Dorothea B. Heitsch is Assistant Professor of French and German at Shippensburg University in Pennsylvania.

A Scientific Integrity Consortium developed a set of recommended principles and best practices that can be used broadly across scientific disciplines as a mechanism for consensus on scientific integrity standards and to better equip scientists to operate in a rapidly changing research environment. The two principles that represent the umbrella under which scientific processes should operate are as follows: Foster a culture of integrity in the scientific process. Evidence-based policy interests may have legitimate roles to play in influencing aspects of (...) the research process, but those roles should not interfere with scientific integrity. The nine best practices for instilling scientific integrity in the implementation of these two overarching principles are Require universal training in robust scientific methods, in the use of appropriate experimental design and statistics, and in responsible research practices for scientists at all levels, with the training content regularly updated and presented by qualified scientists. Strengthen scientific integrity oversight and processes throughout the research continuum with a focus on training in ethics and conduct. Encourage reproducibility of research through transparency. Strive to establish open science as the standard operating procedure throughout the scientific enterprise. Develop and implement educational tools to teach communication skills that uphold scientific integrity. Strive to identify ways to further strengthen the peer review process. Encourage scientific journals to publish unanticipated findings that meet standards of quality and scientific integrity. Seek harmonization and implementation among journals of rapid, consistent, and transparent processes for correction and/or retraction of published papers. Design rigorous and comprehensive evaluation criteria that recognize and reward the highest standards of integrity in scientific research. (shrink)

The transcription factor NF‐κB (p65/p50) plays a central role in the coordination of cellular responses by activating the transcription of numerous target genes. The precise role of the dynamics of NF‐κB signalling in regulating gene expression is still an open question. Here, we show that besides external stimulation intracellular parameters can influence the dynamics of NF‐κB. By applying mathematical modelling and bifurcation analyses, we show that NF‐κB is capable of exhibiting different types of dynamics in response to the same stimulus. (...) We identified the total NF‐κB concentration and the IκBα transcription rate constant as two critical parameters that modulate the dynamics and the fold change of NF‐κB. Both parameters might vary as a result of cell‐to‐cell variability. The regulation of the IκBα transcription rate constant, e.g. by co‐factors, provides the possibility of regulating the NF‐κB dynamics by crosstalk. (shrink)

Introduction Dorothea Frede and Brad Inwood 1. The Stoics on the origin of language and the foundations of etymology James Allen 2. Stoic linguistics, Plato's Cratylus, and Augustine's De dialectica A. A. Long 3. Epicurus and his predecessors on the origin of language Alexander Verlinsky 4. Lucretius on what language is not Catherine Atherton 5. Communicating cynicism: Diogenes' gangsta rap Ineke Sluiter 6. Common sense: concepts, definition and meaning in and out of the Stoa Charles Brittain 7. Varro's anti-analogist (...) David Blank 8. The Stoics on fallacies of equivocation Susanne Bobzien 9. What is a disjunction? Jonathan Barnes 10. Theories of language in the Hellenistic age and in the twelfth and thirteenth centuries Sten Ebbesen. (shrink)

Our goal was to explore self‐care practices among men who have sex with men in the context of Mpox in Brazil. This study used qualitative research methods, including interviews and thematic analysis, to collect and analyze data from male participants across the Brazilian territory. The narratives unveil men's perspectives on self‐care, risk reduction, and health beliefs during the Mpox pandemic. Our findings highlight a multifaceted approach to self‐care among men, encompassing hygiene, physical contact management, mask usage, skin lesion vigilance, and (...) adherence to official guidelines. Men's attitudes toward sexual behaviors emphasize the importance of reducing sexual partners, practicing safe sex, and combating misinformation through accurate information dissemination. The development of these behaviors and self‐care practices can be facilitated by nurses guided by Dorothea Orem's Self‐Care Theory, supported by patient‐centered care, with strategies to address and confront the stigma associated with the disease and provide emotional support. Thus, the study underscores the pivotal role of self‐care in mitigating infection risks, especially in the context of emerging infectious diseases. It acknowledges the impact of socio‐cultural factors and healthcare policies on men's preventive measures. However, it also recognizes limitations, such as potential bias due to stigma concerns and a nonrepresentative sample. Ultimately, the research advocates for tailored education, promotion of gender equity, and healthcare empowerment to effectively manage health risks in such contexts. (shrink)

Showcasing American music and music making during the Great Depression, Hard Luck Blues presents more than two hundred photographs created by the New Deal's Farm Security Administration photography program. With an appreciation for the amateur and the local, FSA photographers depicted a range of musicians sharing the regular music of everyday life, from informal songs in migrant work camps, farmers' homes, barn dances, and on street corners to organized performances at church revivals, dance halls, and community festivals. Captured across the (...) nation from the northeast to the southwest, the images document the last generation of musicians who learned to play without the influence of recorded sound, as well as some of the pioneers of Chicago's R & B scene and the first years of amplified instruments. The best visual representation of American roots music performance during the Depression era, Hard Luck Blues features photographs by Jack Delano, Dorothea Lange, Russell Lee, Arthur Rothstein, Ben Shahn, Marion Post Wolcott, and others. Photographer and image researcher Rich Remsberg breathes life into the images by providing contextual details about the persons and events captured, in some cases drawing on interviews with the photographers' subjects. Also included are a foreword by author Nicholas Dawidoff and an afterword by music historian Henry Sapoznik. Published in association with the Library of Congress. (shrink)

Brian Wormald provides a fundamental reappraisal of one of the most complex and innovative figures of the late-Elizabethan and Jacobean age. In the centuries since his death, Francis Bacon (1561-1626) has been perceived and studied as a promoter and prophet of the philosophy of science--natural science--but he saw himself also as a clarifier and promoter of what he called "policy" or the study and improvement of the structure and function of civil states. Mr. Wormald shows that Bacon was concerned equally (...) with the knowledge of the world of nature and with that of policy. The junction between the two enterprises was effected by his work in history; and in the end it was Bacon's conception and practice of history that provided the answer to his efforts to advance policy and natural philosophy. (shrink)

While the question of free will does not figure as prominently in Buddhist writings as it does in western theology, philosophy, and psychology, it is a topic that was addressed in the earliest Buddhist writings. According to these accounts, for pragmatic and ethical reasons, the Buddha rejected both determinism and indeterminism as understood at that time. Rather than asking the metaphysical question of whether already humans have free will, Buddhist tradition takes a more pragmatic approach, exploring ways in which we (...) can acquire greater freedom to make wise choices that are truly conducive to our own and others' genuine well-being. One key to achieving such freedom is the cultivation of attentional skills so that one can deliberately focus one's attention with continuity and clarity on one's chosen object. A second theme is the cultivation of insight into the manner in which our own attitudes shape experience, allowing for the possibility of altering not only the way we experience events in the present, but also how we are influenced by our memories of the past. Finally, the Great Perfection school of Tibetan Buddhism emphasizes the realization of the deepest dimension of consciousness -- pristine awareness -- which transcends the nexus of causality. This is regarded as the ultimate source of freedom and the ultimate nature of human identity. (shrink)

The General Account of Pleasure in Plato's Philebus THOMAS M. TUOZZO 1. INTRODUCTION DOES PLATO IN THE Philebus present a single general account of pleasure, applicable to all of the kinds of pleasure he discusses in that dialogue? Gosling and Taylor think not;' Dorothea Frede has recently reasserted a version of the contrary, traditional view. 2 The traditional view, I shall argue in this essay, is correct: the Philebus does contain a general account of pleasure applicable to all pleasures. (...) Nonetheless, Gosling and Taylor have pointed to a real difficulty with the traditional view, a difficulty that has never been adequately ad- dressed. To show how it can be overcome will involve showing that Plato's account of pleasure, and his analyses of other phenomena of moral psychol- ogy in the Philebus, are more complex and subtle than has often been realized. Gosling and Taylor offer two considerations in support of their view: Socrates insists against Protarchus that different pleasures can be "most oppo- site" to each other, which suggests that no single account can apply to them all,s and Socrates does not indicate how the most likely candidate for a general account of pleasure, one involving the restoration of a natural har- ,j. c. B. Gosling and C. C. W. Taylor, The Greeks on Pleasure , 14o: "It seems clear that in the Philebus Plato has no general formula to encapsulate the nature of pleasure .... " So, too, C. Hampton, Pleasure,.. (shrink)

Open peer commentary on the article “A Computational Constructivist Model as an Anticipatory Learning Mechanism for Coupled Agent–Environment Systems” by Filipo Studzinski Perotto. Upshot: In making a contribution to artificial intelligence research, Perotto has taken note of work on human cognition. However, there are certain aspects of human cognition that are not taken into account by the author’s model and that, generally, are overlooked or ignored by the artificial intelligence research community at large.

Nanay (2015; 2016) revives manner or attitude accounts of aesthetic experience. While manner-based accounts are promising, Nanay's claim that certain kinds of aesthetic experiences require attention to be focused on one object, but distributed across many properties of that object, that 'aesthetic attention' is necessary for 'Proustian experience', is false. Attention to objects of aesthetic experience frequently involves attention to intra-objects, objects that are proper perceptual parts of the attended objects.