A venerable view holds that a border between perception and cognition is built into our cognitive architecture and that this imposes limits on the way information can flow between them. While the deliverances of perception are freely available for use in reasoning and inference, there are strict constraints on information flow in the opposite direction. Despite its plausibility, this approach to the perception-cognition border has faced criticism in recent years. This article develops an updated version of the architectural approach, which (...) I call the dimension restriction hypothesis (DRH). According to DRH, perceptual processes are constrained to compute over a bounded range of dimensions, while cognitive processes are not. This view allows that perception is cognitively penetrable, but places strict limits on the varieties of penetration that can occur. The article argues that DRH enjoys both theoretical and empirical support, and also defends the view against several objections. (shrink)

The increasing application of network models to interpret biological systems raises a number of important methodological and epistemological questions. What novel insights can network analysis provide in biology? Are network approaches an extension of or in conflict with mechanistic research strategies? When and how can network and mechanistic approaches interact in productive ways? In this paper we address these questions by focusing on how biological networks are represented and analyzed in a diverse class of case studies. Our examples span from (...) the investigation of organizational properties of biological networks using tools from graph theory to the application of dynamical systems theory to understand the behavior of complex biological systems. We show how network approaches support and extend traditional mechanistic strategies but also offer novel strategies for dealing with biological complexity. (shrink)

Mesoscale modeling is often considered merely as a practical strategy used when information on lower-scale details is lacking, or when there is a need to make models cognitively or computationally tractable. Without dismissing the importance of practical constraints for modeling choices, we argue that mesoscale models should not just be considered as abbreviations or placeholders for more “complete” models. Because many systems exhibit different behaviors at various spatial and temporal scales, bottom-up approaches are almost always doomed to fail. Mesoscale models (...) capture aspects of multi-scale systems that cannot be parameterized by simple averaging of lower-scale details. To understand the behavior of multi-scale systems, it is essential to identify mesoscale parameters that “code for” lower-scale details in a way that relate phenomena intermediate between microscopic and macroscopic features. We illustrate this point using examples of modeling of multi-scale systems in materials science and biology, where identification of material parameters such as stiffness or strain is a central step. The examples illustrate important aspects of a so-called “middle-out” modeling strategy. Rather than attempting to model the system bottom-up, one starts at intermediate scales where systems exhibit behaviors distinct from those at the atomic and continuum scales. One then seeks to upscale and downscale to gain a more complete understanding of the multi-scale system. The cases highlight how parameterization of lower-scale details not only enables tractable modeling but is also central to understanding functional and organizational features of multi-scale systems. (shrink)

Some philosophers have suggested that certain shifts in perceptual organization are counterexamples to representationalism about phenomenal character. Representationalism about phenomenal character is, roughly, the view that there can be no difference in the phenomenal character of experience without a difference in the representational content of experience. In this paper, I examine three of these alleged counterexamples: the dot array (Peacocke 1983), the intersecting lines (Speaks 2010), and the 3 X 3 grid (Nickel 2007). I identify the two features of their (...) phenomenology that call for explanation: grouping and prominence. I then argue that representationalists can adequately account for both of these features. I also critique some previous treatments of grouping and prominence. (shrink)

Perceptual constancy has played a significant role in philosophy of perception. It figures in debates about direct realism, color ontology, and the minimal conditions for perceptual representation. Despite this, there is no general consensus about what constancy is. I argue that an adequate account of constancy must distinguish it from three distinct phenomena: mere sensory stability through proximal change, perceptual categorization of a distal dimension, and stability through irrelevant proximal change. Standard characterizations of constancy fall short in one or more (...) of these respects. I develop an account of constancy that overcomes these problems. The account has two parts: an analysis of constancy mechanisms, and an analysis of the conditions under which a constancy capacity is exercised. I then employ this account to evaluate whether constancy is a necessary condition for perceptual representation, as some have conjectured. I argue that explanatory practice in perceptual psychology fails to support this view. Rather, it fits better with the weaker principle that representation requires specific tracking of a distal dimension. (shrink)

Many authors have posited an “object file” system, which underlies perceptual selection and tracking of objects. Several have proposed that this system internalizes principles specifying what counts as an object and relies on them during tracking. Here I consider a popular view on which the object file system is tuned to entities that satisfy principles of three-dimensionality, cohesion, and boundedness. I argue that the evidence gathered in support of this view is consistent with a more permissive view on which object (...) files select and track according to well-known perceptual organization criteria. Further evidence supplies positive support for the permissive view. (shrink)

The epistemic relevance of forgiveness has been neglected by both the discussion of forgiveness in moral psychology and by social epistemology generally. Moral psychology fails to account for the forgiveness of epistemic wrongs and for the way that wrongs in general have epistemic implications. Social epistemology, for its part, neglects the way that epistemic trust is not only conferred but repaired. In this essay, I show that the repair of epistemic trust through forgiveness is necessary to the economy of knowledge (...) for fallible persons like us. Despite the fact that forgiveness is never included on lists of important intellectual virtues or epistemic activities, it is vital to our lives as social knowers. Likewise, an account of forgiveness that neglects its epistemic dimension is importantly incomplete. (shrink)

This is the first book to take a comprehensive look at white collar criminal offenses from the perspective of moral and legal theory. Focussing on the way in which key white collar crimes such as fraud, perjury, false statements, obstruction of justice, bribery, extortion, blackmail, insider trading, tax evasion, and regulatory and intellectual property offenses are shaped and informed by a range of familiar, but nevertheless powerful, moral norms.

Evolutionary systems biology (ESB) aims to integrate methods from systems biology and evolutionary biology to go beyond the current limitations in both fields. This article clarifies some conceptual difficulties of this integration project, and shows how they can be overcome. The main challenge we consider involves the integration of evolutionary biology with developmental dynamics, illustrated with two examples. First, we examine historical tensions between efforts to define general evolutionary principles and articulation of detailed mechanistic explanations of specific traits. Next, these (...) tensions are further clarified by considering a recent case from another field focused on developmental dynamics: stem cell biology. In the stem cell case, incompatible explanatory aims block integration. Experimental approaches aim at mechanistic explanation while dynamical system models offer explanation in terms of general principles. We then discuss an ESB case in which integration succeeds: search for general attractors using a dynamical systems framework synergizes with the experimental search for detailed mechanisms. Contrasts between the positive and negative cases suggest general lessons for achieving an integrated understanding of developmental and evolutionary dynamics. The key integrative move is to acknowledge two complementary aims, both relevant to explanation: identifying the space of possible dynamic states and trajectories, and mechanistic understanding of causal interactions underlying a specific phenomenon of interest. These two aims can support one another in a joint project characterizing dynamic aspects of evolving lineages. This more inclusive project can lead to insights that cannot be reached by either approach in isolation. (shrink)

Many philosophers, both past and present, object to materialism not from any romantic anti-scientific bent, but from sheer inability to understand the thesis. It seems utterly inconceivable to some that qualia should exist in a world which is entirely material. This paper investigates the grain objection, a much neglected argument which purports to prove that sensations could not be brain events. Three versions are examined in great detail. The plausibility of the first version is shown to depend crucially on whether (...) one holds a direct or non-direct theory of perception. Only on the latter is this version plausible. An analysis of the second "semantic" version concludes that a materialist description and explanation of the world should not be expected to transparently convey all that would be of interest or importance to human beings. The final version explicitly makes use of Grover Maxwell's non-direct perceptual theory of structural realism. Although a confusion is charged to Maxwell between phenomenal and objective properties, the critical difficulty for the grain objection is its failure to characterize "structure" from a non-percipient point of view. As the grain objection is ultimately found wanting, the real difficulty for materialism crystallizes as its irreconciliability with the mere existence of sentience, which seems to force some sort of emergence upon us. (shrink)

In the face of mounting criticism against advance directives, we describe how a novel, computer-based decision aid addresses some of these important concerns. This decision aid, Making Your Wishes Known: Planning Your Medical Future , translates an individual's values and goals into a meaningful advance directive that explicitly reflects their healthcare wishes and outlines a plan for how they wish to be treated. It does this by (1) educating users about advance care planning; (2) helping individuals identify, clarify, and prioritize (...) factors that influence their decision-making about future medical conditions; (3) explaining common end-of-life medical conditions and life-sustaining treatment; (4) helping users articulate a coherent set of wishes with regard to advance care planning—in the form of an advance directive readily interpretable by physicians; and (5) helping individuals both choose a spokesperson, and prepare to engage family, friends, and health care providers in discussions about advance care planning. (shrink)

Frege and many following him, such as Dummett, Geach, Stenius and Hare, have envisaged a role for illocutionary force indicators in a logically perpspicuous notation. Davidson has denied that such expressions are even possible on the ground that any putative force indicator would be used by actors and jokers to heighten the drama of their performances. Davidson infers from this objection a Thesis of the Autonomy of Linguistic Meaning: symbolic representation necessarily breaks any close tie with extra-linguistic purpose. A modified (...) version of Frege's ideal is here propounded according to which all expression is a force indicator just in case it indicates force in any speech act in which it occurs. It is shown that attainment of such an ideal would not have deprived Frege of what he desired of a perspicuous notation. In elaborating this ideal we also espouse an illocutionary conception of validity and argue that the ideal is one to which English conforms: parenthetical speech act verbs in the first person present indicative active are force indicators in the modified sense. But the mere possibility of force indicators in the modified sense is enough to show Davidson's Autonomy Thesis to be at best at half-truth. (shrink)

This paper argues that scale-dependence of physical and biological processes offers resistance to reductionism and has implications that support a specific kind of downward causation. I demonstrate how insights from multiscale modeling can provide a concrete mathematical interpretation of downward causation as boundary conditions for models used to represent processes at lower scales. The autonomy and role of macroscale parameters and higher-level constraints are illustrated through examples of multiscale modeling in physics, developmental biology, and systems biology. Drawing on these examples, (...) I defend the explanatory importance of constraining relations for understanding the behavior of biological systems. (shrink)

Timothy Williamson and others have made a strong case for the claim that knowledge is the norm of assertion. Reasons to think that assertion has an epistemic norm also, interestingly, provide a reason to think that conversational implicature has a norm as well. This norm, it is argued, cannot be knowledge. In addition to highlighting an under-explored topic at the intersection of epistemology and linguistics, the discussion of conversational implicature puts dialectical pressure on the knowledge norm of assertion account. The (...) fact that knowledge is not the norm of conversational implicature forces one either to claim that there is one epistemic norm for the conveying of information and that it is not knowledge, or else to embrace a heterogeneous picture of communicative norms generally that undercuts some of the grounds for thinking that the norm of assertion should be presumed to be a simple norm as Williamson argues. (shrink)

Proponents of the emerging field of P4 medicine argue that computational integration and analysis of patient-specific “big data” will revolutionize our health care systems, in particular primary care-based disease prevention. While many ambitions remain visionary, steps to personalize medicine are already taken via personalized genomics, mobile health technologies and pilot projects. An important aim of P4 medicine is to enable disease prevention among healthy persons through detection of risk factors. In this paper, we examine the current status of P4 medicine (...) in light of historical and current challenges to predictive and preventive medicine, including overdiagnosis and overtreatment. Moreover, we ask whether it is likely that in silico integration of patient-specific data will be able to better deal such challenges and to turn risk predictions into disease-preventive actions in a wider social context. Given the lack of evidence that P4 medicine can tip the balance between benefits and harms in preventive medicine, we raise concerns about the current promotion of P4 medicine as a solution to the current challenges in public health. (shrink)

When does benefiting from others’ wrongdoing effectively make one a moral accomplice in their evil deeds? If stem cell research lives up to its therapeutic promise, this question (which has previously cropped up in debates over fetal tissue research or the use of Nazi research data) is likely to become a central one for opponents of embryo destruction. I argue that benefiting from wrongdoing is prima facie morally wrong under any of three conditions: (1) when the wrongdoer is one’s agent; (...) (2) when acceptance of benefit directly encourages the repetition of the wrongful deed (even though no agency relationship is involved); and (3) when acceptance of a benefit legitimates a wrongful practice. I conclude by showing that, because of the ways in which most embryonic stem cell lines come into being, people who oppose embryo destruction may use human embryonic stem cells without incurring moral blame. (shrink)

In articles such as “Speech Acts without Propositions?” (2006), Marina Sbisà advocates a “strong” conception of speech acts as means by which speakers modify their own and others’ deontic statuses, including their rights, obligations, and commitments. On this basis Sbisà challenges an influential approach to speech acts as typically if not universally possessing propositional contents. Sbisà argues that such an approach leads to viewing speech acts as primarily aimed at communicating propositional attitudes rather than carrying out socially and normatively significant (...) action. For this reason she advocates eschewing propositions from speech act theory’s conceptual toolkit; she also proposes a liberalization of the distinction between illocutionary force and semantic content, which are widely thought to be mutually exclusive. In this chapter we examine Sbisà’s reasoning and argue that while it does justify denying propositional attitudes a central role in communication, it does not justify dispensing with propositions or other contents in our theorizing about speech acts. In addition, we endorse Sbisà’s proposal for liberalizing the force/content distinction, and show a variety of ways in which force indicators may also possess semantic content. (shrink)

The moral problem, as articulated by Smith, arises out of the attempt to introduce the experimental method of reasoning into moral subjects, developed by Hume. This paper returns to Locke’s earlier attempt to provide an empirically adequate account of morality and the debate his attempt generated. It argues that the seeds of a more adequate, naturalistic account of the metaphysics and epistemology of morals than that developed by either Locke or Hume can already be found in aspects of Locke’s Essay (...) and in the defence of his views published by Catharine Trotter Cockburn. Locke and Cockburn find a natural, intrinsically moral, human disposition in our tendency to judge the moral good or evil of persons or actions in the light of their conformity with a moral law. It is constitutive of our nature as social beings that we are endowed ‘with a moral sense or conscience, that approves of virtuous actions, and disapproves the contrary.’ Moral laws are those prohibitions and obligations that benefit others and society as a whole. Thus, the question of natural, moral motivation is seen to be independent of the question of the objective grounds of moral truth. In virtue of our nature as social beings we are motivated to do what is approved of by other members of our society. Whether what is approved of by a society genuinely fosters the welfare of its members is an independent, a posteriori question that can only be answered through reasoned, empirically informed debate. (shrink)

We explore the desirability of an idea that has not received the attention it deserves by political philosophers: that governments should bring privately-owned fossil fuel companies into public ownership with a view to managing their wind-down in the public interest – often simply referred to as ‘nationalising the fossil fuel industry’. We aim to make a conditional case for public ownership of fossil fuel companies. We will assume certain conditions about government motivations and capacities that are similar to assumptions made (...) generally in the philosophical and economic analysis of climate policies: that the government is suitably motivated, has effective control over the companies it acquires, and is able to sustain this motivation and control for long-enough to wind-down acquired companies in the public interest. We argue that bringing fossil fuel companies into public ownership, under these conditions, allows the government to take ten actions that are in the public interest, which will enhance social justice, enable a fair division of burdens and benefits, and strengthen democracy. We consider four plausible objections. While some of these point to the need for further research, they do not undermine our claim that nationalising the fossil fuel industry is a policy option that merits serious consideration. (shrink)

Recent years have witnessed a revival of scientific, political and philosophical discourse concerning the notion of ecological limits. This article provides a conceptual overview of descriptive ecological limit claims—i.e. claims that there are real, biophysical limits—and reviews work in political and social philosophy in which such claims form the basis of proposals for normative limits. The latter are classified in terms of three broad types of normative theorising: distributive justice, institutional/legal reform, and the good life. Within these three categories, the (...) article reviews normative proposals for limits on both aggregate‐level and individual‐level ecological exploitation. It also considers the relevance of political and ideological facts to the normative analysis of ecological limits, raising methodological questions about how normative theorists should respond to a world facing escalating ecological challenges. (shrink)

Patient-derived xenografts are currently promoted as new translational models in precision oncology. PDXs are immunodeficient mice with human tumors that are used as surrogate models to represent specific types of cancer. By accounting for the genetic heterogeneity of cancer tumors, PDXs are hoped to provide more clinically relevant results in preclinical research. Further, in the function of so-called “mouse avatars”, PDXs are hoped to allow for patient-specific drug testing in real-time. This paper examines the circulation of knowledge and bodily material (...) across the species boundary of human and personalized mouse model, historically as well as in contemporary practices. PDXs raise interesting questions about the relation between animal model and human patient, and about the capacity of hybrid or interspecies models to close existing translational gaps. We highlight that the translational potential of PDXs not only depends on representational matching of model and target, but also on temporal alignment between model development and practical uses. Aside from the importance of ensuring temporal stability of human tumors in a murine body, the mouse avatar concept rests on the possibility of aligning the temporal horizons of the clinic and the lab. We examine strategies to address temporal challenges, including cryopreservation and biobanking, as well as attempts to speed up translation through modification and use of faster developing organisms. We discuss how featured model virtues change with precision oncology, and contend that temporality is a model feature that deserves more philosophical attention. (shrink)

The disappearance of Catharine Macaulay’s eighteenth-century defense of the doctrines that justified the seventeeth-century republican parliament, has served to obscure an important strand of enlightenment faith, that was active in the lead up to the American and French Revolutions, and that also played a significant role in the history of feminism. This faith was made up of two intertwined strands, ‘Christian eudaimonism’ and ‘rational altruism’. Dominant contemporary accounts of the origins of republicanism and democratic theory during the eighteenth-century have excluded (...) serious consideration of Macaulay’s writing. Bringing her works into the mix, both poses difficulties for certain genealogies of the political thought of the period, and tends to favour a once popular view, which emphasized the centrality of Locke. Nevertheless, the Locke whose influence is found in Macaulay’s writing is not the possessive individualist, or rational egoist, that he and other liberals have been represented as being, but rather a rational altruist, whose political philosophy is grounded in natural law and harks back to Milton. This same philosophy provides the philosophical foundations for Wollstonecraft’s two most significant political texts, the Vindication of the Rights of Men and Vindcation of the Rights of Woman. (shrink)

The Christian intellectual tradition consistently affirms that God is present in and continues to speak through Scripture. These functions of the Christian Scriptures have been underexamined in contemporary philosophy of religion and philosophical theology. Careful attention to the phenomenon of shared attention is instructive for providing an account of these matters, and the shared attention account developed here provides a useful conceptual framework within which to situate recent work on Scripture by scholars such as Kevin Vanhoozer, Nicholas Wolterstorff, and Michael (...) Rea. (shrink)

Critical thinking about international politics often involves reasoning about the beliefs, goals, appraisals, actions, and plans of actors such as countries, governments, politicians, etc. We analyzed arguments in interpretive reports about international politics, in order to develop a prototype argument diagramming tool for this domain, AVIZE (Argument Visualization and Evaluation). The purpose of AVIZE is to aid users in the construction and self-evaluation of real-world arguments in the domain of international politics. AVIZE provides a set of argument schemes as cognitive (...) building blocks for constructing argument diagrams. Most of the schemes are related to concepts from the field of automated plan recognition in artificial intelligence. While some currently available argument diagramming tools provide schemes, they are not tailored to the domain of international politics. This paper describes the argument schemes for this domain and the design of the argument diagramming tool. (shrink)

Journal Name: Cognitive Linguistics Issue: Ahead of print.

In this essay reviewing Brian Leiter’s recent book Naturalizing Jurisprudence, I focus on two positions that distinguish Leiter’s reading of the American legal realists from those offered in the past. The first is his claim that the realists thought the law is only locally indeterminate – primarily in cases that are appealed. The second is his claim that they did not offer a prediction theory of law, but were instead committed to a standard positivist theory. Leiter’s reading is vulnerable, because (...) he fails to discuss in detail those passages from the realists that inspired past interpretations. My goal is to see how Leiter’s reading fares when these passages are considered. I argue that Leiter is right that the realists’ indeterminacy thesis has only a local scope. Those passages that appear to claim that the law is globally indeterminate actually address three other topics: judicial supremacy, judges’ roles as finders of fact, and the moral obligation to adjudicate as the law commands. With respect to the prediction theory, however, I conclude that Leiter’s position cannot be defended. Indeed the realists offered two “prediction” theories of law. According to the first, which is best described as a decision theory, the law concerning an event is whatever concrete judgment a court will issue when the event is litigated. According to the second, the law is reduced, not to concrete judgments, but to regularities of judicial (and other official) behavior in a jurisdiction. I end this essay with the suggestion that the realists’ advocacy of the second prediction theory indirectly vindicates Leiter’s reading of the realists as prescient jurisprudential naturalists. (shrink)