The aim of this review is to identify and provide a structured overview of quantitative models in the pharmaceutical supply chain, a subject not exhaustively studied in the previous reviews on healthcare logistics related mostly to quantitative models in healthcare or logistics studies in hospitals. The models are classified into three categories of classification: network design, inventory models, and optimization of a pharmaceutical supply chain. A taxonomy for each category is shown describing the principal features of each echelon included in (...) the review; this taxonomy allows the readers to identify easily a paper based on the actors of the pharmaceutical supply chain. The search process included research articles published in the databases between 1984 and November 2016. In total 46 studies were included. In the review process we found that in the three fields the most common source of uncertainty used is the demand in the 56% of the cases. Within the review process we can conclude that most of the articles in the literature are focused on the optimization of the pharmaceutical supply chain and inventory models but the field on supply chain network design is not deeply studied. (shrink)

Narrative fictions have surely become the single most widespread source of entertainment in the world. In their free time, humans read novels and comics, watch movies and TV series, and play video games: they consume stories that they know to be false. Such behaviors are expanding at lightning speed in modern societies. Yet, the question of the origin of fictions has been an evolutionary puzzle for decades: Are fictions biological adaptations, or the by-products of cognitive mechanisms that evolved for another (...) purpose? The absence of any consensus in cognitive science has made it difficult to explain how narrative fictions evolve culturally. We argue that current conflicting hypotheses are partly wrong, and partly right: narrative fictions areby-productsof the human mind, because they obviously co-opt some pre-existing cognitive preferences and mechanisms, such as our interest for social information, and our abilities to do mindreading and to imagine counterfactuals. But humans reap some fitness benefits from producing and consuming such appealing cultural items, making fictionsadaptive. To reconcile these two views, we put forward the hypothesis that narrative fictions are best seen asentertainment technologiesthat is, as items crafted by some people for the proximate goal to grab the attention of other people, and with the ultimate goal to fulfill other evolutionary-relevant functions that become easier once other people’s attention is caught. This hypothesis explains why fictions are filled with exaggerated and entertaining stimuli, why they fit so well the changing preferences of the audience they target, and why producers constantly make their fictions more attractive as time goes by, in a cumulative manner. (shrink)

We review recent evidence that game rules, rules of etiquette, and supernatural beliefs, that the authors see as “ritualistic” conventions, are in fact shaped by instrumental inference. In line with such examples, we contend that cultural practices that may appear, from the outside, to be devoid of instrumental utility, could in fact be selectively acquired and preserved because of their perceived utility.

This article presents a case that former President of the United States Donald Trump was a tyrant-like leader in the mold of the tyrant in Plato’s Republic. While he does not perfectly embody the tyrant as presented in the Republic, he captures its core feature. Like the tyrant, Trump is driven by unregulated desires that reflect what Plato describes as an extreme freedom that underlies and threatens democratic regimes. Extreme freedom is manifested in Trump’s disregard for social and legal norms, (...) which mirrors the lawlessness of the tyrant. The people, in turn, interpret that posture as a mark of authenticity. Understanding Trump’s appeal in the United States helps alert friends of democracy to the possible rise of tyrant-like figures. In closing, and as a way of remedying the harm done by the tyrannical soul, the article recommends that society help temper tyrant-like passions in the people through a rededication to civic equality. (shrink)

A partir de una lectura conjunta de la Pítica 8 de Píndaro y el libro 10 de la República de Platón, se estudian las relaciones que en la vida humana guarda lo efímero con la dicha. El poema pindárico ofrece determinaciones decisivas para la comprensión de lo efímero en el ser humano, en el sentido de que en medio de la precariedad la dicha aún puede alcanzar al ser humano. Hay razones para pensar que el texto platónico trabaja sobre el (...) texto pindárico, lo que ofrece elementos nuevos para la interpretación del mito de Er como gesto poético supremo de Platón, lo que permitirá plantear una nueva comprensión de las relaciones entre filosofía y poesía. (shrink)

El presente artículo es una propuesta de una nueva lectura del capítulo quinto del libro tercero del De anima de Aristóteles. Por lectura se entiende no una interpretación, sino una cuidadosa atención al momento filológico: qué dice literalmente el texto, antes de las interpretaciones filosóficas. Para esto, se atiende minuciosamente a la semántica de los términos, al modo de adjetivación de la lengua griega, y al contexto general, gramatical y semántico de este capítulo quinto. El resultado de este análisis filológico (...) es una es una nueva comprensión del texto, que permite una nueva traducción, que se ofrece al final. (shrink)

La aceptación de la esclavitud es una de las cuestiones donde la Antigüedad muestra un mayor rezago en relación con el mundo contemporáneo; esto suele aducirse para criticar la filosofía griega. En este artículo se examina hasta qué punto el pensamiento de Platón en las Leyes puede caer bajo esta imputación o sustraerse a ella. Se plantea que en el autor se encuentra una dialéctica del esclavo, que consiste en mantener, por un lado, la función de la esclavitud dentro de (...) la estructura social y política propuesta, mientras que, por el otro lado, se cuestiona la existencia del esclavo como tal. Así, se hace primero una presentación general de la esclavitud en las Leyes y de la función que dicha institución cumple en la comprensión filosófica del propio diálogo y, después, se adelanta un examen detenido del pasaje central de 6.777d5-7. Se concluye que si bien, en clave histórica, Platón no logra eludir la tensión de esta dialéctica, en clave filosófica ofrece su resolución en el obrar del hombre verdaderamente justo. (shrink)

La investigación se inscribe dentro de un movimiento que busca poner de relieve la pertinencia de textos poéticos para la comprensión de los diálogos de Platón. En este caso, se parte de la comunidad de la expresión “el jardín de Zeus” en la Pítica 9 de Píndaro y en el Discurso de Diotima en el Banquete. Primero, se presenta un esquema temático de los dos textos. Luego, se ofrece un recorrido en tres etapas: el paso del deseo a la mediación, (...) el estudio de la figura del mediador, y la apertura de la mediación al ámbito metapoético y lo que se sigue de ello. En la primera etapa se muestra cómo Eros dirige a la inmortalidad por medio de la generación, que se guía por la virtud en su condición más noble, al instituirse la ciudad, a la vez que, en el diálogo entre Apolo, enamorado de Cirene, y Quirón, se identifican los mismos pasos de una pulsión erótica que conduce a lo cívico. En la segunda etapa se destaca la tarea mediadora de Quirón ante Apolo, semejante a la relación de Diotima con Sócrates; esta mediación de Quirón produce un nuevo ámbito, que lleva su impronta, por lo que se entiende que la mediación de Diotima haya generado al filósofo erótico Sócrates, también ahora mediador. En la tercera etapa se muestra cómo franquea el sabio la diferencia entre los tiempos divino y humano mediante la creación metapoética, cuya consumación poética y filosofica es la constitución de la ciudad bella. (shrink)

Se investigan las relaciones complejas que se dan entre el creer y el conocer, relaciones que constituyen un círculo que discurre entre el creer y el conocer y entre el conocer y el cree sin que sea posible asignarle prioridad a ningunos de dichos actos. Este círculo es fundamental para la constitución de la vida humana, como lo muestra su enraizamiento en el lenguaje, don primordial que posible la dinámica de la creencia.

The case of nonvoluntary euthanasia shows that the current definition of euthanasia must be more accurately determined. Euthanasia refers necessarily to the ending of life due to serious illness which must be expanded to include the lack of any capacity to give sense to life. A person in this latter position would be under lasting and unbearable suffering, perhaps unconscious, and incapable of leading her own life. The ethics of euthanasia must take these considerations into account. The will does not (...) found the ethical decision. This is based instead on the reasonableness of continuing life under these circumstances. Voluntary euthanasia, as well as nonvoluntary, is founded on the right that every person who suffers under these conditions has to put an end to her life. It is understood that this is the only way to escape from such misfortune when life does not make sense any longer. The topic of euthanasia has a political dimension that is associated with the contemporary practice of medicine and the defense of human rights in our society. At the foundational level, euthanasis is unitary; the distinction between voluntary and nonvoluntary establishes only further precision, not a fundamental one. (shrink)

The merging/fusion of belief/data collections in propositional logic form is a topic that has received due attention within the domains of database and AI research. A distinction can be made between two types of scenarios to which the process of merging can be applied. In the first type, the collections represent preferences, such as the voting choices of a group of people, that need to be aggregated so as to give a consistent result that in some way best represents the (...) collective judgement of the group. In the second type, the collections represent factual data that is to be aggregated with an aim of obtaining a result that maximises factual correctness. After introducing a general framework for belief merging via some prominent literature on the topic, this paper then introduces and considers a method for belief merging with the second type of scenario in mind. Its suitability is corroborated by demonstrating how it can be seen as a special case of a merging procedure that combines aggregation of probabilities and maximisation of expected truthlikeness. (shrink)

En Dialéctica negativa, Adorno justifica históricamente la necesidad de que la teoría crítica de la sociedad adopte la forma de filosofía. Esta transformación representa un cambio profundo desde la tradición marxista y tiene gran trascendencia para el desarrollo de la teoría crítica en el presente. En este artículo se busca clarificar los argumentos sociohistóricos que llevan a Adorno a redirigir el pensamiento crítico hacia la filosofía, sustentados en una crítica inmanente a la teoría de Marx y a la filosofía de (...) la identidad de Hegel. También se examinará la importancia de la crítica inmanente para la Escuela de Frankfurt, enfocándose en aspectos que son esenciales para comprender su desarrollo y significado. Este análisis establecerá las bases para abordar la tesis de Adorno sobre necesidad histórica de la filosofía en la formulación de una dialéctica negativa. Finalmente, se tratará la disyuntiva que surge al confrontar la teoría crítica de Adorno con la de Moishe Postone, es decir, si se debe concebir a la teoría crítica como una teoría social o como una filosofía dialéctica negativa. El objetivo es ofrecer una respuesta a esta cuestión. (shrink)

Crying is an ubiquitous human behavior through which an emotion is expressed on the face together with visible tears and constitutes a slippery riddle for researchers. To provide an answer to the question “How our gaze reacts to another person’s tears?,” we made use of eye tracking technology to study a series of visual stimuli. By presenting an illustrative example through an experimental setting specifically designed to study the “tearing effect,” the present work aims to offer methodological insight on how (...) to use eye-tracking technology to study non-verbal cues. A sample of 30 healthy young women with normal visual acuity performed a within-subjects task in which they evaluated images of real faces with and without tears while their eye movements were tracked. Tears were found to be a magnet for visual attention in the task of facial attribution, facilitating a greater perception of emotional intensity. Moreover, the inspection pattern changed qualitatively and quantitatively, with our participants becoming fully focused on the tears when they were visible. The mere presence of a single tear running down a cheek was associated with an increased emotional inference and greater perception of sincerity. Using normalized and validated tools (Reading the Eyes in the Mind Test and the SALAMANCA screening test for personality disorders), we measured the influence of certain characteristics of the participants on their performance of the experimental task. On the one hand, a higher level of cognitive empathy helped to classify tearful faces with higher emotional intensity and tearless faces with less emotional intensity. On the other hand, we observed that less sincerity was attributed to the tearful faces as the SALAMANCA test scores rose in clusters A (strange and extravagant) and B (immature and emotionally unstable) of our sample. The present findings highlight the advantages of using eye tracking technology to study non-verbal cues and draw attention to methodological issues that should be taken into account. Further exploration of the relationship between empathy and tear perception could be a fruitful avenue of future research using eye tracking. (shrink)

The question ''Was 'existence' ever a predicate?" in a way already suggests its own answer, that this is really the wrong question to ask, because 'existence' has always been a predicate. Even those, such as Kant, who supposedly opposed this view, in fact held it. They merely denied that 'existence' is a "normal" first-order predicate. Not only Kant, but also Bolzano, Frege and Russell claimed that it is a second-order predicate. There is substantive disagreement between Kant and Bolzano on the (...) one hand and Frege and Russell on the other over two issues: the former claim that this second-order predicate apphes to no concept analytically and that it can be properly ascribed to a singular concept, whereas the latter deny both of these claims. (shrink)

It does not typically seem to be worthwhile rewatching a sport match, for example, in a video recording, once the result is known. Sports matches are like detective stories. Once one knows ‘whodunit’, there seems little point in revisiting the tale. By drawing on an argument from musicologist Edward T. Cone, this paper argues that certain sports matches may be revisited with profit. The initial experience of a game may be of a series of events that are often ambiguous or (...) confusing as to their meaning or purpose. The full appreciation of a sport match requires, not just this initial familiarity with the immediately perceived events of the game, but also an awareness of the tactics being deployed by both sides. An understanding of tactics and strategy is akin to the analysis of a piece of music. A further viewing of the game, during which one can appreciate how the tactics inform the events naively experienced in the first viewing, will yield, it will be argued, an aesthetic pleasure. This takes the experience of sport beyond the merely entertaining or exciting. In certain games, the third viewing may also transcend an appreciation of the merely formal qualities of the game, and so offer substantial insights into what it is to be human. (shrink)

El siguiente ensayo rastrea las reflexiones de Friedrich Hölderlin en torno a lo mítico. El argumento, expuesto una y otra vez en su correspondencia, sus ensayos y poemas, continuamente refinado y corregido, es que, expresado en lenguaje poético, el mito permite recuperar una visión del mundo fragmentada con el ímpetu analítico finisecular. El concepto de lo mítico de Hölderlin no solo está profundamente influido por el contexto histórico e intelectual en los lindes del Frühromantik, la filosofía de Fichte, la estética (...) de Schiller y la Revoluciónfrancesa como notas principales, sino también por las experiencias de la niñez, las lecturas de los colegios conventuales o los encuentros en Tubinga o Fráncfort. Finalmente, el texto muestra cómo estas indagaciones cristalizan en distintos motivos de su producción lírica. (shrink)

El presente artículo es un estudio teórico sobre las similitudes entre las doctrinas gnósticas, que florecieron alrededor del siglo ii de nuestra era, y el pensamiento estético del pintor ruso Vasili Kandinsky. El objetivo es analizar estos dos marcos de ideas filosóficas y espirituales para exponer sus similitudes y diferencias. De esta manera, se indagará si, pese a los siglos que las separan y la diferencia de contextos históricos que las rodean, pueden existir en los orígenes de ambas propuestas doctrinales (...) unas problemáticas existenciales y filosóficas comunes. El estudio buscará, con ello, dilucidar si es posible entender la estética de Kandinsky como una especial gnosis moderna estructurada a través de sus planteamientos conceptuales y artísticos. Los resultados de la investigación pretenden no solo dar luces sobre la originalidad de Kandinsky dentro de la historia del arte, sino que también llegar a ser útiles para resaltar y comprender algunos puntos importantes de la discusión cultural dentro de la cual se enmarca su obra. (shrink)

A critique of J. L. Schellenberg's argument from Divine Hiddenness: Schellenberg's conclusion that since apparently there are 'capable inculpable non-believers in God' the cognitive problem of divine hiddenness is actually an argument for the non-existence of God. Schellenberg's conclusion seems at least partly based on his misunderstanding or disregard of significant aspects of the Judeo-Christian tradition and certain assumptions, especially regarding nature of religious belief as well as primacy and instrumentality of reason. I suggest that given the kind of God (...) proposed by the Judeo-Christian tradition it is not necessary that reasonable non-belief in His existence be impossible; moreover it may even be the case that possibility of reasonable non-belief is necessary given the nature and purposes of God as proposed by the Judeo-Christian tradition. (shrink)

In a successful series of papers, Schroer and Schroer presented a reductionist narrative account of personal identity. They claimed that their reductionist account had advantages over traditional narrative theories. In this paper I intend to show that they were wrong. Although it is possible to defend a reductionist narrative account, the Schroers’ theory has a problem of circularity. And solving that problem will cause their theory to have much more problems than non-reductionist narrative theories. Consequently, they should either present a (...) new and improved reductionist narrative account, or accept that non-reductionist narrative theories are better suited to account for the problem of personal identity. (shrink)

Bernard Bolzano's most fruitful invention was his method of variation. He used it in defining such fundamental logical concepts as logical consequence, analyticity and probability. The following three puzzles concerning this method of variation seem particularly worth considering, (i) How can we define the range of variation of an idea or the categorial conformity of two ideas without already using the concept of variation? This question was raised by Mark Siebel in his M. A. thesis, (ii) Why must we define (...) analyticity by means of (simultaneous or successive) variation of several ideas rather than by means of replacing a single idea? This problem is suggested by an example due to W.V.O. Quine, John R. Myhill and Benson Mates, (iii) Must every 'there is...' sentence be synthetic for Bolzano, as his pupil Franz Příhonský claims in his booklet Neuer Anti-Kant, or can a 'there is...' sentence be logically analytic? (shrink)

Este trabajo se centra en cómo en la España de la segunda mitad del siglo XVIII con motivo de la reforma de los estudios teológicos tanto en los Seminarios –necesaria para la mejora de la formación de uno de los principales agentes del propugnado y urgente cambio religioso– como en las Universidades –en las que se quería sustituir la influencia jesuítica por otra más de acorde con las ideas regalistas– se impulsó la creación de las cátedras De locis theologicis, muchas (...) de las cuales debían seguir el tratado de Melchor Cano y otras seguir a otros tratadistas, pero teniendo presente en sus explicaciones la docta obra de Melchor Cano. También se estudiará en la reforma del Plan de Estudios de la Orden de Frailes Predicadores, así como el rechazo que de todo ello tuvo el importante ilustrado valenciano Gregorio Mayans y Ciscar. The work is about how in the Spain of the second half of the 18th century owing to the theological studies reform as much in Seminaries-necessary to the education improvement of one of the main agents of the proposed and urgent religious change-as in Universities-in which it was wanted to substitute the Jesuitical influence for another more appropriate to the regalist ideas– the creation of the Locis theologicis chairs, many of which had to follow Melchor Cano’s treatise, and other chairs had to follow other authors, was promoted; but bearing in mind in their explanations Melchior Cano’s erudite work. Such treatise will also be studied in the reform of the Order of Preacher’ curriculum, as well as the rejection of all that by the important learned Gregorio Mayans y Ciscar, native of Valencia. (shrink)

IN THE first chapter of the second book of the Analytica Posteriora Aristotle offers a fourfold classification of objects of inquiry He refers to each of them by means of a shorthand expression.