How is a disease contracted, and how does it progress through the body? Answers to these questions are fundamental to understanding both basic biology and medicine. Advances in the biomedical sciences continue to provide more tools to address these fundamental questions and to uncover questions that have not been thought of before. Despite these major advances, we are still facing conceptual and technical challenges when learning about the etiology of disease, especially for genetic diseases. In this review, we illustrate this (...) point by discussing the causal links between molecular mechanisms and systems-level phenotypes in molecular diseases. We begin with an examination of sickle cell anemia, and how mechanisms of the disease have been comprehended over the last century. While sickle cell anemia involves a mutation in a single protein in a single cell type, other diseases involve mutations in networks with many protein interactions and in diverse cell types. We introduce the challenges that result from these differences and illustrate the current obstacles by discussing the RASopathies, a recently discovered class of developmental syndromes that result from mutations in signaling networks. Methods to study mutant genotypes that lead to mutant phenotypes are discussed, particularly the use of model organisms and mutant proteins to study protein interactions that may be important for development of disease. These studies will point toward the future of diagnosing and treating genetic disease. (shrink)

Voice: Malagasy presents morphologically distinct verbs built from the same root which assign different grammatical cases to DPs with given theta roles, yielding Ss that are theta equivalent, and, with appropriate choice of DPs, logically equivalent, much like active and agented passive Ss in English. The problem is to derive and interpret such Ss so as to yield these judgments of semantic equivalence as theorems. Our solution, which is purely structural, invoking no notion of ‘subject’, ‘topic’, ‘pivot’, ‘trigger’, etc., is (...) simply an explicit syntactic and semantic interpretation of voice affixes. Deriving Ss built from verbs in different voices involves no A movement of DPs. Voice morphology determines the distinctive syntactic and semantic properties of nuclear clauses. This supports that “Variation of language is essentially morphological ...” (Chomsky 1995:7). (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Frederick J. Streng Book Award:An Interview with Harold Kasimow, John Keenan, and Linda KeenanHarold Kasimow, John P. Keenan, and Linda Klepinger KeenanThe recipient of the Frederick J. Streng Book of the Year Award for 2004 is Beside Still Waters: Jews, Christians, and the Way of the Buddha, edited by Harold Kasimow, John P. Keenan, and Linda Klepinger Keenan. This book provides the reader with a (...) combination of reflection on the creatively transformative power of interreligious dialogue and documentation of that creative transformation in the lives of committed Jews and Christians in dialogue with Buddhism. The bulk of this book consists of candid, autobiographical essays by seven Jewish and Christian scholars in the form of personal testimony, which, taken as a whole, presents an extended argument for the value of interfaith dialogue in general and Buddhist-Christian-Jewish dialogue in particular. The final section of the book consists of four essays written from sociological, Jewish, Christian, and Buddhist perspectives by authors who have read the primary essays and reflect on interreligious dialogue more broadly in light of their own particular experience and research.Those who read Beside Still Waters as seekers will find themselves in the company of fellow pilgrims on the Way who offer their particular life stories filled with focused insight and theological sophistication. The strength of this collection of essays is that it robustly displays Jewish and Christian encounter with Buddhism as a new direction that contemporary Buddhist-Christian dialogue as practiced within the Society for Buddhist-Christian Studies would do well to emulate.Buddhist-Christian Studies asked the editors a few questions.Buddhist-Christian Studies: Why did you write Beside Still Waters?John Keenan: Because Harold and I wanted to write a book together. Each of us is much involved in our own tradition as well as in the study and practice of Buddhism, and we wanted to show that this kind of encounter with another religious tradition does not mutate one's own identity. For this reason, we wanted contributors to speak out of their personal experience rather than to address the philosophical and doctrinal issues that are engendered by such interfaith encounters—although these issues should of course be addressed elsewhere.Harold Kasimow: Perhaps the following Hassidic tale best answers this question: "Rabbi Eizik, son of Rabbi Yekel, travels to Prague in search of treasure. He ultimately discovers, after meeting with a Christian, that the treasure is in fact buried [End Page 205] at his family's home back in Krakow. Thus it is a Christian who helps Rabbi Eizik to find the treasure in Judaism, to perceive more profoundly the depth and uniqueness of the Jewish tradition." This has been my own experience and is the reason why I was interested in writing this book together with people with whom I have a very strong karmic connection.Was it difficult to solicit and edit the contributors' essays?Linda Keenan: Not at all. With only one exception, everyone we contacted agreed to write an essay for the book. In one or two instances, we pushed for something more personal than was first submitted, and we were very pleased with the final collection.How did the three of you work together?HK: I often spoke to Linda over the phone, and John could speak to her in person, and Linda did all the work.LK: Harold and John conceived the idea and contacted potential contributors. The three of us consulted a great deal over the telephone and by e-mail. And Harold kept us on task at each stage of the book and has been its greatest promoter.JK: The above is accurate, but the book was written by the contributors.Is there anything you would have done differently if you could do it over? Any contributors you missed this time for one reason or another that you would recruit for a new edition?LK: We would not change what we did, but there are certainly many more Jews and Christians who could make excellent contributions to a new edition of the book. In fact, the most difficult thing was knowing so many people—including, among others, most of the membership of the... (shrink)

An introduction to Catholic theological ethics through the lens of its historical development from the beginning of the church until today.

Most foundational texts on theological ethics address the person or the society; the point of departure determines, inevitably, fairly different trajectories. By starting with the experience of grief, this book posits the human as ineluctably social: grief is an epiphany that reveals how the human is inseparable from the collective. Indeed, grief inevitably summons us to grieve socially. Nothing discloses the human more rawly than grief that "it is not good for the human to be alone." Keenan then develops (...) an ethics of vulnerability, following Judith Butler, understanding it not primarily as a compromised state of being but rather as that which establishes the human as capacious for recognizing and responding to others. Mutual recognition, a theme that can be found from Georg Hegel and Sigmund Freud to Axel Honneth, Nancy Frasier and Jessica Benjamin, emerges as the first moral act of the vulnerable human. In light of vulnerability and recognition, Keenan shows how we can now understand conscience as guiding the activity of one who has first vulnerably recognized others. The second half of the book works out a Christian ethics of vulnerability, starting with discipleship, then grace and sin, then the virtues, and finally the communion of saints, the works of mercy, and the beatitudes. (shrink)

McCarthy et al. rightly point out many of the ways in which theological traditions can complement secular bioethics and correct for some of its biases. These predispositions include an overl...

What if thought freed itself from common sense and decided to think only at the extreme point of its singularity? What if it mischievously practiced the bias of paradox, instead of complacently accepting its citizenship in the doxa? What if it thought difference differentially, instead of searching out the common elements underlying difference?1.

BioShock Infinite follows the journey of Booker DeWitt, a reluctant detective from New York City who is transplanted via rowboat and lighthouse‐turned‐rocket to the city of Columbia. Booker is charged with the task of bringing back a girl in order to wipe away his debt. The girl, Elizabeth Comstock, has been locked in a tower since infancy by her father, Zachary Comstock, and is protected by a menacing Songbird. Although the game centers on Booker and his story, this chapter focuses (...) on Elizabeth, looking at her through a feminist lens. Freeing Elizabeth from her tower, one could argue, is in a way freeing her from oppression of men. If we take Elizabeth as her own person, rather than as a mere companion, does Elizabeth's freedom from tower mean real freedom for her? Does Booker treat Elizabeth any differently than Comstock does? And, what really is Elizabeth's role in Booker's drowning?. (shrink)

This chapter focuses on the important friendships Veronica has formed over the course of Veronica Mars. It considers the extent to which they approach or fall short of Aristotelian perfection. From the start, the Wallace‐Veronica relationship exemplifies Aristotle's friendship of utility. At this early stage, Veronica and Wallace are not yet friends in Aristotle's sense, since every form of friendship, including one of utility, needs some time to get off the ground. While friendships of utility thrive on an exchange of (...) goods between friends, Aristotle argues that these friendships can dissolve into acrimony and resentment if one friend feels that she's giving more than she gets in return. Aristotle argues that, in order to have a perfect friendship, both friends must be good and virtuous people. The chapter investigates the moral characters of these two close friends to see if either can be considered truly virtuous. (shrink)

From sex abuse scandals to the treatment of adjunct professors, universities are mired in thorny ethical questions. In this book, Keenan exposes the problems that arise from the lack of professional ethics in the college environment, then proposes concrete solutions for issues ranging from athletics and adjuncts to tuition and salaries.

Predicting future trends in bioethics depends on the recognition of contemporary innovations. Because of the extraordinary challenges brought on by the HIV/AIDS pandemic, bioethics has had to undergo a critical examination of its own effectiveness. This essay examines 10 developments that have helped shape the future of bioethics in a time of HIV/AIDS.

avant propos This paper is basically Keenan (1992) augmented by some new types of properly polyadic quantification in natural language drawn from Moltmann (1992), Nam (1991) and Srivastav (1990). In addition I would draw the reader's attention to recent mathematical studies of polyadic quantiicationz Ben-Shalom (1992), Spaan (1992) and Westerstahl (1992). The first and third of these extend and generalize (in some cases considerably) the techniques and results in Keenan (1992). Finally I would like to acknowledge the stimulating (...) and constructive discussions ofthe earlier paper with many scholars, notably Dorit Ben-Shalom, Jaap van der Does, Hans Kamp, Uwe Mormich, Arnim von Stechow, Mats Rooth, and Ede Zimmermann. And I repeat here the acknowledgment in the earlier paper to Jim Lambek, Ed Stabler and two anonymous referees for Linguistics and Philosophy (the latter responsible for substantial improvements in the proofs - see footnote 10). (shrink)

A volume of studies in natural language semantics which brings together work by philosophers, logicians and linguists. The main topics treated are: quantification and reference in natural language; the relations between formal logic, programming languages and natural language; pragmatics and discourse meaning; surface syntax and logical meaning. The volume derives from a colloquium organised in 1973 by the Kings College Research Centre, Cambridge and the papers have been edited for publication by Professor Keenan. It is hoped that the collection (...) will make available some of the best work in this fast-moving field and will stimulate further progress by juxtaposing the different approaches and interests represented here. (shrink)

Company–community agreements are widely considered to be a practical mechanism for recognising the rights, needs and priorities of peoples impacted by mining, for managing impacts and ensuring that mining-derived benefits are shared. The use and application of company–community agreements is increasing globally. Notwithstanding the utility of these agreements, the gender dimensions of agreement processes in mining have rarely been studied. Prior research on women and mining demonstrates that women are often more adversely impacted by mining than men, and face greater (...) challenges in accessing development opportunities that mining can bring. Nonetheless, there is currently little guidance for companies, government or communities in bringing a gender perspective to the fore in mining and agreement processes. It is undisputed in human development literature that investment in women and sensitivity to gender delivers long-term health, education and local development outcomes. In mining and development, a number of key factors remain unexplored. These include: women’s participation in agreement processes, the gendered distribution of agreement benefits, and the extent to which impacts and benefits influence women’s development and economic inclusion. This paper presents the results of the first phase of an applied research project undertaken by the Centre for Social Responsibility in Mining at The University of Queensland and funded by the Minerals Council of Australia and the Department of Foreign Affairs and Trade. The project sought to connect with experienced practitioners who had been directly involved in mining and agreement processes to document and analyse grounded perspectives on gender dynamics and agreements, and connect those experiences with the broader literature. Findings from this study have implications for the role of mining companies and governments in promoting gender equality and empowerment as part of their commitments to sustainable development. They also have implications for community groups and their representatives in terms of how they might engage in agreement processes to maximise women’s participation and influence. In many social contexts, a key challenge will be navigating the territory of cultural norms and gender equality, particularly in cultures where women’s influence in the public sphere is not strong. The authors argue that without consideration of a gender perspective, including gender’s intersection with other factors such as class, race, poverty level, ethnic group and age, mining agreements will not be inclusive, may exacerbate gender inequalities, and fail to contribute to long-term sustainable development. (shrink)

Recent work in natural language semantics leads to some new observations on generalized quantifiers. In § 1 we show that English quantifiers of type $ $ are booleanly generated by their generalized universal and generalized existential members. These two classes also constitute the sortally reducible members of this type. Section 2 presents our main result--the Generalized Prefix Theorem (GPT). This theorem characterizes the conditions under which formulas of the form Q1x 1⋯ Qnx nRx 1⋯ xn and q1x 1⋯ qnx nRx (...) 1⋯ xn are logically equivalent for arbitrary generalized quantifiers Qi, qi. GPT generalizes, perhaps in an unexpectedly strong form, the Linear Prefix Theorem (appropriately modified) of Keisler & Walkoe (1973). (shrink)

We consider the logical form of a natural language sentence to be a formal object which determines both the logical properties of the sentence and, more generally, the ways the sentence is logically related to other sentences. Thus if some NL sentence logically entails another, this fact must follow, given the logical forms of the two sentences. The power of a theory of logical forms of natural language then lies first in what logical properties and relations it can define, and (...) second, in which NL sentences it can show to be logically related to which others. (shrink)

In this chapter we shall examine the characteristic properties of a construction wide-spread in the world’s languages, the passive. In section 1 below we discuss defining characteristics of passives, contrasting them with other foregrounding and backgrounding constructions. In section 2 we present the common syntactic and semantic properties of the most wide-spread types of passives, and in section 3 we consider passives which differ in one or more ways from these. In section 4, we survey a variety of constructions that (...) resemble passive constructions in one way or another. In section 5, we briefly consider differences between languages with regard to the roles passives play in their grammars. Specifically, we show that passives are a more essential part of the grammars of some languages than of others. (shrink)

In their article “Psychedelic Medicine Exceptionalism,” Cohen and Marks (2025) aim to chart a middle course between two extreme positions—the Scylla and Charybdis of psychedelic “exceptionalism” an...

In this chapter we shall examine the characteristic properties of a construction wide-spread in the world’s languages, the passive. In section 1 below we discuss defining characteristics of passives, contrasting them with other foregrounding and backgrounding constructions. In section 2 we present the common syntactic and semantic properties of the most wide-spread types of passives, and in section 3 we consider passives which differ in one or more ways from these. In section 4, we survey a variety of constructions that (...) resemble passive constructions in one way or another. In section 5, we briefly consider differences between languages with regard to the roles passives play in their grammars. Specifically, we show that passives are a more essential part of the grammars of some languages than of others. (shrink)

Response to wrongdoing is modeled as a decision process in an organizational context. The model is grounded in theory of risk, ambiguity, and informational influences on decision making. Time pressure, inadequate information and coworker influences are addressed. Along the way, a handful of propositions are provided which emphasize influences on the actual choice between response options.

States are in the process of creating controversial legislation aimed at subjecting ‘harmful’ online communication on social media and search engines to new regulatory regimes. Critics argue that these measures are serious threats to the right to freedom of expression and freedom from surveillance. This article first draws on elements of systems theory to reframe the right to freedom of expression in democracy as a means of protecting the value of generalised second-order observation. Taking the UK’s Online Safety bill as (...) the paradigm example of the new laws, the article analyses the concept of harmful communication at three levels: society, organisation, and subject. It identifies a shift in the law’s epistemic approach to communication, by which individuals are reconfigured from agential subjects into contingent users, whose capacities are determined by the structure of online communication platforms. In this configuration, norms previously considered indispensible are relegated to second-order effects of the affordances of media. Arguing that it is insufficient to merely reaffirm subjective rights in light of this shift, the article suggests systems theoretical analysis as a means of identifying lines of critique. (shrink)

This essay explores how vulnerability, understood not as precarity but as capacious responsiveness, much as the Philosopher Judith Butler identifies it, and recognition are key moral concepts that are prior conditions for the expression of conscience. Appreciating Thomas Aquinas' argument that conscience is neither a power or a habit, but rather an act, the essay argues that Aquinas' inclination synderesis, that prompts us to the good and away from evil, functions in a way similar to vulnerability. Fundamentally, vulnerability prompts us (...) to recognize the neighbor who needs our response. (shrink)

In Research on Language and Computation, Co-editor with Alastair Butler (primary editor) and Jason Mattausch of the special issue. Vol: 5.1 Springer Verlag.

Localizing the self in the brain has been the goal of consciousness research for centuries. Recently, there has been an increase in attention to the localization of the self. Here we present data from patients suffering from a loss of self in an attempt to understand the neural correlates of consciousness. Focusing on delusional misidentification syndrome , we find that frontal regions, as well as the right hemisphere appear to play a significant role in DMS and DMS related disorders. These (...) data are placed in the context of neuroimaging findings. (shrink)