Understanding how transcription factor (TF) binding is related to gene regulation is a moving target. We recently uncovered genome‐wide evidence for a “Hit‐and‐Run” model of transcription. In this model, a master TF “hits” a target promoter to initiate a rapid response to a signal. As the “hit” is transient, the model invokes recruitment of partner TFs to sustain transcription over time. Following the “run”, the master TF “hits” other targets to propagate the response genome‐wide. As such, a TF may act (...) as a “catalyst” to mount a broad and acute response in cells that first sense the signal, while the recruited TF partners promote long‐term adaptive behavior in the whole organism. This “Hit‐and‐Run” model likely has broad relevance, as TF perturbation studies across eukaryotes show small overlaps between TF‐regulated and TF‐bound genes, implicating transient TF‐target binding. Here, we explore this “Hit‐and‐Run” model to suggest molecular mechanisms and its biological relevance. (shrink)

This paper is about an avian influenza outbreak in South Africa’s commercial ostrich industry. The outbreak was managed according to international best practice and led to the destruction of 30,000 ostriches in two of South Africa’s provinces. However, the industry has a long history of managing low pathogenic avian influenza outbreaks in a different way. We use the 2004 outbreak and earlier approaches to managing disease to shed light on recent debates on how we might live differently with livestock diseases. (...) The paper is based on in-depth interviews with farmers, veterinarians, scientists and agriculture officials. (shrink)

This article is the lead piece in a special report that presents the results of a bioethical investigation into chimeric research, which involves the insertion of human cells into nonhuman animals and nonhuman animal embryos, including into their brains. Rapid scientific developments in this field may advance knowledge and could lead to new therapies for humans. They also reveal the conceptual, ethical, and procedural limitations of existing ethics guidance for human‐nonhuman chimeric research. Led by bioethics researchers working closely with an (...) interdisciplinary work group, the investigation focused on generating conceptual clarity and identifying improvements to governance approaches, with the goal of helping scholars, funders, scientists, institutional leaders, and oversight bodies (embryonic stem cell research oversight [ESCRO] committees and institutional animal care and use committees [IACUCs]) deliver principled and trustworthy oversight of this area of science. The article, which focuses on human‐nonhuman animal chimeric research that is stem cell based, identifies key ethical issues in and offers ten recommendations regarding the ethics and oversight of this research. Turning from bioethics’ previous focus on human‐centered questions about the ethics of “humanization” and this research's potential impact on concepts like human dignity, this article emphasizes the importance of nonhuman animal welfare concerns in chimeric research and argues for less‐siloed governance and oversight and more‐comprehensive public communication. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:The Stagecraft and Performance of Roman ComedyAmy RichlinC. W. Marshall. The Stagecraft and Performance of Roman Comedy. Cambridge: Cambridge University Press, 2006. xiv + 320 pp. 2 black-and-white figs. Cloth, $90.C. W. Marshall's new book forms part of the productive trend towards treating ancient theater as performance. In 1991 David Wiles began The Masks of Menander (Cambridge: Cambridge University Press, xi) by commenting on the institutional (...) divide between classics and drama studies. Marshall, as a writer, occupies the unusual position of being able to speak both as a classicist and a professional actor, with substantial credits in both improv and Shakespeare. His work is influenced by writers in theater studies, particularly Susan Bennett on audiences, Keith Johnstone on improv, and Jacques Lecoq on masking and physical movement. Among writers on ancient comedy, he shares with David Wiles a commitment to the serious study of masking, and with Timothy Moore a focus on the interaction between actors and audience. As a performer and director, he has often worked with Mark Damen and Mary-Kay Gamel towards an understanding of ancient drama through hands-on production. Above all, this book is based in Marshall's experience as an actor; having had the privilege of working with him on a production of Persa, I can attest that the physicality of his acting pops his sense of what happened on the stage of Plautus into vivid 3-D.Marshall throughout prefers complex to simple models: the audience was not monolithic (no "Romans" here), venues differed in nature, the actors did not share a single status, literary influences on the plays were multiple (no tyranny of the "Greek original"). The introduction begins with a satisfyingly spiderwebby chart (2) laying out a stemma of influences on Plautus and, separately, Terence. As Marshall observes, audience members bring along their own performance codes, and "For Rome such codes are unlikely even to include knowledge of the play which the playwright claims as his source for the present entertainment" (109). (That is, to get a laugh out of Strange Brew, it is not necessary to know much [End Page 131] about Hamlet.) Venues for production would have been "found spaces" (47), often (following Sander Goldberg) a flat space in front of a temple, with the audience sitting on the steps, but generally any public space capable of holding a simple stage, backdrop, and seats. Marshall envisions the troupe as a mix of free and slave actors, some of whom owned others, opening up "convoluted situations" in the assignment of roles (87–88). Masks, as he demonstrates, could not have followed any rigid typology, especially (151) when they had to put a face on slaves who turned out to be free men (Captivi), whores who turned out to be virgins, and, I would add, Calydonians who turned out to be Carthaginians (Poenulus). The content of plays was determined by a simple bottom line: "the troupe sells an audience to the magistrates for a price" (83). Audiences were "heterogeneous" (186), and, while performance works to create a "consolidated audience," the "economic and social diversity of the audience itself exists in tension with this" (185); if the magistrates wanted to emphasize "Roman social stratigraphy," the plays worked to question divisions (77).The theme throughout is "flexibility," in keeping with what for me is the book's most important hypothesis: the plays of Plautus were collaborative creations (186–87): they "contain lines that did not originate with the playwright" but from "the collective of the theatrical troupe" (268–69). Here, Marshall persuasively draws on his own experience with improv groups, invoking the lazzi of commedia dell'arte and the shtick of vaudeville (165, n. 10) to suggest how Plautus's plays were put together by what he felicitously dubs "shtickomythia" (193). Speaking here as a translator of Plautus, I would vigorously agree: the register often slips into jokes that are corny (e.g., Poenulus 279), and what is corn but a shtick-on plaster? Even the inventiveness of slave-torture insults feels a lot like "yo mama" jokes, the kind of call-and-response humor that young men in agonistic cultures perfect in verbal dueling. Most... (shrink)

In June 1993, conjoined twins Amy and Angela Lakeberg became the focus of national attention. They shared a complex six‐chambered heart and one liver; only one could survive separation surgery, and even her chances were slim. The medical challenge was great and the ethical challenges were even greater.

While post- and decolonial theorists have thoroughly debunked the idea of historical progress as a Eurocentric, imperialist, and neocolonialist fallacy, many of the most prominent contemporary thinkers associated with the Frankfurt School--Jürgen Habermas, Axel Honneth, and Rainer Forst--have persistently defended ideas of progress, development, and modernity and have even made such ideas central to their normative claims. Can the Frankfurt School's goal of radical social change survive this critique? And what would a decolonized critical theory look like? Amy Allen fractures (...) critical theory from within by dispensing with its progressive reading of history while retaining its notion of progress as a political imperative, so eloquently defended by Adorno. Critical theory, according to Allen, is the best resouce we have for achieving emancipatory social goals. In reimagining a decolonized critical theory after the end of progress, she rescues it from oblivion and gives it a future. (shrink)

The authors offer ways to encourage and educate Americans to participate in the public deliberations that make democracy work and lay out the principles of..

Imagination has been assigned an important explanatory role in a multitude of philosophical contexts. This paper examines four such contexts: mindreading, pretense, our engagement with fiction, and modal epistemology. Close attention to each of these contexts suggests that the mental activity of imagining is considerably more heterogeneous than previously realized. In short, no single mental activity can do all the explanatory work that has been assigned to imagining.

The puzzle of imaginative desire arises from the difficulty of accounting for the surprising behaviour of desire in imaginative activities such as our engagement with fiction and our games of pretend. Several philosophers have recently attempted to solve this puzzle by introducing a class of novel mental states—what they call desire-like imaginings or i-desires. In this paper, I argue that we should reject the i-desire solution to the puzzle of imaginative desire. The introduction of i-desires is both ontologically profligate and (...) unnecessary, and, most importantly, fails to make sense of what we are doing in the imaginative contexts in question. (shrink)

Intuitions about the transparency of experience have recently begun to play a key role in the debate about qualia. Specifically, such intuitions have been used by representationalists to support their view that the phenomenal character of our experience can be wholly explained in terms of its intentional content.[i] But what exactly does it mean to say that experience is transparent? In my view, recent discussions of transparency leave matters considerably murkier than one would like. As I will suggest, there is (...) reason to believe that experience is not transparent in the way that representationalism requires. Although there is a sense in which experience can be said to be transparent, transparency in this sense does not give us any particular motivation for representationalism—or at least, not the pure or strong representationalism that it is usually invoked to support. (shrink)

Despite their intuitive appeal and a long philosophical history, imagery-based accounts of the imagination have fallen into disfavor in contemporary discussions. The philosophical pressure to reject such accounts seems to derive from two distinct sources. First, the fact that mental images have proved difficult to accommodate within a scientific conception of mind has led to numerous attempts to explain away their existence, and this in turn has led to attempts to explain the phenomenon of imagining without reference to such ontologically (...) dubious entities as mental images. Second, even those philosophers who accept mental images in their ontology have worried about what seem to be fairly obvious examples of imaginings that occur without imagery. In this paper, I aim to relieve both these points of philosophical pressure and, in the process, develop a new imagery-based account of the imagination: the imagery model. (shrink)

The Noctes Atticae, written by Aulus Gellius in the mid-second century, is a collection of short chapters dealing with a great variety of topics including philosophy, history, law, grammar, and literary criticism. In this reissue there is a complete re-examination of the codices, the first since the nineteenth-century.

La personalidad es un aspecto de la experiencia humana que es complejo y está lleno de matices. En este artículo, Nyary explora el tema de la personalidad en relación con la novela _Piranesi_ de Susanna Clarke, cuyo personaje principal, el londinense Piranesi, está atrapado en la Casa, un laberinto con cientos de habitaciones, sin ningún recuerdo de su vida pasada. Tras una estancia prolongada en este lugar, Piranesi se transforma en una persona diferente. Lo anterior refleja que, como consecuencia de (...) la naturaleza humana, las personas tienden a crear una imagen pública para parecer más agradables, mientras ocultan sus verdaderas personalidades. Nyary afirma que la Casa representa nuestra verdadera personalidad y Londres, la versión que mostramos al mundo. Al ampliar el alcance de esta metáfora, Nyary hace énfasis en la importancia de comprender y nutrir nuestra verdadera personalidad y las implicaciones que esto tiene para la sociedad. (shrink)

What is consciousness and why is it so philosophically and scientifically puzzling? For many years philosophers approached this question assuming a standard physicalist framework on which consciousness can be explained by contemporary physics, biology, neuroscience, and cognitive science. This book is a debate between two philosophers who are united in their rejection of this kind of "standard" physicalism - but who differ sharply in what lesson to draw from this. Amy Kind defends dualism 2.0, a thoroughly modern version of dualism (...) (the theory that there are two fundamentally different kinds of things in the world: those that are physical and those that are mental) decoupled from any religious or non-scientific connotations. Daniel Stoljar defends non-standard physicalism, a kind of physicalism different from both the standard version and dualism 2.0. The book presents a cutting-edge assessment of the philosophy of consciousness and provides a glimpse at what the future study of this area might bring. (shrink)

Who should have the authority to shape the education of citizens in a democracy? This is the central question posed by Amy Gutmann in the first book-length study of the democratic theory of education. The author tackles a wide range of issues, from the democratic case against book banning to the role of teachers' unions in education, as well as the vexed questions of public support for private schools and affirmative action in college admissions.

According to representationalism, the qualitative character of our phenomenal mental states supervenes on the intentional content of such states. Strong representationalism makes a further claim: the qualitative character of our phenomenal mental states _consists in_ the intentional content of such states. Although strong representationalism has greatly increased in popularity over the last decade, I find the view deeply implausible. In what follows, I will attempt to argue against strong representationalism by a two-step argument. First, I suggest that strong representationalism must (...) be _unrestricted_ in order to serve as an adequate theory of qualia, i.e., it must apply to all qualitative mental states. Second, I present considerations to show that an unrestricted form of strong representationalism is problematic. (shrink)

Introduction -- Karl Marx's concept of alienation -- Objectification, alienation, and estrangement -- Other origins of alienation and objectification -- Marx's account of alienation : from early to late -- The alienated object of production : commodity fetishism -- The alienated means of production : machine fetishism -- Machines and the transformation of work -- Marx's energeticist turn -- The first law of thermodynamics -- From arbeit to arbeitskraft -- The second law of thermodynamics -- Machines in the communist future (...) -- Technology and the boundaries of nature -- Material wealth and value : the Grundrisse's fragment on machines -- The strife between technology and capital : the fall in the rate of profit -- Enjoyment not value : challenging the logic of exhaustion -- Man himself as fixed capital -- Class kinship and the redistribution of the means of production -- Machines in the capitalist reality -- Between thermodynamics and humanism : approaching capital -- Machinery as an historical category of production -- Machines, trains, and other capitalist monsters -- Rough, foul-mouthed boys : women's monstrous laboring bodies -- Wage labor and race -- Wage labor and sexuality -- Machinery and revolution -- Alienation beyond Marx -- Science and technology in Marx's excerpt notebooks -- Karl Marx and Charles Babbage -- Machines and temporality : the treadmill effect and free time -- Technophobia and technophilia -- Technophobia and twentieth-century theory. (shrink)

Organisms' environments are thought to play a fundamental role in determining their fitness and hence in natural selection. Existing intuitive conceptions of environment are sufficient for biological practice. I argue, however, that attempts to produce a general characterization of fitness and natural selection are incomplete without the help of general conceptions of what conditions are included in the environment. Thus there is a "problem of the reference environment"—more particularly, problems of specifying principles which pick out those environmental conditions which determine (...) fitness. I distinguish various reference environment problems and propose solutions to some of them. While there has been a limited amount of work on problems concerning what I call "subenvironments", there appears to be no earlier work on problems of what I call the "whole environment". The first solution I propose for a whole environment problem specifies the overall environment for natural selection on a set of biological types present in a population over a specified period of time. The second specifies an environment relevant to extinction of types in a population; this kind of environment is especially relevant to certain kinds of long-term evolution. (shrink)

One controversy about the existence of so called evolutionary forces such as natural selection and random genetic drift concerns the sense in which such “forces” can be said to interact. In this paper I explain how natural selection and random drift can interact. In particular, I show how population-level probabilities can be derived from individual-level probabilities, and explain the sense in which natural selection and drift are embodied in these population-level probabilities. I argue that whatever causal character the individual-level probabilities (...) have is then shared by the population-level probabilities, and that natural selection and random drift then have that same causal character. Moreover, natural selection and drift can then be viewed as two aspects of probability distributions over frequencies in populations of organisms. My characterization of population-level probabilities is largely neutral about what interpretation of probability is required, allowing my approach to support various positions on biological probabilities, including those which give biological probabilities one or another sort of causal character. ‡This paper has benefited from feedback on and discussions of this and earlier work. I want to thank André Ariew, Matt Barker, Lindley Darden, Patrick Forber, Nancy Hall, Mohan Matthen, Samir Okasha, Jeremy Pober, Robert Richardson, Alex Rosenberg, Eric Seidel, Denis Walsh, and Bill Wimsatt. †To contact the author, please write to: Department of Philosophy, University of Alabama at Birmingham, HB 414A, 900 13th Street South, Birmingham, AL 35294-1260; e-mail: [email protected]. (shrink)

It is often held that identity properties like the property of being identical to Paris are intrinsic. It is also often held that, while some logically uninstantiable properties are intrinsic, some logically uninstantiable properties are non-intrinsic. The combination of these views, however, raises a problem, since virtually every existing account of intrinsicality fails to analyse a notion of intrinsicality on which both these views are true. In this paper, I argue that, given the orthodox theory of counterlogicals, there is no (...) notion of intrinsicality on which both these views are true. If this argument is sucessful, then, at least given orthodoxy about counterlogicals, we face no challenge in analysing a notion of intrinsicality on which both these views are true, since there is no such notion. In addition, if we are also convinced that there is a notion of intrinsicality on which one of these views is true and a notion of intrinsicality on which the other of these views is true, we should hold that there is more than one notion of intrinsicality. (shrink)

in The Case for Qualia,ed. by Edmond Wright , MIT Press (2008), pp. 285-298.

Over the past few decades, as philosophers of mind have begun to rethink the sharp divide that was traditionally drawn between the phenomenal character of an experience (what it’s like to have that experience) and its intentional content (what it represents), representationalist theories of consciousness have become increasingly popular. On this view, phenomenal character is reduced to intentional content. This article explores a key motivation for this theory, namely, considerations of experiential transparency. Experience is said to be transparent in that (...) we ‘look right through it’ to the objects of that experience, and this is supposed to support the representationalist claim that there are no intrinsic aspects of our experience. (shrink)

The Zhuangzi offers two apparently incompatible models of bereavement. Zhuangzi sometimes suggests that the sage will greet loss with unfractured equanimity and even aplomb. However, upon the death of his own wife, Zhuangzi evinces a sorrow that, albeit brief, fits ill with this suggestion. In this essay, I contend that the grief that Zhuangzi displays at his wife’s death better honors wider values averred elsewhere in the text and, more generally, that a sage who retains a capacity for sorrow will (...) be better positioned for the robust joy so often identified as central to the Zhuangzi’s vision of flourishing. The sagely figures who entirely forego sorrow, I argue, achieve equanimity only through a sacrifice of the emotional range and responsiveness necessary not only for grief but also for the delight Zhuangzi recommends. (shrink)

The Presidential Commission for the Study of Bioethical Issues released its first report, New Directions: The Ethics of Synthetic Biology and Emerging Technologies, on December 16, 2010.1 President Barack Obama had requested this report following the announcement last year that the J. Craig Venter Institute had created the world’s first self-replicating bacterial cell with a completely synthetic genome. The Venter group’s announcement marked a significant scientific milestone in synthetic biology, an emerging field of research that aims to combine the knowledge (...) and methods of biology, engineering, and related disciplines in the design of chemically synthesized DNA to create organisms with novel or enhanced .. (shrink)

Ruth Millikan and others advocate theories which attempt to naturalize wide mental content (e.g. beliefs.

In modern pluralist societies, political disagreement often reflects moral disagreement, as citizens with conflicting perspectives on fundamental values debate the laws that govern their public life. Any satisfactory theory of democracy must provide a way of dealing with this moral disagreement. A fundamental problem confronting all democratic theorists is to find a morally justifiable way of making binding collective decisions in the face of continuing moral conflict.

This article examines the productive capacity of emotion through the concept of emotional fundamentalism. Emotional fundamentalism combines several key concepts—fundamentalism, affective labor, biopolitics, and capitalism’s contradictions—developed by Michael Hardt and Antonio Negri in Empire, Multitude, and Commonwealth to describe the intensified attention to the body in education. I investigate the implications of the increased organizational and corporate interest in emotion using an ongoing socio-emotional learning study and the introduction of artificial intelligence aggression detectors in schools. Doing so demonstrates the tendency (...) of Empire to manage emotions in order to ensure viable production by educating the body as data and human capital. However, though Empire depends on emotions as a resource, these same emotions display a creative unruliness that exposes potential avenues to reproduce the common and enact multitude. (shrink)

This paper examines the relationship between gender and ethical decision models employed by managers. Subjects completed a survey that measured the extent to which they focused on actions or the outcomes of those actions in determining whether a behavior was ethical or not. The study also examined subjects' reactions to other managers' responses to ethical dilemmas. Results suggest that men and women do not differ in their underlying ethical models, that they do differ in the way in which they evaluate (...) others in ethical situations, and that ethical predispositions play an important role in those evaluations. (shrink)

This chapter explores a philosophical hypothesis about the nature of (some) probabilities encountered in social sciences. It should be of interest to those with philosophical concerns about the foundations of probability, and to social scientists and philosophers of science who are somewhat puzzled by the nature of probability in social domains. As will become clear below, the chapter is not intended as a contribution to an empirical methodology such as a particular way of applying statistics.

This article explores some of the philosophical implications of the Bayesian modeling paradigm. In particular, it focuses on the ramifications of the fact that Bayesian models pre‐specify an inbuilt hypothesis space. To what extent does this pre‐specification correspond to simply ‘‘building the solution in''? I argue that any learner must have a built‐in hypothesis space in precisely the same sense that Bayesian models have one. This has implications for the nature of learning, Fodor's puzzle of concept acquisition, and the role (...) of modeling in cognitive science. (shrink)

I show how the 'innersense' (quasiperceptual) view of introspection can be defended against Shoemaker's influential 'argument from selfblindness'. If introspection and perception are analogous, the relationship between beliefs and introspective knowledge of them is merely contingent. Shoemaker argues that this implies the possibility that agents could be selfblind, i.e., could lack any introspective awareness of their own mental states. By invoking Moore's paradox, he rejects this possibility. But because Shoemaker's discussion conflates introspective awareness and selfknowledge, he cannot establish his conclusion. (...) There is thirdperson evidence available to the selfblind which Shoemaker ignores, and it can account for the considerations from Moore's paradox that he raises. (shrink)

This book answers both the 'what' and the 'why' question raised by indexical shift in crosslinguistic perspective. What are the possible profiles of an indexical shifting language, and why do we find these profiles and not various equally conceivable others? Drawing both from the literature (published and unpublished) and from original fieldwork on the language Nez Perce, Amy Rose Deal puts forward several major generalizations about indexical shift crosslinguistically and present a theory that attempts to explain them. This account has (...) consequences for the way we think about the semantics of attitude verbs, the nature of contexts, the typology of first person, and the relationship between indexicals and logophors, of course along with numerous consequences for the analysis of particular languages (e.g. Nez Perce, Uyghur, Korean, English, Zazaki, Amharic, Mishar Tatar). The book contains numerous glossed examples from a range of languages (including a detailed description of Nez Perce indexical shift, based on original fieldwork, as described above); a bibliography; and an appendix providing grammatical background about Nez Perce. (shrink)

Despite how revered Socrates is among many educators nowadays, he can seem in the end to be a poor model for them, particularly because of how often he refutes his interlocutors and poses leading questions. As critics have noted, refuting people can turn them away from inquiry instead of drawing them in, and being too directive with them can squelch independent thought. I contend, though, that Socrates' practices are more defensible than they often look: although there are risks in refuting (...) people and posing leading questions, Socrates has sensible ways of minimizing the risks, ways that are feasible even for teachers nowadays, and there are times when the risks are worth taking. I illustrate my point by discussing Plato's _Meno_. (shrink)

It’s recently been argued that biological fitness can’t change over the course of an organism’s life as a result of organisms’ behaviors. However, some characterizations of biological function and biological altruism tacitly or explicitly assume that an effect of a trait can change an organism’s fitness. In the first part of the paper, I explain that the core idea of changing fitness can be understood in terms of conditional probabilities defined over sequences of events in an organism’s life. The result (...) is a notion of “conditional fitness” which is static but which captures intuitions about apparent behavioral effects on fitness. The second part of the paper investigates the possibility of providing a systematic foundation for conditional fitness in terms of spaces of sequences of states of an organism and its environment. I argue that the resulting “organism–environment history conception” helps unify diverse biological perspectives, and may provide part of a metaphysics of natural selection. (shrink)

A unified interpretation of the evolution of species, humanity, and society.

and was correct to conclude that the way a biological population is described should affect conclusions about whether natural selection occurs, but wrong to conclude that natural selection is therefore not a cause. After providing a new argument that ignored crucial biological details, I give a biological illustration that motivates a fairly extreme dependence on description. I argue that contrary to an implication of , biologists allow much flexibility in describing populations, as contemporary research on recent human evolution shows. Properly (...) understood, such description-dependence is consistent with descriptions capturing different causal relations involving the same population. I thus show that Walsh’s arguments fail for reasons that have not previously been understood; I argue that Walsh’s more recent “Sure Thing” argument fails for similar reasons. The resulting view provides a new perspective on causation in evolutionary processes. (shrink)

This paper examines the relationship between individuals' gender and their ethical decision models. The study seeks to identify asymmetries in men's and women's approaches to ethical decision making and differences in their perceptions of how same-sex and other-sex managers would likely act in business and nonbusiness situations that present an ethical dilemma. Results indicate that the models employed by men and women differ in both business and nonbusiness settings, that both sexes report changing models when leaving business settings, and that (...) women were better predictors of both sex's likely ethical models. (shrink)

One finds intertwined with ideas at the core of evolutionary theory claims about frequencies in counterfactual and infinitely large populations of organisms, as well as in sets of populations of organisms. One also finds claims about frequencies in counterfactual and infinitely large populations—of events—at the core of an answer to a question concerning the foundations of evolutionary theory. The question is this: To what do the numerical probabilities found throughout evolutionary theory correspond? The answer in question says that evolutionary probabilities (...) are “hypothetical frequencies” (including what are sometimes called “long-run frequencies” and “long-run propensities”). In this paper, I review two arguments against hypothetical frequencies. The arguments have implications for the interpretation of evolutionary probabilities, but more importantly, they seem to raise problems for biologists’ claims about frequencies in counterfactual or infinite populations of organisms and sets of populations of organisms. I argue that when properly understood, claims about frequencies in large and infinite populations of organisms and sets of populations are not threatened by the arguments. Seeing why gives us a clearer understanding of the nature of counterfactual and infinite population claims and probability in evolutionary theory. (shrink)

Philosophical Studies 104: 143-162 (2001).