punto de inicio y el eje sobre el que se ha ido expandiendo su visión. (shrink)

In this article, I offer a reassessment of the influence of two disparate bodies of thought – republicanism and existentialism – on Hannah Arendt. Arendt, I argue, is not involved in an ‘agonistic appropriation’ of Heidegger. Arendt identifies two opposed attitudes in Heidegger’s work. The first Promethean moment places Heidegger squarely in the tradition of Western political philosophy, and the second seemingly correcting for this recommends a quietism. Arendt rejects both these attitudes. Machiavelli rather than Heidegger, I argue, is the (...) key influence on Arendt's political thought. Through a reading of Arendt’s published works and her unpublished 1955 lecture notes on Machiavelli I show that the central categories of Arendt’s thought emerge from her meditation on Machiavelli’s texts. Arendt finds in Machiavelli a performative understanding of politics, an accurate understanding of the connection between morality and politics, and a primacy given to politics that she thought it deserves. (shrink)

The on-the-ground case conference at the interface of philosophical ethics and clinical psychiatry is an innovative idea that advances pedagogy in presenting a creative approach to teaching and practicing psychiatric ethics. In the current exercise of the proposed partnership, there was a generally positive outcome. The philosopher and the psychiatrist learned from each other, were able to find norms that made their collaboration productive, and found that clinical care was enhanced. My commentary aims to help others replicate this model, and (...) preserve its virtues without its vulnerabilities.Would a mathematical logician or philosopher of aesthetics be as good of a collaborator as a moral philosopher? Probably not.... (shrink)

En este trabajo abordamos la cuestión de la inflación tropológica a partir de los trabajos de Hans Kellner y el debate suscitado a partir de ellos con Wallace Martin. Se trata de la proyección indefinida de los tropos desde el lenguaje hacia dominios que lo exceden, tales como la conciencia o un periodo histórico. Nuestro objetivo es revisitar los problemas que acarrea la inestabilidad y la proliferación tropológica con el fin de evaluar el estatus de la solución aportada por la (...) tropología tetrádica contemporánea. Sostenemos que la tesis de la base figurativa del lenguaje siempre debe dar cuenta de la inestabilidad que introducen los tropos en los intercambios lingüísticos. En este sentido, la tétrada tropológica debe ser evaluada a partir de su productividad heurística, de lo que permite o no hacer con el lenguaje, y no como la versión correcta o definitiva de la clasificación de los tropos. Finalmente, todo esto supone el rechazo de la clásica oposición entre lógica y retórica o tropología como una manera de estabilizar el significado. Para ello, dividimos este trabajo en tres apartados: en el primero presentamos las características de la cuestión de la inflación tropológica y lo ejemplificamos con los trabajos de R. Jakobson y H. White; en el segundo, analizamos algunos problemas implicados en la tesis de la base figurativa del lenguaje que da lugar a la inflación tropológica, especialmente el problema de la inestabilidad del significado; en el tercero, presentamos dos objeciones realizadas por Wallace Martin a los trabajos de Kellner con el fin de ilustrar algunas de las dificultades que acarrea este problema. ARK: ark:/s18537960/pmr1iax/5. (shrink)

Con base en la teoría valorativa de las emociones, desarrollada por Frijda y sus colegas, se argumenta que los sentimientos pueden entenderse como parcialmente isomorfos a las emociones, cuyo rasgo fundamental radica en las disposiciones de un individuo a creer en sus experiencias emocionales y actu..

Today we are all familiar with the iconic pictures of the nebulae produced by the Hubble Space Telescope’s digital cameras. But there was a time, before the successful application of photography to the heavens, in which scientists had to rely on handmade drawings of these mysterious phenomena. Observing by Hand sheds entirely new light on the ways in which the production and reception of handdrawn images of the nebulae in the nineteenth century contributed to astronomical observation. Omar W. Nasim (...) investigates hundreds of unpublished observing books and paper records from six nineteenth-century observers of the nebulae: Sir John Herschel; William Parsons, the third Earl of Rosse; William Lassell; Ebenezer Porter Mason; Ernst Wilhelm Leberecht Tempel; and George Phillips Bond. Nasim focuses on the ways in which these observers created and employed their drawings in data-driven procedures, from their choices of artistic materials and techniques to their practices and scientific observation. He examines the ways in which the act of drawing complemented the acts of seeing and knowing, as well as the ways that making pictures was connected to the production of scientific knowledge. An impeccably researched, carefully crafted, and beautifully illustrated piece of historical work, Observing by Hand will delight historians of science, art, and the book, as well as astronomers and philosophers. (shrink)

For this year’s Virtual Issue, our guest editor, Omar W. Nasim, has collected together papers from the Aristotelian Society archives that represent a substantial part of a dispute that contributed to the emergence of analytic philosophy in Britain at the turn of the 20th Century. The dispute was primarily concerned with the problem of the external world – the nature of the sensible objects of perception, and how they relate to physical things and the perceiving subject. The participants in (...) this controversy contested the nature of the appearance-reality distinction, whether it is it is possible for a thing to instantiate contrary sensible qualities at the same place and time, the distinction between presentation and representation, the nature of knowledge by acquaintance, and the nature of sense-data – e.g., whether sense-data are psychical or physical, whether they persist unperceived, and how they give rise to knowledge of the external world. G. E. Moore and Bertrand Russell were significant contributors to these debates, but so too were several philosophers whose names are now less well known: G. F. Stout, G. Dawes Hicks, Abraham Wolf, T. Percy Nunn, and S. Alexander. This Virtual Issue collects together, for the first time, the important contributions made to these debates by all of these figures. In doing so it provides a fascinating insight into the ways in which Russell’s earliest attempts to construct the external world from sense-data were influenced by the ideas and arguments of his immediate contemporaries. Omar W. Nasim’s specially commissioned introduction to the Virtual Issue sets out the historical context of these disputes about the external world, and details the prominent role played by the Aristotelian Society in making them possible. (shrink)

Muslim physicians and Islamic jurists analyze the moral dimensions of biomedicine using different tools and processes. While the deliberations of these two classes of experts involve judgments about the deliverables of the other's respective fields, Islamic jurists and Muslim physicians rarely engage in discussions about the constructs and epistemic frameworks that motivate their analyses. The lack of dialogue creates gaps in knowledge and leads to imprecise guidance. In order to address these discursive and conceptual gaps we describe the sources of (...) knowledge and reasoning employed by Islamic jurists and clinicians to resolve the question of when a patient must seek healthcare. As we examine both the scriptural evidence and legal reasoning of jurists and the types of medical evidence used by clinicians to address the same question, we draw attention to the epistemic frameworks and constructs at play and identify how constructs from one field may sharpen the deliberative exercises of the other. Hence our work advances discourses at the intersection of Islam and medicine and offers building blocks for a comprehensive Islamic framework that fully integrates the deliverables of medical science within the deliberations of Islamic jurists. (shrink)

Desde el enfoque del pensamiento ambiental estético-complejo, el artículo presenta un esbozo de lo que podría llamarse una ontología de la agricultura. Su objetivo es aportar con algunas reflexiones para la construcción de una epistemología de los estudios agroecológicos.

Legends thrive, but there is little tangible evidence about dozens of Malay kingdoms, which are said to have flourished long before the emergence of Melaka in the late 14th century. The Bujang Valley in South Kedah, for one, is Malaysia’s richest archaeological site. The valley is the guardian of countless hidden tales which are waiting to be unveiled. Here, the beliefs of the Malay ancestors were centred upon nature and the spirits which permeate every aspect of their lives. These beliefs (...) have been passed down to the next generation by the elderly. They have valuable information to share about their families and ethnicity of which written evidence is often scarce. Such tales may perish if they are not well documented. Oral history, adopted as its testimony, permits us to gather data not available in written records. Oral history techniques are able to elicit facts, feelings, and descriptions, contributing to social history. Moreover, this technique is able to reveal how individual values and actions shaped the past, and how the past shapes present-day values and actions. Findings include offerings made to appease the spirits of the rivers and lands. Other findings include the revelation of the Bujang Valley as the centre of knowledge. The establishment of madrasah – “sekolah pondok” brought about a better understanding of Islam resulting in the inherent beliefs in the supernatural to slowly diminish. All these recollections form a body of knowledge that is priceless and worth recording. Knowledge published in tangible forms is a key factor to worldwide recognition. Therefore, these efforts to safeguard oral history and family stories should be a top priority for new knowledge development and commercial enhancement for generations to come. (shrink)

Understanding how culture evolves in society is an extremely difficult task. The bifocal stance theory (BST) deploys two copying strategies which can be linked to dual-system theories of behavior. BST would benefit from incorporating results from these theories, such as the evolution of attention to goals or steps of a behavioral sequence, and the role of the environment in prompting different copying strategies.

Para la investigación que conllevó al presente artículo se utilizó el método hermenéutico analógico. Con base en los pasos primordiales de análisis e interpretación se acudió al lenguaje narrativo literario y a su relación inmediata con otros tipos de lenguaje: visual, audiovisual, de imagen, televisivo y mixto. Se estudiaron textos escritos, hablados y actuados. Se efectuó un recorrido narrativo, textual, argumentativo siendo fiel a los planteamientos del autor, al medio y al lector, y se acudió a los textos que presentan (...) un mensaje polisémico. Los interrogantes apuntaron a ¿qué quiere decir el autor con el texto referido a la piel? Y, en particular, ¿qué le significa o resignifica el texto analizado a la temática del proyecto? Así, la estructura clásica discursiva se enmarca desde un preludio con un horizonte epistemológico del mito y su relación con la piel hasta un posludio haciendo eco a la virtus hermenéutica que plantea e implementa Beucheot y que implica una interpretación “adecuada” y ceñida a la “verdad” del texto: la piel, el órgano más grande y complejo del ser humano supone una trascendencia biológica y anatómica determinante, la cual debe ser entendida, analizada e interpretada desde diversos contextos estéticos, éticos y narrativos. (shrink)

Famously posed by seventeenth-century French philosopher René Descartes, the mind–body problem remains unresolved in western philosophy and science, with both disciplines unable to move convincingly beyond the dualistic model. The persistence of dualism calls for a reframing of the problem through interdisciplinary modes of inquiry that include non-western points of view. One such perspective is Islamic theology of the soul, which, while approaching the problem from a distinct point of view, also adopts a position commensurate with dualism. Using this point (...) of convergence as a conceptual starting point, we argue that bringing into dialogue contemporary neuroscientific, philosophy of mind, and Sunni Islamic theological discourses may provide a fruitful way of reframing the age-old mind–body problem. This paper provides an overview of how these three discourses have approached the issue of the mind–body problem. Juxtaposing these three discourses, we hope, may ignite further scholarly di... (shrink)

This paper aims to balance the conceptual reception of Bourdieu's sociology in the United States through a conceptual re-examination of the concept of Habitus. I retrace the intellectual lineage of the Habitus idea, showing it to have roots in Claude Levi-Strauss structural anthropology and in the developmental psychology of Jean Piaget, especially the latter's generalization of the idea of operations from mathematics to the study of practical, bodily-mediated cognition. One important payoff of this exercise is that the common misinterpretation of (...) the Habitus as an objectivist and reductionist element in Bourdieu's thought is dispelled. The Habitus is shown to be instead a useful and flexible way to concep-tualize agency and the ability to transform social structure. Thus ultimately one of Bourdieu's major contributions to social theory consists of his development of a new radical form of cognitive sociology, along with an innovative variety of multilevel sociological explanation in which the interplay of different structural orders is highlighted. In keeping with the usual view, the goal of sociology is to uncover the most deeply buried structures of the different social worlds that make up the social universe, as well as the "mechanisms" that tend to ensure their reproduction or transformation. Merging with psychology, though with a kind of psychology undoubtedly quite different from the most widely accepted image of this science, such an exploration of the cognitive structures that agents bring to bear in their practical knowledge of the social worlds thus structured. Indeed there exists a correspondence between social structures and mental structures, between the objective divisions of the social world . . . and the principles of vision and division that agents apply to them. (shrink)

I this paper, I draw on recent research on the radically embodied and perceptual bases of conceptualization in linguistics and cognitive science to develop a new way of reading and evaluating abstract concepts in social theory. I call this approach Sociological Idea Analysis. I argue that, in contrast to the traditional view of abstract concepts, which conceives them as amodal “presuppositions” removed from experience, abstract concepts are irreducibly grounded in experience and partake of non-negotiable perceptual-symbolic features from which a non-propositional (...) “logic” naturally follows. This implies that uncovering the imagistic bases of allegedly abstract notions should be a key part of theoretical evaluation of concepts in social theory. I provide a case study of the general category of “structure” in the social and human sciences to demonstrate the analytic utility of the approach. (shrink)

Despite the obvious link between spirituality, religiosity and ethical judgment, a definition for the nature of this relationship remains elusive due to conceptual and methodological limitations. To address these, we propose an integrative Spiritual-based model derived from categories presumed to be universal across religions and cultural contexts, to guide future business ethics research on religiosity. This article aims to empirically test in the context of Islam. It examines how different Muslims' views of God influence their ethical judgments in organizations, and (...) how this process is mediated by their religious practice and knowledge. Comprising focus group and vignette designs, the study was carried out with a random sample of 427 executives and management professionals from Saudi. After data collection, the study hypotheses were tested using structural equation modeling. The findings confirmed that a view of God based on hope might be more closely associated with unethical judgments than a view based on fear or one balancing hope and fear. Furthermore, religious practice and knowledge were found to mediate the relationship between Muslims' different views of God and their ethical judgments. These results provide unique theoretical insights into religiosity's influence on ethical judgment, with important implications for management. (shrink)