Adaptive immunity provides the unique ability to respond to a nearly infinite range of antigenic determinants. Given the inherent plasticity of the adaptive immune system, a series of tolerance mechanisms exist to reduce reactivity toward self. While this reduces the probability of autoimmunity, it also creates an important gap in adaptive immunity: the ability to recognize microbes that look like self. As a variety of microbes decorate themselves in self‐like carbohydrate antigens and tolerance reduces the ability of adaptive immunity to (...) react with self‐like structures, protection against molecular mimicry likely resides within the innate arm of immunity. In this review, we will explore the potential consequences of microbial molecular mimicry, including factors within innate immunity that appear to specifically target microbes expressing self‐like antigens, and therefore provide protection against molecular mimicry. (shrink)

How do the ways we argue represent a practical philosophy or a way of life? Are concepts of character and ethos pertinent to our understanding of academic debate? In this book, Amanda Anderson analyzes arguments in literary, cultural, and political theory, with special attention to the ways in which theorists understand ideals of critical distance, forms of subjective experience, and the determinants of belief and practice. Drawing on the resources of the liberal and rationalist tradition, Anderson interrogates the limits (...) of identity politics and poststructuralism while holding to the importance of theory as a form of life. Considering high-profile trends as well as less noted patterns of argument, The Way We Argue Now addresses work in feminism, new historicism, queer theory, postcolonialism, cosmopolitanism, pragmatism, and proceduralism. The essays brought together here--lucid, precise, rigorously argued--combine pointed critique with an appreciative assessment of the productive internal contests and creative developments across these influential bodies of thought. Ultimately, The Way We Argue Now promotes a revitalized culture of argument through a richer understanding of the ways critical reason is practiced at the individual, collective, and institutional levels. Bringing to the fore the complexities of academic debate while shifting the terms by which we assess the continued influence of theory, it will appeal to readers interested in political theory, literary studies, cultural studies, gender studies, and the place of academic culture in society and politics. (shrink)

The growing proportion of elderly people in society, together with recent advances in robotics, makes the use of robots in elder care increasingly likely. We outline developments in the areas of robot applications for assisting the elderly and their carers, for monitoring their health and safety, and for providing them with companionship. Despite the possible benefits, we raise and discuss six main ethical concerns associated with: (1) the potential reduction in the amount of human contact; (2) an increase in the (...) feelings of objectification and loss of control; (3) a loss of privacy; (4) a loss of personal liberty; (5) deception and infantilisation; (6) the circumstances in which elderly people should be allowed to control robots. We conclude by balancing the care benefits against the ethical costs. If introduced with foresight and careful guidelines, robots and robotic technology could improve the lives of the elderly, reducing their dependence, and creating more opportunities for social interaction. (shrink)

Much has been written about the history of the work of men and women in the premodern past. It is now generally acknowledged that early modern ideological assumptions about a strict division of work and space between men and productive work outside the house on the one hand, and women and reproduction and consumption inside the house, on the other, bore little relation to reality. Household work strategies, out of necessity, were diverse. Yet what this spatial complexity meant in particular (...) households on a day-to-day basis and its consequences for gender relationships is less clear and has received relatively little historical attention. The aim of this paper is to add to our knowledge through a case study of the way that men and women used and organized space for work in the county of Essex during the “long seventeenth century”. Drawing on critiques of the concept of “separate spheres” and the models of economic change to which it relates, together with local/micro historical methods, it places evidence within an appropriate regional context to argue that spatial patterns were enormously varied in early modern England and a number of factors—time, place, occupation, and status, as well as gender—determined them. Understanding of the dynamic, complex, uneven purchase of patriarchy upon the organization, imagination, and experience of space has important implications for approaches to gender relations in early modern England. It raises additional doubts about the utility of the separate spheres analogy, and particularly the use of binary oppositions of male/female and public/private, to describe gender relations and their changes in this period and shows that a deeper understanding demands more research into the local contexts in which the gendered division and meaning of work was negotiated. (shrink)

In this paper, we aim to show that the framework of embedded, distributed, or extended cognition offers new perspectives on social cognition by applying it to one specific domain: the psychology of memory. In making our case, first we specify some key social dimensions of cognitive distribution and some basic distinctions between memory cases, and then describe stronger and weaker versions of distributed remembering in the general distributed cognition framework. Next, we examine studies of social influences on memory in cognitive (...) psychology, and identify the valuable concepts and methods to be extended and embedded in our framework; we focus in particular on three related paradigms: transactive memory, collaborative recall, and social contagion. Finally, we sketch our own early studies of individual and group memory developed within our framework of distributed cognition, on social contagion of autobiographical memories, collaborative flashbulb memories, and memories of high school at a high school reunion. We see two reciprocal benefits of this conceptual and empirical framework to social memory phenomena: that ideas about distributed cognition can be honed against and tested with the help of sophisticated methods in the social cognitive psychology of memory; and conversely, that a range of social memory phenomena that are as yet poorly understood can be approached afresh with theoretically motivated extensions of existing empirical paradigms. (shrink)

As the cognitive revolution was slow to come to the study of animal behavior, the vast majority of what we know about primate cognition has been discovered in the last 30 years. Building on the recognition that the physical and social worlds of humans and their living primate relatives pose many of the same evolutionary challenges, programs of research have established that the most basic cognitive skills and mental representations that humans use to navigate those worlds are already possessed by (...) other primates. There may be differences between humans and other primates, however, in more complex cognitive skills, such as reasoning about relations, causality, time, and other minds. Of special importance, the human primate seems to possess a species-unique set of adaptations for “cultural intelligence,” which are broad reaching in their effects on human cognition. (shrink)

Concerns over medical paternalism are especially salient when there exists a conflict of values between patient and clinician. This is particularly relevant for psychiatry, the field of medicine for which the phenomenon of conflicting values is most present and for which the specter of medical paternalism looms large. Few cases are as glaring as that of anorexia nervosa (AN), a disorder that is considered to be egosyntonic (meaning its symptoms are reflectively endorsed by the patient) and maintained by the presence (...) of pathological values. One might think, given this, that an approach to medicine that foregrounds the role of values in clinical encounters would be particularly well suited to address the problem of medical paternalism in treating AN. As it happens, this is precisely the goal of values-based medicine, an approach to medicine that prioritizes the integration of patients’ unique values into the aims of treatment and that has been touted as being particularly applicable to psychiatric conditions such as AN. Although this strategy may initially appear promising, in this paper I will argue that the directive to incorporate patient values (as dictated by values-based medicine) cannot do the work of mitigating medical paternalism in the treatment of egosyntonic disorders such as AN. Rather than chalking this up as a failure due to AN being a particularly challenging case, I will instead conclude that the failure of values-based medicine in this context cuts to the heart of the limitations of rectifying medical paternalism within psychiatry as it currently exists. (shrink)

This paper assesses the potential of organisational culture as a means for improving ethics in organisations. Organisational culture is recognised as one determinant of how people behave, more or less ethically, in organisations. It is also incresingly understood as an attribute that management can and should influence to improve organisational performance. When things go wrong in organisations, managers look to the culture as both the source of problems and the basis for solutions. Two models of organisational culture and ethical behaviour (...) are evaluated. They rest on different understandings of organisational culture and the processes by which ethics are enhanced. Firstly, the prevailing approach holds that creating a unitary cohesive culture around core moral values is the solution to enhancing ethical behaviour. Both the feasibility and desirability of this approach, in terms of ethical outcomes, is questioned. The second model queries the existence of organisational culture at all, arguing that organisations are nothing more than shifting coalitions of subcultures. In this second model, the very porousness of the subcultures provides a catalyst for the scrutiny and critique of norms and practices. Such diversity and debate is construed as potentially a better safeguard for ethical behaviour than the uniformity promised by the unitary, strong culture model. (shrink)

Amanda Kelly À la recherche d'un bain romain dans la région de Malia p. 607-627 On aborde ici l'importance de l'activité romaine dans la région de Malia et on examine l'éventualité de la présence d'un bain romain (public ou privé, mais plus vraisemblablement privé) dans la zone du marais. L'identification de trois clous d'espacement en terre cuite et de plusieurs fragments de pilae recueillis lors de la prospection de Malia, près de la basilique, suggère l'existence d'un bain romain dans (...) les environs, quelque part dans le marais (probablement dans la région de la basilique). La présence de clous d'espacement en terre cuite dans l'arrière-pays maliote est révélatrice, puisque leur usage est presque exclusivement associé à des bains romains, ailleurs dans l'Orient romain (généralement datés des IIe et IIIe siècles apr. J.-C.). (shrink)

Amanda Porterfield documents the claim that for Puritan men and women alike the ideals of selfhood were conveyed by female images. Constructed largely by men, Porterfield argues, these female images taught self-control, shaped pious ideals, and also established the standards against which the moral character of actual women was measured. Porterfield's work reflects a synthesis of literary critical and historical methods, combining analysis of Puritan theological writings with detailed examinations of historical records of changing patterns of church membership and (...) domestic life. (shrink)

In The Culture of Control Garland describes the ‘policy predicament’ of late modern society as involving the normality of high crime rates and the acknowledged limitations of the criminal justice system. This combination has triggered a contradictory range of policy responses that Garland describes as adaptive and non‐adaptive, with the non‐adaptive responses characterised as ‘denial’ and ‘acting out’. Garland’s invocation of these Freudian constructs invites a more fully developed psychoanalytic reading of the contemporary landscape of penal policy. Drawing on the (...) writings of Jung and Freud as well as more recent psychoanalytic interpretations of punishment and punitiveness, we aim in this paper to put the Culture of Control ‘on the couch’. That is, we try to draw out some of the psychoanalytic themes that Garland so tantalisingly dangles before us, and begin to flesh out the implications of a full‐fledged psychoanalytic interpretation of Garland’s argument. (shrink)

This edited volume brings together a range of perspectives on Educational Leadership, Management and Administration (ELMA) and various theories of resistance or compliance along with how policy and politics play out in school communities. The book makes a significant contribution to debates around theorising educational leadership and the implications of discourses on schooling and the politics of education. It brings together a broad array of international scholars to examine theories of resistance in ELMA and establish a resistance-oriented agenda for critical (...) ELMA research that promotes change and diverse ideas about leadership. Using both empirical data and conceptual analysis, the chapters provide opportunities for theorising the work and working conditions of educational leaders alongside questions of compliance and resistance that further improve the understanding of these concepts in the field. Providing cutting-edge research and theorisation into this emerging area, the book will be highly relevant for researchers, academics and postgraduate students in the fields of educational leadership, management and administration, and educational policy. It will also be of interest to school leaders. (shrink)

The present study investigated relations between personality and values on the one hand and compensation preferences on the other. We hypothesized that HEXACO Honesty-Humility and self-transcendence versus self-enhancement values predict preference for higher relative compensation level and that HEXACO Openness to Experience and openness to change versus conservation values predict preference for compensation variability. Furthermore, we expected perceived utility of money and risk aversion to mediate the respective relations. The hypotheses were tested using a sample of 2,210 employees from a (...) large international organization. The results provided support for the direct and mediated relations between personality and values on the one hand and preferences for compensation variability and level on the other. (shrink)

This article argues that Augustine’s understanding of the internal dynamics of number, order, and weight as they pertain to corporeal creatures supplies the basis for an analogy which characterizes the process of the soul’s reformation. In other words, Augustine understands the soul’s simplicity in an analogous manner to the simplicity of corporeal creatures, and the simplicity of corporeal creatures is determined by the relations between number, order, and weight. This analogy shows that Augustine conceives of the soul as a composite (...) entity with different loves as its constituent parts. In the process of reformation, the soul acquires an ordered disposition as those loves become more like one another. By virtue of this ordered disposition, the soul also acquires a greater degree of integration or number because the likeness of weight among its constituent parts allows the soul to move as a unity toward God as its final end. (shrink)

Stigma is a factor of diseases of craniofacial disfigurement, associated with negative health outcomes. Psychosocial interventions can improve the “illness” experience. The law can improve care by framing patients' rights, defining physicians' obligations to make psychological referrals, and fostering an activist orientation among patients.

Increasing student involvement in classes has always been a challenge for teachers and school managers. In online learning, some interactivity mechanisms like quizzes are increasingly used to engage students during classes and tasks. However, there is a high demand for tools that evaluate the efficiency of these mechanisms. In order to distinguish between high and low levels of engagement in tasks, it is possible to monitor brain activity through functional near-infrared spectroscopy. The main advantages of this technique are portability, low (...) cost, and a comfortable way for students to concentrate and perform their tasks. This setup provides more natural conditions for the experiments if compared to the other acquisition tools. In this study, we investigated levels of task involvement through the identification of correct and wrong answers of typical quizzes used in virtual environments. We collected data from the prefrontal cortex region of 18 students while watching a video lecture. This data was modeled with supervised learning algorithms. We used random forests and penalized logistic regression to classify correct answers as a function of oxyhemoglobin and deoxyhemoglobin concentration. These models identify which regions best predict student performance. The random forest and penalized logistic regression obtained, respectively, 0.67 and 0.65 area of the ROC curve. Both models indicate that channels F4-F6 and AF3-AFz are the most relevant for the prediction. The statistical significance of these models was confirmed through cross-validation and a permutation test. This methodology can be useful to better understand the teaching and learning processes in a video lecture and also provide improvements in the methodologies used in order to better adapt the presentation content. (shrink)

I argue that a number of non-utopian accounts of ethical progress—specifically, those offered by Wiggins, Moody-Adams, and Rorty—face a trade-off between objectivity and the radical revision of values. I suggest that each of these views is unsatisfactory because they face the Goldilocks problem—none of the views is able to get the trade-off between objectivity and radical revision of values “just right.” Moody-Adams and Wiggins offer accounts which are too conservative with regard to ethical progress in not allowing radical revision of (...) values, while Rorty’s account is too liberal in not maintaining enough objectivity. Despite thisdifficulty, however, I conclude on an optimistic note about the potential of non-utopian accounts of progress. I sketch out a Dewey-inspired view of progress which I believe can overcome the Goldilocks problem. (shrink)

We extend Tomasello's framework by addressing the functional challenge of obligation. If the long-run social consequences of a decision are sufficiently costly, obligation motivates the actor to forgo potential immediate benefits in favor of long-term social interests. Thus, obligation psychology balances the downstream socially-mediated payoffs from a decision. This perspective can predict when and why obligation will be experienced.

ZusammenfassungIm gesundheitspolitischen Kontext werden die internationale Rekrutierung und Migration von Ärztinnen, Ärzten und Personal in Gesundheitsfachberufen seit langem diskutiert. Diese Studie untersucht die thematischen Schwerpunkte dieser Debatten um ethische Aspekte der internationalen Rekrutierung in der Public Health Literatur mit Peer Review. Unser Artikel diskutiert, welche Implikationen für gesundheitspolitische Maßnahmen bezogen auf gesundheitliche Ungleichheiten diese fachspezifischen akademischen Diskussionen aufwerfen. Wir erstellten eine qualitative Übersichtsarbeit basierend auf Literaturrecherchen zu fachspezifischen internationalen Studien mit Schwerpunkt auf theoriebasierten und qualitativen Forschungsdesigns in den Datenbanken PubMed (...) und Web of Science. In die Analyse einbezogene Artikel wurden mit der Critical Appraisal Skills Program Checkliste für qualitative Forschung bewertet und anhand eines thematischen Inhaltsanalyseverfahrens auf gemeinsame Muster untersucht und kodiert. 17 Artikel wurden in die Analyse einbezogen. Diese Artikel befassten sich mehrheitlich entweder mit Pflegeberufen oder mit Ärztinnen bzw. Ärzten, und wurden verfasst aus Perspektiven des globalen Nordens. Die thematische Inhaltsanalyse ergab, dass ethische Aspekte generell zusammen mit einer allgemeinen Übersicht über Gesundheitssysteme und Ungleichheiten zwischen Ländern genannt wurden und Migration zwischen Ländern stärker im Fokus stand als Migration innerhalb einzelner Landesgrenzen. Vorgeschlagene Lösungsansätze in der Public Health Literatur sind meist ökonomischer Natur und stellen globale Finanzausgleiche zwischen Ländern oder nationale Verbesserung von Arbeitsbedingungen zur Diskussion. Möglichkeiten der Evaluation solcher Lösungen werden selten vertieft. Insgesamt fokussiert diese fachspezifische Diskussion mehrheitlich auf einen systemischen Ansatz und problematisiert die Migration von Personal in Gesundheitsfachberufen sowie von Ärztinnen und Ärzten. Unsere Ergebnisse deuten darauf hin, dass die akademische Forschung im gesundheitswissenschaftlichen und medizinischen Feld derzeit nur Vorschläge für politische Maßnahmen formuliert, die nicht grundsätzlich die globale Ordnung der Gesundheitssysteme in Frage stellen. Die Diskussion scheint daher geeignet zu sein, ein Bewusstsein für Benachteiligungen zu schaffen, ohne diese radikal beseitigen zu wollen. Eine vertiefte Auseinandersetzung mit Aspekten von Gender, Ethnizität und übergeordneten intersektionalen Bedingungen sowie Auswirkungen für und von internationaler Rekrutierung und Migration könnte die Diskussion schärfen. (shrink)

In this paper, I argue that it is possible to have an account of shame and guilt as mature concepts in moral psychology that sit alongside immature ones. In arguing for this, I adopt the critical r...

Both epistolary rhetoric and the practice of epistolography reflect the fact that competition for prestige was pervasive in Roman culture. Indeed, even Ciceronian letters of consolation, which a modern reader might expect to be exempt from social striving, are shaped by emulation and evaluation. Additionally, consolatory exchanges—letters of consolation preserved together with their replies—show that the challenges to a consolatory letter's bereaved addressee to meet or exceed a certain standard of behavior, and specifically to emulate the letter's author, were answered (...) and challenged in turn. (shrink)

Fiction is an important tool in an artist/designer/developer’s vocabulary, but its usage is polyvalent. Speculative research in this article introduces the ‘rudiment’ to embrace the undeveloped and the improvisory phases of research practice. Fiction is used to reflect on the ways practicing designers and developers might already engage in misanthropic thinking – involving automated technologies. Tracing the misanthropic agencies in relation to automated technologies contributes to expanding the ways designers and developers reflect on the technical potential of their designs, with (...) whom they are designing (and for) and the way they understand their reflexive self. Bringing together Colson Whitehead’s novel The Intuitionist (1999) and its account of an elevator crash, their design and maintenance, with a narrative account of software agents enables an investigation into the promises made through a design-for-the-prevention-of-failure imperative. These examples highlight the relation between physical and non-physical failures such as failures to connect or to create intimacy. Those who contribute to designing in this article get caught up in configuring misanthropic agencies involving themselves, the designed artefact and the spaces they both inhabit be that an elevator in a housing block, or a sexbot in an online chat room. I will argue that the misanthropic agencies of automated technologies can have a confining impact on our emergent modes of design. Automated software operating in virtual spaces are confining in as much as they attempt to connect things to exploit the de-personalized aspects of automated, misanthropic agency. (shrink)

This paper explores the relationship between dignity and robot care for older people. It highlights the disquiet that is often expressed about failures to maintain the dignity of vulnerable older people, but points out some of the contradictory uses of the word ‘dignity’. Certain authors have resolved these contradictions by identifying different senses of dignity; contrasting the inviolable dignity inherent in human life to other forms of dignity which can be present to varying degrees. The Capability Approach (CA) is introduced (...) as a different but tangible account of what it means to live a life worthy of human dignity. It is used here as a framework for the assessment of the possible effects of eldercare robots on human dignity. The CA enables the identification of circumstances in which robots could enhance dignity by expanding the set of capabilities that are accessible to frail older people. At the same time, it is also possible within its framework to identify ways in which robots could have a negative impact, by impeding the access of older people to essential capabilities. It is concluded that the CA has some advantages over other accounts of dignity, but that further work and empirical study is needed in order to adapt it to the particular circumstances and concerns of those in the latter part of their lives. (shrink)

Some philosophers challenge the advisability of naturalizing social metaphysics by appeal to social science. They argue that social science fails to meet criteria for realist commitment, such as unity and novel predictive power, and that social science would therefore be a poor basis for naturalization. These skeptical challenges are rooted in traditions in the philosophy of science that have held the social sciences in poor esteem. Through a case study that highlights the ways in which archaeology is methodologically converging on (...) hard science, I show that the philosophical bias against social science is outmoded. I suggest that at least some of the methodological advances of archaeology and other social sciences are epistemologically significant and are relevant to the question of realism. However, I conclude with the thought that realist commitment need not be a precondition for naturalization. The paper therefore accomplishes two main things: 1) it allays objections to using social science to naturalize social metaphysics, and 2) it motivates a higher estimation of the epistemological credentials of social science as compared with more skeptical traditions. (shrink)

How were various strata of local history—Classical, Christian, and Muslim—incorporated into the building of imperial Seville (sixteenth and seventeenth centuries), and what was the impact of the critical approach to evidence developed in Renaissance Italy on actual urban projects? Three case-studies—of a noble palace, the Casa de Pilatos; of a public park, the Alameda de Hércules; and of a carpentry treatise by master builder Diego López de Arenas—reveal the malleable role of historical evidence in monumental construction projects based on classical (...) and Christian ideals and demonstrate a more methodical use of evidence among artisans practicing traditional medieval craftsmanship. (shrink)

In this chapter, I introduce a novel conception of pacifism. This conception arises out of considering two key insights drawn from Cheyney Ryan’s work, specifically his characterization of the ‘pacifist impulse’ as a felt rejection of killing and his analysis of contemporary Western attitudes to war and methods of fighting, as reflecting a condition of alienated war. I expand on these claims and argue that considering them together reveals an important problem for pacifism. Specifically, the alienated condition of contemporary violence (...) renders the pacifist impulse impotent with respect to its usual function, i.e. to inhibit violence. In response, I propose re-conceiving of pacifism: Building on the Marxist-Hegelian notion of alienation and re-appropriation, I describe this proposed alternative view of pacifism as re-appropriated violence. (shrink)

In this dissertation, I develop an engaged understanding of objectivity, or good knowledge practices. I argue that for knowledge practices to be good, they must both be truth-conducive and engaged, that is, explicitly implicated in the critical appraisal of background values and assumptions. I pursue this argument in six stages. First, I consider work in epistemology that countenances a place for values in objectivity. I conclude from this that truth-conduciveness is not sufficient for objectivity, and that a social approach to (...) knowledge is called for. Second, I consider standpoint theory, a prominent feminist approach to objectivity. This allows me to show the possible insights available to marginalized perspectives, while indicating that this will be a component of rather than itself offering an account of objectivity. Third, I consider a more comprehensive approach in Helen Longino's critical contextual empiricism, which locates objectivity in the social features of inquiry. Her approach is promising, but requires the insights of early phenomenology in order to develop that potential. I develop the phenomenological framework in Chapter 4, where I consider Husserlian phenomenology. Fifth, I bring the insights of phenomenology to the challenges presented by critical contextual empiricism, and develop my positive view, critical phenomenological objectivity. On this view, inquiry is objective when individuals and communities foster critical perspectives, seek transformative epistemic experiences, build coalitions, foster diversity, and pursue empirical adequacy. In the final chapter, I consider a case study that enables me to defend the merit and warrant of these features of objectivity. (shrink)

Name der Zeitschrift: Kierkegaard Studies Yearbook Jahrgang: 23 Heft: 1 Seiten: 55-73.

A PIRATARIA COMO CONDUTA SOCIALMENTE ACEITA: UM ESTUDO DO CASO MEGAFILMES HD.

PRIVATIZAÇÃO DAS ÁGUAS: UMA ANÁLISE NA PERSPECTIVA LATINO AMERICANA A PARTIR DOS DIREITOS HUMANOS FUNDAMENTAIS.