A Scientific Integrity Consortium developed a set of recommended principles and best practices that can be used broadly across scientific disciplines as a mechanism for consensus on scientific integrity standards and to better equip scientists to operate in a rapidly changing research environment. The two principles that represent the umbrella under which scientific processes should operate are as follows: Foster a culture of integrity in the scientific process. Evidence-based policy interests may have legitimate roles to play in influencing aspects of (...) the research process, but those roles should not interfere with scientific integrity. The nine best practices for instilling scientific integrity in the implementation of these two overarching principles are Require universal training in robust scientific methods, in the use of appropriate experimental design and statistics, and in responsible research practices for scientists at all levels, with the training content regularly updated and presented by qualified scientists. Strengthen scientific integrity oversight and processes throughout the research continuum with a focus on training in ethics and conduct. Encourage reproducibility of research through transparency. Strive to establish open science as the standard operating procedure throughout the scientific enterprise. Develop and implement educational tools to teach communication skills that uphold scientific integrity. Strive to identify ways to further strengthen the peer review process. Encourage scientific journals to publish unanticipated findings that meet standards of quality and scientific integrity. Seek harmonization and implementation among journals of rapid, consistent, and transparent processes for correction and/or retraction of published papers. Design rigorous and comprehensive evaluation criteria that recognize and reward the highest standards of integrity in scientific research. (shrink)

A novel Protocol Ethics Tool Kit (‘Ethics Tool Kit’) has been developed by a multi-stakeholder group of the Multi-Regional Clinical Trials Center of Brigham and Women9s Hospital and Harvard. The purpose of the Ethics Tool Kit is to facilitate effective recognition, consideration and deliberation of critical ethical issues in clinical trial protocols. The Ethics Tool Kit may be used by investigators and sponsors to develop a dedicated Ethics Section within a protocol to improve the consistency and transparency between clinical trial (...) protocols and research ethics committee reviews. It may also streamline ethics review and may facilitate and expedite the review process by anticipating the concerns of ethics committee reviewers. Specific attention was given to issues arising in multinational settings. With the use of this Tool Kit, researchers have the opportunity to address critical research ethics issues proactively, potentially speeding the time and easing the process to final protocol approval. (shrink)

In honor of William Wainwright, this article takes up his interest in interreligious dialogue. It pursues two goals simultaneously: One is to provide a better model for understanding philosophy of religion. Terrence Tilley claims that there is the standard model which is mistaken in that it takes arguing for religious beliefs to be equivalent to justifying commitment to a religion. He promotes a practical model, which has its ancestry in the writings of Michel de Montaigne and Blaise Pascal. This model (...) begins with the lived practices of religion and justifies its intellectual content as explanation for the rightness of this way of life. Wainwright’s work fits into the practical model, but Tilley provides a description and a stronger basis for it. The second goal is to provide much more adequate epistemological resources than those used by the standard model, with contributions from Catholic modernist theologian George Tyrrell, recent philosopher of science Imre Lakatos, and Alasdair MacIntyre, who became interested in evaluating traditions, in science, in moral reasoning, and finally what he came to call large-scale traditions. The problem he needed to overcome is the fact that such traditions carry their own, often different, concepts of reasoning. The possibility of fruitful rational conversation between religions is illustrated here by an account of dialogue between Christianity and Shi’ia Islam, as exemplified in David Burrell’s ability to use conversation with Islamic thought to clarify for Christians their own doctrines of the Trinity, the mediation of Christ, and original sin. (shrink)

In many ways, we live in propitious times for gay and lesbian people. In 1996, the Supreme Court struck down Colorado law prohibiting any kind of protected status based on sexual orientation. In 2003, the Supreme Court held that states may not criminalize sexual conduct between consenting adults of the same sex in private, so long as no money changes hands. In 2010, the Congress repealed the “Don't Ask, Don't Tell” policy that excluded openly gay men and lesbians from military (...) service. In 2013, the Supreme Court struck down key elements of the Defense of Marriage Act that prohibited any federal recognition of same‐sex marriage. Most states do not allow same‐sex marriage, but more and more states are joining the fold. Likewise, most U.S. states do not forbid discrimination based on sexual orientation, but the number that does is increasing. Arguably, no other social minority has made as much legal progress in so short a time. Despite these advances, the story of gay and lesbian people and the law is not yet finished, and the meaning of homosexuality for bioethics is still being written too. Concerns about gay and lesbian people remain important to bioethics in key domains, especially in seeing to the conferral of optimal health care benefits and in sorting through the priorities and social effects of research. Progress in these domains still involves lifting certain burdens of medical and social misjudgments about same‐sex attraction. (shrink)

Higher education has not been spared from the effects of the disruptive aspects of technology. MOOCs, teach bots, virtual learning platforms, and Wikipedia are among technics marking a digi...

Abstract:Because the demand for intensive care unit (ICU) beds exceeds the supply in general, and because of the formidable costs of that level of care, clinicians face ethical issues when rationing this kind of care not only at the point of admission to the ICU, but also after the fact. Under what conditions—if any—may patients be denied admission to the ICU or removed after admission? One professional medical group has defended a rule of “first come, first served” in ICU admissions, (...) and this approach has numerous moral considerations in its favor. We show, however, that admission to the ICU is not in and of itself guaranteed; we also show that as a matter of principle, it can be morally permissible to remove certain patients from the ICU, contrary to the idea that because they were admitted first, they are entitled to stay indefinitely through the point of recovery, death, or voluntary withdrawal. What remains necessary to help guide these kinds of decisions is the articulation of clear standards for discontinuing intensive care, and the articulation of these standards in a way consistent with not only fiduciary and legal duties that attach to clinical care but also with democratic decision making processes. (shrink)

Background This study introduces an empirical approach for studying the role of prudence in physician treatment of end-of-life (EOL) decision making.Methods A mixed-methods analysis of transcripts from 88 simulated patient encounters in a multicenter study on EOL decision making. Physicians in internal medicine, emergency medicine, and critical care medicine were asked to evaluate a decompensating, end-stage cancer patient. Transcripts of the encounters were coded for actor, action, and content to capture the concept of Aristotelian prudence, and then quantitatively and qualitatively (...) analyzed to identify actions associated with preference-concordant treatment.Results Focusing on codes that describe characteristics of physician-patient interaction, the code for physicians restating patient preferences was associated with avoiding intubation. Multiple codes were associated with secondary measures of preference-concordant treatment.Conclusions Prudent actions can be identified empirically, and research focused on the virtue of prudence may provide a new avenue for assessment and training in EOL care. (shrink)

A commentary on “Time to Decriminalize HIV Status,” from the September‐October 2013 issue.

© 2016 RCNi Ltd. All rights reserved. Background Conceptual frameworks are important to ensure a clear underpinning research philosophy. Further, the use of conceptual frameworks can support structured research processes. Aim To present a partnership model for a reflective narrative for researcher and participant. Discussion This paper positions the underpinning philosophical framework of the model in social constructionism and narrative enquiry. The model has five stages - study design, invitation to share a research space and partnership, a metaphorical research space, (...) building a community story, and reading the community story to others. Core principles of the partnership model are continual reflection by the researcher, potential reflections by participants, reciprocal sharing, and partnership in research. Conclusion A 'trajectory of self' for both participants and researchers can be enhanced within reflective partnerships. Implications for practice This model can be applied to studies that use narrative enquiry and are seeking a humanistic approach with participant engagement. (shrink)

Cyprian’s appropriation of Scripture and his theological emphases are closely connected with the circumstances of his congregation. As a case study in Cyprian’s biblical interpretation, this article considers all his quotations of and allusions to Philippians through the lens of his pastoral concerns: the unity of the Church; care for the poor and captive; discipline and repentance; and divine truth and eternal glory. The reading strategies Cyprian uses can be categorized as contextual exegesis, model, image, direct application, and prophetic fulfilment. (...) The study provides a fresh perspective on patronage and almsgiving in Cyprian, deepens our understanding of the reception of Paul, and elucidates the interplay of text, context and theology in an important exponent of early Latin exegesis. (shrink)

Collagen is the most abundant vertebrate protein and forms a stable fibrous architecture in connective tissues, such as bone, cartilage, skin and tendon. Much recent research has been directed towards an understanding of the molecular and cellular mechanisms involved in the synthesis and degradation of collagen, because a change in the normal balance, or an increased destruction of collagen, can cause loss of function of specialized tissues. This short review attempts to summarize present knowledge about the proteolytic destruction of collagen (...) and the exciting new work on the factors that are emerging as important controlling agents. An understanding of the regulatory processes is yielding some important clues regarding the levels at which they can fail in pathological conditions and we speculate about evolving strategies for preventing uncontrolled resorption. (shrink)

Should parents be able to select the sexual orientation of their children, if that were possible through prenatal interventions? _Ethics, Sexual Orientation, and Choices about Children_ reviews the history of this debate which started in the 1970s and has been invigorated by scientific reports about the origins of sexual orientation. This book describes the debate and offers an evaluation of key issues in parental rights, children's rights, and family welfare.

Drawing inspiration from Susan Sontag’s notion of ‘rhetorical ownership’—applied not only to illness but also to the body more generally—this essay argues that philosophy, like medicine, has privileged a metaphorics of war and violence in its own discourses on embodiment. Drawing inspiration from Barbara Christian’s seminal essay ‘The Race for Theory,’ as well as literary theorist Eve Sedgwick’s account of what she calls ‘paranoid’ forms of inquiry in her book Touching Feeling, this essay explores the status of violence as an (...) especially resonant trope in discourses on materiality. One worry is that the omnipresence of violent metaphors in contemporary philosophy of the body may be narrowing the space for the elaboration of nonviolent understanding of corporeality that would imagine the body otherwise than as a battlefield or a site of violence. (shrink)

Sex selection of children by pre-conception and post-conception techniques remains morally controversial and even illegal in some jurisdictions. Among other things, some critics fear that sex selection will distort the sex ratio, making opposite-sex relationships more difficult to secure, while other critics worry that sex selection will tilt some nations toward military aggression. The human sex ratio varies depending on how one estimates it; there is certainly no one-to-one correspondence between males and females either at birth or across the human (...) lifespan. Complications about who qualifies as ‘male’ and ‘female’ complicate judgments about the ratio even further. Even a judiciously estimated sex ratio does not have, however, the kind of normative status that requires society to refrain from antenatal sex selection. Some societies exhibit lopsided sex ratios as a consequence of social policies and practices, and pragmatic estimates of social needs are a better guide to what the sex ratio should be, as against looking to ‘nature’. The natural sex ratio cannot be a sound moral basis for prohibiting parents from selecting the sex of their children, since it ultimately lacks any normative meaning for social choices. (shrink)

Both Thomas Hobbes and John Austin identify civil law with commands issued by a sovereign; thus it is common to think of Austin’s theory of law as closely continuous with Hobbes’s view. Yet this “command of the sovereign” formulation masks deep differences between Hobbes and Austin, not only in their understandings of command and sovereign but also in the commitments that gave rise to their offering theories of law formulated in these terms. Nor is it correct to think that innovations (...) in Hobbes’s conception of law paved the way for Austin’s more full-blown legal positivism: Hobbes’s jurisprudence is, in fundamentals, closely akin to Thomas Aquinas’s natural law jurisprudence. The idea that Hobbes and Austin are jurisprudential allies ought to be abandoned. (shrink)

ABSTRACT John Rundell’s Kant explores the themes of imagination, anthropology and freedom across the entire Kantian corpus. The book casts a revealing light on Kant’s conception of the imagination. It does so in a sustained dialogue with Immanuel Kant’s views on the human condition and political and civil freedom. Rundell explores different approaches that Kant employs to account for the imagination. Rundell’s Kant discusses reproductive, productive, synthesising, monogrammatical, schematic, free, wild and sublime forms of imagination and how these are deeply (...) interwoven with both the antinomies of human freedom and the distinctive philosophical anthropology of humankind. (shrink)

This article proposes how theatre, as a site of expert adult imaginative play, provides a unique window into how E-cognition can advance our understanding of imagination as a lifelong practice. I characterize theatrical activity as highly developed actions and strategies for wielding bodies, objects, and environments as imaginative practice. Through an enactively based case study of the play _Provenance_ by Autopoetics ( 2018 ), I reveal how creation and performance processes literally and epistemically engineer novel niches for the spectator. This (...) case study investigates how _Provenance_’s recurring theatrical device of newspaper manipulation constitutes a cognitive device for an affordance-oriented and predictive spectator. As I track the priorities and processes of these longstanding play development and performance techniques informed by the theatrical tradition of Jacques Lecoq (1921–1999), I suggest how concepts such as affordances, affordance spaces, predictive engagement, and the free energy principle are apt conceptual tools for understanding how these practices engender imaginative encounters. I follow this analysis by suggesting, via the free energy principle’s conception of “models,” that there may be cognitive consequences to the possible changes experienced by the spectator that exceed theatrical experience. I conclude this discussion by pointing toward how my 4-E inflected insights on the imaginative practices of _Provenance_ may be applicable to imagination and pretense in other arenas not just behind but also beyond the footlights. (shrink)

This book provides a rich collection of readings that challenge traditional understandings of knowledge and the view of mind that underpins them.