The eukaryotic genome is packaged into a periodic nucleoprotein structure termed chromatin. The repeating unit of chromatin, the nucleosome, consists of DNA that is wound nearly two times around an octamer of histone proteins. To facilitate DNA‐directed processes in chromatin, it is often necessary to rearrange or to mobilize the nucleosomes. This remodeling of the nucleosomes is achieved by the action of chromatin‐remodeling complexes, which are a family of ATP‐dependent molecular machines. Chromatin‐remodeling factors share a related ATPase subunit and participate (...) in transcriptional regulation, DNA repair, homologous recombination and chromatin assembly. In this review, we provide an overview of chromatin‐remodeling enzymes and discuss two possible mechanisms by which these factors might act to reorganize nucleosome structure. BioEssays 25:1192–1200, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

El artículo analiza el método de estudio del alumnado de FLE con el objetivo de conocer: dónde y cómo estudian, qué planificación del trabajo establecen, qué apoyo reciben al estudio, cómo organizan sus apuntes y cómo preparan sus exámenes. Una vez que hayamos analizado los resultados del diagnóstico, daremos consejos al alumnado para enseñarle a estudiar eficazmente y con mayor autonomía. Pondremos en práctica el Aprendizaje Basado en el Pensamiento (ABP) formado por las destrezas de pensamiento, los hábitos de la (...) mente y la metacognición. Finalmente, evaluaremos en qué medida los estudiantes han conseguido ser conscientes del interés del ABP. (shrink)

The aim of this review is to show the fruitfulness of using images of facial expressions as experimental stimuli in order to study how neural systems support biologically relevant learning as it relates to social interactions. Here we consider facial expressions as naturally conditioned stimuli which, when presented in experimental paradigms, evoke activation in amygdala–prefrontal neural circuits that serve to decipher the predictive meaning of the expressions. Facial expressions offer a relatively innocuous strategy with which to investigate these normal variations (...) in affective information processing, as well as the promise of elucidating what role the aberrance of such processing might play in emotional disorders. (shrink)

Cognitive test batteries are widely used in diverse research fields, such as cognitive training, cognitive disorder assessment, or brain mechanism understanding. Although they need flexibility according to their usage objectives, most test batteries are not available as open-source software and are not be tuned by researchers in detail. The present study introduces an open-source cognitive test battery to assess attention and memory, using a javascript library, p5.js. Because of the ubiquitous nature of dynamic attention in our daily lives, it is (...) crucial to have tools for its assessment or training. For that purpose, our test battery includes seven cognitive tasks, common in cognitive science literature. By using the test battery, we conducted an online experiment to collect the benchmark data. Results conducted on 2 separate days showed the high cross-day reliability. Specifically, the task performance did not largely change with the different days. Besides, our test battery captures diverse individual differences and can evaluate them based on the cognitive factors extracted from latent factor analysis. Since we share our source code as open-source software, users can expand and manipulate experimental conditions flexibly. Our test battery is also flexible in terms of the experimental environment, i.e., it is possible to experiment either online or in a laboratory environment. (shrink)

Max Bense gilt als Vorreiter der Computerkunst und der Technikphilosophie und war ein engagierter Förderer von Kunst und Literatur, Promotor interdisziplinären Denkens und politischer Provokateur. Häufig ist es bei der Auseinandersetzung mit Bense jedoch bei diesen Etikettierungen geblieben. Der Sammelband nimmt daher eine konzertierte Neuaufnahme der Diskussion von Max Benses Arbeiten aus literaturwissenschaftlicher, philosophie- und wissenschaftshistorischer sowie aus medien- und ästhetiktheoretischer Perspektive vor. Er versammelt Beiträge zu Themenkomplexen wie der Semiotik, Technikphilosophie, experimentellen Poesie und Ästhetiktheorie, zu Benses lokalen und internationalen (...) Kontakten und Netzwerken sowie zu seinem publizistischen Verhalten im Nationalsozialismus und in der Nachkriegszeit. (shrink)

Jusqu’à présent, les discussions au sein de la communauté universitaire et dans la littérature scientifique sur la conduite responsable en recherche (CRR), incluant l’intégrité scientifique et l’éthique de la recherche, ont principalement été menées par les chercheurs en sciences de la santé et en sciences fondamentales. Préoccupés, à juste titre, par des problèmes d’inconduite, leurs effets négatifs sur la rigueur scientifique et la confiance du public dans l’entreprise de la recherche, ces débats ont conduit à l’élaboration et à la mise (...) en œuvre de lignes directrices nationales et de politiques institutionnelles. Ces lignes directrices visent entre autres à promouvoir la CRR, notamment dans le but de prévenir ces inconduites. Cependant, pour garantir la pertinence et une application appropriée de ces normes à tous les domaines universitaires, il est nécessaire que les sciences humaines et sociales (SHS) contribuent plus directement à ces discussions. Un tel engagement devrait permettre d’exprimer les particularités disciplinaires et méthodologiques des SHS, dont certaines peuvent être très différentes des sciences appliquées et fondamentales. Cela permettrait également de s’assurer que la littérature sur la CRR ainsi que les politiques et les directives qui en découlent soient à la fois fondées sur des principes universellement généralisables, mais aussi appliquées avec nuance afin de refléter la diversité des pratiques disciplinaires. Dans ce chapitre, nous explorons trois grands domaines dans lesquels les SHS pourraient contribuer à façonner les discussions dans la littérature sur la CRR, tout en informant les chercheurs en SHS des meilleures pratiques en matière de CRR : l’autorat/paternité, la collaboration et l’autorégulation. (shrink)

Objectives To characterize the prevalence and content of pediatric triage policies.Methods We surveyed and solicited policies from U.S. hospitals with pediatric intensive care units. Policies were analyzed using qualitative methods and coded by 2 investigators.Results Thirty-four of 120 institutions (28%) responded. Twenty-five (74%) were freestanding children’s hospitals and 9 (26%) were hospitals within a hospital. Nine (26%) had approved policies, 9 (26%) had draft policies, 5 (14%) were developing policies, and 7 (20%) did not have policies. Nineteen (68%) institutions shared (...) their approved or draft policy. Eight (42%) of those policies included neonates. The polices identified 0 to 5 (median 2) factors to prioritize patients. The most common factors were short- (17, 90%) and long- (14, 74%) term predicted mortality. Pediatric scoring systems included Pediatric Logistic Organ Dysfunction-2 (12, 63%) and Score for Neonatal Acute Physiology and Perinatal Extensions-II (4, 21%). Thirteen (68%) policies described a formal algorithm. The most common tiebreakers were random/lottery (10, 71%) and life cycles (9, 64%). The majority (15, 79%) of policies specified the roles of triage team members and 13 (68%) precluded those participating in patient care from making triage decisions.Conclusions While many institutions still do not have pediatric triage policies, there appears to be a trend among those with policies to utilize a formal algorithm that focuses on short- and long-term predicted mortality and that incorporates age-appropriate scoring systems. Additional work is needed to expand access to pediatric-specific policies, to validate scoring systems, and to address health disparities. (shrink)

© The Author 2016. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved.Cell walls of grasses, including cereal crops and biofuel grasses, comprise the majority of plant biomass and intimately influence plant growth, development and physiology. However, the functions of many cell wall synthesis genes, and the relationships among and the functions of cell wall components remain obscure. To better understand the patterns of cell wall accumulation and identify genes that act in grass (...) cell wall biosynthesis, we characterized 30 samples from aerial organs of rice at 10 developmental time points, 3-100 d post-germination. Within these samples, we measured 15 cell wall chemical components, enzymatic digestibility and 18 cell wall polysaccharide epitopes/ligands. We also used quantitative reverse transcription-PCR to measure expression of 50 glycosyltransferases, 15 acyltransferases and eight phenylpropanoid genes, many of which had previously been identified as being highly expressed in rice. Most cell wall components vary significantly during development, and correlations among them support current understanding of cell walls. We identified 92 significant correlations between cell wall components and gene expression and establish nine strong hypotheses for genes that synthesize xylans, mixed linkage glucan and pectin components. This work provides an extensive analysis of cell wall composition throughout rice development, identifies genes likely to synthesize grass cell walls, and provides a framework for development of genetically improved grasses for use in lignocellulosic biofuel production and agriculture. (shrink)

La presente investigación surge como parte del análisis para la creación de políticas de ecoeficiencia en las empresas y tiene como finalidad el conocer las buenas prácticas ambientales aplicadas por las empresas del sector servicios en la ciudad de Girardot. Se presenta como un estudio descriptivo-analítico con enfoque cualitativo, utilizando como instrumento la ficha de observación aplicada a una muestra de 30 empresas del sector de servicios. Dentro de los resultados obtenidos se encuentra la calificación de acuerdo con un puntaje (...) entre 0.0 y 1.0 y el análisis del resultado total con ponderación de 0% a 100% a 11 criterios evaluados. (shrink)

The article argues that there are different ways of justifying suspension of judgement. We suspend judgement not only privatively, that is, because we lack evidence, but also positively, that is, because there is evidence that provides reasons for suspending judgement: suspension is more than the rational fallback position in cases of insufficient evidence. The article applies the distinction to recent discussions about the role of suspension for inquiry, Turri's puzzle about withholding, and formal representations of suspension.

In _The Cosmic Perils of Qadi Ḥusayn Maybudī in Fifteenth-Century Iran_ Alexandra Dunietz explores the life and works of a provincial judge whose life exemplifies the intellectual, spiritual and political tensions of the Timurid, Ak Koyunlu and Safavid spheres.

Democracy and the Divine articulates a democracy that is based on the principle of giving oneself to another. For this project, the author highlights two traditions that rarely have been read side by side or considered seminal to the philosophical idea of democracy: nineteenth-century German romanticism and French postmodernism.

Are WEIRD societies unrepresentative of humanity? According to Henrich et al., they are not useful for generalizing about humans because they are at the extreme end of the distribution for societal formations. In their vision, it is best to stick with the traditional societies for speculations about human nature. This commentary offers a more realistic starting point, and, oddly enough, concludes that WEIRD populations may be more compatible with humans' evolved nature than are most traditional societies.

While examples of bacteria benefiting eukaryotes are increasingly documented, studies examining effects of eukaryote hosts on microbial fitness are rare. Beneficial bacteria are often called “mutualistic” even if mutual reciprocity of benefits has not been demonstrated and despite the plausibility of other explanations for these microbes' beneficial effects on host fitness. Furthermore, beneficial bacteria often occur in diverse communities, making mutualism both empirically and conceptually difficult to demonstrate. We suggest reserving the terms “mutualism” and “parasitism” for pairwise interactions where the (...) relationship is largely independent of other species and can be verified by measuring the fitness effect experienced by both partners. In hosts with diverse microbial communities, we propose re‐formulating some of the essential questions of symbiosis research – e.g. concerning specificity, transmission mode, and common evolutionary fates – as questions of community ecology and ecosystem function, allowing important biological interactions to be investigated without making assumptions about reciprocity. Understanding the fitness of host‐associated bacteria is a crucial component of investigations into the role of microbes in eukaryote evolution. (shrink)

The paper argues that relations of probabilistic independence between evidence statements must be preserved in enumerative induction. It further shows that, given such a preservation principle, there is a straightforward Bayesian solution to Goodman's new riddle of induction.

The purpose of this article is to examine the struggle of alternative subcultures for recognition from a philosophical perspective. This examination makes use of Honnethian critical theory to examine the philosophical dimensions of the formation of subcultural groups. More specifically, this article makes use of the Goth subculture as a case study in order to shed light on the centrality of the concept of recognition to the activities of subcultures, and to outline the material harms that follow from a lack (...) of recognition. (shrink)

Wie bedeutsam ist die Unterscheidung zwischen den Philosophien von Leibniz und Wolff? Was hat Leibniz' China-Bild fur Folgen? Welchen Einfluss hatte die Theodizee-Rezeption auf die Ubersetzung der Wertheimer Bibel?

This book examines Greek engagements with the past as articulations of memory formulated against the contingency of chance associated with temporality. Based on a phenomenological understanding of temporality, it identifies four memorializing strategies: continuity , regularity , development, and acceptance of chance. This framework serves in pursuing a twofold aim: to reconstruct the literary field of memory in fifth-century bce Greece; and to interpret Greek historiography as a memorializing mode. The key contention advanced by this approach is that acts of (...) memory entailed an “idea of history” that was articulated not only in historiography, but also in epinician poetry, elegy, tragedy, and oratory. The book offers a rich account of poetic conventions and contexts through which each of these genres counterbalanced contingency through the use of exemplary and traditional modes of memory. This fine analysis highlights the grip of the present on the past as a significant feature of both historiographical and nonhistoriographical genres.The essay argues that this work fills a disciplinary gap by extending the reflection on memory to a new period, Greek antiquity. The retrospective positioning of this period at the outset of Western historical thought brings Grethlein's investigation to the center of debates about memory, temporality, and the meaning history. In engaging with the book's argument, the essay suggests that historiographical memory emerged in Greece not as a first-order encounter with time, but as a second-order encounter with forgetting. This confrontation marked a certain separation of historiography from other memorializing genres. Whereas poetic and rhetorical memories were posited against contingency, historiography sought to retrieve those aspects of the past that may otherwise have been irretrievably lost and forgotten. In doing so, it formulated the historiographical imperative as a negation of forgetting that problematized the truth-value of memory and the very act of remembering the past. (shrink)

Name der Zeitschrift: Paragrana Jahrgang: 25 Heft: 1 Seiten: 89-109.

This paper surveys the recent developments in the area that grew out of attempts to solve an analog of Hilbert's Tenth Problem for the field of rational numbers and the rings of integers of number fields. It is based on a plenary talk the author gave at the annual North American meeting of ASL at the University of Notre Dame in May of 2009.

Do neuromodulation technologies change patients’ personal identities? Haeusermann et al. claim that there is not enough evidence to support this worry. In their study, participants, following a res...

The aim of this paper is to propose a systematic classification of emotions which can also characterize their nature. The first challenge we address is the submission of clear criteria for a theory of emotions that determine which mental phenomena are emotions and which are not. We suggest that emotions as a subclass of mental states are determined by their functional roles. The second and main challenge is the presentation of a classification and theory of emotions that can account for (...) all existing varieties. We argue that we must classify emotions according to four developmental stages: 1. pre-emotions as unfocussed expressive emotion states, 2. basic emotions, 3. primary cognitive emotions, and 4. secondary cognitive emotions. We suggest four types of basic emotions (fear, anger, joy and sadness) which are systematically differentiated into a diversity of more complex emotions during emotional development. The classification distinguishes between basic and non-basic emotions and our multi-factorial account considers cognitive, experiential, physiological and behavioral parameters as relevant for constituting an emotion. However, each emotion type is constituted by a typical pattern according to which some features may be more significant than others. Emotions differ strongly where these patterns of features are concerned, while their essential functional roles are the same. We argue that emotions form a unified ontological category that is coherent and can be well defined by their characteristic functional roles. Our account of emotions is supported by data from developmental psychology, neurobiology, evolutionary biology and sociology. (shrink)

This paper provides the first examples of rings of algebraic numbers containing the rings of algebraic integers of the infinite algebraic extensions of where Hilbert's Tenth Problem is undecidable.

Regulatory agencies vary widely in their classification of FMT, with significant impact on patient access. This article conducts a global survey of national regulations and collates existing FMT classification statuses, ultimately suggesting that the human cell and tissue product designation best fits FMT's characteristics and that definitional objectives to that classification may be overcome.

According to the classical invariance criterion, a term is logical if and only if its extension is isomorphism-invariant. However, a number of authors have devised examples that challenge the sufficiency of this condition: accepting these examples as logical constants would introduce objectionable contingent elements into logic. Recently, Gil Sagi has responded that these objections are based on a fallacious inference from the modal status of a sentence to the modal status of the proposition expressed by that sentence. The present paper (...) demonstrates that Sagi’s response, though successful, is futile. There is another objection, based on the same type of example, that is not susceptible to Sagi’s criticism: accepting the examples as logical terms would have the fatal consequence that any contingent metalanguage sentence is entailed by the truth of some logically true object-language sentence. I conclude with a sketch of an alternative to the classical invariance criterion. (shrink)

We can distinguish two non-equivalent ways in which a natural language argument can be valid: it can be interpretationally or representationally valid. However, there is just one notion of classical first-order validity for formal languages: truth-preservation in all classical first-order models. To ease the tension, Baumgartner suggests that we should understand interpretational and representational validity as imposing different adequacy conditions on formalizations of natural language arguments. I argue against this proposal. To that end, I first show that Baumgartner’s definition of (...) representational validity is extensionally inadequate. I present a number of natural language arguments that we pre-theoretically hold to be representationally valid, but are not representationally valid according to Baumgartner’s definition. I then point to two further untenable features of Baumgartner’s definitions: according to Baumgartner’s definition of a representationally correct formalization, we cannot arrive at formalizations in a recursive way, and Baumgartner’s definition of representational validity is non-monotonic. I conclude that interpretational and representational validity cannot be understood as merely imposing different adequacy conditions on formalizations. If we want to capture our interpretational and representational intuitions, we need two different formal definitions of validity. (shrink)

In this paper, we put forward an interdisciplinary framework describing different levels of self-representations, namely non-conceptual, conceptual and propositional self-representations. We argue that these different levels of self-representation are differently affected by cultural upbringing: while propositional self-representations rely on “theoretical” concepts and are thus strongly influenced by cultural upbringing, non-conceptual self-representations are uniform across cultures and thus universal. This differentiation offers a theoretical specification of the distinction between an independent and interdependent self-construal put forward in cross-cultural psychology. Hence, this does (...) not only allow for a deeper understanding of different self-conceptions, but also for a formulation of new hypotheses regarding the cultural influence on self-representations. As one example, we will highlight the role of the proposed levels of self-representation for emotional experience and formulate some major implications of our interdisciplinary framework for future empirical research. (shrink)

The ministerial recruitment strategies in Communist Romania are a symmetric replica of the elite selection patterns in parliamentary democracies. Starting with the mid-60s, all the major traditional pathways to power formally mirror mechanisms of the elite selection and differentiation, which are commonly encountered in Western democracies. During the Communist regime, “atypical” credentials such as education, academia, and the economic experiences also increased the likelihood of a promotion in public office. Starting from the notable differences between the Romanian elites and those (...) in other Communist countries in the region, the paper argues that intertwined patterns of “Westernisation” and patrimonial-type credentials contributed to the consolidation of the Romanian Communist Party and hindered, in the aftermath of the regime change, the first attempts at elite renewal and democratisation. (shrink)

Post-war Japan has seen profound and rapid social change and transformation. One of the most visible areas of change in Japan has been medicine, and particularly the ethical practices and policies that guide medical decision-making. The formal discipline of bioethics, Seimei Rinri in Japanese, has grown by leaps and bounds since the late 1970s, when it began to appear in the curriculum and professional activities of Japanese medical schools and philosophy departments. The introduction of bioethics to Japan was timely, as (...) innovation in medicine and technology was evolving in ways that revealed that the intersection of medicine, traditional Japanese values, and new cultural trends was an area of great moral complexity. In its infancy, bioethics in Japan was more or less an import from the United States, where the discipline took its roots. Quickly, however, it became clear that Japan's history and tradition would call for a different approach, and the engagement of slightly different ethical issues. Organ transplantation, for example, sparked much greater controversy in Japan than it ever did in the United States. Today, Japan has one of the most dynamic bioethics programs in the world, and it is one that reflects both traditional Japanese culture and the need for inter-cultural engagement in an increasingly global world. Through a series of original chapters written by bioethicists and covering a range of ethical issues, this anthology shows that, in contrast to previous assumptions, Japanese bioethics has, in fact, taken on an identity that is undoubtedly separate from its American origins. Rich philosophical questions raised by medicine, human subjects research, and psychiatric care are being posed by scholars in a way that reflect Japanese tradition and is no longer simply reflective of, or shaped by, American traditions and philosophical problems. The book highlights and showcases these trends through a series of chapters written by some of the leading scholars in contemporary Japanese bioethics, many of whom were pioneers of the field when it began and are now nearing retirement. (shrink)

We consider the problem of constructing first-order definitions in the language of rings of holomorphy rings of one-variable function fields of characteristic 0 in their integral closures in finite extensions of their fraction fields and in bigger holomorphy subrings of their fraction fields. This line of questions is motivated by similar existential definability results over global fields and related questions of Diophantine decidability.

It is frequently claimed that the human mind is organized in a modular fashion, a hypothesis linked historically, though not inevitably, to the claim that many aspects of the human mind are innately specified. A specific instance of this line of thought is the proposal of an innately specified geometric module for human reorientation. From a massive modularity position, the reorientation module would be one of a large number that organized the mind. From the core knowledge position, the reorientation module (...) is one of five innate and encapsulated modules that can later be supplemented by use of human language. In this paper, we marshall five lines of evidence that cast doubt on the geometric module hypothesis, unfolded in a series of reasons: (1) Language does not play a necessary role in the integration of feature and geometric cues, although it can be helpful. (2) A model of reorientation requires flexibility to explain variable phenomena. (3) Experience matters over short and long periods. (4) Features are used for true reorientation. (5) The nature of geometric information is not as yet clearly specified. In the final section, we review recent theoretical approaches to the known reorientation phenomena. (shrink)

Over the last twenty years, wildlife biologists and transportation planners have worked with environmental groups and state and tribal governments to mitigate the effects of human transportation arteries on animal habitats and movements. This paper draws connections between this growing field of road ecology and feminist science studies in order to accomplish two things. First, it aims to highlight the often unacknowledged roots that the interdisciplinary field of animal studies has in feminist theory. Second, it seeks to contribute to conversations (...) in the humanities and social sciences on roadkill and on wildlife biology by steering us into a world of practice that foregrounds mundane details. I approach this topic through interdisciplinary methods, including interviews with tribal and state wildlife biologists and participation in fieldwork on a western painted turtle tagging project. Although engaging in science and formulating policy are often understandably regarded by nonspecialists as practices that distance observers from their topic, in the world of roadkill prevention, I argue that the opposite is the case. What I call “intimate bureaucracies” are formed: arrangements of papers, policies, and people that bring a world of counting, and accountability, into being. (shrink)

Nicholas J.J. Smith (2014) has argued that there are different kinds of degrees of belief, but that they must be fused into one ‘all kinds considered’ degree of belief. We provide an example which shows that different kinds of degrees of belief can have diverging impacts on the rationality of a decision: there are cases in which two rational subjects with identical preferences and the same ‘all kinds considered’ degree of belief make different decisions. Thus, different kinds of degrees of (...) belief should not be merged into a single degree-of-belief function. (shrink)

Cet article a déjà paru dans Techniques & Culture en ligne, 48-49 | 2007 Résumé : L'œuvre d'André Leroi-Gourhan est traversée par une anthropologie du rythme. Celle-ci ne part pas d'une socialité constituée, de rythmes dits « sociaux », mais inscrit au contraire l'analyse de la rythmicité dans une approche de l'homme comme être vivant, comme totalité indivise. Elle pose en des termes renouvelés le problème classique du groupement des hommes et des liens entre l'individu et son milieu. Avec la (...) question - Anthropologie. (shrink)

Despite our interests in conceptual schemes, paradigms, styles of reasoning, levels of explanation, and populationist modes of theorizing, many philosophers ignore the fact that instruction occurs in situ. This paper highlights the importance of cultural location by reflecting upon the author’s experience as an instructor of modernity at Marshall University, a regional state institution in Huntington, West Virginia. For many Appalachian students, issues barely tolerated by others (as part of their required history sequence) are uniquely resonant. At the same time, (...) existing power structures—and the very real limits established by those structures—discourage Appalachian students from embracing or even entertaining the canonical themes of modernity. Immersing oneself in the regional culture, instead of bemoaning it, enables a philosophy instructor to examine modernity from both the pre- and postmodern perspectives, while also conveying to students that their education matters a great deal to the fate of the region. (shrink)