We have synthesized a 582,970-base pair Mycoplasma genitalium genome. This synthetic genome, named M. genitalium JCVI-1.0, contains all the genes of wild-type M. genitalium G37 except MG408, which was disrupted by an antibiotic marker to block pathogenicity and to allow for selection. To identify the genome as synthetic, we inserted "watermarks" at intergenic sites known to tolerate transposon insertions. Overlapping "cassettes" of 5 to 7 kilobases (kb), assembled from chemically synthesized oligonucleotides, were joined by in vitro recombination to produce intermediate (...) assemblies of approximately 24 kb, 72 kb ("1/8 genome"), and 144 kb ("1/4 genome"), which were all cloned as bacterial artificial chromosomes in Escherichia coli. Most of these intermediate clones were sequenced, and clones of all four 1/4 genomes with the correct sequence were identified. The complete synthetic genome was assembled by transformation-associated recombination cloning in the yeast Saccharomyces cerevisiae, then isolated and sequenced. A clone with the correct sequence was identified. The methods described here will be generally useful for constructing large DNA molecules from chemically synthesized pieces and also from combinations of natural and synthetic DNA segments. 10.1126/science.1151721. (shrink)

A Life Decoded is an exhilarating document, to begin with, reading like a novel or even a science epic. In the author’s own words, it is “a tale of seemingly impossible quests and grand objectives”, of “great rivalries and bitter disputes”, of “battles of ideologies, morals and ethics” and of “clashes of egos” (p. 2), an adventure that swept the author “from peaks of incredible exhilaration as I marshaled a relatively small but dedicated army of scientists, computers and robots to (...) achieve what seemed almost impossible, and then plunged me into black pits of depression as I faced opposition from Nobel laureates and senior government officials, my colleagues, and even my wife” (p. 2). Moreover, besides being an autobiography proper, the book also contains a series of reflections on the genes present in the author’s own genome, one of the first individual genomes that was sequenced and made publicly available on the web – the “recipe” that made Craig Venter, as he himself describes it. In separate boxes dedicated to his sequenced genome, he especially focuses on genes that are associated with behavioural characteristics such as thrill-seeking behaviour, ADHD and the ability to cope with almost superhuman amounts of stress. Thus, in Venter’s case, autobiography and the genome are connected in more than one way with one another. (shrink)

This article examines how minimal genome research mobilizes philosophical concepts such as minimality and essentiality. Following a historical approach the article aims to uncover what function this terminology plays and which problems are raised by them. Specifically, four historical moments are examined, linked to the work of Harold J. Morowitz, Mitsuhiro Itaya, Eugene Koonin and Arcady Mushegian, and J. Craig Venter. What this survey shows is a historical shift away from historical questions about life or descriptive questions about (...) specific organisms towards questions that explore biological possibilities: what are possible forms of minimal genomes, regardless of whether they exist in nature? Moreover, it highlights a fundamental ambiguity at work in minimal genome research between a universality claim and a standardization claim: does a minimal genome refer to the minimal gene set for any organism whatsoever? Or does it refer rather to a gene set that will provide stable, robust and predictable behaviour, suited for biotechnological applications? Two diagnoses are proposed for this ambiguity: a philosophical diagnosis of how minimal genome research either misunderstands the ontology of biological entities or philosophically misarticulates scientific practice. Secondly, a historical diagnosis that suggests that this ambiguity is part of a broader shift towards technoscience. (shrink)

Recently at the J. Craig Venter Institute, a microorganism has been created through synthetic biology. In the future, more complex living beings will very probably be produced. In our natural environment, we live amongst a whole variety of beings. Some of them have moral status — they have a moral importance and we cannot treat them in just any way we please —; some do not. When it becomes possible to create artificially living beings who naturally possess moral (...) status, will this artificiality modify their status? Many people contend that it will, but I am not of the same mind and will develop three arguments against it. (shrink)

Mortal and immortal DNA : Craig Venter and the lure of "lamia" -- Homeopathy : Holmes, hogwarts, and the Prince of Wales -- Citizen Pinel and the madman at Bellevue -- The experimental pathology of stress : Hans Selye to Paris Hilton -- Gore's fever and Dante's Inferno : Chikungunya reaches Ravenna -- Giving things their proper names : Carl Linnaeus and W.H. Auden -- Spinal irritation and fibromyalgia : Lincoln's surgeon general and the three graces -- Tithonus (...) and the fruit fly : new science and old myths -- Swiftboating "America the beautiful" : Katharine Lee Bates and a Boston marriage -- Nothing makes sense in medicine except in the light of biology -- Apply directly to the forehead : Holmes, Zola, and Hennapecia -- Elizabeth Blackwell breaks the bonds -- Chronic lyme disease and medically unexplained syndromes -- Eugenics and the immigrant : Rosalyn Yalow and Rita Levi-Montalcini -- Science in the Middle East : Robert Koch and the cholera war -- How to win a Nobel prize : thinking inside and outside the box -- Homer Smith and the lungfish : the last gasp of intelligent design -- DDT is back : let us spray! -- Academic boycotts and the Royal Society -- Teach evolution, learn science : John William Draper and the "bone bill" -- Diderot and the yeti crab : the encyclopedias of life -- Dengue fever in Rio : Macumba versus Voltaire. (shrink)

This essay builds on the literatures on ‘biocapitalism’ and ‘informationalism’ (or ‘informational capitalism’) to develop the concept of ‘bio-informational capitalism’ in order to articulate an emergent form of capitalism that is self-renewing in the sense that it can change and renew the material basis for life and capital as well as program itself. Bio-informational capitalism applies and develops aspects of the new biology to informatics to create new organic forms of computing and self-reproducing memory that in turn has become the (...) basis of bioinformatics. The paper begins with a review of the successes of the ‘new biology’, focusing on Craig Venter’s digitizing of biology and, as he remarks, the creation of new life from the digital universe. The paper then provides a brief account of bioinformatics before brokering and discussing the term ‘bioinformational capitalism’. (shrink)

The Presidential Commission for the Study of Bioethical Issues released its first report, New Directions: The Ethics of Synthetic Biology and Emerging Technologies, on December 16, 2010.1 President Barack Obama had requested this report following the announcement last year that the J. Craig Venter Institute had created the world’s first self-replicating bacterial cell with a completely synthetic genome. The Venter group’s announcement marked a significant scientific milestone in synthetic biology, an emerging field of research that aims to (...) combine the knowledge and methods of biology, engineering, and related disciplines in the design of chemically synthesized DNA to create organisms with novel or enhanced .. (shrink)

Shortly after the Presidential Commission for the Study of Bioethical Issues was constituted in 2010 and days before the commission members were to join a conference call to discuss possible topics for their deliberation, Craig Venter held a press conference announcing that his lab had created a synthetic chromosome for a species of mycoplasma and had inserted this genetic material into organisms of another species of mycoplasma (the genes of which had been deactivated), transforming the host species into (...) the donor species. While not overtly claiming to have “created life in the test tube,” Venter's publicity seemed cleverly designed to provoke the media into reporting his discovery in just that way. The resulting uproar caused President Obama to give his new bioethics commission the assignment of investigating the ethics of the emerging field of synthetic biology. The commission went right to work. It formed working groups to deliberate about parts of the report, feeding ideas and language to the staff members who would do the actual writing, and then present the working group suggestions to the commission as a whole for public deliberation at open meetings. One of those working groups was charged with coming up with ethical principles that would guide the analysis. Having served as a member of that working group, I report here on the process by which these principles emerged and reflect upon the suitability of that process for the work of public bioethics commissions. (shrink)

In this paper I analyse the ethical implications of the two main competing methodologies in genomic research. I do not aim to provide another contribution from the mainstream legal and public policy perspective; rather I offer a novel approach in which I analyse and describe the patent-and-publish regime (the proprietary regime) led by biologist J. Craig Venter and the 'open-source' methodologies led by biotechnology Nobel laureate John Sulston. The 'open-source methodologies' arose in biotechnology as an alternative to the (...) patent-and-publish regime in the wake of the explosion in computer technology. Indeed, the tremendous increase in computer technology has generated a corresponding increase in the pace of genomics research. I conclude this paper by arguing that while the patent-and-publish method is a transactional method based on the exchange of extrinsic goods (patents in exchange for research funds), the free and open-source methodology (FLOSS) 1 is a transformational method based on a visionary ideal of science, which leads to prioritizing intrinsic goods in scientific research over extrinsic goods. (shrink)

Resumen Hace 78 años, en “Un Mundo Feliz”, el escritor Aldous Huxley, en un prodigioso tono satírico, se anticipó con asombrosa precisión a los grandes temas de la agenda científica y política del Siglo XXI: la reproducción controlada, el choque de civilizaciones y la clonación humana, entre otros. Hace unos días, a mediados de mayo de 2010, el J. Craig Venter Institute anunció que había producido la primera célula sin historia genética creada en un laboratorio a partir de (...) un genoma sintetizado químicamente. Hoy, describiendo el estado “posthumano” de la historia, Francis Fukuyama afirma: “Huxley tenía razón”. Palabras clave: bioética; ingeniería genética; democracia; totalitarismo; biotécnica; eugenesia ;utopías; distopias. Huxley’s Prophecy and the Biotech Century: Post-human society is reaching usSeventy-eight years ago, in “A Happy World”, the writer Aldous Huxley, in a prodigious satiric tone, anticipated with astonishing accurateness the big topics of the XXI Century’s scientific and political agenda: controlled reproduction, civilization clash and human cloning, among others. Some days ago, in mid-May 2010, the J. Craig Venter Institute announced that it had produced the first genetic history free cell created in a laboratory from a chemically synthesized genome. Today, in describing the “post-human” state of history, Francis Fukuyama asserts: “Huxley was right”. Keywords: Bioethics;Genetic Engineering; Democracy; Totalitarianism; Biotechnology;Eugenics ; Utopias; Dystopias. (shrink)

Synthetic biology emerged around 2000 as a new biological discipline. It shares with systems biology the same modular vision of organisms, but is more concerned with applications than with a better understanding of the functioning of organisms. A herald of this new discipline is Craig Venter who aims to create an artificial microorganism with the minimal genome compatible with life and to implement into it different 'functional modules' to generate new micro-organisms adapted to specific tasks. Synthetic biology is (...) based on the possibilities raised by genetic engineering, but it aims to engineer organisms, and not simply to modify them, mimicking the practice of computer engineers. Three points will be discussed: In what regard does synthetic biology represent a new epistemology of the life sciences? What are the relations between synthetic biology and evolutionary biology? What is the raison d'être of synthetic biology as a discipline independent of nanotechnologies? (shrink)

On June 26, 2000, President Clinton, together with Francis Collins and Craig Venter, solemnly announced, from the East Room of the White House, that the grand effort to sequence the human genome, the Human Genome Project (HGP), was rapidly nearing its completion. Symbolism abounded. The event was framed as a crucial marker in the history of both humanity and knowledge by explicitly connecting the completion of the HGP with a number of already acknowledged and established scientific highlights. Tensions (...) abounded as well, however, notably between competing metaphors. In the course of the HGP, metaphors had become crucially important in framing and conveying what the HGP was really about. They had proved themselves to be of key importance when it came to defining and explaining the project’s significance for both science and society. Powerful images and metaphors had been deployed in order to secure unprecedented amounts of funding, on the one hand by comparing the HGP to other big technoscientific projects such as space travel, high energy physics, the atomic bomb and a territorial mapping exercise, and on the other hand through the suggestion that, once we have our “blueprint”, “code of codes”, “parts list”, etc. available, cancer genes will no longer have a place to hide. This article sets out to analyze this clash of metaphors, firmly embedded within the HGP but culminating at the press conference, arguing that the June 2000 event is even reminiscent of a somewhat similar event, depicted by a famous altarpiece, ‘The adoration of the Lamb’, on display in Ghent Cathedral and finished more than five centuries before. (shrink)

Some religious believers may see synthetic biology as usurping God's creative role. The Catholic Church has yet to issue a formal teaching on the field (though it has issued some informal statements in response to Craig Venter's development of a ‘synthetic’ cell). In this paper I examine the likely reaction of the Catholic Magisterium to synthetic biology in its entirety. I begin by examining the Church's teaching role, from its own viewpoint, to set the necessary backround and context (...) for the discussion that follows. I then describe the Church's attitude to science, and particularly to biotechnology. From this I derive a likely Catholic theology of synthetic biology.The Church's teachings on scientific and biotech research show that it is likely to have a generally positive disposition to synbio, if it and its products can be acceptably safe. Proper evaluation of, and protection against, risk will be a significant factor in determining the morality of the research. If the risks can be minimized through regulation or other means, then the Church is likely to be supportive. The Church will also critique the social and legal environment in which the research is done, evaluating issues such as the patenting of scientific discoveries and of life. (shrink)

The topic of synthetic life has long been a subject for science fiction writers, philosophers, and even scientists. With the announcement in 2010 by renowned biologist J. Craig Venter that he and a team of scientists from the J. Craig Venter Institute (JCVI) had created a bacterial cell with chemically synthesized genome, discussions of synthetic life were no longer just conjecture.Humans had assembled nonliving components to make a living cell (Gibson et al. 2010). I was one (...) of the leaders of that endeavor, and this article will be a first-person account of how we made our cell, along with my conjectures about what will come next in the new fields of synthetic biology and synthetic genomics.Scanning electron .. (shrink)

On April 6, 2000, Dr. J. Craig Venter of Celera Genomics told a Congressional committee that his company finished its analysis of the human DNA and would have a completed map of the human genome by early summer, 2000. Scientists expect the completed human genome to revolutionize drug therapies through the creation of treatments tailored to specific genetic makeups. In order to create a map of the human genome, three billion letters of DNA that encode eighty thousand genes (...) must be identified and ordered. In March, 2000, Celera released a successful sequence of the fruit fly genome, and it employed the same methods in creating the human genome. (shrink)

Francis Collins had an impressive track record as a gene hunter (cystic fibrosis, neurofibromatosis, Huntington’s disease) when he was appointed Director of the Human Genome Project (HGP) in 1993. In June 2000, together with Craig Venter and President Bill Clinton, he presented the draft version of the human genome sequence to a worldwide audience during a famous press conference. And in 2009, President Barack Obama nominated him as director of the National Institutes of Health (NIH), the largest Tfunding (...) agency for biomedical research in the world. s The In 2006, Collins published his book The Language of God,3 an autobiographical account of the HGP and its scientific, historical, and societal significance, with special attention paid to the impact of the human sequence on the way we see our world and ourselves.4 Now, by way of a sequel, he has written The Language of Life. Wherea Language of God focused on the genome sequence of mankind in general, and on the HGP as a “revolution” in biomedicine, the new book, as indicated by its subtitle, is oriented towards “the revolution in personalized medicine”, the impact of the genomics revolution on the personal lives of individuals. Before subjecting Collins’ book to a closer reading, I first of all would like to explain how I will read it and from what perspective. Why is genomics in general, and the HGP and its aftermath in particular, a subject of interest to a philosopher like me? Why did I become interested in assessing the HGP and in studying the work and views of some of its key contributors? (shrink)

Over the course of six years and more than two dozen meetings, members of the Presidential Commission for the Study of Bioethical Issues learned so many things: about emerging science; technological challenges; citizen engagement; the public's, experts’, and our own understandings and misperceptions; and even the nature of our own most cherished values. Our commission's commitment to democratic deliberation began deliberatively, when we decided (in the summer of 2010) upon basic principles to guide our first report. At the time, (...) class='Hi'>Craig Venter had just announced that he had used techniques of synthetic biology to “create life,” albeit the most elementary form of life, from nonliving building blocks. Headlines alternated between applauding Venter for creating life and accusing him of playing God. It was one of those all‐too‐frequent instances where sound‐bite democracy was headed toward shedding more heat and fear than light and understanding. The commission was asked to take synthetic biology under review and make recommendations to President Obama on how to proceed. We saw the need to question the most salient facts of the matter: what were the fundamental values at stake in this kind of discovery? (shrink)

This paper discusses the mistake of understanding the laws and concepts of thermodynamics too literally in the foundations of statistical mechanics. Arguing that this error is still made in subtle ways, the article explores its occurrence in three examples: the Second Law, the concept of equilibrium and the definition of phase transitions.

Many contemporary theorists charge that naïve realists are incapable of accounting for illusions. Various sophisticated proposals have been ventured to meet this charge. Here, we take a different approach and dispute whether the naïve realist owes any distinctive account of illusion. To this end, we begin with a simple, naïve account of veridical perception. We then examine the case that this account cannot be extended to illusions. By reconstructing an explicit version of this argument, we show that it depends critically (...) on the contention that perceptual experience is diaphanous, or more minimally and precisely, that there can be no difference in phenomenal properties between two experiences without a difference in the scenes presented in those experiences. Finding no good reason to accept this claim, we develop and defend a simple, naïve account of both veridical perception and illusion, here dubbed Simple, Austere Naïve Realism. (shrink)

Visual experiences seem to exhibit phenomenological particularity: when you look at some object, it – that particular object – looks some way to you. But experiences exhibit generality too: when you look at a distinct but qualitatively identical object, things seem the same to you as they did in seeing the first object. Naïve realist accounts of visual experience have often been thought to have a problem with each of these observations. It has been claimed that naïve realist views cannot (...) account for the generality of visual experiences, and that the naïve realist explanation of particularity has unacceptable implications for self- knowledge: the knowledge we have of the character of our own experiences. We argue in this paper that neither claim is correct: naïve realism can explain the generality of experiences, and the naïve realist explanation of particularity raises no problems for our self-knowledge. (shrink)

Researchers in all management specialties have discussed and investigated the important role values play in personal and organizational phenomena. However, because research on values has been performed in a wide range of social science disciplines and at different levels of analysis, much of thiswork has been uninformed by other work and is neither well integrated nor systematized, resulting in a great deal of confusion concerning the topic. This article attempts to add order and clarity to this area of research by (...) proposing a framework of values research based on level of analysis and by cataloguing and reviewing the vast theoretical and empirical research in light of this framework. It concludes with a critique of the extant literature and recommendations for further research. (shrink)

The ancient problem of fatalism, more particularly theological fatalism, has resurfaced with surprising vigour in the second half of the twentieth century. Two questions predominate in the debate: (1) Is divine foreknowledge compatible with human freedom and (2) How can God foreknow future free acts? Having surveyed the historical background of this debate in "The Problem of Divine Foreknowledge" and "Future Contingents from Aristotle to Suarez" (Brill: 1988), William Lane Craig now attempts to address these issues critically. His wide-ranging (...) discussion brings together a thought- provoking array of related topics such as logical fatalism, multivalent logic, backward causation, precognition, time travel, counterfactual logic, temporal necessity, Newcomb's Problem, middle knowledge, and relativity theory. The present work serves both as a useful survey of the extensive literature on theological fatalism and related fields and as a stimulating assessment of the possibility of divine foreknowledge of future free acts. (shrink)

The Past Hypothesis is the claim that the Boltzmann entropy of the universe was extremely low when the universe began. Can we make sense of this claim when *classical* gravitation is included in the system? I first show that the standard rationale for not worrying about gravity is too quick. If the paper does nothing else, my hope is that it gets the problems induced by gravity the attention they deserve in the foundations of physics. I then try to make (...) plausible a very weak claim: that there is a well-defined Boltzmann entropy that *can* increase in *some* interesting self-gravitating systems. More work is needed before we can say whether this claim answers the threat to the standard explanation of entropy increase. (shrink)

Two females, Nadine and Fatu, are the sole surviving Northern White Rhinos (NWR). The subspecies is functionally extinct. Hope for NWR now lies in emerging reproductive and genetic technologies, which could potentially produce NWR from induced pluripotent stem cells. What is the rationale for this project? This question raises almost every philosophical issue facing conservation science today. I argue that NWR recovery is hard to justify via many traditional paths (e.g., historical fidelity, ecosystem health, biodiversity), but if we shift focus (...) to white rhinos in general or even mammals then clear benefits emerge. (shrink)

This paper considers the possibility that nonrelativistic quantum mechanics tells us that Nature cares about time reversal. In a classical world we have a fundamentally reversible world that appears irreversible at higher levels, e.g., the thermodynamic level. But in a quantum world we see, if I am correct, a fundamentally irreversible world that appears reversible at higher levels, e.g., the level of classical mechanics. I consider two related symmetries, time reversal invariance and what I call ‘Wigner reversal invariance.’ Violation of (...) the first is interesting, for not only would it fly in the face of the usual story about temporal symmetry, but it also appears to imply (as I’ll explain) that time is ‘handed’, or as some have misleadingly said in the literature, ‘anisotropic’. Violation of the second is, as I hope to show, even more interesting. The paper also contains a discussion of two mostly neglected topics: what it means to say time is handed and what warrants such an attribution to time. (shrink)

In Recovering Hegel from the Critique of Leo Strauss, Sara MacDonald and Barry Craig provide a study unique in its focus on Leo Strauss’s reading of Hegel. While MacDonald and Craig find value in Strauss’s thought, they argue that his pessimism concerning modernity lies in a misunderstanding of both modernity’s greatest philosophical advocate, G.W.F. Hegel, and modernity’s virtues.

People who approach philosophy, as it figures in the activities of mostEnglish-speaking universities, often find their expectations curiously wideof the mark. They have expectations, of course, because the word ‘philosophy’ is not a technical term; there is no need to have taken any exams to use it happily enough in general conversation.

Philosophical Issues, Volume 30, Issue 1, Page 102-119, October 2020.

Incorporating techniques from book history into traditional intellectual history, this article traces the effective origin of indexing to the early printed editions of two lexicographical works, Lorenzo Valla's Elegantie and Niccolò Perotti's Cornu copiae, and then follows its development through the editions of the Roman poet Virgil published between 1500 and 1800. Indexing practices turn out to be tied to how books were read, with a new way of consuming books, which is labeled "transverse reading," emerging during this period.

Advocates of the Everett interpretation of quantum mechanics have long claimed that other interpretations needlessly invoke "new physics" to solve the measurement problem. Call the argument fashioned that gives voice to this claim the Redundancy Argument, or ’Redundancy’ for short. Originating right in Everett’s doctoral thesis, Redundancy has recently enjoyed much attention, having been advanced and developed by a number of commentators, as well as criticized by a few others.[1] Although versions of this argument can target collapse theories of quantum (...) mechanics, it is usually conceived with no-collapse "hidden variable" interpretations in mind, e.g., modal and Bohmian interpretations. In particular, the argument is an attack against theories committed to both realism about the quantum state and realism about entities – what Bell 1987 calls "beables" – that supplement this state. Particles, fields, value states, and more have been suggested as possible ontology to supplement the quantum state. Redundancy is the argument that this supplementation is methodologically otiose, the superfluous pomp that Newton scorned. (shrink)

Justification for psychiatric paternalism is most easily established where mental illness renders the person mentally incompetent, depriving him of the capacity for rational agency and for autonomy, hence undermining the basis for liberal rights against paternalism. But some philosophers, and no doubt some doctors, have been deeply concerned by the inadequacy of the concept of mental incompetence to encapsulate some apparently appealing cases for psychiatric paternalism. We ought to view mental incompetence as just one subset of a broader justification for (...) psychiatric paternalism. The very basis of liberal limitations on psychiatric paternalism, whether described in terms of rights to autonomy or as respect for differences in values and lifestyles, presupposes a sense of moral persistence, and hence some sufficiently persistent self. Paternalistic intervention is warranted when we are unable to govern our lives in a manner consistent with the goals and values that comprise that ‘self’. One way that can occur is when we lack the mental capacities required for autonomy, such that we are unable to interpret and interact with our environment in order to meaningfully pursue our goals, i.e. mental incompetence. But it can also occur when we are subject to impositions that alter our goals without altering our capacity to pursue them — i.e. when it is our ‘self’ that is impaired rather than our competence. (shrink)

This introductory textbook presents Christian philosophical and theological approaches to ethics. Combining their expertise in philosophy and theology, the authors explain the beliefs, values, and practices of various Christian ethical viewpoints, addressing biblical teachings as well as traditional ethical theories that contribute to informed moral decision-making. Each chapter begins with Words to Watch and includes a relevant case study on a vexing ethical issue, such as caring for the environment, human sexuality, abortion, capital punishment, war, and euthanasia. End-of-chapter reflection questions, (...) illustrations, and additional information tables are also included. (shrink)

Includes bibliographical references (p. ) and index.

Shedding new light on the understudied Italian Renaissance scholar, Andrea Cesalpino, and the diverse fields he wrote on, this volume covers the multiple traditions that characterize his complex natural philosophy and medical theories, taking in epistemology, demonology, mineralogy, and botany. By moving beyond the established influence of Aristotle's texts on his work, Andrea Cesalpino and Renaissance Aristotelianism reflects the rich influences of Platonism, alchemy, Galenism, and Hippocratic ideas. Cesalpino's relation to the new sciences of the 16th century are traced through (...) his direct influences, on cosmology, botany, and medicine. In combining Cesalpino's reception of these traditions alongside his connections to early modern science, this book provides a vital case study of Renaissance Aristotelianism. (shrink)

Taking a cue from one of the most (in)famous postmodern thinkers, Friedrich Nietzsche, the essays in this book put forth “experiments” in thought rather than arguments for fixed conclusions. Blum brings John Howard Yoder to the same table with Nietzsche, Michel Foucault, and Jacques Derrida, and provides a provocative glimpse of what the resulting conversation might look like. As Anne Lamott and others have recently insisted, faith is not the opposite of doubt, but of certainty. Blum’s essays explore some of (...) our commonly held ways of talking about knowledge, meaning, commitment, and action. He suggests that some postmodern theoretical work, often dismissed or assumed to be anti-Christian, is well worth bringing into contemporary Anabaptist-Mennonite conversations about discipleship and corporate life. Part of the Polyglossia series, this book is intended for conversation among academics, ministers, and laypersons regarding knowledge, beliefs, and practices of the Christian faith. (shrink)

Volume 39 of the Tanner Lectures on Human Values includes lectures initially scheduled during the academic year 2019-2020. Owing to the global coronavirus pandemic, some were delivered at a later date. The Tanner Lectures are published in an annual volume. In addition to permanent lectures at nine universities, the Tanner Lectures on Human Values funds special one-time lectures at selected higher educational institutions in the United States and around the world.