Ernst Mayr argued that the emergence of biology as a special science in the early nineteenth century was possible due to the demise of the mathematical model of science and its insistence on demonstrative knowledge. More recently, John Zammito has claimed that the rise of biology as a special science was due to a distinctive experimental, anti-metaphysical, anti-mathematical, and anti-rationalist strand of thought coming from outside of Germany. In this paper we argue that this narrative neglects the important role played (...) by the mathematical and axiomatic model of science in the emergence of biology as a special science. We show that several major actors involved in the emergence of biology as a science in Germany were working with an axiomatic conception of science that goes back at least to Aristotle and was popular in mid-eighteenth-century German academic circles due to its endorsement by Christian Wolff. More specifically, we show that at least two major contributors to the emergence of biology in Germany—Caspar Friedrich Wolff and Gottfried Reinhold Treviranus—sought to provide a conception of the new science of life that satisfies the criteria of a traditional axiomatic ideal of science. Both C.F. Wolff and Treviranus took over strong commitments to the axiomatic model of science from major philosophers of their time, Christian Wolff and Friedrich Wilhelm Joseph Schelling, respectively. The ideal of biology as an axiomatic science with specific biological fundamental concepts and principles thus played a role in the emergence of biology as a special science. (shrink)

The volume collects classics of Marxist historiography of science, including a new translation of Boris Hessen's “The Social and Economic Roots of Newton's ...

In this paper, we analyse conceptions of induction and certainty in Wolff and Crusius, highlighting their competing conceptions of physics. We discuss (i) the perspective of Wolff, who assigned induction an important role in physics, but argued that physics should be an axiomatic science containing certain statements, and (ii) the perspective of Crusius, who adopted parts of the ideal of axiomatic physics but criticized the scope of Wolff’s ideal of certain science. Against interpretations that take Wolff’s proofs in physics to (...) be based on empirical statements that are probable, we show how inductively established statements, coupled with assumptions concerning the uniformity of nature, can be certain according to Wolff. We examine Crusius’ little known work on physics and show that he attacked Wolff, arguing that many statements of physics are probable. We provide a discussion of the reception of methodological rules similar to Newton’s Regulae Philosophandi, discussing different interpretations of such rules. We conclude by briefly hinting at how the debate between Wolff and Crusius provides historical context for understanding Kant’s philosophy of natural science. (shrink)

Sleep spindles are frequently studied for their relationship with state and trait cognitive variables, and they are thought to play an important role in sleep-related memory consolidation. Due to their frequent occurrence in NREM sleep, the detection of sleep spindles is only feasible using automatic algorithms, of which a large number is available. We compared subject averages of the spindle parameters computed by a fixed frequency (11-13 Hz for slow spindles, 13-15 Hz for fast spindles) automatic detection algorithm and the (...) individual adjustment method (IAM), which uses individual frequency bands for sleep spindle detection. Fast spindle duration and amplitude are strongly correlated in the two algorithms, but there is little overlap in fast spindle density and slow spindle parameters in general. The agreement between fixed and manually determined sleep spindle frequencies is limited, especially in case of slow spindles. This is the most likely reason for the poor agreement between the two detection methods in case of slow spindle parameters. Our results suggest that while various algorithms may reliably detect fast spindles, a more sophisticated algorithm primed to individual spindle frequencies is necessary for the detection of slow spindles as well as individual variations in the number of spindles in general. (shrink)

There is a growing trend in European countries for childbearing to occur later in women’s lives. The recent increase in the use of ART, together with the long-term trend towards later childbearing, raises questions as to the acceptable age of childbearing in contemporary society. ART legislation varies considerably across Europe and age limits for access to fertility treatment are rarely defined. The legislation takes into account the preferences of potential parents; children’s preferences, however, are not ascertained. The article discusses a (...) research method used in a survey of older children and young adults. The objective of the survey was to answer the following questions: What age would children prefer their parents to be if they could choose? What are their reasons? Respondents were asked the following question: “How old would you like your mother and father to be when you are 20 (version for respondents younger than 16) or 25 (version for those older than 16) if you could wave a magic wand?” Furthermore, their reasons for wishing a change were identified through an open question, “Why would you like to change the age of your parents?”. (shrink)

Using the Friedman-Koepke Hyperfine Structure Theory of [2], we provide a short construction of a gap 1 morass in the constructible universe.

Boris Kment takes a new approach to the study of modality that emphasises the origin of modal notions in everyday thought. He argues that the concepts of necessity and possibility originate in counterfactual reasoning, which allows us to investigate explanatory connections. Contrary to accepted views, explanation is more fundamental than modality.

Recently, there has been a strong push for binding human rights due diligence (HRDD) legislation, both at the national and European levels. As empirical evidence of such legislation's impact gradually emerges, it is time to take stock. In this article, we conduct a systematic literature review to assess available empirical evidence on (1) how HRDD legislation affects the policies and practices through which companies engage with human rights; (2) how these policies and practices, in turn, affect different actors in companies’ (...) value chains. While it is too early to make conclusive judgements, existing evidence allows us to identify several worrying trends: most companies opt for managerialist and compliance-oriented approaches to HRDD; revert primarily to earlier (and flawed) private governance mechanisms; and try to cascade responsibilities and costs in their supply chain. This risks perpetuating or reinforcing marginalisation and exclusion dynamics. Based on these findings, we formulate some lessons for policy-makers. (shrink)

Background: Although convolutional neural networks (CNNs) achieve high diagnostic accuracy for detecting Alzheimer’s disease (AD) dementia based on magnetic resonance imaging (MRI) scans, they are not yet applied in clinical routine. One important reason for this is a lack of model comprehensibility. Recently developed visualization methods for deriving CNN relevance maps may help to fill this gap as they allow the visualization of key input image features that drive the decision of the model. We investigated whether models with higher accuracy (...) also rely more on discriminative brain regions predefined by prior knowledge. Methods: We trained a CNN for the detection of AD in N = 663 T1-weighted MRI scans of patients with dementia and amnestic mild cognitive impairment (MCI) and verified the accuracy of the models via cross-validation and in three independent samples including in total N = 1655 cases. We evaluated the association of relevance scores and hippocampus volume to validate the clinical utility of this approach. To improve model comprehensibility, we implemented an interactive visualization of 3D CNN relevance maps, thereby allowing intuitive model inspection. Results: Across the three independent datasets, group separation showed high accuracy for AD dementia versus controls (AUC ≥ 0.91) and moderate accuracy for amnestic MCI versus controls (AUC ≈ 0.74). Relevance maps indicated that hippocampal atrophy was considered the most informative factor for AD detection, with additional contributions from atrophy in other cortical and subcortical regions. Relevance scores within the hippocampus were highly correlated with hippocampal volumes (Pearson’s r ≈ −0.86, p < 0.001). Conclusion: The relevance maps highlighted atrophy in regions that we had hypothesized a priori. This strengthens the comprehensibility of the CNN models, which were trained in a purely data-driven manner based on the scans and diagnosis labels. The high hippocampus relevance scores as well as the high performance achieved in independent samples support the validity of the CNN models in the detection of AD-related MRI abnormalities. The presented data-driven and hypothesis-free CNN modeling approach might provide a useful tool to automatically derive discriminative features for complex diagnostic tasks where clear clinical criteria are still missing, for instance for the differential diagnosis between various types of dementia. (shrink)

This volume brings together the religious and philosophical writings of the founders of Russian religious philosophy, Aleksei Khomiakov and Ivan Kireevsky. Both began their intellectual careers in the literary world of the 1820s. The texts collected here make the philosophical concepts of Sobornost (community, universality, wholeness, ecumenicity) and integral knowledge, available to western readers. Based on the primacy of the heart, the spiritual wholeness of the human being and the cognitive will, integral knowing moves beyond rationality to union with the (...) object of knowledge in knowing. This book provides an introduction to Russian religious philosophy, and a profound, meditative text for anyone concerned with human and spiritual unity. Also included are two responses to Slavophile ideas by the prominent Russian philosophers Pavel Florensky and Nikolai Berdiaev. (shrink)

The Ukrainian photographer Sergey Bratkov started his career in 1987 with his first solo shows in Kharkiv, Cheb, and Tel Aviv. He has since enjoyed international recognition from solo and group exhibitions in Europe an.

BackgroundThe UN Convention on the Rights of Persons with Disabilities, and the reformed guardianship law in Germany, require that persons with a disability, including people with dementia in Alzheimer’s disease (PwAD), are supported in making self-determined decisions. This support is achieved through communication. While content-related communication is a deficit of PwAD, relational aspects of communication are a resource. Research in supported decision-making (SDM) has investigated the effectiveness of different content-related support strategies for PwAD but has only succeeded in improving understanding, (...) which, although one criterion of capacity to consent, is not sufficient to ensure overall capacity to consent. The aim of the ‘spatial intervention study’ of the DECIDE project is to examine an innovative resource-oriented SDM approach that focuses on relational aspects. We hypothesise that talking to PwAD in their familiar home setting (as opposed to a clinical setting) will reduce the complexity of the decision-making process and enhance overall capacity to consent. MethodsPeople with a suspected or confirmed diagnosis of dementia in Alzheimer’s disease will be recruited from two memory clinics (N = 80). We will use a randomised crossover design to investigate the intervention effect of the decision-making place on capacity to consent. Besides reasoning capacity, which is part of overall capacity to consent and will be the primary outcome, various secondary outcomes (e.g., other aspects of capacity to consent, subjective task complexity, decisional conflict) and suspected moderating or mediating variables (e.g., meaning of home, demographic characteristics) will be assessed.DiscussionThe results of the study will be used to develop a new SDM strategy that is based on relational resources for PwAD. If a change in location achieves the anticipated improvement in capacity to consent, future research should focus on implementing this SDM strategy in a cost-effective manner in clinical practice.Trial registration: DRKS00030799. (shrink)

Beck uses the term `subpolitics' to refer to forms of politics outside and beyond the representative institutions of the political system of nation-states. From the perspective of the theory of reflexive modernization, the proliferation of subpolitics indicates a weakening of the `iron cage' of bureaucratic, state-oriented politics. We argue that subpolitics does indeed challenge conventional notions of politics. It mobilizes sources of societal influence that transcend the formal political system. In particular, subpolitics correlates with the command over positive or negative (...) sanctions and the capacity for uncertainty absorption. This can be illustrated in the areas of scientific expertise, corporate decision-making and political consumption. Those cases show that the political system cannot monopolize the means of societal influence. For a political system that regards itself as the centre of society, this must be irritating. For sociology, however, it provides the opportunity to part with such an inappropriate account of the role of politics in modern society. (shrink)

In a wide-ranging 2007 study of Claude Lévi-Strauss's aesthetic thought, Boris Wiseman demonstrates not only its centrality within his oeuvre but also the importance of Levi-Strauss for contemporary aesthetic enquiry. Reconstructing the internal logic of Lévi-Strauss's thinking on aesthetics, and showing how anthropological and aesthetic ideas intertwine at the most elemental levels in the elaboration of his system of thought, Wiseman demonstrates that Lévi-Strauss's aesthetic theory forms an integral part of his approach to Amerindian masks, body decoration and mythology. (...) He reveals the significance of Lévi-Strauss's anthropological analysis of an 'untamed' mode of thinking at work in totemism, classification and myth-making for his conception of art and aesthetic experience. In this way, structural anthropology is shown to lead to ethnoaesthetics. Lévi-Strauss, Anthropology and Aesthetics adopts a broad-ranging approach that combines the different perspectives of anthropology, philosophy, aesthetic theory and literary criticism into an unusual and imaginative whole. (shrink)

During the last quarter of a century, a number of philosophers have become attracted to the idea that necessity can be analyzed in terms of a hyperintensional notion of essence. One challenge for proponents of this view is to give a plausible explanation of our modal knowledge. The goal of this paper is to develop a strategy for meeting this challenge. My approach rests on an account of modality that I developed in previous work, and which analyzes modal properties in (...) terms of the notion of a metaphysical law. I discuss what information about the metaphysical laws is required for modal knowledge. Moreover, I describe two ways in which we might be able to acquire this information. The first way employs inference to the best explanation. The metaphysical laws, including the essential truths, play a crucial role in causal and grounding explanations and we can gain knowledge of these laws by abductive inferences from facts of which we have perceptual or a priori knowledge. The second way of gaining information about the metaphysical laws rests on knowledge that is partly constitutive of competence with the concepts that are needed to express the relevant information. Finally, I consider how knowledge of the metaphysical laws can be used to establish modal claims, paying special attention to the much-discussed connection between conceiving and possibility. (shrink)

We further investigate a divisibility relation on the set of BN ultrafilters on the set of natural numbers. We single out prime ultrafilters (divisible only by 1 and themselves) and establish a hierarchy in which a position of every ultrafilter depends on the set of prime ultrafilters it is divisible by. We also construct ultrafilters with many immediate successors in this hierarchy and find positions of products of ultrafilters.

Attempts are often made to explain collective action in terms of the interaction of individuals. A common objection to such attempts is that they are circular: Since every interaction presupposes the existence of common practices and common practices involve collective action, no analysis of collective agency in terms of interaction can reduce collectivity away. In this essay I will argue that this does not constitute a real circularity. It is true that common practices are presupposed in every attempt to explain (...) collective action. However, this does not mean that every analysis of collective action presupposes an understanding of collective action. Common practices do not involve or presuppose particular collective actions. They are more fundamental than individual or collective agency. The subject of a common practice is not a ‘us’ or ‘them’, but the impersonal ‘one’: ‘One does this and that’. What ‘one does’ is not yet a joint activity. It is not a particular action at all. (shrink)

On the received view, counterfactuals are analysed using the concept of closeness between possible worlds: the counterfactual 'If it had been the case that p, then it would have been the case that q' is true at a world w just in case q is true at all the possible p-worlds closest to w. The degree of closeness between two worlds is usually thought to be determined by weighting different respects of similarity between them. The question I consider in the (...) paper is which weights attach to different respects of similarity. I start by considering Lewis's answer to the question and argue against it by presenting several counterexamples. I use the same examples to motivate a general principle about closeness: if a fact obtains in both of two worlds, then this similarity is relevant to the closeness between them if and only if the fact has the same explanation in the two worlds. I use this principle and some ideas of Lewis's to formulate a general account of counterfactuals, and I argue that this account can explain the asymmetry of counterfactual dependence. The paper concludes with a discussion of some examples that cannot be accommodated by the present version of the account and therefore necessitate further work on the details. (shrink)

Starting from the idea that functions are formally similar to actions in that they are described and explained in a similar way, so that both admit of an accordion effect, I turn to Anscombe’s insight that the point of practical reasoning is to render explicit the relation between the different descriptions of an action generated by the accordion effect. The upshot is, roughly, that an item has a function if what it does can be accounted for by functional reasoning. Put (...) differently, a part of a system has a function if what it does is a functional part of what the system does. (shrink)

I propose a general alethic theory of epistemic risk according to which the riskiness of an agent’s credence function encodes her relative sensitivity to different types of graded error. After motivating and mathematically developing this approach, I show that the epistemic risk function is a scaled reflection of expected inaccuracy. This duality between risk and information enables us to explore the relationship between attitudes to epistemic risk, the choice of scoring rules in epistemic utility theory, and the selection of priors (...) in Bayesian epistemology more generally. (shrink)

We continue the exploration of various aspects of divisibility of ultrafilters, adding one more relation to the picture: multiplicative finite embeddability. We show that it lies between divisibility relations \ and \. The set of its minimal elements proves to be very rich, and the \-hierarchy is used to get a better intuition of this richness. We find the place of the set of \-maximal ultrafilters among some known families of ultrafilters. Finally, we introduce new notions of largeness of subsets (...) of \, and compare it to other such notions, important for infinite combinatorics and topological dynamics. (shrink)

La quatrième de couverture indique : "Ils souffrent comme nous. Comme nous aussi, ils jouissent du bien-être. Mieux que nous parfois, ils s'imposent par la ruse et l'intelligence. Comment continuer à les traiter comme des " choses " dont on se contenterait de condamner l'abus? Mais faut-il pour autant leur accorder des droits, et si oui lesquels? Et qui veillera à leur application? Pour répondre à ces questions et à tant d'autres, Boris Cyrulnik l'éthologue, Elisabeth de Fontenay la philosophe, (...) Peter Singer le bioéthicien croisent leurs regards et confrontent leurs savoirs sur la question animale. Trois sensibilités, trois parcours, trois formes d'engagement : la voie est tracée, au-delà des divergences et des contradictions, et en partie grâce à elles, pour que le législateur s'attelle à la rédaction du contrat qu'il nous faut maintenant passer sans délai avec nos frères en animalité, au nom de la dignité humaine.". (shrink)

Many philosophers have argued that statistical evidence regarding group characteristics (particularly stereotypical ones) can create normative conflicts between the requirements of epistemic rationality and our moral obligations to each other. In a recent article, Johnson-King and Babic argue that such conflicts can usually be avoided: what ordinary morality requires, they argue, epistemic rationality permits. In this article, we show that as data get large, Johnson-King and Babic’s approach becomes less plausible. More constructively, we build on their project and develop a (...) generalized model of reasoning about stereotypes under which one can indeed avoid normative conflicts, even in a big data world, when data contain some noise. In doing so, we also articulate a general approach to rational belief updating for noisy data. (shrink)

If definitive evidence concerning treatment effectiveness becomes available from an ongoing randomized clinical trial, then the trial could be stopped early, with the public release of results benefiting current and future patients. However, stopping an ongoing trial based on accruing outcome data requires methodological rigor to preserve validity of the trial conclusions. This has led to the use of formal interim monitoring procedures, which include inefficacy monitoring that will stop a trial early when the experimental treatment appears not to be (...) working. For participants, inefficacy monitoring is especially important as it ensures that they are not being treated worse than if they had not enrolled on the trial. We discuss the importance of reporting with trial results the formal interim inefficacy monitoring guidelines that were utilized, and, if none were used, the reasons for their absence. A survey of two leading medical journals suggests that this is not current practice. (shrink)