Like most bilaterian animals, the annelid Platynereis dumerilii generates the majority of its body axis in an anterior to posterior temporal progression with new segments added sequentially. This process relies on a posterior subterminal proliferative body region, known as the "segment addition zone" (SAZ). We explored some of the molecular and cellular aspects of posterior elongation in Platynereis, in particular to test the hypothesis that the SAZ contains a specific set of stem cells dedicated to posterior elongation.We cloned and characterized (...) the developmental expression patterns of orthologs of 17 genes known to be involved in the formation, behavior, or maintenance of stem cells in other metazoan models. These genes encode RNA-binding proteins(e.g., tudor, musashi, pumilio) or transcription factors(e.g., myc, id, runx) widely conserved in eumetazoans. Most of these genes are expressed both in the migrating primordial germ cells and in overlapping ring-like patterns in the SAZ, similar to some previously analyzed genes(piwi, vasa). The SAZ patterns are coincident with the expression of proliferation markers cyclin B and PCNA. EdU pulse and chase experiments suggest that new segments are produced through many rounds of divisions from small populations of teloblast-like posterior stem cells. The shared molecular signature between primordial germ cells and posterior stem cells in Platynereis thus corresponds to an ancestral "stemness" program. (shrink)

Sponges branch basally in the metazoan phylogenetic tree and are believed to be composed of four distinct lineages with still uncertain relationships. Indeed, some molecular studies propose that Homoscleromorpha may be a fourth Sponge lineage, distinct from Demospongiae in which they were traditionally classified. They harbour many features that distinguish them from other sponges and are more evocative of those of the eumetazoans. They are notably the only sponges to possess a basement membrane with collagen IV and specialized cell‐junctions, thus (...) possessing true epithelia. Among Homoscleromorphs, we have chosen Oscarella lobularis as a model species. This common and easily accessible sponge is characterized by relatively simple histology and cell composition, absence of skeleton, and strongly pronounced epithelial structure. In this review, we explore the specific features that make O. lobularis a promising homoscleromorph sponge model for evolutionary and developmental researches. (shrink)

For over 20 years, the Schmid Training Course (STC) has offered unique opportunities for marine biology students from European universities to learn about marine model organisms. While the topics of the course have continuously changed over the years with the advent of new research techniques and discoveries, the pedagogical approach has remained largely the same – a combination of lectures, lab practicals, and field excursions. Several life science researchers, who have taught in the STC for many years, sought to bring (...) the course's pedagogical approach into the 21st century, and with the support of Erasmus+ Programme of the European Community funding, the Digital Marine project was developed. Digital Marine began in 2018 as an international partnership between the six research centers from which the STC instructors hail, and its main objective was to introduce a flipped, blended approach to learning and teaching with respect to established and emerging marine biological model systems. The Digital Marine platform, which covers 12 marine model organisms, is now publicly available. (shrink)

Individual neurons display characteristic firing patterns determined by the number and kind of ion channels in their membranes. We describe experimental and computational studies that suggest that neurons use activity sensors to regulate the number and kind of ion channels and receptors in their membrane to maintain a stable pattern of activity and to compensate for ongoing processes of degradation, synthesis and insertion of ion channels and receptors. We show that similar neuronal and network outputs can be produced by a (...) number of different combinations of ion channels and synapse strengths. This suggests that individual neurons of the same class may each have found an acceptable solution to a genetically determined pattern of activity, and that networks of neurons in different animals may produce similar output patterns by somewhat variable underlying mechanisms. BioEssays 24:1145–1154, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

This book offers a new approach to the analysis of the multiple meanings of English modals, conjunctions, conditionals, and perception verbs. Although such ambiguities cannot easily be accounted for by feature-analyses of word meaning, Eve Sweetser's argument shows that they can be analyzed both readily and systematically. Meaning relationships in general cannot be understood independently of human cognitive structure, including the metaphorical and cultural aspects of that structure. Sweetser shows that both lexical polysemy and pragmatic ambiguity are shaped by our (...) metaphorical folk understanding of epistemic processes and of speech interaction. Similar regularities can be shown to structure the contrast among root, epistemic and speech act uses of modal verbs, multiple uses of conjunctions and conditionals, and certain processes of historical change observed in Indo-European languages. Since polysemy is typically the intermediate step in semantic change, the same regularities observable in polysemy can be extended to an analysis of semantic change. (shrink)

This dissertation intends to contribute to the discussion about the asymmetry W. V. Quine sees between indeterminacy of translation and underdetermination of theory. Quine often formulates the asymmetry by saying that there is a fact of the matter to physics but none to translation. The first chapters of the dissertation constitute an attempt of clarification of that notion of fact of the matter. They contain an analysis of the relations between Quine's notion of fact of the matter, his physicalism, and (...) his conception of truth. The main conclusion of those chapters is that the notion of fact of the matter is physicalistic, which means that it is what, according to Quine, embodied the nature of extralinguistic reality that determines truth. The next chapters contain an analysis of Quine's indeterminacy of translation thesis and underdetermination of theory. The main conclusions of those chapters are the following: indeterminacy of translation is an ontological thesis, and its content has not changed through Quine's writings, although the formulations of the thesis have varied; Quine's definitive arguments for indeterminacy of translation are not to be found in his physicalism, but in his behaviorism; underdetermination of theory is a methodological doctrine, for it concerns the evidential link between observation and theory; there is an asymmetry between indeterminacy of translation and underdetermination of theory. The remaining chapters of the dissertation constitute a review of the main texts by other authors addressing Quine's claim that there is an asymmetry between indeterminacy of translation and underdetermination of theory. The positions of Noam Chomsky, Richard Rorty, and Micheal Friedman are analyzed and criticized. The positions of Dagfinn Follesdal and Roger Gibson have appeared to our lights as the ones that should be taken most seriously. Follesdal is the one who seems to have accomplished the last progresses in the discussion over the asymmetry between underdetermination of theory and indeterminacy of translation by distinguishing clearly Quine's epistemological arguments for indeterminacy of translation thesis from the ontological content of that thesis. (shrink)

This essay focuses on conceptual engineers who aim to improve other people's patterns of inference and attention by shaping their concepts. Such conceptual engineers sometimes engage in a form of epistemic paternalism that I call paternalistic cognitive engineering: instead of explicitly persuading, informing and educating others, the engineers non-consultatively rely on assumptions about the target agents’ cognitive systems to improve their belief forming. The target agents could reasonably regard such benevolent exercises of control as violating their sovereignty over their own (...) belief formation. This is a pro tanto reason against such engineering. In addition to the relevant projects of conceptual engineering, paternalistic cognitive engineering plausibly includes certain kinds of nudging and evidence suppression. I distinguish the sovereignty-based concern from other ethical worries about conceptual engineering and discuss how one might justify the relevant conceptual engineering projects despite the sovereignty-based reason against them. (shrink)

Introduction -- The perceptual part of the soul -- Human perception -- The duality of the human soul -- Phronesis -- Conclusion.

In the past forty years, Bruno Latour’s claim that Science Is Politics By Other Means (SIPBOM) has been the underlying creed of Science and Technology Studies (STS), most of us simply taking it for granted. In contrast, this special issue is predicated on the observation of an enduring lack of exegesis of this catchphrase so remarkable that is has caused an outcry among natural scientists, echoed in some social science quarters. If SIPBOM has been a resource for decades, by turning (...) it into a topic this special issue revisits one of the most exciting and challenging insights of contemporary thought. (shrink)

Le développement du recours aux outils numériques engendre des problèmes nouveaux résultant entre autres de l’imperfection inévitable des logiciels, qui a parfois pour conséquence la divulgation de données confidentielles ou personnelles. La révélation des failles de sécurité est nécessaire pour permettre aux éditeurs de logiciels d’y remédier. Cependant, le droit pénal français, sur la base de la Convention européenne sur la cybercriminalité, sanctionne la mise à disposition de « toute donnée conçue ou spécialement adaptée » pour commettre un piratage : (...) le législateur français réprime donc potentiellement la révélation de failles de sécurité, sans pour autant assurer une indemnisation satisfactoire aux victimes de fuites de données personnelles engendrées par l’exploitation de ces défauts de sécurité. L’adoption d’une démarche éthique de la révélation des failles de sécurité pourrait remédier aux défauts du système actuel. (shrink)

Abstract“Science Is Politics By Other Means” (SIPBOM) was coined in The Pasteurization of France, Latour’s 1984 empirical study of the birth of microbiology. Yet, it encapsulates an outstanding political theory of science that Latour has never formalized and that has remained unnoticed to this day. The theory is comprised of two dimensions. The first one is the ontological labor performed by science, that is, the laboratory production of new nonhumans. The second one is the ability of science to devise and (...) implement novel policies targeted at the new beings it produces. These “other means” are incorporated in political projects and contribute to the shaping of society. Fifteen years later, Latour published Politics of Nature ([1999] 2004), a full-blown political treatise equally devoted to the political character of science. It would be mistaken, however, to assume that it falls in the same SIPBOM paradigm as the Pasteur study. The compositionist theory it offers redefines politics as the institution of the nonhumans that make up external reality, a task that has traditionally been monopolized by Science. In this sense, “science is politics by other means” has become “politics is science by other means,” these “other means” now referring to “cosmopolitics,” that is, the due process advocated by compositionism. The first claim of the present paper is that the respective weight ascribed to politics and ontology is different in The Pasteurization of France and in Politics of Nature. The second claim is that compositionism is not as successful as Latour’s early theory to account for the politicity of science. (shrink)

Nagel ist es nicht geglückt, die Möglichkeit des Verzichts auf teleologische Formulierungen und Erklärungen plausibel zu begründen. Bei seinem Versuch, die Äquivalenz teleologischer und nichtteleologischer Erklärungen nachzuweisen und den Bedeutungsüberschuß teleologischer Sprache hinwegzuformulieren, ist er immer schon an die Voraussetzung dieses Bedeutungsüberschusses gebunden, dessen er sich nicht, wie seine Beschreibung zielgerichteter Systeme beweist, entledigen kann. Unser Ergebnis dispensiert jedoch nicht von der Frage, ob der Anspruch 'der in teleologischen Wendungen geltend gemacht wird, auch zu Recht besteht. Denn die semantische Unmöglichkeit (...) der Reduktion von Relevanzrelationen auf Bedingungsrelationen verbürgt ja noch nicht, daß die teleologische Sprache den Gegenstandsbereich der Biologie auch adäquat trifft. Eine über unsere Studie hinausgehende Untersuchung müßte daher die hier aufgeworfene Frage in den größeren Zusammenhang der als klassisch geltenden Stellungnahmen einbetten und unter Einbeziehung der Resultate der kybernetischen Wissenschaften dem Problem nachgehen, ob Teleologie nur heuristischer Leitfaden der Reflexion ist, der aus forschungsstrategischen Gründen der Organisation des Gegenstandes an diesen von außen herangetragen wird, oder darüberhinaus eine Struktureigenschaft von Objekten selbst bezeichnet. Ist Teleologie also nur eine "Sache der Formulierung" oder eine "Formulierung der Sache"? (shrink)

The decision to publish a doctoral dissertation, especially one which has only been “lightly edited” (foreword, first sentence) and with a bibliography only partially updated to reflect the scholarship of the intervening years, must always seem a risky one. In this case the risk is well taken and the resultant book is a delightful addition to our too meager store of book length overviews of Epictetus’ philosophy in the wider context of Stoic ethics.

Deficits in cognitive flexibility have been associated with anxiety and worry, however few studies have assessed cognitive flexibility in the context of emotional stimuli (i.e. affective flexibilit...

Like Joan Didion's The Year of Magical Thinking, an extraordinarily moving and engaging look at loss and death. Eve Joseph is an award-winning poet who worked for twenty years as a palliative care counselor in a hospice. When she was a young girl, she lost a much older brother, and her experience as a grown woman helping others face death, dying, and grief opens the path for her to recollect and understand his loss in a way she could not as (...) a child. In the Slender Margin is an insider's look at an experience that awaits us all, and that is at once deeply fascinating, frightening, and in modern society shunned. The book is an intimate invitation to consider death and our response to it without fear or morbidity, but rather with wonder and a curious mind. Writing with a poet's precise language and in short meditative chapters leavened with insight, warmth, and occasional humor, Joseph cites her hospice experience as well as the writings of others across generations--from the realms of mythology, psychology, science, religion, history, and literature--to illuminate the many facets of dying and death. Offering examples from cultural traditions, practices, and beliefs from around the world, her book is at once an exploration of the unknowable and a very humane journey through the land of grief. (shrink)

The study of the notion of ideology shows that this corpus lends itself to a wide variety of different definitions. A certain opposition runs all the way through this set of definitions. Ideology would appear to be torn between a conception that emphasises its distortion and dissimulation dimensions and another conception which views as a set of social representations. After rapidly presenting the main characteristics of these two polar extremes, Paul Ricoeur's suggestion that these two conceptions can be united is (...) discussed and illustrated by the concept of the `spirit of capitalism', as defined in the book by Boltanski and Chiapello (1999). It is shown that this constitutes an ideology which is in fact an attempt to encompass both these conceptions. It is also shown that the concept of `trial' as proposed in that book helps greatly to understand how this reconciliation is actually possible. (shrink)

This article analyzes the institutionalization of the global organic agriculture field and sheds new light on the conventionalization debate. The institutions that shape the field form a tripartite standards regime of governance that links standard-setting, certification, and accreditation activities, in a layering of markets for services that are additional to the market for certified organic products. At each of the three poles of the TSR, i.e., for standard-setting, certification, and accreditation, we describe how the corresponding markets were constructed over time (...) and the role of the different actors in their evolution. We analyze the politics at stake among the actors at each pole, their competing or cooperative interests and visions, and the tensions between them in the promotion of markets. Through the lens of the TSR heuristic, we show that the institutionalization of the organic field beginning in the 1990s and its de facto inclusion in the broader sustainability field beginning in the 2000s contribute to a progressive distancing between the organic movement and its initial political project of alterity, to which public and private actors both contribute actively. As a set of interlinked market institutions, the TSR orients and narrows the scope of debate, which becomes restricted to “market-compatible” dimensions and objects. We conclude that the TSR is a promising heuristic for analyzing contemporary global regulation. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Clinical Ethics Consult: Transforming Ambivalence to ActionEve MakoffAs palliative care practitioners, we’re good at diffusing explosive family dynamics and holding space for patients and families in emotional crises. We also help everyone involved with the care of seriously ill patients focus on what is best based on the values of the most important person in the room; the one in the hospital bed. So, when we call for (...) a bioethics consultation from a clinical ethicist, it’s because something has gotten stuck or, perhaps, we could benefit from a reframe—or a new set of eyes to ground the scenario or the emotional miasma that tends to linger and drift when on the cusp between life and death.In the 1990s, at least in my medical school and residency programs, medical ethicists in the hospital were not often a part of direct patient care. They were like philosophers, available to curbside and advise on ethically murky cases but at a distance from the trenches. These wise, generally older men with white beards parceled out all potential ethical sides of the case, leaving us to decide the best way forward. The Socratic Method1 was often employed, so we were left to grapple with the ambiguity that exists in most issues about what’s right or wrong. It sometimes felt frustrating but now I realize the importance of honing the skill of tolerating the feeling of not immediately knowing the best way to proceed in the practice of medicine. As it turned out, by the time I started practicing palliative care in 2013 and began to regularly collaborate with what was then our clinical ethics partners in care, our ethics director Dr. F was also a wise older man with a white beard. But he and the rest of his (non-male, un-bearded) team didn’t have that untouchable ivory tower kind of protection around them. They were accessible. They dug into the hard stuff right alongside us when they were asked to get involved.One time when I consulted ethics on a case, I’d been navigating a switch from practicing internal medicine to palliative care. At the time I was dealing with personal ambivalence—feeling mired in the heaviness that infused my workdays and unsure if I could take it. It turned out that a clinical consultation, and a family meeting with Dr. F, helped in more ways than one.That day, we gathered in the medical intensive care unit conference room. It doubled as a storage closet, so the team, including our patient’s family, dragged in chairs and stools and crowded around the oblong melamine table next to the whiteboard with half-erased arterial blood gas calculations. We hunched together to see where things stood and make some essential decisions.As we do in family meetings, we reconfirmed our roles on the team: ICU fellow, resident, and medical student. Nurses fluttered in and out as their patient care allowed. The patient’s daughter with silver-streaked hair was in attendance, as well as her son, who was slumped in his seat. Both looked sleepless and frazzled. And finally, Dr. F and myself—clinical ethicist and palliative care doctor—gathered. Dr. F then took the lead, announcing our intention to come together and discuss what was best for our patient—their mother. Dr. F then requested a medical update from the ICU team.“Mrs. Lyons is on a ventilator. She’s sedated and medicated for pain. But her organs aren’t doing well. She’s not getting better,” the resident read off of his white paper of scribbles. [End Page 12]Suspended between her life and her death, Mrs. Lyons lay unperturbed but unreachable, and her family was agonizing about what to do. For days our palliative team had discussed the options with the family—we could cut back on the medications and try to wake her up, knowing she’d likely have considerable pain, and to what end? We could reconsider that surgery for her infected bowels, but she’d likely not survive.Or we could let her go—discontinue the ventilator and likely let her die.They could not decide... (shrink)

This case study of the feminist drag troupe the Disposable Boy Toys examines the relationship between drag and gender identity. Drawing on multiple methods, the author explores the range of gender identities that emerged through participation in DBT. Members saw DBT as the central catalyst for their own identity shifts. The author suggests that these identity transformations occurred through four collective mechanisms: imaginative possibility, information and resources, opportunities for enactment, and social support. The author finds that DBT served as an (...) identity incubator in which participants were able and encouraged to interrogate, play with, and sometimes adopt new gender identities. The author concludes that context is critical in understanding the meaning and importance of drag. Performing gender in this politicized, feminist context shaped the gender identities of the troupe's members in fundamental and varied ways, suggesting that oppositional communities can be an important venue for identity work. (shrink)

Digital spaces are saturated with metaphor: we have pages, sites, mice, and windows. Yet, in the world of digital textuality, these metaphors no longer function as we might expect. Martin Paul Eve calls attention to the digital-textual metaphors that condition our experience of digital space, and traces their history as they interact with physical cultures. Eve posits that digital-textual metaphors move through three life phases. Initially they are descriptive. Then they encounter a moment of fracture or rupture. Finally, they go (...) on to have a prescriptive life of their own that conditions future possibilities for our text environments - even when the metaphors have become untethered from their original intent. Why is "whitespace" white? Was the digital page always a foregone conclusion? Over a series of theses, Eve addresses these and other questions in order to understand the moments when digital-textual metaphors break and to show us how it is that our textual softwares become locked into paradigms that no longer make sense. Contributing to book history, literary studies, new media studies, and material textual studies, Theses on the Metaphors of Digital-Textual History provides generative insights into the metaphors that define our digital worlds. (shrink)

I will defend explication, in a Carnapian sense, as a strategy for revisionary ontologists and radical sceptics. The idea is that these revisionary philosophers should explicitly commit to using expressions like “S knows that p” and “Fs exist” differently from how these expressions are used in everyday contexts. I will first motivate this commitment for these revisionary philosophers. Then, I will address the main worries that arise for this strategy: the unintelligibility worry and the topic shift worry. I will focus (...) on the latter worry and provide a solution that makes use of a distinction between practically and theoretically oriented beliefs. On my view, the revisionary philosophers who admit to departing from the everyday language can still criticize everyday knowledge and existence claims, by arguing that while the language embedded in these claims is suitable for beliefs-1, it is not suitable for beliefs-2. (shrink)

In this paper, the principal objections to unconditional forgiveness are canvassed, primarily that it fails to take wrongdoing seriously enough, and that it displays a lack of self-respect. It is argued that these objections stem from a mistaken understanding of what forgiveness actually involves, including the erroneous view that forgiveness involves some degree of condoning of the offence, and is incompatible with blaming the offender or punishing him. Two positive reasons for endorsing unconditional forgiveness are considered: respect for persons and (...) human solidarity; and it is argued that the latter provides more plausible grounds for it than the former. (shrink)

I will clarify when and how a tension arises between epistemic environmentalism (a new focus on assessing and improving the epistemic environment) and respect for epistemic autonomy (allowing, empowering, and requiring people to each govern their own beliefs). Using the example of participatory conceptual engineering (improving the linguistic environment through rational discussion with broad participation), I will also identify an option for avoiding the tension—namely, participatory environmentalism. This means a new focus on how people can each contribute to improving the (...) shared epistemic environment through rational deliberation and thereby govern their own beliefs that are shaped by that environment. (shrink)

The jury remains out about the bottom-line relevance of organisational spirituality. This article reviews the arguments made thus far, using those sources most commonly cited as providing ‹evidence’ that organisational spirituality adds value to the bottom line. Having collated the evidence, this article offers some observation about the robustness of this existing ‹business case’. It then offers some preliminary conclusions on the literature review, examining the merits of pursuing a ‹business case’ in this field and identifying some specific questions for (...) future research. (shrink)

Aristotle’s writings contain more direct statements about priorities and rankings among the various sciences, degrees of accuracy within them, routes to knowledge from first principles, “first philosophy” and its characteristics, and the relation between sciences and practical concerns than almost any other philosopher we know.Yet taken together, Aristotle’s statements on these matters belie the apparent systematicity of his philosophical temperament. Almost every devotee of Aristotle is compelled to choose certain texts as authoritative and relegate others to some specific topic-context in (...) which they have limited validity. An only slightly shaky consensus among Aristotle’s readers has emerged through this process over time: on that consensus, Aristotelian first philosophy equals what later came to be called metaphysics, and is characterized by its remoteness from particular human discourses and desires, and from the types of knowledge we connect most directly with perception. First principles are also divorced from perception and are known through an incompletely explained intuitive process, but remain indemonstrable. Theoretical wisdom or contemplation soars above the domain of the human struggle, providing a stabilizing but distanced and abstract mode of considering the highest and most divine matters of which we are capable of thinking. (shrink)

"These essays advance a reinterpretation of pivotal categories such as self-knowing, moral agency, and altruism... A must for all students and researchers/faculty engaged in the study of ethics." —Choice "This is an extraordinarily valuable collection of essays in feminist ethics." —Teaching Philosophy A range of recent work in feminist ethics, exploring such issues as the ethic of care, a viable feminist ethics, Pythagoreanism, existentialism, utilitarianism, self-knowing, emotion, and moral vision. Also discussed is the process of applying feminist ethics to work (...) situations. The concluding essays point to the future and present new visions for the field. (shrink)