Introduction of O2 to Earth's early biosphere stimulated remarkable evolutionary adaptations, and a wide range of electron acceptors allowed diverse, energy-yielding metabolic pathways. Enzymatic reduction of O2 yielded a several-fold increase in energy production, enabling evolution of multi-cellular animal life. However, utilization of O2 also presented major challenges as O2 and many of its derived reactive oxygen species are highly toxic, possibly impeding multicellular evolution after the Great Oxidation Event. Remarkably, ROS, and especially hydrogen peroxide, seem to play a major (...) part in early diversification and further development of cellular respiration and other oxygenic pathways, thus becoming an intricate part of evolution of complex life. Hence, although harnessing of chemical and thermo-dynamic properties of O2 for aerobic metabolism is generally considered to be an evolutionary milestone, the ability to use ROS for cell signaling and regulation may have been the first true breakthrough in development of complex life. The importance of Earth's oxygen cycle and reactive oxygen species produced on the evolution of complex life. The ability to detoxify oxygen species is not a trait that emerged as a response to increased O2 levels but rather crucial adaptation to the early Earth's weakly oxic microenvironments. (shrink)

Foucault is often thought to have a great deal to say about the history of madness and sexuality, but little in terms of a general analysis of government and the state.; This volume draws on Foucault's own research to challenge this view, demonstrating the central importance of his work for the study of contemporary politics.; It focuses on liberalism and neo- liberalism, questioning the conceptual opposition of freedom/constraint, state/market and public/private that inform liberal thought.

This review focuses on the Ogdoas scholastica by Jacob Lorhard, published in 1606. The importance of this document turns on the fact that it contains what is almost certainly the first published occurrence of the term “ontology.” The body of the work consists in a series of diagrams called “diagraphs.” Relevant features of this compendium of diagraphs are: 1. that it does not in fact contain the word “ontology,” and 2. that Lorhard himself was not responsible for its content.

Martial-arts practice is not quite anything else: it is like sport, but is not sport; it constantly refers to and as it were cohabits with violence, but is not violent; it is dance-like but not dance. It shares a common athleticism with sports and dance, yet stands apart from both, especially through its paradoxical commitment to the external value of being an instrument of violence. My discussion seeks to illuminate martial arts practice by systematic contrast to games of sport and (...) works of performance art, especially dance. (shrink)

The book concludes that it is a mistake to think of Art as something subjective, or as an arbitrary social representation, and of Technology as an instrumental ..

ABSTRACTWe seem to have a direct experience of our freedom when we act. Many philosophers take this feeling of freedom as evidence that we possess libertarian free will. Spinoza denies that we have free will of any sort, although he admits that we nonetheless feel free. Commentators often attribute to him what I call the ‘Negative Account’ of the feeling: it results from the fact that we are conscious of our actions but ignorant of their causes. I argue that the (...) Negative Account is flawed. The feeling of freedom also depends on a vacillation of the mind. When the mind forms too many incompatible associations, it vacillates between them. When we act, the mind vacillates back and forth between the kinds of actions that we associate with our present mental state. We then mistake this subjective vacillation for an objective feature of ourselves—namely, the power to do otherwise. (shrink)

Henri Bergson and William James were great admirers of each other, and James seemed to think he got valuable ideas from Bergson. But early critics were right to see in Bergson the antithesis of pragmatism. Unfolding this antithesis is a convenient way to study important concepts and innovations in Bergson's philosophy. I concentrate on his ideas of duration and intuition, and show how they prove the necessity of going beyond pragmatism. The reason is because knowledge itself goes beyond the utilitarian (...) limitations in which pragmatism confines it. Knowledge is more than utility, more than adaptation, more than pragmatism, because our cognitive powers prove capable of more than any naturally selected service to survival. (shrink)

McTaggart's argument against the reality of the A series poses a serious problem for the moving-now block theory of time. A defender of MNBT can respond along lines suggested by Broad: by denying that we should understand ‘e was present’ as saying that e is present at some past moment t. There is, however, a serious—plausibly defeating—objection to this type of response: it implicitly denies a non-negotiable platitude about time. As a result, MNBT is not tenable. Growing block theories are (...) also defeated by a similar objection. (shrink)

It seems plausible to extend to the field of Disability Studies a certain nominalist point of view which is evident in Foucault’s work. What I have in mind is an “implantation of impairments” thesis, modelled after what Foucault calls the “implantation of perversions.” After sketching some features of this Foucauldian argument, I discuss the ideas of knowledge and power that it presupposes, then outline a critical perspective on Foucault’s nominalism.

Kripke's Wittgenstein on Rules and Private Language has enlivened recent discussion of Wittgenstein's later philosophy. Yet it is quite possible to disengage his interpretive thesis from its supporting argumentation. Doing so leaves one with an intriguing sceptical argument which Kripke first powerfully advances, then tries to halt. But contrary to the impression his argument may leave, Kripke's solution and the position it concedes to the Sceptic are deeply allied. Here I shall demonstrate their common assumption, and on that basis argue (...) that Kripke's solution begs the Sceptic's question. Furthermore, I believe we can live with the Sceptic. The sceptical argument can be turned into a reasonable contribution to a kind of nominalism in the philosophy of meaning and truth. (shrink)

The claim that chimpanzees make and use tools stands on two feet. One is a simplistic conception of tool; the other is a range of field observations, whose interpretation is not always as ingenuous and objective as their advocates suggest. An important difference little attended to by friends of the chimpanzee’s tool concerns how little their way of life seems to hang on their so-called tools. For us nearly everything does. Without tools, chimpanzees would find other things to eat. But (...) without our tools we are not a naked ape thrown back on its animal nature. We are an nonviable species rapidly heading for extinction. Tools belong to the very ecology of our evolved form of life. The myth of the chimpanzee’s tool has already proved damaging in the history and philosophy of technology. It obscures the unique contribution of technical culture to human ecology, which has no counterpart among chimpanzees. The myth has also inspired the bizarre idea that there is something arbitrary about technical culture — that in a sense we could do without it. That is certainly a mistake, and more serious than a specialist’s error, because any decision about the chimpanzee’s tool is replete with implications for understanding our humanness. (shrink)

Essays discuss the social and moral meanings of Freudian thought and examine the changes Freud's ideas have undergone in various fields of psychology.

I take a skeptical view of the experimentalism Dorf and Sable advocate. I discuss three kinds of doubts: Doubt about the idea of “best practices”; doubt about their understanding of scientific experimentation; and doubt about the value of the Constitutional reform they envision. Their program reduces democracy to competitive rituals and managerial predation. The imperative of comparison threatens practice with destruction. “Benchmarking” is a machine to destroy divergence. To compel such comparison with the force of law would be a catastrophe (...) for the ecology of human practices, an enforced monoculturalism that would make democracy infinitely easier to manage at the price of making it infinitely less democratic. (shrink)

Kant empahtically denied that living forms unfold according to a mechanical law. Yet if living nature were not law-like, natural science would be futile. The justification for a concept of purposiveness is to ensure “the lawfulness of the contingent” against the last exception. It was not until we learned to think about contingency without effacing it that natural history crossed the threshold of a science, Darwin leading the way. While his theory of evolution proposes mechanical explanations for a wide range (...) of natural historical phenomena, the explanations do not overcome but actually presuppose life’s ultimate contingency. (shrink)

Instead of following the behaviorists and abandoning the concept of experience, Dewey wanted to reconstruct it. Dewey was an ardent Darwinist, so whatever experience is, it has to be an evolved, presumably adaptive power. “Experience” became for him one word for the multiplex relation between the evolved, adapted organism and its environment. Human environments include groups and social relations mediated by language. But “experience” is not centered there, or restricted to the use of language. Experience comprises our total interaction with (...) the environment. It is with this experience that knowledge begins and where its value is proved. (shrink)