Galvani's discovery provoked an animated debate that lasted for about a decade. So far, historians have studied only the controversy between Volta and Galvani. I show that a more extensive examination of the response to Galvani's treatise reveals a number of important issues that were characteristic of the contemporary physics and physiology but have not much attracted the attention of historians. In particular, the analysis shows the need to reappraise Galvani's role in establishing animal electricity.

During the mid-18th century, when electricity was coming into its own, natural philosophers began to entertain the possibility that electricity is the mysterious nerve force. Their attention was first drawn to several species of strongly electric fish, namely torpedoes, a type of African catfish, and a South American "eels." This was because their effects felt like those of discharging Leyden jars and could be transmitted along known conductors of electricity. Moreover, their actions could not be adequately explained (...) by popular mechanical theories. Many of the early documents supportive of the hypothesis of animal electricity were associated with the Dutch colonies in South America. This article presents and examines those documents, and shows how Dutch scientists on both sides of the Atlantic conducted experiments and communicated with each other in the 1750s and 1760s. It reveals the important roles played by inquisitive physicians and lovers of nature in South America, and by natural philosophers and collectors of exotic specimens in the Netherlands—learned men who began to make a credible case for animal electricity in some exciting places at a pivotal moment in time. (shrink)

This essay addresses the subject of animal representation via an historical account of the place of the animal in visual culture. It emphasizes the relationship between the animal as a visual image and the technology that produces this image. It explores three examples in a period covering c. 1895 to the 1930s, in Britain, that analyze the relations between animal representation, technology, and the public domain. These are film, zoo display, and slaughterhouse practice. The overall goal (...) of the essay is to move away from emphasis on the textual, metaphorical animal, which reduces the animal to a mere icon, to achieve a more integrated view of the effects of the presence of the animals and the power of its imagery in human history."[s]i l'animal a le temps, s'il est «constitué» par un «temps»" ["[w]hether the animal has time, whether the animal is 'constituted' by a 'time.'"]. (shrink)

Seeking a historical-philosophical approach to science teaching, narrative texts have been used as pedagogical tools to improve the learning experience of students. A review of the literature of different types of narrative texts and their different rates of effectiveness in science education is presented. This study was developed using the so-called Historical Narrative as a tool to introduce science content from a historical-philosophical approach, aiming to discuss science as a human construction. This project was carried out in a 9th grade (...) Physics class in K-12 school, in Rio de Janeiro, Brazil. The steps involved in constructing a Historical Narrative based on the controversy over animal electrical fluid between Luigi Galvani and Alessandro Volta is reported herein. Finally, qualitative research results of the activities inspired by this Historical Narrative are presented with the purpose of answering the research question: to what extent do Historical Narratives support and enhance discussions about the Nature of Science, through teaching the scientific content in a historical-philosophical approach with 9th grade students? The results indicate that Historical Narrative, based on historical episodes, is a good “door opener” to teach scientific content in a historical-philosophical approach, introducing discussions about the Nature of Science without neglecting the scientific content or simplifying the discussions about the NOS. (shrink)

Researchers are enthusiastically concerned about neural stem cell (NSC) therapy in a wide array of diseases, including stroke, neurodegenerative disease, spinal cord injury (SCI) and depression. Although enormous evidences have demonstrated that neurobehavioral improvement may benefit from NSC-supporting regeneration in animal models, approaches to endogenous and transplanted NSCs are blocked by hurdles of migration, proliferation, maturation and integration of NSCs. Electrical stimulation (ES) may be a selective nondrug approach for mobilizing NSCs in the central nervous system (CNS). This technique (...) is suitable for clinic application, because it is well established and its potential complications are manageable. Here, we provide a comprehensive review of the emerging positive role of different electrical cues in regulating NSC biology in vitro and in vivo, as well as biomaterial-based and chemical stimulation of NSCs. In the future, ES combined with stem cell therapy or other cues probably becomes an approach for promoting brain repair. (shrink)

This paper explores the relationship between psychology and neurobiology in the context of cognitive science. Are the sciences that constitute cognitive science independent and theoretically autonomous, or is there a necessary interaction between them? I explore Fodor's Multiple Realization Thesis (MRT) which starts with the fact of multiple realization and purports to derive the theoretical autonomy of special sciences (such as psychology) from structural sciences (such as neurobiology). After laying out the MRT, it is shown that, on closer inspection, the (...) argument is either circular or self-undermining--the argument either assumes the very autonomy it seeks to demonstrate or the concluded autonomy is contradicted by the theoretical interdependence invoked by the premises of the argument. Next, I explore a concrete example of multiple realization in the explanation of animal behavior: the convergent evolution of jamming avoidance behaviors in three genera of weakly electric fish. Contrary to the image painted by the MRT, the work on these animals involves a high degree of interaction between the various levels of investigation. The fact that our understanding of electric fish behavior involves functional theories and multiple realization without the kind of disunified science that is supposed to follow from such a situation indicates that the mere fact of multiple realization cannot be the basis for an autonomous psychology. (shrink)

Conscious sentient AI seems to be all but a certainty in our future, whether in fifty years’ time or only five years. When that time comes, we will be faced with entities with the potential to experience more pain and suffering than any other living entity on Earth. In this paper, we look at this potential for suffering and the reasons why we would need to create a framework for protecting artificial entities. We look to current animal welfare laws (...) and regulations to investigate why certain animals are given legal protections, and how this can be applied to AI. We use a meta-theory of consciousness to determine what developments in AI technology are needed to bring AI to the level of animal sentience where legal arguments for their protection can be made. We finally speculate on what a future conscious AI could look like based on current technology. (shrink)

The position advanced in this paper is that the bedrock of emotional feelings is contained within the evolved emotional action apparatus of mammalian brains. This dual-aspect monism approach to brain–mind functions, which asserts that emotional feelings may reflect the neurodynamics of brain systems that generate instinctual emotional behaviors, saves us from various conceptual conundrums. In coarse form, primary process affective consciousness seems to be fundamentally an unconditional “gift of nature” rather than an acquired skill, even though those systems facilitate skill (...) acquisition via various felt reinforcements. Affective consciousness, being a comparatively intrinsic function of the brain, shared homologously by all mammalian species, should be the easiest variant of consciousness to study in animals. This is not to deny that some secondary processes cannot be evaluated in animals with sufficiently clever behavioral learning procedures, as with place-preference procedures and the analysis of changes in learned behaviors after one has induced re-valuation of incentives. Rather, the claim is that a direct neuroscientific study of primary process emotional/affective states is best achieved through the study of the intrinsic , albeit experientially refined, emotional action tendencies of other animals. In this view, core emotional feelings may reflect the neurodynamic attractor landscapes of a variety of extended trans-diencephalic, limbic emotional action systems—including SEEKING, FEAR, RAGE, LUST, CARE, PANIC, and PLAY. Through a study of these brain systems, the neural infrastructure of human and animal affective consciousness may be revealed. Emotional feelings are instantiated in large-scale neurodynamics that can be most effectively monitored via the ethological analysis of emotional action tendencies and the accompanying brain neurochemical/electrical changes. The intrinsic coherence of such emotional responses is demonstrated by the fact that they can be provoked by electrical and chemical stimulation of specific brain zones—effects that are affectively laden. For substantive progress in this emerging research arena, animal brain researchers need to discuss affective brain functions more openly. Secondary awareness processes, because of their more conditional, contextually situated nature, are more difficult to understand in any neuroscientific detail. In other words, the information-processing brain functions, critical for cognitive consciousness, are harder to study in other animals than the more homologous emotional/motivational affective state functions of the brain. (shrink)

In the mid-nineteenth century, the house sparrow ( Passer domesticus) was introduced to the United States, quickly spreading across the country. For a brief period in the late nineteenth and early twentieth centuries, the observation of sparrow behavior was something of an urban pastime. Traits such as intelligence, reason, persistence, and craftsmanship were conferred onto sparrows by American urbanites. This paper argues that sparrow intelligence was often conflated with domestication: the ability of the birds to adapt to living alongside humans. (...) Praise for the ingenuity of sparrows generally revolved around their nest building, particularly when such structures overcame the challenges posed by urban infrastructure and technology. Sparrows were far less praiseworthy when they caused electricity outages or contaminated water supplies. The sparrow in the United States demonstrates how the relationship between these anecdotes and their implications for animal minds was mediated by the technology and infrastructure of cities. Admirers of sparrows were not measuring the birds’ mental capacity, but rather their ability to adapt to human habitations. Sparrows were only granted intelligence once they had demonstrated their ability to become domesticated. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Matter and Spirit in the Age of Animal MagnetismEric G. WilsonDuring the Romantic period, writers on both sides of the Atlantic explored the sleepwalker as a merger of holiness and horror. Emerging when scientific thinkers for the first time were connecting spirit to electricity and magnetism, the somnambulist became to certain Romantics a disclosure of the difficulty of harmonizing unseen and seen, agency and necessity. This problem (...) prominently arose in Anton Mesmer's late eighteenth-century experiments in animal magnetism, in which the sleepwalker proved a paradox: an opaque revelation of transparent currents and an unconscious vehicle of sophisticated thought. Romantics such as Coleridge embraced the somnambulist as an embodiment of these troubles involved in relating motion and meaning. Coleridge and those who responded to him saw in the hypnotized human this sobering possibility: the invisible requires the visible to make itself manifest while the visible needs the invisible to become significant. 1 This is sublime and sinister: to elevate a material form to spiritual power is transcendence; to sink the boundless into a body is grotesque.Here I explore the philosophical implications of animal magnetism, the place of the sleepwalker in the history of ideas, and the role of the hypnotized human in Romantic writers, especially Coleridge. I also meditate on relationships between matter and spirit, machine and human, word and thing. Along the way, I place the history of ideas and the works of Romantic writers in mutually illuminating dialogues. The literary texts shed fresh light on philosophical problems while the ideas reveal hidden literary elements.The somnambulistic trance had been around long before Mesmer's magnetic sleeps. For centuries, shamans had used auto-hypnosis to sound [End Page 329] their souls and other-hypnosis to cure their tribe-members' ailments. However, somnambulism could not become a scientific phenomenon until Europeans in laboratories began to study electricity and magnetism. In the early modern period, Paracelsus argued that a vital fluid courses through the cosmos. The human being draws this flow like a magnet attracts force. When the body pulls to itself evil effluvia, it falls ill. To return patients to health, Paracelsus placed magnets on painful areas. He hoped to extract the unwanted current and return it to the cosmic swirl. 2 In "magnetizing" spirit, Paracelsus opened a door for empirical inquiry into the invisible world. In 1600, William Gilbert claimed that magnets correspond to the earth: both are animated by universal attraction and repulsion. 3 By the end of the seventeenth-century, Newton proposed that things are impelled by a force that draws and repels. Newton's theory of gravity inspired natural philosophers of the next centuries to search for a principle of which the magnet and the spark are manifestations. 4During the second half of the eighteenth century and the early part of the nineteenth, natural philosophers explored electricity and magnetism with unprecedented precision. In 1752, Benjamin Franklin revealed the mystery of lightning and perhaps the spark of life. 5 Inspired by Franklin, F. C. Oetinger, J. L. Fricker, and Prokop Divisch developed a theology of electricity, based on the belief that God is the electrical current. 6 Later in the century, Luigi Galvani and Alessandro Volta debated over whether the galvanic flow might be the origin and principle of life itself. 7 A few years before Franklin harvested lightning, John Michell argued that the magnetic force is not constrained to lodestones but is possibly pervasive. Some years later, Franz Aepinus suggested that magnetism and electricity manifest a deep energy. Soon after, C. A. de Coulomb discovered the mathematical law by which electrical and magnetic forces operate (Whittaker, pp. 50–59).These findings led to the breakthroughs of the nineteenth century. 8 In 1807, Humphry Davy hypothesized that chemical elements interact through electromagnetic affinity or repulsion. 9 In 1820, H. C. Oersted demonstrated the correspondence between electricity and magnetism. The same year, A. M. Ampere formulated the laws by which electrical and magnetic currents interact (Whittaker, pp. 81–86). Michael Faraday in 1831 revealed electromagnetic induction and thus inaugurated a second Copernican revolution: he showed that matter is not solid and discrete but a field of electromagnetic energy. 10 The dreams of [End... (shrink)

To show how the case of Mary Shelley’s Victor Frankenstein brings light to the ethical and moral issues raised in Institutional Review Board protocols, we nest an imaginary IRB proposal dated August 1790 by Victor Frankenstein within a discussion of the importance and function of the IRB. Considering the world of science as would have appeared in 1790 when Victor was a student at Ingolstadt, we offer a schematic overview of a fecund moment when advances in comparative anatomy, medical experimentation (...) and theories of life involving animalcules and animal electricity sparked intensive debates about the basic principles of life and the relationship between body and soul. Constructing an IRB application based upon myriad speculations circulating up to 1790, we imagine how Victor would have drawn upon his contemporaries’ scientific work to justify the feasibility of his project, as well as how he might have outlined the ethical implications of his plan to animate life from “dead” tissues. In Mary Shelley’s Frankenstein, Victor failed to consider his creature’s autonomy, vulnerability, and welfare. In this IRB proposal, we show Victor facing those issues of justice and emphasize how the novel can be an important component in courses or workshops on research ethics. Had Victor Frankenstein had to submit an IRB proposal tragedy may have been averted, for he would have been compelled to consider the consequences of his experiment and acknowledge, if not fulfill, his concomitant responsibilities to the creature that he abandoned and left to fend for itself. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Ideas 63.1 (2002) 105-128 [Access article in PDF] The Metaphoric Circuit: Organic and Technological Communication in the Nineteenth Century Laura Otis [Figures]In a public lecture in 1851, Emil DuBois-Reymond proposed that the wonder of our time, electrical telegraphy, was long ago modeled in the animal machine. But the similarity between the two apparatus, the nervous system and the electric telegraph, has a much (...) deeper foundation. It is more than similarity; it is a kinship between the two, an agreement not merely of the effects, but also perhaps of the causes. 1In 1851 the telegraph and the nervous system appeared to be doing the same things and for the same reasons. Their common purpose was the transmission of information, and they both conveyed this information as alterations in electrical signals. By calling the nervous system a "model" for the telegraph, DuBois-Reymond suggested that organic communications systems offered solutions to problems encountered by technological ones.In the same decade, however, Claude Bernard remained skeptical about the epistemological value of metaphor. From the classical notion of nervous fluid to the more recent ones of animal spirits and animal electricity, he pointed out, people's "knowledge" of the nervous system had consisted largely of a series of comparisons, "the expression of a way of seeing meant to explain the facts." 2 Priding himself on his empiricism, Bernard mistrusted analogy as a means of constructing knowledge. Does one know more or less about something, if one asserts that it is like something else? What exactly is the relationship between metaphor and knowledge? [End Page 105]Many scientific investigators have shared Bernard's concern that claims of likeness will change their perceptions of physiological systems, but for the same reason some scholars of language are more optimistic about the epistemological possibilities of metaphor. George Lakoff and Mark Johnson assert that the role of metaphor in scientific thinking provides one of the best illustrations of how metaphors reflect and influence what we see and do. "Formal scientific theories are attempts to consistently extend a set of ontological and structural metaphors," they argue. 3 This "extension," though, is just what worried Bernard. Metaphors provoke and give birth to new images. By establishing and reinforcing connections, they encourage us to see in new ways. While Bernard is correct that assertions of likeness alter the way we see, Lakoff and Johnson are equally correct in claiming that "much of cultural change arises from the introduction of new metaphorical concepts and the loss of old ones." 4 Alterations in the way we see can be extremely productive.One of the most intriguing cases through which to study the epistemological role of metaphor is that of comparisons between physiological and technological communications systems. Throughout the nineteenth century scientists' electrophysiological understanding of the nervous system closely paralleled technological knowledge that allowed for the construction of telegraph networks. Timothy Lenoir has demonstrated that Hermann Helmholtz and Emil DuBois-Reymond, the nineteenth-century scientists who made some of the greatest contributions to neurophysiology, worked closely with communications engineers like Werner Siemens. By developing models that reflected the apparatus they had adapted from physics and media technology, Helmholtz, and DuBois-Reymond changed people's understanding of the way nerves transmitted impulses. I agree with Lenoir that these comparisons between organic and technological systems were not mere devices for popularization but became incorporated into the scientists' own vision and understanding of the nervous system. 5 When one reads the proposals of nineteenth-century engineers, one begins to suspect that communication in the body and in society can only be understood in terms of each other. But can one claim that comparisons of communication mediated by bodies and machines actually contributed to knowledge of the nervous system and of early telecommunications networks?From the late eighteenth century onward, scientists studying organic and technological communications systems continually inspired one another. As Friedrich Kittler argues in Discourse Networks, nineteenth-century media for writing and communication—the telegraph, typewriter, and telephone—affected not just the way people wrote and... (shrink)

Animals search for food and shelter by locomotion through time and space. The elemental step is the action-perception cycle, which has three steps. In the first step a volley of action potentials initiated by an act of search triggers the formation of a macroscopic wave packet that constitutes the memory of the stimulus. The wave packet is filtered and sent to the entorhinal cortex, where it is combined with wave packets from all sensory systems. This triggers the second step forming (...) a unified memory that is passed through the hippocampal formation where it is assigned a place in the life-long memory of the subject. In the third step the output of the entorhinal cortex triggers the formation of a global wave packet that synchronizes the oscillatory activity of most of not all of the cerebral cortex. This shared oscillation caries a pattern of amplitude modulation, that can be observed non-invasively from the scalp EEG of human volunteers perceiving the stimulus and correlated with the stimulus. The same dendritic electric currents that drive the output of the brains of the wave packet drive the observed EEG signs. Therefore I postulate that the global wave packet, the third step in the cycle requiring only 0.2 seconds expresses the memory of the global accommodation that initiates the next action-perception cycle. Some unspecified fraction of the AM pattern is available to me the observer, and some other unspecified fraction of the total activity in the subject who is expected to respond to the stimulus. There is reason to hope that these fractions will coincide often enough to support refinements in techniques for extending these correlates of consciousness. Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;}. (shrink)

Primal emotional feelings are an optimal way to make scientific progress on the neural constitution of consciousness. Such research has revealed the existence of profound neuroanatomical and neurochemical homologies in the systems that control emotionality in mammalian and avian species. Wherever in their brains one applies localized Deep Brain Stimulation (DBS), whether electrical or chemical, and obtains coherent instinctual emotional behavior patterns, animals treat these within‐brain state shifts as 'rewards' and 'punishments' in various learning tasks. Humans consistently report desirable and (...) undesirable affective changes to such DBS. These effects serve as gold standards for the detailed scientific study of affective qualia in animal and human brains. (shrink)

Since its development about 15 years ago, functional magnetic resonance imaging (fMRI) has become the leading research tool for mapping brain activity. The technique works by detecting the levels of oxygen in the blood, point by point, throughout the brain. In other words, it relies on a surrogate signal, resulting from changes in oxygenation, blood volume and flow, and does not directly measure neural activity. Although a relationship between changes in brain activity and blood flow has long been speculated, indirectly (...) examined and suggested and surely anticipated and expected, the neural basis of the fMRI signal was only recently demonstrated directly in experiments using combined imaging and intracortical recordings. In the present paper, we discuss the results obtained from such combined experiments. We also discuss our current knowledge of the extracellularly measured signals of the neural processes that they represent and of the structural and functional neurovascular coupling, which links such processes with the hemodynamic changes that offer the surrogate signal that we use to map brain activity. We conclude by considering applications of invasive MRI, including injections of paramagnetic tracers for the study of connectivity in the living animal and simultaneous imaging and electrical microstimulation. D 2004 Elsevier Inc. All rights reserved. (shrink)

It is traditionally believed that cerebral activation (the presence of low voltage fast electrical activity in the neocortex and rhythmical slow activity in the hippocampus) is correlated with arousal, while deactivation (the presence of large amplitude irregular slow waves or spindles in both the neocortex and the hippocampus) is correlated with sleep or coma. However, since there are many exceptions, these generalizations have only limited validity. Activated patterns occur in normal sleep (active or paradoxical sleep) and during states of anesthesia (...) and coma. Deactivated patterns occur, at times, during normal waking, or during behavior in awake animals treated with atropinic drugs. Also, the fact that patterns characteristic of sleep, arousal, and waking behavior continue in decorticate animals indicates that reticulo-cortical mechanisms are not essential for these aspects of behavior. (shrink)

A minor modification of the arguments of Press and Lightman leads to an estimate of the height of the tallest running, breathing organism on a habitable planet as the Bohr radius multiplied by the three-tenths power of the ratio of the electrical to gravitational forces between two protons (rather than the one-quarter power that Press got for the largest animal that would not break in falling over, after making an assumption of unreasonable brittleness). My new estimate gives a height (...) of about 3.6 meters rather than Press’s original estimate of about 2.6 cm. It also implies that the number of atoms in the tallest runner is very roughly of the order of the nine-tenths power of the ratio of the electrical to gravitational forces between two protons, which is about 3×1032. (shrink)

On the stupidity of oysters -- Divining creaturely love -- Horsing around: the marriage blanc of Nietzsche, Andreas-Salomø, and Røe -- Groping for an opening: Rilke between animal and angel -- Electric caresses:Rilke, Balthus, and Mitsou -- Between perfection and temptation: Musil, Claudine, and Veronica -- The biological travesty -- "The creature whom we love": Proust and jealousy -- The love tone: capture and captivation -- "The soft word that comes deceiving": Fournival's bestiary of love -- The cuckold and (...) the cockatrice: Fourier and Hazlitt -- The animal bride and horny toads -- Unsettled being: Ovid's metamorphoses -- Fickle metaphysics -- Nymphomania and faunication -- Senseless arabesques: Wendy and Lucy -- The goat in the machine (a reprise) -- On cetaceous maidens -- Animal magnetism and alternative currents (or Tesla and the white dove). (shrink)

All cells have electric potentials across their membranes, but is there really compelling evidence to think that such potentials are used as instructional cues in developmental biology? Numerous reports indicate that, in fact, steady, weak bioelectric fields are observed throughout biology and function during diverse biological processes, including development. Bioelectric fields, generated upon amputation, are also likely to play a key role during vertebrate regeneration by providing the instructive cues needed to direct migrating cells to form a wound epithelium, a (...) structure unique to regenerating animals. However, mechanistic insight is still sorely lacking in the field. What are the genes required for bioelectric‐dependent cell migration during regeneration? The power of genetics combined with the use of zebrafish offers the best opportunity for unbiased identification of the molecular players in bioelectricity. BioEssays 29:1133–1137, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Ascidian tadpole larvae, composed of only about 2500 cells, have a primitive nervous system which is derived from the neural plate. The stereotyped cell cleavage pattern and well characterized cell lineage in these animals allow the isolation and culture of identified blastomeres in variable combinations. Ascidian embryos express cell‐type‐specific markers corresponding to their cell fates, even when cultured under cleavage‐arrest by cytochalasin B. This system provides us with a unique opportunity to study the roles of cell lineage and cell contact (...) in early neuronal differentiation in the absence of events associated with complex morphogenesis. In addition, the isolated, cleavage‐arrested blastomeres are ideally suited to electrical recording, permitting the use of ionic channels as specific markers for differentiation. In the cleavage‐arrested embryos, suppression of one type of K+ channel, and induction of two types of Na+ channels, occur following cell contact with the vegetal blastomere. The combination of molecular and electrophysiological analyses on this simple animal system may provide insights into the nature of the cell interactions important in early neurogenesis, both in ascidians and in vertebrates. (shrink)

Linsky’s central point is correct; Kripke’s distinction between rigid and nonrigid designators can be extended in a straightforward way from singular terms to general terms. In both cases, for an expression to rigidly designate its extension is for it to designate the same extension with respect to every possible world-state (in which it has an extension at all). On this account, simple natural kind terms like water, gold, electricity, blue, and tiger – as well as ordinary general terms like (...) bachelor, philosopher, automobile and triangle – designate the same extension with respect to each world-state. As I see it, however, the two differ importantly in the metaphysics of their designata. Whereas a term like bachelor designates a property that may be distinguished from other properties that are necessarily coextensive with it, natural kinds differ from one another only if there are possible world-states in which some of their instances are different. Intuitively this seems plausible; it is hard to imagine two distinct species of animal, two distinct substances, or two distinct colors which have precisely the same instances in every possible world-state. This is important for my linguistic model. Consider, for example, the color blue (which I take to be a natural kind). Color science tells us that the object-color blue is determined.. (shrink)

In classical physics, the world is considered as a matter-based reality, the arrangement of whose parts in time is uniquely determined by certain dynamic laws. By contrast, modern quantum physics reveals that matter is not composed of matter, but reality is merely potentiality. The world has a holistic structure, which is based on fundamental relations and not material objects, admitting more open, indeterministic developments. In this more flexible causal framework, inanimate and animate matter are not to be considered as fundamentally (...) different but as different order structures of the same immaterial entity. In a stable configuration, effectively all the uncertainties are statistically averaged out, thus the unique and deterministic behavior of ordinary inanimate matter is exhibited; whereas in the case of statically unstable but dynamically stable configurations, the “lively” features of the underlying quantum structure have a chance to surface to the mesocopic level and to be connected with what we observe as the phenomenon of life. This supposition can be more explicitly treated and clarified by identifying the electric dipole moment of biomolecules as the ordering parameter of the corresponding macroquantum system. This has important consequences for biology and medicine. In particular, it suggests the existence of a quantum-based “software,” essential perhaps for the logistics of biological processes, which are hidden behind the matter/energy-based “hardware” that alone is considered in the conventional approach. In medicine it opens an opportunity to build bridges between conventional medicine based essentially on the classical paradigm, and the various forms of complementary medicine, which have strong affinities with the new features of the modern holistic worldview. (shrink)

Franz Anton Mesmer (1734–1815), a physician who graduated from the University of Vienna, invented a therapy based on the concept of a universal fluid, similar to electricity, that flowed through all living things. By restoring the circulation of this fluid in the nerves of human bodies, he believed he could cure illness without resorting to medication. Few medical theories have enjoyed as great success as Mesmer's, first among French high society and then in Germany, Switzerland, the Netherlands, Italy, Sweden, (...) Russia, Britain, and the US. Mesmerism was the circulatory phenomenon par excellence. Its success was founded not only on the hypothesis of the circulation of a fluid common to human physiology and the entire universe, but also on the scientific practices of the time—correspondence, translations, and periodicals—and some ardent and highly active supporters who ensured its spread. However, far from functioning along the lines of direct exportation–importation from one country to another, or a centre to the periphery, mesmerism's dissemination was the work of diffuse institutions and individual mobilities influenced by the modalities of communication. In seeking to reconstitute the wellsprings of these circulations, the first sources that come to mind are printed matter: the many pamphlets and especially the articles and reviews that appeared in periodicals, as well as the Romantic literature that flourished after 1810. Such documents are foundational for authoritative studies of mesmerism in Germany, which proceed from the thesis of successive “waves” of reception. Such sources, however, are somewhat misleading. Rather than taking them as our starting point, it would be better to reconstitute the channels of information by using many sources, both printed and handwritten. The complexity of the circulation of knowledge generated by mesmerism is implicitly testament to the difficulties arising from the institutionalization of this current. (shrink)

Essay I explores brain machine interface technologies. These make direct communication between the brain and a machine possible by means of electrical stimuli. This essay reviews the existing and emerging technologies in this field and offers an inquiry into the ethical problems that are likely to emerge. Essay II, co-written with professor Sven-Ove Hansson, presents a novel procedure to engage the public in deliberations on the potential impacts of technology. This procedure, convergence seminar, is a form of scenario-based discussion that (...) is founded on the idea of hypothetical retrospection. The theoretical background and the results of the five seminars are presented. Essay III discusses moral bioenhancement, an instance of human enhancement that alters a person’s dispositions, emotions or behavior. Moral bioenhancement could be carried out in three different ways. The first strategy is behavioral enhancement. The second strategy, favored by prominent defenders of moral enhancement, is emotional enhancement. The third strategy is the enhancement of moral dispositions, such as empathy and inequity aversion. I argue that we ought to implement a combination of the second and third strategies. Essay IV considers the possibility and potential desirability of sensory enhancement. It is proposed that existing sensory modalities in vertebrate animals are proof of concept of what is biologically possible to create in humans. Three considerations on the normative aspects of sensory enhancement are also presented in this essay. Essay V rejects disease prioritarianism, the idea that the healthcare system ought to prioritize the treatment of diseases. Instead, an approach that focuses on what medicine can accomplish is proposed. Essay VI argues that from the idea that species have an intrinsic value and that humanity has a collective responsibility to protect animal species from extinction, the conclusion that we ought to recreate species follows. Essay VII argues that unknown existential risks have not been properly addressed. It proposes a heuristic for doing so, and a concrete strategy. This strategy consists in building refuges that could withstand a large number of catastrophic events. (shrink)

Electronic machinic phenomena yield fascinating links with biological processes. Either in the macro-micro-structure of binary encoded information ‐ bytes on media ‐ to the processual flow programs execute on hardware while operating it. Observing micro-electronic worlds akin to living entities: electronic voltages running throughout electronic architectures pipelining data to memory registers; operating systems executing programs on electronic substrates; data flows taking place in machines and in communications protocols within networks. Static art-sci constructs explore and visualize these observations as 2D drawings (...) (Neon Paleolitikos Drawings, 2017‐present) or 3D sculptures (Binary and Biological Sculpture Series, 2018‐present), creatively exposing their inherent rhythmic organization of information, while dynamic installations (Phoenix.Wolfanddotcom.info, Wolfanddotcom, Half-Plant, 2017, Ant Ennae Labyrinths, 2019‐present) propose immersive interference mechanisms that attempt user entanglement in non-human environments. Seven aesthetic case examples are introduced and explored, observing and seeking resonances between micro-granular electronic, biological and hybrid data as source synthesis. This research proposes a look at bio-electronic aggregates on Neon Paleolitikos strata. After the Anthropocene, Neon Paleolitikos is an imaginary epoch dating since the decline of mankind until the zenith of bio-electronic life forms: operational symbioses combined among ruins of silica, transistors, algorithms, cells, plants, animals and electricity. (shrink)

In a similar way to what happens when a wave of electricity impacts the animal body and provokes a convulsive stir of muscles and nerves which can burn and ultimately paralyze the affected surface, some rough emotional experiences may lead us to sudden numbness. Keeping abreast with the most sophisticated phenomenological tools to account for an extremely damaging kind of psychological experience that can ultimately defeat the purpose of a sheer descriptive approach, this chapter does provide a descriptive (...) analysis of the kind of emotional shock that risks threatening the moral integrity of an agent. I shall zoom in my analysis on the typically acknowledged moment when disturbing information from a socially shared context outside ourselves comes suddenly to the fore of our attention, thus disrupting the focus even of the the most trivial perceptive input. I argue that in the longer run the outcome of such an experience may amount to a reconfiguration of the subject’s core values, daily routines and even her life-long expectations and projects. (shrink)

Conceptual generalisation occurs when conditional responses generalise to novel stimuli from the same category. Past research demonstrates that physiological fear responses generalise across categories, however, conceptual generalisation of stimulus valence evaluations during fear conditioning has not been examined. We investigated whether conceptual generalisation, as indexed by electrodermal responses and stimulus evaluations, would occur, and differ after training with single or multiple conditional stimuli (CSs). Stimuli from two of four categories (vegetables, farm animals, clothing, and office supplies) were used as the (...) CS+ (followed by an electric stimulus) or CS- (presented alone). Generalisation was assessed by presenting novel stimuli from the CS categories after acquisition, extinction, and reinstatement. One category exemplar was used as the CS+ and CS- in the single group, whereas three exemplars were used as the CS+ and CS- in the multiple group. Electrodermal responses generalised in acquisition and extinction but did not differ between groups. In the multiple group, CS evaluations generalised in acquisition and extinction, whereas generalisation was not evident in the single group. Training with multiple CSs also resulted in the extinction of stimulus valence. The current findings have implications for future research examining the generalisation of valence and for exposure-based treatments of anxiety. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 41.1 (2003) 136-137 [Access article in PDF] John Watkins. Human Freedom after Darwin: A Critical Rationalist View. Chicago: Open Court Publishing, 1999. Pp. xi + 348. Cloth, $49.95. Paper, $24.95. John Watkins examines man's place in nature since Darwin. As a critical rationalist, using the methods of science, Watkins hopes to construct a world-view which challenges competing hypotheses and supports his own. He (...) recognizes that his view is, also, a candidate for critical rejection. All scientific views are, in principle, fallible. He divides his book into two parts: Naturalism and Freedom. [End Page 137]In evolutionary development, he accepts, as critically established, the sequence: matter before life, life before mind, and, no mind without a brain. Thus, naturalism is preferred beforesupernaturalism or divine intervention. These guides may support a continuous, steady evolutionaryprocess or discontinuity, mutations, and various stages of change. Darwin acceptedthe former and held physical changes were unaffected by consciousness. All change is, in principle,present from the beginning and unfolds over time. Darwin's view, then, is deterministic.Watkins challenges this position and argues for consciousness affecting physical change in new and unpredictable ways. It is herein that the possibility of animal and human freedom lies. Watkins gives examples of the actions of the hunter and hunted among animals, and of strategies developed by humans during crises, to support the view that there are novel and unpredictable actions by conscious beings. These actions can hardly be called predetermined in the nature of things. There is a huge difference between a general genetic structure for kinds of behavior and specific actions during crises (not that these are the only instances of freedom). At any rate, there is a reciprocal action between an individual and its environment and not merely a unilinear one.In Part II, Freedom, Watkins examines some classical, philosophical views of human freedom. He gives brief, but penetrating, analyses of Hobbes, Descartes, Hume, Kant, Schopenhauer, and Spinoza. Either they account for human action in strictly physical terms that are causally deterministic or they turn to non-empirical sources that are not verifiable. Since the latter make no difference in our account of behavior, they are entities multiplied beyond necessity. Those who give a completely deterministic view—Hobbes, Hume, and Schopenhauer—offer no continuum between cause and chance. Chance turns out to depend upon our ignorance of causes; further examination would show it causally determined.Watkins seems most sympathetic to Spinoza's treatment. In his hard-headed naturalism, Spinoza rejects any non-natural or supernatural accounts of human behavior. He is a strict determinist where man's confrontation with nature is concerned. Human emotions are passive and react to our environment; they do not affect it. Human reason makes no difference, but in its capacity to contemplate eternal truths it offers a way out. Instead of reacting to nature, man may transcend it. This transcendence is the key to Spinoza's view of the intellectual love of God, and human freedom. Watkins criticizes this flight from man's place in nature and the limited use of reason. In this vein, Spinoza seems to abandon the confrontation of nature for a flight to eternal truths. For Watkins, however, reasons must be used in confronting nature. As we saw, he claims that reason may have an effect upon the environment that is novel and unpredictable. Human agency is a part of the evolutionary story. Human agency is not an either/or proposition. There are degrees of effectiveness in human response to nature.In his analysis of human freedom, Watkins turns to the works of Newton, Faraday, Einstein, and others. In studying the problems posed by the consideration of natural phenomena during their time, they showed intellectual perspicacity of the highest order. Faraday's unified field theory brought electrical and magnetic phenomena, previously thought to be disparate, together. Newton's laws of motion brought celestial and terrestrial mechanics under one theory. Einstein changed the way in which space, time, mass, energy, and light were conceived. In a real sense, they were... (shrink)

Western thought has for several hundred years been plagued by the reductionist malady, one form of which is that men and animals are nothing but complex machines. Having failed in this direction, some have invented machines and then promptly endowed them with human attributes. Plato would have been charmed by the ironic twist Other cases include electric current flow, which it appears we have to conceive as consisting of three dimensional objects in motion, the strange idea in biology that the (...) first living entity must be both simple and astonishingly complex, and the psychological notion that every notion is the consequent of antecedent causal chains. All four ideas involve basic contradictions which it would have delighted Socrates and his friends to discuss. (shrink)

A key characteristic of an animal's nervous system is that it can respond to brief environmental stimuli with lasting changes in its structure and function. These changes are triggered by specific patterns of neuronal electrical activity and are manifested as changes in the strength and patterns of synaptic connectivity between activated neurons. The biochemical mechanisms that control these changes are unclear, but cytoplasmic rises in Ca2+ levels may play a critical role, especially in regulating neuronal gene expression for making (...) activity‐induced synaptic changes permanent. Recently, two reports have explored the spatial features by which activity‐induced rises in Ca2+ levels activate transcription factors and gene expression(1,2). The reports suggest that Ca2+ influx acts both locally at the synapse and distantly within the nucleus to regulate transcription factors and gene expression. The results also show that regulatory elements within genes can respond differentially, depending on spatial differences in intracellular Ca2+ rises. These reports suggest new spatial mechanisms by which Ca2+‐dependent gene expression could contribute to activity‐dependent synaptic changes. (shrink)

Like most other subjects under discussion today, the theory of nature is largely controlled by considerations of knowledge. Treatment of it is, consequently, incidental to the treatment of these other problems, and is undertaken, in the main, because they compel it. A brief catalogue of characteristic statements about nature will illustrate this. “Nature,” says one writer, “is that which we observe in perception through the senses”; and another writes, “It is not experience which is experienced, but nature—stones, plants, animals, diseases, (...) health, temperature, electricity, and so on.” Nothing is more apparent in these sentences than the fact that it is not nature that the writers are so much concerned with, as with what it is that appears through the senses. The theory of nature, that is, is not so much guided by an analysis of the word's context and usage, as it is by the question: what is the proper object of knowledge? Consequently it is the latter question that is answered and not the question: what is nature? The reason for this is evident in the purpose of these statements and in their history; their purpose: the desire to do away with the separation between experience and nature, and to transform nature into a field familiar and accessible; and their history: the very framework against which they are directed, for they are embedded in the set-up from which they are trying to disentangle themselves. Perhaps something ought to be said to substantiate the thesis that the sentences cited are controlled by the problem of knowledge, especially since their intent seems to be to escape that problem. In any case, their history should serve to clarify them, and render a different approach to the theory of nature more significant. (shrink)

Capacity of conscious agents to perform genuine choices among future alternatives is a prerequisite for moral responsibility. Determinism that pervades classical physics, however, forbids free will, undermines the foundations of ethics, and precludes meaningful quantification of personal biases. To resolve that impasse, we utilize the characteristic indeterminism of quantum physics and derive a quantitative measure for the amount of free will manifested by the brain cortical network. The interaction between the central nervous system and the surrounding environment is shown to (...) perform a quantum measurement upon the neural constituents, which actualize a single measurement outcome selected from the resulting quantum probability distribution. Inherent biases in the quantum propensities for alternative physical outcomes provide varying amounts of free will, which can be quantified with the expected information gain from learning the actual course of action chosen by the nervous system. For example, neuronal electric spikes evoke deterministic synaptic vesicle release in the synapses of sensory or somatomotor pathways, with no free will manifested. In cortical synapses, however, vesicle release is triggered indeterministically with probability of 0.35 per spike. This grants the brain cortex, with its over 100 trillion synapses, an amount of free will exceeding 96 terabytes per second. Although reliable deterministic transmission of sensory or somatomotor information ensures robust adaptation of animals to their physical environment, unpredictability of behavioral responses initiated by decisions made by the brain cortex is evolutionary advantageous for avoiding predators. Thus, free will may have a survival value and could be optimized through natural selection. (shrink)