Jin Yuelin (1895?1984), a Chinese logician and philosopher, is greatly influenced by Hume's and Russell's philosophies. How should we respond to Hume's problem of induction? This is an important clue to understand Jin's whole philosophical career. The first section of this paper gives a brief historical review of Russell and Jin. The second section outlines Hume's skeptical arguments against causality and induction. The third section expounds Russell's justification of induction by discussing his views on Hume's skepticism, causality, principle of induction, (...) and empirical postulates. The fourth section clarifies Jin's justification of induction by discussing his critique of Hume's epistemology and his arguments for the reliability of causality and the eternal truth and apriority of the principle of induction. The final section compares Jin's justification of induction with Russell's and concludes that there are similarities and differences between their projects and that both their attempts fail. This paper takes the similar responses to the problem of induction by Jin and Russell to demonstrate the communication that there has been between Chinese philosophers and the Western ones. (shrink)

Self-serving leadership is a form of unethical leadership behavior that has destructive effect on its targets and the overall organization. Adopting a social cognition perspective, this study expands our knowledge of its adverse effect and the way to mitigate the effect. Integrating two sub-theories of social cognition, we propose a theoretical model wherein self-serving leadership hinders team creativity through psychological safety as well as knowledge hiding, with task interdependence acting as a contextual condition. Results from a sample of 107 R&D (...) teams revealed that self-serving leadership not only reduced team psychological safety, but also induced team knowledge hiding, both of which ultimately affected team creativity. The presence of high task interdependence buffered the destructive effect of self-serving leadership on team creativity via team psychological safety as well as the indirect effect via knowledge hiding. (shrink)

Several previous studies have reported atypicality in resting-state functional connectivity in autism spectrum disorder, yet the relatively small effect sizes prevent us from using these characteristics for diagnostic purposes. Here, canonical correlation analysis and hierarchical clustering were used to partition the high-functioning ASD group into subgroups. A support vector machine model was trained through the 10-fold strategy to predict Autism Diagnostic Observation Schedule scores within the ASD discovery group, which was further validated in an independent sample. The neuroimage-based partition derived (...) two subgroups representing severe versus mild autistic patients. We identified FCs that show graded changes in strength from ASD-severe, through ASD-mild, to controls, while the same pattern cannot be observed in partitions based on ADOS score. We also identified FCs that are specific for ASD-mild, similar to a partition based on ADOS score. The current study provided multiple pieces of evidence with replication to show that resting-state functional magnetic resonance imaging FCs could serve as neural biomarkers in partitioning high-functioning autistic individuals based on their symptom severity and showing advantages over traditional partition based on ADOS score. Our results also indicate a compensatory role for a frontocortical network in patients with mild ASD, indicating potential targets for future clinical treatments. (shrink)

This paper argues for a hybrid and alternative theory of names—Socio-historical Causal Descriptivism, which consists of six claims: (1) the referring relation between a name and an object originates from a generalized “initial baptism” of that object. (2) The causal chain of the name N firstly and mainly transmits informative descriptions of N’s bearer. (3) The meaning of N consists of an open-ended collection of informative descriptions of N’s bearer acknowledged by a linguistic community. (4) With respect to practical needs (...) of agents there is s weighted order in the collection of descriptions of N’s bearer. (5) The meaning or even partial meaning of N, together with the background of a discourse, the network of knowledge, speaker’s intention, etc., determines the referent of N. (6) All names have their own referents, including physical individuals, and parasitic, fictional, or intensional objects; there are few names absolutely without reference. (shrink)

This study examines the mechanism of maternal parenting stress on marital satisfaction based on the Vulnerability-Stress-Adaptation Model, and draws on the needs theory to explore the role of alone time in marital relationships under different solitude preferences. The marital satisfaction Scale, Self-rating Depression Scale, Parenting Stress Scale, Preference for Solitude Scale, and alone time scale were used to conduct a questionnaire survey of 1,387 Chinese mothers in their parenting stage. The results found that: in the overall group and the high (...) and low solitude preference level group, depression plays a significant mediating role between parenting stress and marital satisfaction. For mothers who prefer solitude, alone time can reduce the positive impact of parenting stress on depression, and but it cannot alleviate the negative impact of parenting stress and depression on marital satisfaction. In the low solitude preference level group, alone time can aggravate the positive impact of parenting stress on depression and the negative impact of parenting stress on marital satisfaction. (shrink)

The process of completing, correcting and prioritising specifications is an essential but very complex task for the maintenance and improvement of software systems. The preservation of functionalities and the ability to accommodate changes are main objectives of the software development cycle to guarantee system reliability. Logical theories able to fully model such processes are still insufficient. In this paper we propose a full formalisation of such operations on software systems inspired by the Alchourrón–Gärdenfors–Makinson paradigm for belief revision of human epistemic (...) states. We represent specifications as finite sets of formulas equipped with a priority relation that models functional entrenchment of properties. We propose to handle specification incompleteness through ordered expansion, inconsistency through ordered safe contraction and prioritisation through revision with reordering, and model all three in an algorithmic fashion. We show how the system satisfies basic properties of the AGM paradigm, including Levi’s and Harper’s identities. We offer a concrete example and complexity results for the inference and model checking problems on revision. We conclude by describing resilience and evolvability of software systems based on such revision operators. (shrink)

The rapid development of the Internet has granted college students easy access to vast amount of online resources, and to some degree has increased the chances of plagiarism problems. A number of studies have suggested that both faculty’s and students’ perceptions toward plagiarism are found to be influential on students’ plagiarizing behaviors, and limited research has been done to explore the perceptional differences between these two roles. This study aims to respond to the growing educational concerns about plagiarism by comparing (...) the perceptions held by faculty and college students. A total of 229 faculty and 634 college students in Taiwan completed the Perceptions of Student Plagiarism Questionnaire designed for the study. The results reveal that faculty held stricter standards than those of students. Results also indicate various causes of plagiarism, such as no interest in the learning subjects, lack of citation knowledge, or lack of research ability. Furthermore, significant disciplinary differences were shown to contribute to students’ plagiarism perception; the results reveal that most students with an Arts or Communication major held a relatively adverse thinking toward plagiarism. Last, this study provides research-based strategies for school and faculty to reduce the likelihood of plagiarism. (shrink)

The mathematical nature of modern science is an outcome of a contingent historical process, whose most critical stages occurred in the seventeenth century. ‘The mathematization of nature’ (Koyré 1957 , From the closed world to the infinite universe , 5) is commonly hailed as the great achievement of the ‘scientific revolution’, but for the agents affecting this development it was not a clear insight into the structure of the universe or into the proper way of studying it. Rather, it was (...) a deliberate project of great intellectual promise, but fraught with excruciating technical challenges and unsettling epistemological conundrums. These required a radical change in the relations between mathematics, order and physical phenomena and the development of new practices of tracing and analyzing motion. This essay presents a series of discrete moments in this process. For mediaeval and Renaissance philosophers, mathematicians and painters, physical motion was the paradigm of change, hence of disorder, and ipso facto available to mathematical analysis only as idealized abstraction. Kepler and Galileo boldly reverted the traditional presumptions: for them, mathematical harmonies were embedded in creation; motion was the carrier of order; and the objects of mathematics were mathematical curves drawn by nature itself. Mathematics could thus be assigned an explanatory role in natural philosophy, capturing a new metaphysical entity: pure motion. Successive generations of natural philosophers from Descartes to Huygens and Hooke gradually relegated the need to legitimize the application of mathematics to natural phenomena and the blurring of natural and artificial this application relied on. Newton finally erased the distinction between nature’s and artificial mathematics altogether, equating all of geometry with mechanical practice. (shrink)

We prove that for a finitely generated infinite nilpotent group $G$ with structure $(G,\cdot,\dots)$, the connected component ${G^*}^0$ of a sufficiently saturated extension $G^*$ of $G$ exists and equals \[ \bigcap_{n\in\N} \{g^n\colon g\in G^*\}. \] We construct an expansion of ${\mathbb Z}$ by a predicate $({\mathbb Z},+,P)$ such that the type-connected component ${{\mathbb Z}^*}^{00}_{\emptyset}$ is strictly smaller than ${{\mathbb Z}^*}^0$. We generalize this to finitely generated virtually solvable groups. As a corollary of our construction we obtain an optimality result for (...) the van der Waerden theorem for finite partitions of groups. (shrink)

In this paper I examine a cognitive mechanism of incommensurability. Using the frame model of concept representation to capture structural relations within concepts, I reveal an ontological difference between object and event concepts: the former are spatial but the latter temporal. Experiments from cognitive sciences further demonstrate that the mind treats object and event concepts differently. Thus, incommensurability can occur in conceptual change across different ontological categories. I use a historical case to illustrate how the ontological difference between an object (...) and an event concept actually caused incommensurability in the context of nineteenth‐century optics. The cognitive and historical analyses indicate that incommensurability can be a local phenomenon and does not necessarily imply incomparability. (shrink)

We examined how the cultural dimension of universalism–particularism influences managers’ attitudes toward relational favoritism. Paradoxically, we found in a survey study that Brazilian and Chinese managers perceived more negative consequences of relational favoritism than did American managers—even though the Brazilians and the Chinese perceived stronger particularistic cultural norms in their countries than Americans did in the United States. We attribute this pattern of results to “cultural reflexivity”—the ability of people from transforming economies to be culturally self-critical during a period of (...) dramatic societal change. This pattern of results also emerged in a scenario study in which we asked these same Brazilian, Chinese, and American participants to assess managerial succession decisions made by a General Manager. We varied the scenarios so that the promoted manager was either a colleague with no pre-existing relation with the GM or a colleague who was a relative, a close friend, from the same town, or from the same school. Consistent with the results of the survey study, we found that perceived cultural norms of particularism were negatively related to perceptions of fairness. In other words, Brazilians and Chinese, even while living in more particularistic cultures, were more harsh in judging relational favoritism. We conclude with a discussion on the implications of these paradoxical relationships. (shrink)

Recent advances in molecular biology and microanatomy have supported homologies of body parts between vertebrates and extant invertebrate chordates, thus providing insights into the body plan of the proximate ancestor of the vertebrates. For example, this ancestor probably had a relatively complex brain and a precursor of definitive neural crest. Additional insights into early vertebrate evolution have come from recent discoveries of Lower Cambrian soft body fossils of Haikouichthys and Myllokunmingia (almost certainly vertebrates, possibly related to modern lampreys) and Yunnanozoon (...) and Haikouella (evidently stem-group vertebrates). The earliest vertebrates had an unequivocally marine origin, probably evolved mineralised pharyngeal denticles before the dermal skeleton, and evidently utilised elastic recoil of the visceral arch skeleton for suction feeding. Moreover, the new data emphasise that the advent of definitive neural crest was supremely important for the evolutionary origin of the vertebrates. BioEssays 23:142–151, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

ABSTRACT This study seeks exploration of how employees’ moral identity is related to voice behavior in the current organizational dynamics. By integrating the self-consistency theory with a situational strength perspective, a moderated mediation model was constructed to examine connections among moral identity, leader secure-base support, work engagement, and voice behavior. Surveys were collected at 2 time points, 1 month apart, from 206 full-time employees in various organizations and industries in Taiwan. Supporting results indicated that employees’ moral identity was positively related (...) to voice behavior. The mediating impact of work engagement as a motivational mechanism between moral identity and voice behavior was observed. Relative to when LSBS was low, the effect of moral identity on work engagement and the indirect effect of moral identity on voice behavior through work engagement were more substantial when LSBS was high. Academic and managerial implications were discussed. (shrink)

In two eye-tracking studies we investigated the influence of Mandarin numeral classifiers – a grammatical category in the language – on online overt attention. Mandarin speakers were presented with simple sentences through headphones while their eye-movements to objects presented on a computer screen were monitored. The crucial question is what participants look at while listening to a pre-specified target noun. If classifier categories influence Mandarin speakers' general conceptual processing, then on hearing the target noun they should look at objects that (...) are members of the same classifier category – even when the classifier is not explicitly present. The data show that when participants heard a classifier they shifted overt attention significantly more to classifiermatch objects than to distractor objects, but when the classifier was not explicitly presented in speech, overt attention to classifier-match objects and distractor objects did not differ. This suggests that although classifier distinctions do influence eye-gaze behavior, they do so only during linguistic processing of that distinction and not in moment-to-moment general conceptual processing. (shrink)

In "Formations of World Literature and Shaw's The Man of Destiny in Chinese and Japanese Translation" Shunqing Cao and Xin Chen expand Franco Moretti's dictum that "world literature is not an object, it's a problem" to elaborate that the concept of world literature is in some sense a problematic one, which is itself under a process of problematization. Cao and Chen discuss how variation and heterogeneity contribute to a more in-depth understanding of formations of world literature. Taking the (...) Bernar Shaw's The Man of Destiny they discuss the writer's presence in world literature from a bi-lateral perspective: Shaw's work in the English-speaking West and Shaw in Asia. For the former, Shaw stands in a specific place in recent postcolonial Irish Studies and thus raise problems for their research paradigm. For the latter, Cao and Chen present an analytical comparison between a Chinese and a Japanese translation of The Man of Destiny. Cao and Chen argue that by such a bilateral approach we may recognize the importance of heterogeneity so as to obtain further reflections on present discussions of world literature. (shrink)

Associated with the sharing economy, collaborative consumption behaviors often take place among customers. Different from the traditional consumption that customers purchase the product and own it, in the sharing economy, customers can access the product only for a particular period and the ownership of the product also belongs to the firm. In this paper, we develop a theoretical analysis model, and investigate the intrinsic connection between collaborative consumption and the sharing channel strategy. Adopting the sharing channel strategy, the firm has (...) a chance to expand the market demand and improve its profit. In addition, we examine the impacts of other influential factors on a firm’s decisions, such as the unit product cost, surplus-value, and service capability coefficient. (shrink)

We aim to construct exact and explicit solutions to a generalized Bogoyavlensky-Konopelchenko equation through the Maple computer algebra system. The considered nonlinear equation is transformed into a Hirota bilinear form, and symbolic computations are made for solving both the nonlinear equation and the corresponding bilinear equation. A few classes of exact and explicit solutions are generated from different ansätze on solution forms, including traveling wave solutions, two-wave solutions, and polynomial solutions.

I propose a new perspective on the study of scientific revolutions. This is a transformation from an object-only perspective to an ontological perspective that properly treats objects and processes as distinct kinds. I begin my analysis by identifying an object bias in the study of scientific revolutions, where it takes the form of representing scientific revolutions as changes in classification of physical objects. I further explore the origins of this object bias. Findings from developmental psychology indicate that children cannot distinguish (...) processes from objects until the age of 7, but they have already developed a core system of object knowledge as early as 4 months of age. The persistence of this core system is responsible for the object bias among mature adults, i.e., the tendency to apply knowledge of physical objects to temporal processes. In light of the distinction between physical objects and temporal processes, I redraw the picture of the Copernican revolution. Rather than seeing it as a taxonomic shift from a geocentric to a heliocentric cosmology, we should understand it as a transformation from a conceptual system that was built around an object concept to one that was built around a process concept. (shrink)

Economic dispatch plays an important role in power system operation, since it can decrease the operating cost, save energy resources, and reduce environmental load. This paper presents an improved particle swarm optimization called biogeography-based learning particle swarm optimization for solving the ED problems involving different equality and inequality constraints, such as power balance, prohibited operating zones, and ramp-rate limits. In the proposed BLPSO, a biogeography-based learning strategy is employed in which particles learn from each other based on the quality of (...) their personal best positions, and thus it can provide a more efficient balance between exploration and exploitation. The proposed BLPSO is applied to solve five ED problems and compared with other optimization techniques in the literature. Experimental results demonstrate that the BLPSO is a promising approach for solving the ED problems. (shrink)

If a benevolent and all-powerful God exists, how can there be so much suffering? Could God have created a better world? Or is evil the price we pay for freedom of the will?

A strong coloring on a cardinal$\kappa $is a function$f:[\kappa ]^2\to \kappa $such that for every$A\subseteq \kappa $of full size$\kappa $, every color$\unicode{x3b3} <\kappa $is attained by$f\restriction [A]^2$. The symbol$$ \begin{align*} \kappa\nrightarrow[\kappa]^2_{\kappa} \end{align*} $$asserts the existence of a strong coloring on$\kappa $.We introduce the symbol$$ \begin{align*} \kappa\nrightarrow_p[\kappa]^2_{\kappa} \end{align*} $$which asserts the existence of a coloring$f:[\kappa ]^2\to \kappa $which isstrong over a partition$p:[\kappa ]^2\to \theta $. A coloringfis strong overpif for every$A\in [\kappa ]^{\kappa }$there is$i<\theta $so that for every color$\unicode{x3b3} <\kappa $is (...) attained by$f\restriction ([A]^2\cap p^{-1}(i))$.We prove that whenever$\kappa \nrightarrow [\kappa ]^2_{\kappa }$holds, also$\kappa \nrightarrow _p[\kappa ]^2_{\kappa }$holds for an arbitrary finite partitionp. Similarly, arbitrary finitep-s can be added to stronger symbols which hold in any model of ZFC. If$\kappa ^{\theta }=\kappa $, then$\kappa \nrightarrow _p[\kappa ]^2_{\kappa }$and stronger symbols, like$\operatorname {Pr}_1(\kappa,\kappa,\kappa,\chi )_p$or$\operatorname {Pr}_0(\kappa,\kappa,\kappa,\aleph _0)_p$, also hold for an arbitrary partitionpto$\theta $parts.The symbols$$ \begin{gather*} \aleph_1\nrightarrow_p[\aleph_1]^2_{\aleph_1},\;\;\; \aleph_1\nrightarrow_p[\aleph_1\circledast \aleph_1]^2_{\aleph_1},\;\;\; \aleph_0\circledast\aleph_1\nrightarrow_p[1\circledast\aleph_1]^2_{\aleph_1}, \\ \operatorname{Pr}_1(\aleph_1,\aleph_1,\aleph_1,\aleph_0)_p,\;\;\;\text{ and } \;\;\; \operatorname{Pr}_0(\aleph_1,\aleph_1,\aleph_1,\aleph_0)_p \end{gather*} $$hold for an arbitrary countable partitionpunder the Continuum Hypothesis and are independent over ZFC$+ \neg $CH. (shrink)

Green housing is a new type of building that advocates energy saving and environmental protection. How to stimulate buyers to buy green housing under the background of high cost is the key problem to guide green consumption. First of all, based on the existing literature, the comment of homebuyers was divided into comment quantity, comment quality, comment titer and evaluator credibility. The psychological distance mediation variable was introduced, and three dimensions of time distance, social distance, and space distance were selected (...) to construct the influence model of homebuyer comment on green housing purchase intention. Meanwhile, the concept model was built, and questionnaires were adopted for empirical analysis. On this basis, considering the long-term purchase behavior of buyers, the influence model of homebuyers' second comment on green housing purchase intention with the Hotelling model was established. The results show that comment quality, comment titer, and the credit rating of the evaluator have a positive effect on green housing purchase intention while comment quantity has no significant effect. Psychological distance plays a mediation role between comment quality, comment titer, the credit rating of the evaluator, and green housing purchase intention while having a mediation effect between comment quantity and green housing purchase intention. In the long-term purchase behavior of green housing, psychological distance plays a greater role than price. At last, some suggestions were proposed. (shrink)

An exhaustive work on Confucius' pedagogic thinking by Chen Jingpan, who is among modern China's first group of scholars with a doctoral degree in education. He started his research into Confucius' teachings on education as early as the 1930s, and the present book, written in English, is the fruit of his long years of study. Chapters: the importance of a scientific study of Confucius; the place of Confucius in Chinese civilization; honors, titles, and ranks conferred upon Confucius throughout Chinese (...) history; modern attitudes towards Confucius; the objective of this study of the philosophy of Confucius, to show the place of Confucius as a teacher, and his contribution as a teacher. (shrink)

The long-running discourse on respect for human dignity and autonomy in the physician-patient relationship pertaining to persons with dementia (PwDs) is explored deeply in this paper through the use of a real-life case, to highlight the complex interplay between autonomy and best interest when it comes to a PwD's experiential and critical interests. Many scenarios and perspectives are described and applies to the case. However, there are a few perspectives, which are touched upon that could do with further scrutiny. Firstly, (...) it has been argued that rigid adherence to the advance directives of PwDs means that PwDs will be the only people who are not allowed to ever change their minds. This withdrawal of a fundamental freedom hardly accords with respect for human dignity, or for any residual autonomy that these individuals may still enjoy. Secondly, viewing this case through the lens of care ethics, and incorporating the recently proposed conceptual framework of anthropological vulnerability, may reveal valuable insights regarding care provision and caring physician-patient relationships. These perspectives would analyse the role of relational ontology, particularly in relation to significant others, significant communities, and caregivers. (shrink)

This study uses appraisal theory to investigate the media attitudinal variations in the context of the recent 2013 air pollution incident in China. Drawing upon the appraisal systems of attitude and engagement, this article examines how the reportage has changed over time in terms of the type and source of attitude. Through a comparative analysis of the news reports and editorials in the latest and back issues of the official English-language newspaper China Daily, this article identifies two major attitudinal shifts: (...) 1) from an absence of inscribed attitude representing air quality as something natural to negative judgement of social sanction judging foreign embassies’ monitoring; 2) from judgement to three interwoven strands of appreciation, with the air quality, Western experience and prospective opportunities evaluated by both Chinese and international communities. When reporting and commenting on environmental issues of global concern, the national media voice may seek to achieve attitudinal consensus with the international community while adhering to the official discourse. (shrink)

This research develops and tests a multiple-mediator model of the relationship between organizational fairness and employees’ perceived meaningfulness. Integrating (Rosso et al., Research in Organizational Behavior 30:91–127, 2010) theoretical framework on meaningfulness with theories on fairness, we examined four parallel mechanisms linking organizational fairness to perceived meaningfulness: organization-based self-esteem (OBSE), authenticity at work, moral identification, and organizational identification. We tested our model with three time-lagged studies. All of the studies found significant mediating effects of OBSE and authenticity at work, whereas (...) the results of moral identification and organizational identification were mixed. Studies 2 and 3 also found that the combined mediating effect of the self-oriented mechanisms (OBSE and authenticity at work) was significantly stronger than that of the other-oriented mechanisms (moral identification and organizational identification). These findings suggest organizational fairness as a key antecedent of perceived meaningfulness and the prominent role of the self in the relationship between fairness and meaningfulness. (shrink)

In this response to the commentary “Disabling Bioethics Futures”, I offer support for the author’s argument that bioethics theory and pedagogy ought to be reframed to better incorporate the perspectives of disabled persons. Specifically, I argue that it is not only a pedagogical flaw but an active harm when bioethics pedagogy preserves disrespectful or discriminatory views by using outdated literature.

The view from inside improves our understanding on market failure and regulation failure in financial market. The EMH fails to understand the causes of financial bubbles and crashes. Behavioral finance introduces insight from psychology. The heuristic and biases approach studied behavioral asymmetry in static environment that leads to market irrationality and information distortion. The fast and frugal thinking in decision-making further explore more complex situation under changing environment. They argue that soft-paternalistic regulation is needed under information overload. The most critical (...) issue is information uncertainty and complexity. Lacking information in frequency domain is the main barrier in managing business cycles. Data form inside reveals current limitations of financial data mainly in the short-term price changes. Microstructure studies show that pricing process is shaped by trading rules. Quantitative analysis reveals severe instability in high frequency trading and derivative market. Feasible regulation should aim to encourage new technology and sustainable growth, rather than protect obsolete technology and short-term speculation. The most fundamental challenge to sustainable economic order is the excessive size of the derivative markets that crowding out investment in real economy. This is a more severe issue than the climate change. (shrink)

This paper presents an autobiographical narrative of two aspects of my history; two events that permeated my moral consciousness and influenced my political development and a sequence of changes in my dominant theoretical and epistemological perspectives. The two events were, as a teenager, the intense experience of briefly witnessing Apartheid culture and, as a young adult, becoming deeply engaged in feminist activism. My intellectual journey began in cognitive developmental theory and progressed to a cultural, discursive perspective in which the role (...) of affect is seen as integrated. The paper explores the intersection of these two strands of my moral and intellectual development and concludes with a preliminary model of action and engagement. (shrink)

This paper investigates some delicate tradeoffs between the generality of an algorithmic learning device and the quality of the programs it learns successfully. There are results to the effect that, thanks to small increases in generality of a learning device, the computational complexity of some successfully learned programs is provably unalterably suboptimal. There are also results in which the complexity of successfully learned programs is asymptotically optimal and the learning device is general, but, still thanks to the generality, some of (...) those optimal, learned programs are provably unalterably information deficient—in some cases, deficient as to safe, algorithmic extractability/provability of the fact that they are even approximately optimal. For these results, the safe, algorithmic methods of information extraction will be by proofs in arbitrary, true, computably axiomatizable extensions of Peano Arithmetic. (shrink)

Replication protein A (RPA) is the main eukaryotic single‐stranded DNA (ssDNA) binding protein, having essential roles in all DNA metabolic reactions involving ssDNA. RPA binds ssDNA with high affinity, thereby preventing the formation of secondary structures and protecting ssDNA from the action of nucleases, and directly interacts with other DNA processing proteins. Here, we discuss recent results supporting the idea that one function of RPA is to prevent annealing between short repeats that can lead to chromosome rearrangements by microhomology‐mediated end (...) joining or the formation of hairpin structures that are substrates for structure‐selective nucleases. We suggest that replication fork catastrophe caused by depletion of RPA could result from cleavage of secondary structures by nucleases, and that failure to cleave hairpin structures formed at DNA ends could lead to gene amplification. These studies highlight the important role RPA plays in maintaining genome integrity. (shrink)

Erickson's treatise intertwines and confuses two major, but separable, issues: whether there are basic tastes and how taste stimuli are encoded. The idea of basic tastes may reflect a natural process of concept formation. By only discussing two spatial coding schemes for taste, Erickson ignores the temporal dimension of taste responses and the contribution of neuronal cooperativity.

Collection of texts on philosophical positions (sidhānta) of Vaibhāṣika, Sautrāntika, Yogācārya, and Mādhyamika schools of Buddhism with Hindusim.