Three‐dimensional structured illumination microscopy (3D‐SIM) has opened up new possibilities to study nuclear architecture at the ultrastructural level down to the ∼100 nm range. We present first results and assess the potential using 3D‐SIM in combination with 3D fluorescence in situ hybridization (3D‐FISH) for the topographical analysis of defined nuclear targets. Our study also deals with the concern that artifacts produced by FISH may counteract the gain in resolution. We address the topography of DAPI‐stained DNA in nuclei before and after (...) 3D‐FISH, nuclear pores and the lamina, chromosome territories, chromatin domains, and individual gene loci. We also look at the replication patterns of chromocenters and the topographical relationship ofXist‐RNA within the inactive X‐territory. These examples demonstrate that an appropriately adapted 3D‐FISH/3D‐SIM approach preserves key characteristics of the nuclear ultrastructure and that the gain in information obtained by 3D‐SIM yields new insights into the functional nuclear organization. (shrink)

Disagreements about the morality of markets, and about self-interested behavior within markets, run deep. They arise from perspectives within economics and political philosophy that appear to have nothing in common. In this book, Daniel Finn provides a framework for understanding these conflicting points of view. Recounting the arguments for and against markets and self-interest, he argues that every economy must address four fundamental problems: allocation, distribution, scale, and the quality of relations. In addition, every perspective on the morality of (...) markets addresses explicitly or implicitly the economic, political, and cultural contexts of markets, or what Finn terms 'the moral ecology of markets'. His book enables a dialogue among the various participants in the debate over justice in markets. In this process, Finn engages with major figures in political philosophy, including John Rawls, Robert Nozick, and Michael Walzer, as well as in economics, notably Milton Friedman, Friedrich Hayek, and James Buchannan. (shrink)

In a pair of influential papers, Tamar Schapiro argues that childhood is a ‘predicament’, in that children lack stable characters that allow them to be subjects of ascriptions of moral responsibility. Comparing childhood to the political ‘state of nature’, Schapiro holds that childhood is a stage of life from which agents must be liberated. I argue that the comparison to the state of nature gives rise to the implication that ‘instantaneous adulthood’ would be a desirable state. Canvassing the nascent literature (...) on ‘intrinsic goods of childhood’, I hold that such views cannot defeat Schapiro's implications, as they are based on theories of value that beg the question against Schapiro's. Only if childhood can be shown to be a necessary stage toward a normatively attractive adulthood can the ‘instantaneous adulthood’ implication be defeated. I show that Schapiro's view is only plausible if it incorporates the endorsement condition and the articulacy condition. But these are incompatible with instantaneous adulthood. Childhood can be seen as the stage in life in which agents actively endorse their characters, and gain articulacy with respect to the maxims that constitute them. (shrink)

Metaphysics has undergone two major innovations in recent decades. First, naturalistic metaphysicians have argued that our best science provides an important source of evidence for metaphysical theories. Second, social metaphysicians have begun to explore the nature of social entities such as groups, institutions, and social categories. Surprisingly, these projects have largely kept their distance from one another. Katherine Hawley has recently argued that, unlike the natural sciences, the social sciences are not sufficiently successful to provide evidence about the metaphysical nature (...) of social entities. By contrast, I defend an optimistic view of naturalistic social metaphysics. Drawing on a case study of research into contextual effects in social epidemiology, I show that social science can provide a valuable evidence for social metaphysicians. (shrink)

The process of constructing a social reality where “difference” becomes a social asset rather than a monster that threatens peace and progress must commence with a phenomenological understanding of social interactions within and among human societies. In my opinion, Hegel, more than any other thinker, has constructed a phenomenological framework that adequately captures and represents the nature of group interactions within human societies. This paper explores the Hegelian phenomenon of social identity, and, especially, characterizes the interactions between and among various (...) social identities. It is a modest effort to contribute theoretically to the available discourse on the management of “difference” in multi-ethnic societies. (shrink)

In this dissertation I advance a Jaspersian account of the formation and possession of irrational attitudes. This account stands in opposition to two competing views – externalism and internalism with respect to rational and irrational attitudes. According to externalism, a subject’s attitudes are irrational when they fail to satisfy standards or criteria independent of the subject, such as laws of logic, methods for evidence acquisition, and rules of decision theory. According to internalism, a subject’s attitudes are irrational when they are (...) not supported by reasons selected by the subject. In this dissertation, I take Donald Davidson’s theory of rational and irrational attitudes to be a case of externalism and John Searle’s theory of rational and irrational attitudes to be a case of internalism. While articulating and identifying the merits of externalism and internalism with respect to rational or irrational attitudes, I argue that each account ends up in difficulties: Davidson’s externalism cannot account for the experience of freedom, an individual’s subjectivity, and is unable to avoid an infinite regress of rules; Searle’s internalism struggles to avoid solipsism and an infinite regress of reasons. Karl Jaspers’ account of rational and irrational attitude formation, I argue, avoids the pitfalls of Davidson’s and Searle’s views while preserving the merits of each. On Jaspers’ account, a subject possesses rational attitudes insofar as that subject holds those attitudes to be always open to revision while, at the same time, using those attitudes to bring unity to all manner of phenomena and other attitudes. Irrationality, by contrast, occurs, on the Jaspersian view, when a subject holds onto attitudes with complete and absolute resolution and interprets all else according to these attitudes. Having defined a Jaspersian account of rational and irrational attitudes, I show how it accounts for the irrationality of delusional beliefs and the irrationality of certain worldviews. On Jaspers’ view, I argue, delusions and worldviews are irrational insofar as they are held with absolute conviction, are unamenable to modification, and are used to understand all available evidence, views, and opinions. (shrink)

Over the years, American colleges and universities have made various efforts to provide prisoners with access to education. However, few of these outreach programs presume that incarcerated men and women can rise to the challenge of a truly rigorous college curriculum. The Bard Prison Initiative is different. _College in Prison_ chronicles how, since 2001, Bard College has provided hundreds of incarcerated men and women across the country access to a high-quality liberal arts education. Earning degrees in subjects ranging from Mandarin (...) to advanced mathematics, graduates have, upon release, gone on to rewarding careers and elite graduate and professional programs. Yet this is more than just a story of exceptional individuals triumphing against the odds. It is a study in how the liberal arts can alter the landscape of some of our most important public institutions giving people from all walks of life a chance to enrich their minds and expand their opportunities. Drawing on fifteen years of experience as a director of and teacher within the Bard Prison Initiative, Daniel Karpowitz tells the story of BPI’s development from a small pilot project to a nationwide network. At the same time, he recounts dramatic scenes from in and around college-in-prison classrooms pinpointing the contested meanings that emerge in moments of highly-charged reading, writing, and public speaking. Through examining the transformative encounter between two characteristically American institutions—the undergraduate college and the modern penitentiary—_College in Prison_ makes a powerful case for why liberal arts education is still vital to the future of democracy in the United States. (shrink)

Epistemology is a branch of philosophy that studies the origin, nature and limits of human knowledge. Contemporary epistemology is a theory of knowledge in terms of reasons, evidence, justification and explanation. This book shows how Anglo-American philosophers captivated by the power of modern science and concomitant advances in logic and mathematics mistook knowledge itself to be reducible to the propositions of science and logic. Ethics, along with metaphysics and religion, were cast off as mere expressions of sentiment at best, or (...) as utter nonsense at worst. Is science the only source of knowledge? Can ethics count as knowledge? Are there kinds of knowledge beyond epistemology? This book develops innovative answers to these and other related questions. (shrink)

Belief -- Trust -- Loyalty -- World-view -- Concluding thoughts.

A pergunta pelo sentido do ser será aqui orientada para a afirmação do postulado de uma condição essencialmente precária do mortal, a partir da qual ele deverá ser radicalmente situado em seu horizonte histórico-metafísico fundamentalmente através do seu comprometimento existencial com uma abertura abissal do fenômeno de mundo que excede sua capacidade de apreensão.

We propose the use of variable declarations in natural deduction. A variable declaration is a line in a derivation that introduces a new variable into the derivation. Semantically, it can be regarded as declaring that the variable denotes an element of the universe of discourse. Undeclared variables, in contrast, do not denote anything, and may not occur free in any formula in the derivation. Although most natural deduction systems in use today do not have variable declarations, the idea can be (...) traced back to one of the first papers on natural deduction. We show how the use of variable declarations in natural deduction leads to a formal system that has a number of desirable features: It is simple, easy to use and understand, and corresponds closely to ordinary informal reasoning. Soundness and completeness of the system are easily proven. Furthermore, the system clarifies the role of the existential instantiation rule in natural deduction. (shrink)

Pour certains philosophes pluralistes politiques, accepter la thèse de pluralisme des valeurs entraîne le rejet de l’autonomie libérale en faveur d’une forme de libéralisme fondée sur l’idéal de la tolérance. Cette idée est fausse. D’abord le pluralisme des valeurs partage avec le relativisme la difficulté inhérente à toute tentative de tirer une conclusion normative d’une thèse descriptive. Chercher à soutenir l’argument en comblant les prémisses manquantes montre que le pluralisme des valeurs est plus naturellement lié au libéralisme autonomiste qu’à un (...) libéralisme fondé sur la tolérance. C’est parce que les individus doivent posséder une capacité de choix autonome pour que le pluralisme puisse les concerner. (shrink)

Kant's relation to religion and theology is complex since he tries both to delimit theology's influence and to inherit its discursive power. The essay explores the different critical strategies and rhetorical means that Kant uses to deal with theology: theological analogies and metaphors in his systematic thought, a new kind of,philosophy of religion,' a political theology of civil society, and finally a specific way of reading the Bible.

Current medical and legal literature generally favors a definition of death based on total cessation of brain functioning. It does not, however, supply the reasoning for this recommendation. None of the arguments for whole-brain death is convincing; there exists, however, a satisfactory rationale for identifying death with cortical death. Policymakers should refrain from endorsing any of these arguments, focussing instead on the pragmatic tasks involved in guiding medical care at the end of life.

Two elderly sisters embroider the house of their childhood at either end of a white bedspread, each as she remembers it, with results that surprise them.

How can a just peace be built in sites of genocide, massive civil war, dictatorship, terrorism, and poverty? In Strategies of Peace, the first volume in the Studies in Strategic Peacebuilding series, fifteen leading scholars propose an imaginative and provocative approach to peacebuilding. Today the dominant thinking is the "liberal peace," which stresses cease fires, elections, and short run peace operations carried out by international institutions, western states, and local political elites. But the liberal peace is not enough, the authors (...) argue. A just and sustainable peace requires a far more holistic vision that links together activities, actors, and institutions at all levels. By exploring innovative models for building lasting peace-a United Nations counter-terrorism policy that also promotes good governance; coordination of the international prosecution of war criminals with local efforts to settle civil wars; increasing the involvement of religious leaders, who have a unique ability to elicit peace settlements; and many others--the authors advance a bold new vision for peacebuilding. (shrink)