PstS and DING proteins are members of a superfamily of secreted, high‐affinity phosphate‐binding proteins. Whereas microbial PstS have a well‐defined role in phosphate ABC transporters, the physiological function of DING proteins, named after their DINGGG N termini, still needs to be determined. PstS and DING proteins co‐exist in some Pseudomonas strains, to which they confer a highly adhesive and virulent phenotype. More than 30 DING proteins have now been purified, mostly from eukaryotes. They are often associated with infections or with (...) dysregulation of cell proliferation. Consequently, eukaryotic DING proteins could also be involved in cell–cell communication or adherence. The ubiquitous presence in eukaryotes of proteins structurally and functionally related to bacterial virulence factors is intriguing, as is the absence of eukaryotic genes encoding DING proteins in databases. DING proteins in eukaryotes could originate from unidentified commensal or symbiotic bacteria and could contribute to essential functions. Alternatively, DING proteins could be encoded by eukaryotic genes sharing special features that prevent their cloning. Both hypotheses are discussed. (shrink)

Public opinion in recent years has soured on multiculturalism, due in large part to fears of radical Islam. In Multiculturalism without Culture, Anne Phillips contends that critics misrepresent culture as the explanation of everything individuals from minority and non-Western groups do. She puts forward a defense of multiculturalism that dispenses with notions of culture, instead placing individuals themselves at its core. Multiculturalism has been blamed for encouraging the oppression of women--forced marriages, female genital cutting, school girls wearing the hijab. (...) Many critics opportunistically deploy gender equality to justify the retreat from multiculturalism, hijacking the equality agenda to perpetuate cultural stereotypes. Phillips informs her argument with the feminist insistence on recognizing women as agents, and defends her position using an unusually broad range of literature, including political theory, philosophy, feminist theory, law, and anthropology. She argues that critics and proponents alike exaggerate the unity, distinctness, and intractability of cultures, thereby encouraging a perception of men and women as dupes constrained by cultural dictates. Opponents of multiculturalism may think the argument against accommodating cultural difference is over and won, but they are wrong. Phillips believes multiculturalism still has an important role to play in achieving greater social equality. In this book, she offers a new way of addressing dilemmas of justice and equality in multiethnic, multicultural societies, intervening at this critical moment when so many Western countries are poised to abandon multiculturalism. (shrink)

Dans les Esquisses pyrrhoniennes, Sextus Empiricus entreprend de réfuter le sunèmmenon, qui correspond en logique à notre « implication ». Sa réfutation procède circulairement, chacun des quatre critères proposés se voyant réfuté par le critère qui lui succède, de sorte que la dernière réfutation marque implicitement le retour à la première. Une telle situation est exemplaire parce qu’elle trouve un étrange écho dans la controverse qui oppose les logiciens du xx e siècle : savoir si la conséquence logique peut être (...) réduite à la validité du conditionnel matériel ou si elle n’exige pas plutôt ce que les logiciens appellent la « pertinence ». Envisagée dans cette perspective, la batterie des réfutations sceptiques se réduit au rôle d’adjuvant dans une controverse qui la dépasse, comme si la logique elle-même devenait sceptique lorsqu’elle se heurte à une aporie constitutive. (shrink)

Purpose – The purpose of this paper is to explore artificial moral agency by reflecting upon the possibility of a Moral Turing Test and whether its lack of focus on interiority, i.e. its behaviouristic foundation, counts as an obstacle to establishing such a test to judge the performance of an Artificial Moral Agent. Subsequently, to investigate whether an MTT could serve as a useful framework for the understanding, designing and engineering of AMAs, we set out to address fundamental challenges within (...) the field of robot ethics regarding the formal representation of moral theories and standards. Here, typically three design approaches to AMAs are available: top-down theory-driven models and bottom-up approaches which set out to model moral behaviour by means of models for adaptive learning, such as neural networks, and finally, hybrid models, which involve components from both top-down and bottom-up approaches to the modelling of moral agency. With inspiration from Allen and Wallace as well as Prior, we elaborate on theoretically driven approaches to machine ethics by introducing deontic tense logic. Finally, within this framework, we explore the character of human interaction with a robot which has successfully passed an MTT. Design/methodology/approach – The ideas in this paper reflect preliminary theoretical considerations regarding the possibility of establishing a MTT based on the evaluation of moral behaviour, which focusses on moral reasoning regarding possible actions. The thoughts reflected fall within the field of normative ethics and apply deontic tense logic to discuss the possibilities and limitations of artificial moral agency. Findings – The authors stipulate a formalisation of logic of obligation, time and modality, which may serve as a candidate for implementing a system corresponding to an MTT in a restricted sense. Hence, the authors argue that to establish a present moral obligation, we need to be able to make a description of the actual situation and the relevant general moral rules. Such a description can never be complete, as the combination of exhaustive knowledge about both situations and rules would involve a God eye’s view, enabling one to know all there is to know and take everything relevant into consideration before making a perfect moral decision to act upon. Consequently, due to this frame problem, from an engineering point of view, we can only strive for designing a robot supposed to operate within a restricted domain and within a limited space-time region. Given such a setup, the robot has to be able to perform moral reasoning based on a formal description of the situation and any possible future developments. Although a system of this kind may be useful, it is clearly also limited to a particular context. It seems that it will always be possible to find special cases in which a given system does not pass the MTT. This calls for a new design of moral systems with trust-related components which will make it possible for the system to learn from experience. Originality/value – It is without doubt that in the near future we are going to be faced with advanced social robots with increasing autonomy, and our growing engagement with these robots calls for the exploration of ethical issues and stresses the importance of informing the process of engineering ethical robots. Our contribution can be seen as an early step in this direction. (shrink)

A new emphasis on diversity and difference is displacing older myths of nation or community. A new attention to gender, race, language or religion is disrupting earlier preoccupations with class. But the welcome extended to heterogeneity can bring with it a disturbing fragmentation and closure. Can we develop a vision of democracy through difference: a politics that neither denies group identities nor capitulates to them? In this volume, Anne Phillips develops the feminist challenge to exclusionary versions of democracy, citizenship (...) and equality. Relating this to the crisis in socialist theory, the growing unease with the pretensions of Enlightenment rationality, and the recent recuperation of liberal democracy as the only viable politics, she builds on debates within feminism to address general questions of difference. When democracies try to wish away group difference and inequality, they fail to meet their egalitarian promise. When yearnings towards an undifferentiated unity become the basis for radical politics and change, too many groups drop out of the picture. Through her critical discussions of recent feminist and socialist theory Anne Phillips rejects this democracy of denial. She also warns, however, of the dangers on the other side. The simpler celebrations of diversity risk freezing group differences as they are, encouraging a patchwork of local identities from which people can speak only to themselves. Her arguments then combine in a powerful restatement of the case for a more active and participatory democracy. It is only through enhanced communication and discussion that people can respect and learn from their differences. (shrink)

Examines the relationship between art and journalism in the 1930s, and discusses how intellectuals strove to be relevant during this trying time by using their own involvement in labor struggles to influence their art.

Este estudio trata de la dinámica de la voluntad que, como facultad espiritual junto con la inteligencia, existe en un relacionamiento con el ser; en el caso de la primera, con el ser como bondad, lo que ontológicamente se llama amor natural. Ahora bien, el mundo ético exige un amor de elección, lo que abre el tema de la libertad humana y su papel en el sentido de la existencia del hombre. En la síntesis tomista queda claro que, aunque el (...) hombre es principalmente un ser cognitivo, él no puede conocerse plenamente sin dar significado adecuado a su capacidad volitiva. También queda claro que el papel de la voluntad en la acción humana no puede ser comprendido sin ver la relación que la misma tiene con su raíz en el ser. En consecuencia se puede decir que el amor al bien surge como seña de identidad de la voluntad, tanto en Ontología cuanto en Ética. (shrink)

Anne-Marie Søndergaard Christensen presents a new account of the role of moral philosophy and its relationship to our ordinary moral lives. She challenges the idea that moral theories have an authoritative explanatory or action-guiding role, and develops instead a descriptive, pluralistic, and elucidatory conception of moral philosophy.

This book explores five Platonic dialogues: Lysis, Charmides, Protagoras, Euthydemus, and the Republic. This book uses Socrates’ narrative commentary as its primary interpretive framework. No one has engaged in a sustained attempt to explore the Platonic dialogues from this angle. As a result, it offers a unique contribution to Plato scholarship. The portrait of Socrates that emerges challenges the traditional view of Socrates as an intellectualist and offers a holistic vision of philosophical practice.

Depuis près d'un demi-siècle, Madame Hélène Ackermans a coopéré très activement à l'organisation de l'École des sciences philosophiques et religieuses des F.U.S.L. Avec Monseigneur Henri Van Camp, elle a donné à la tribune des leçons publiques sa renommée internationale; auprès de l'actuel comité de direction, elle n'a cessé de prodiguer ses multiples compétences et ses conseils avisés. En hommage à son travail, il a été demandé à quelques-uns des penseurs avec lesquels Madame Hélène Ackermans a noué des liens d'amitié, de (...) réfléchir au rôle de la philosophie dans la Cité. (shrink)

In the course of our daily lives we make lots of evaluations of actions. We think that driving above the speed limit is dangerous, that giving up one’s bus seat to the elderly is polite, that stirring eggs with a plastic spoon is neither good nor bad. We understand too that we may be praised or blamed for actions performed on the basis of these evaluations. The same is true in the case of certain beliefs. Sometimes we blame people for (...) what they believe falsely or irrationally. On occasion, we praise them for their intellectual discoveries. The goal of the present study is to describe the foundations which allow for these kinds of judgments. If you think that people are not always forgivable for what they believe, you will find in this book the resources to defend this thought. (shrink)

Schizophrenia is associated with a series of visual perception impairments, which might impact on the patients’ every day life and be related to clinical symptoms. However, the heterogeneity of the visual disorders make it a challenge to understand both the mechanisms and the consequences of these impairments, i.e., the way patients experience the outer world. Based on earlier psychiatry literature, we argue that issues regarding time might shed a new light on the disorders observed in patients with schizophrenia.We will briefly (...) review the mechanisms involved in the sense of time continuity and clinical evidence that they are impaired in patients with schizophrenia.We will then summarize a recent experimental approach regarding the coding of time-event structure in time, namely the ability to discriminate between simultaneous and asynchronous events. The use of an original method of analysis allowed us to distinguish between explicit and implicit judgments of synchrony.We showed that for SOAs below 20ms neither patients nor controls fuse events in time. On the contrary subjects distinguish events at an implicit level even when judging them as synchronous. In addition, the implicit responses of patients and controls differ qualitatively. It is as if controls always put more weight on the last occurred event, whereas patients have a difficulty to follow events in time at an implicit level. In patients, there is a clear dissociation between results at short and large asynchronies, that suggest selective mechanisms for the implicit coding of time-event structure. These results might explain the disruption of the sense of time continuity in patients.We argue that this line of research might also help us to better understand the mechanisms of the visual impairments in patients and how they see their environment. (shrink)

Does Cantorian set theory alter our intuitive conception of number? Yes. In particular, Cantorian set theory revises our intuitive conception of when two sets have the same size (cardinal number). Consider a variant of Galileo’s Paradox, which notes that the members of the set of natural numbers, N, can be put in one-to-one correspondence with the members of the set of even numbers, E.

This book provides an interdisciplinary perspective on working with young people, focusing on education, health and social work, and draws on projects and perspectives from the United Kingdom, the United States, Canada and Australia. The volume highlights the ethical challenges and dilemmas as these and other services are integrated and addresses how ethical practices are confronted and shared across disciplines.<BR> The first section looks at professional practice; the second foregrounds children's and young people's voices and is especially concerned with children (...) and young people as co-researchers. Subjects addressed within the text include sex education, health education, custodial care, confidentiality and gaining consent, ethical issues around ICT and researching with vulnerable populations.<BR> The book is intended for both scholars and practitioners. It places examples in clearly articulated theoretical frameworks as well as considering professional principles and practice. (shrink)

The phenomenon of ‘innocent guilt’ regards cases where people feel guilty without being responsible for the wrongdoing or suffering at which the guilt is directed. The aim of this article is to develop a consistent account of innocent guilt and show how it may arise in the aftermath of conflicts. In order to do this, innocent guilt is contrasted with guilt and collective guilt, and the account is substantiated by drawing on the writings of Ludwig Wittgenstein and Emmanuel Levinas, who (...) both consider the phenomenon of innocent guilt a necessary element in the fundamental structure of the ethical subject. These thinkers, furthermore, show a connection between guilt and possible victims of wrongdoing, rather than between guilt and personal acts of wrongdoing. Innocent guilt may thus appear in the aftermath of conflicts as an ethical and emotional response to the fact of finding oneself in a post-conflict situation still marked by suffering. It thus reveals a fundamental need to contribute to the relieving of such suffering. (shrink)

How does understanding occur in encounters of living beings? What is experienced by the interaction partners and what happens in the ‘In-Between’? And how can this be captured? In this paper an enactive approach to interaction is proposed with the focus on reciprocal inter-corporeal attunement and co-creation of meaning in a specific environment. As alternative framework this approach is applied to the interaction of d/Deaf persons and animals. In the interaction with an animal, verbal communication – which is challenging for (...) d/Deaf persons – is of secondary importance, so this frame is well suited to focus on intercorporeal attunement. In the interaction discourse regarding d/Deaf persons as well as Human-Animal-Interaction the assessment of the interaction process as such and embodied research methodologies are scarcely to be found. With the enactive approach new perspectives on the mechanisms of interaction and the influencing conditions can be opened as well as new approaches to respective research options. (shrink)

This paper investigates empowerment within manufacturing production. Empowerment is multidimensional. Understanding the implications of operationalising empowerment requires an appreciation of all its dimensions. These dimensions are captured in Empowerment Profiles, which are incorporated within a conceptual framework. A sample of the Empowerment Profiles is validated using case studies. The Empowerment Profiles appear to have potential as a tool to assist in preparing to implement empowered work strategies, focusing attention on issues to be considered.

« Personne est mon nom », dit Ulysse au cyclope Polyphème, qui n’y voyait déjà que d’un œil avant d’être totalement plongé dans les ténèbres par la ruse d’Ulysse, auquel il avait pourtant offert, en toute magnanimité, de ne le dévorer qu’en dernier, pour le récompenser de ce vin divin qu’il lui versait à boire. Ulysse aux mille tours fait ici à son redoutable hôte les honneurs de sa mètis (« intelligence, sagesse habile ») la plus achevée – car sémantique (...) – en prétendant se nommer Outis, Pers... (shrink)

This article criticizes recent suggestions that the current ELSI research field should accommodate a new direction towards a ‘post-ELSI’ agenda. Post-ELSI research seeks to avoid the modernist division of responsibility for technical and social issues said to characterize ELSI research. Collaboration and integration are consequently the key terms of post-ELSI strategies that are to distinguish it from ELSI strategies. We argue that this call for a new direction relies on an inadequate generalized analysis of ELSI research as modern that will (...) affect the construal of post-ELSI strategies. We are concerned that the call for post-ELSI shift will exclude imaginative proposals and intellectual freedom by narrowing down the scope and methodologies of ELSI and thereby missing opportunities to play a critical and constructive normative role. Instead of framing current trends in ELSI research as a radical and progressive shift from ELSI to post-ELSI, we suggest an alternative story of expansion and diversification described in terms of a drift from ELSA 1 to ELSA 2, pertaining to acronyms in use in Europe. ELSI research has never been modern. It has been experimenting from the very start on ways to mesh the works of humanist, social and natural scientist in order to bridge and build alignments of emerging scientific and societal goals and matters of concern. The development from ELSA 1 to ELSA 2 expands in our account the range of intellectual and methodological capacities of analysis and engagement of complex and dynamic science-society relationships. We present three areas of ELSA expertise to illustrate that the expertise within the field builds on scholarly achievements within the humanities, social sciences as well as the natural sciences. The plurality of disciplinary background of ELSA researchers represents a valuable diversity that enables mutual criticism and formulations of complementary approaches that together constitute a viable ELSA field. (shrink)

L'art occupe dans la pensée de Deleuze une place déterminante. De la littérature au cinéma, de la lettre à l'image, Deleuze théorise le domaine de l'art avec des concepts très nouveaux, attrayants et difficiles : corps sans organes, machines désirantes, devenir-animal, rhizome, lignes de fuite... Il s'agit ici d'en exposer le fonctionnement exact en montrant pourquoi l'art, selon Deleuze, devient une machine à explorer les devenirs des sociétés : critique et clinique, il détecte et rend sensibles les forces sociales. Mais (...) l'art produit surtout des effets réels, et non pas simplement imaginaires : l'image n'est donc pas une donnée mentale mais bien une réalité existante. Cet ouvrage se propose de faciliter l'accès à l'œuvre décisive de Deleuze, en restituant ses parcours dans un souci d'extrême clarté. (shrink)

We examine recent evolution in corporate responsibility in the forest industry, an important natural-resource-based industry which is under rapid internationalisation and structural change under challenging financial pressures. We address two recent trends in corporate communication: corporate disclosure, that is the adoption of consistent external reporting standards [namely the Global Reporting Initiative (GRI) ], and the growing awareness of engagement with and impact on local communities through philanthropy, generation of prosperity, communication and the social impact of core activities. This study uses (...) a comparative qualitative case approach to forest industry multinational enterprises (MNEs) based on a combination of secondary (reporting, company newsletters and other documentation) and interview data. Three large-scale multinational forest industry firms, all pursuing different strategies in terms of internationalisation and geographical and product diversification, were chosen for the study: Stora Enso, SCA and Sappi Ltd. Our results show that the overall quality of sustainability reporting has improved in these companies from 2005 to 2009 with the adoption of GRI. However, based on our fourfold categorisation of social impact, the core social impact indicator in GRI (SO1) has been interpreted very differently in these MNEs, and the adoption of GRI has not actually much improved the comparability of the reports or transparency of practices. (shrink)

The aim of this chapter is to open the question of this pervasiveness of the moral by arguing for the impossibility of delimiting the moral in one specific case, that of psychological self-ascription. The first part presents two views of the relationship between nature and morality found in forms of scientific and relaxed naturalism. In the main part, I argue, first, that psychological self-ascriptions are in most cases not to be understood on the standard model of observation and descriptions, but (...) rather as expressions of thoughts and feelings already present for us. And in the second, I contend that psychological self-ascriptions therefore always involve elements of endorsement and responsibility, which means that they are ways of situating ourselves morally in relations to others. (shrink)

This is a story about a single letter and its circulation. It began as a letter addressed to an unnamed nun in France in the mid-twelfth century, and made its way into a vita of a Franciscan holy woman in Italy in the late thirteenth century. The letter was composed by Arnulf, the bishop of Lisieux from 1141 to 1181. Arnulf later included it in the various collections of his letters that he prepared for publication. Although transmission of Arnulf's letter (...) in Italy was very minimal, it somehow got into the hands of Stefania, a member of the Sorores minores inclusae at San Silvestro in Capite, and it became part of her story about the founder of her community, Margherita Colonna. From Arnulf's hand to... (shrink)