The eukaryotic genome is packaged into a periodic nucleoprotein structure termed chromatin. The repeating unit of chromatin, the nucleosome, consists of DNA that is wound nearly two times around an octamer of histone proteins. To facilitate DNA‐directed processes in chromatin, it is often necessary to rearrange or to mobilize the nucleosomes. This remodeling of the nucleosomes is achieved by the action of chromatin‐remodeling complexes, which are a family of ATP‐dependent molecular machines. Chromatin‐remodeling factors share a related ATPase subunit and participate (...) in transcriptional regulation, DNA repair, homologous recombination and chromatin assembly. In this review, we provide an overview of chromatin‐remodeling enzymes and discuss two possible mechanisms by which these factors might act to reorganize nucleosome structure. BioEssays 25:1192–1200, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

El artículo analiza el método de estudio del alumnado de FLE con el objetivo de conocer: dónde y cómo estudian, qué planificación del trabajo establecen, qué apoyo reciben al estudio, cómo organizan sus apuntes y cómo preparan sus exámenes. Una vez que hayamos analizado los resultados del diagnóstico, daremos consejos al alumnado para enseñarle a estudiar eficazmente y con mayor autonomía. Pondremos en práctica el Aprendizaje Basado en el Pensamiento (ABP) formado por las destrezas de pensamiento, los hábitos de la (...) mente y la metacognición. Finalmente, evaluaremos en qué medida los estudiantes han conseguido ser conscientes del interés del ABP. (shrink)

Jusqu’à présent, les discussions au sein de la communauté universitaire et dans la littérature scientifique sur la conduite responsable en recherche (CRR), incluant l’intégrité scientifique et l’éthique de la recherche, ont principalement été menées par les chercheurs en sciences de la santé et en sciences fondamentales. Préoccupés, à juste titre, par des problèmes d’inconduite, leurs effets négatifs sur la rigueur scientifique et la confiance du public dans l’entreprise de la recherche, ces débats ont conduit à l’élaboration et à la mise (...) en œuvre de lignes directrices nationales et de politiques institutionnelles. Ces lignes directrices visent entre autres à promouvoir la CRR, notamment dans le but de prévenir ces inconduites. Cependant, pour garantir la pertinence et une application appropriée de ces normes à tous les domaines universitaires, il est nécessaire que les sciences humaines et sociales (SHS) contribuent plus directement à ces discussions. Un tel engagement devrait permettre d’exprimer les particularités disciplinaires et méthodologiques des SHS, dont certaines peuvent être très différentes des sciences appliquées et fondamentales. Cela permettrait également de s’assurer que la littérature sur la CRR ainsi que les politiques et les directives qui en découlent soient à la fois fondées sur des principes universellement généralisables, mais aussi appliquées avec nuance afin de refléter la diversité des pratiques disciplinaires. Dans ce chapitre, nous explorons trois grands domaines dans lesquels les SHS pourraient contribuer à façonner les discussions dans la littérature sur la CRR, tout en informant les chercheurs en SHS des meilleures pratiques en matière de CRR : l’autorat/paternité, la collaboration et l’autorégulation. (shrink)

Cognitive test batteries are widely used in diverse research fields, such as cognitive training, cognitive disorder assessment, or brain mechanism understanding. Although they need flexibility according to their usage objectives, most test batteries are not available as open-source software and are not be tuned by researchers in detail. The present study introduces an open-source cognitive test battery to assess attention and memory, using a javascript library, p5.js. Because of the ubiquitous nature of dynamic attention in our daily lives, it is (...) crucial to have tools for its assessment or training. For that purpose, our test battery includes seven cognitive tasks, common in cognitive science literature. By using the test battery, we conducted an online experiment to collect the benchmark data. Results conducted on 2 separate days showed the high cross-day reliability. Specifically, the task performance did not largely change with the different days. Besides, our test battery captures diverse individual differences and can evaluate them based on the cognitive factors extracted from latent factor analysis. Since we share our source code as open-source software, users can expand and manipulate experimental conditions flexibly. Our test battery is also flexible in terms of the experimental environment, i.e., it is possible to experiment either online or in a laboratory environment. (shrink)

The Tri-Council Policy Statement: Ethical Conduct for Research Involving Humans was first developed to establish a standard of practice in research ethics by the three federal agencies responsible for funding institutional research in Canada: Canadian Institutes of Health Research, Natural Sciences and Engineering Research Council, and Social Sciences and Humanities Research Council. In 2010, a second edition of the policy, known as the TCPS 2, was released with updated information and expanded coverage of research ethics issues. According to the TCPS (...) 2, the Agencies’ mandate is “to promote research that is conducted according to the highest ethical standards,” and the TCPS 2 serves as a benchmark for this with respect for human dignity as its underlying value. Research institutions receiving Agency funding are to comply with this policy statement by forming Research Ethics Boards to review all research involving human participants. The intention behind this review requirement is to provide a proportionate assessment of the benefit-to-risk ratio of the research, and in that process, to safeguard “respect for persons”, express a “concern for welfare”, and uphold “justice”. Research may not proceed until ethics approval is granted by an institution’s REB. The current study evaluates REB members’ perspectives on their knowledge of research ethics, and juxtaposes these perceptions with those of researchers. Specifically, we are interested in the extent to which REB members with less experience read the TCPS 2, and whether those with less experience have decreased confidence in their ethics knowledge. (shrink)

BackgroundThere is a growing interest in using cognitive–behavioural therapy (CBT) with people who have Asperger syndrome and comorbid mental health problems.AimsTo examine whether modified group CBT for clinically significant anxiety in an Asperger syndrome population is feasible and likely to be efficacious.MethodUsing a randomised assessor-blind trial, 52 individuals with Asperger syndrome were randomised into a treatment arm or a waiting-list control arm. After 24 weeks, those in the waiting-list control arm received treatment, while those initially randomised to treatment were followed (...) up for 24 weeks.ResultsThe conversion rate for this trial was high (1.6:1), while attrition was 13%. After 24 weeks, there was no significant difference between those randomised to the treatment arm compared with those randomised to the waiting-list control arm on the primary outcome measure, the Hamilton Rating Scale for Anxiety.ConclusionsTrials of psychological therapies with this population are feasible. Larger definitive trials are now needed. (shrink)

Through advances in production and treatment technologies, transparent glass has become an increasingly versatile material and a global hallmark of modern architecture. In the shape of invisible barriers, it defines spaces while simultaneously shaping their lighting, noise, and climate conditions. Despite these unique architectural qualities, little is known regarding the human experience with glass barriers. Is a material that has been described as being simultaneously there and not there from an architectural perspective, actually there and/or not there from perceptual, behavioral, (...) and social points of view? In this article, we review systematic observations and experimental studies that explore the impact of transparent barriers on human cognition and action. In doing so, the importance of empirical and multidisciplinary approaches to inform the use of glass in contemporary architecture is highlighted and key questions for future inquiry are identified. (shrink)

The inclusion of stakeholders and knowledge systems is increasingly valued in research to address complex socio-ecological challenges around the world. Often these projects take place in cross-cultural setting where external researchers risk perpetuating historically extractive research models that not only harm local communities but damage the validity of research projects. Responsible community engagement is increasingly recognized as a practice that can improve researcher-community relationships and research quality by incorporating principles of ethics, reciprocity, and power sharing. In partnership with local community (...) leaders, researchers from a U.S. university coded 76 research articles for indicators of responsible community engagement conducted in the Samburu, Kenya community since 2000. Findings from this study suggest that most of the research in Samburu has followed extractive models. Of the 76 articles reviewed many failed to acknowledge ethical protocols, did not address relevance of the study to the local community, and did not report any indication of outreach or community change as a result of the research. While a portion of articles showed evidence of community involvement in the studies, the involvement was primarily limited to secondary roles with little to no shared decision-making power over the research process. We discuss methodological considerations for future research and steps that must be taken in order to shift the norm and practice of academic research in sites such as Samburu, Kenya. (shrink)

We improve on and generalize a 1960 result of Maltsev. For a field F, we denote by $H(F)$ the Heisenberg group with entries in F. Maltsev showed that there is a copy of F defined in $H(F)$, using existential formulas with an arbitrary non-commuting pair of elements as parameters. We show that F is interpreted in $H(F)$ using computable $\Sigma _1$ formulas with no parameters. We give two proofs. The first is an existence proof, relying on a result of Harrison-Trainor, (...) Melnikov, R. Miller, and Montalbán. This proof allows the possibility that the elements of F are represented by tuples in $H(F)$ of no fixed arity. The second proof is direct, giving explicit finitary existential formulas that define the interpretation, with elements of F represented by triples in $H(F)$. Looking at what was used to arrive at this parameter-free interpretation of F in $H(F)$, we give general conditions sufficient to eliminate parameters from interpretations. (shrink)

Civility is formed by social norms that guide our behavior and allow us to interact appropriately with others. These norms affect everyone and are learned through the socialization process. However, in the same process, people also learn gender norms that dictate how men and women should behave, leading to gender stereotypes and differentiated behavioral characteristics. The purpose of this research is to examine the relationship between gender and civility, and how we react to those who behave uncivilly given their gender. (...) The results of Study 1 showed that even in a fictional and gender-neutral society, uncivil behaviors were associated with stereotypically masculine characteristics, and those who behaved uncivilly were dehumanized. In Study 2, gender differences were observed in incivility. Women were harsher when facing uncivil transgressors than men, especially if the transgressor was another woman. Our findings support the notion that gender norms are applied to civility, leading those supposedly equal social norms to unequal perceptions and evaluations. (shrink)

In _The Cosmic Perils of Qadi Ḥusayn Maybudī in Fifteenth-Century Iran_ Alexandra Dunietz explores the life and works of a provincial judge whose life exemplifies the intellectual, spiritual and political tensions of the Timurid, Ak Koyunlu and Safavid spheres.

Democracy and the Divine articulates a democracy that is based on the principle of giving oneself to another. For this project, the author highlights two traditions that rarely have been read side by side or considered seminal to the philosophical idea of democracy: nineteenth-century German romanticism and French postmodernism.

Are WEIRD societies unrepresentative of humanity? According to Henrich et al., they are not useful for generalizing about humans because they are at the extreme end of the distribution for societal formations. In their vision, it is best to stick with the traditional societies for speculations about human nature. This commentary offers a more realistic starting point, and, oddly enough, concludes that WEIRD populations may be more compatible with humans' evolved nature than are most traditional societies.

While examples of bacteria benefiting eukaryotes are increasingly documented, studies examining effects of eukaryote hosts on microbial fitness are rare. Beneficial bacteria are often called “mutualistic” even if mutual reciprocity of benefits has not been demonstrated and despite the plausibility of other explanations for these microbes' beneficial effects on host fitness. Furthermore, beneficial bacteria often occur in diverse communities, making mutualism both empirically and conceptually difficult to demonstrate. We suggest reserving the terms “mutualism” and “parasitism” for pairwise interactions where the (...) relationship is largely independent of other species and can be verified by measuring the fitness effect experienced by both partners. In hosts with diverse microbial communities, we propose re‐formulating some of the essential questions of symbiosis research – e.g. concerning specificity, transmission mode, and common evolutionary fates – as questions of community ecology and ecosystem function, allowing important biological interactions to be investigated without making assumptions about reciprocity. Understanding the fitness of host‐associated bacteria is a crucial component of investigations into the role of microbes in eukaryote evolution. (shrink)

Wie bedeutsam ist die Unterscheidung zwischen den Philosophien von Leibniz und Wolff? Was hat Leibniz' China-Bild fur Folgen? Welchen Einfluss hatte die Theodizee-Rezeption auf die Ubersetzung der Wertheimer Bibel?

This book examines Greek engagements with the past as articulations of memory formulated against the contingency of chance associated with temporality. Based on a phenomenological understanding of temporality, it identifies four memorializing strategies: continuity , regularity , development, and acceptance of chance. This framework serves in pursuing a twofold aim: to reconstruct the literary field of memory in fifth-century bce Greece; and to interpret Greek historiography as a memorializing mode. The key contention advanced by this approach is that acts of (...) memory entailed an “idea of history” that was articulated not only in historiography, but also in epinician poetry, elegy, tragedy, and oratory. The book offers a rich account of poetic conventions and contexts through which each of these genres counterbalanced contingency through the use of exemplary and traditional modes of memory. This fine analysis highlights the grip of the present on the past as a significant feature of both historiographical and nonhistoriographical genres.The essay argues that this work fills a disciplinary gap by extending the reflection on memory to a new period, Greek antiquity. The retrospective positioning of this period at the outset of Western historical thought brings Grethlein's investigation to the center of debates about memory, temporality, and the meaning history. In engaging with the book's argument, the essay suggests that historiographical memory emerged in Greece not as a first-order encounter with time, but as a second-order encounter with forgetting. This confrontation marked a certain separation of historiography from other memorializing genres. Whereas poetic and rhetorical memories were posited against contingency, historiography sought to retrieve those aspects of the past that may otherwise have been irretrievably lost and forgotten. In doing so, it formulated the historiographical imperative as a negation of forgetting that problematized the truth-value of memory and the very act of remembering the past. (shrink)

This paper provides the first examples of rings of algebraic numbers containing the rings of algebraic integers of the infinite algebraic extensions of where Hilbert's Tenth Problem is undecidable.

The aim of this paper is to propose a systematic classification of emotions which can also characterize their nature. The first challenge we address is the submission of clear criteria for a theory of emotions that determine which mental phenomena are emotions and which are not. We suggest that emotions as a subclass of mental states are determined by their functional roles. The second and main challenge is the presentation of a classification and theory of emotions that can account for (...) all existing varieties. We argue that we must classify emotions according to four developmental stages: 1. pre-emotions as unfocussed expressive emotion states, 2. basic emotions, 3. primary cognitive emotions, and 4. secondary cognitive emotions. We suggest four types of basic emotions (fear, anger, joy and sadness) which are systematically differentiated into a diversity of more complex emotions during emotional development. The classification distinguishes between basic and non-basic emotions and our multi-factorial account considers cognitive, experiential, physiological and behavioral parameters as relevant for constituting an emotion. However, each emotion type is constituted by a typical pattern according to which some features may be more significant than others. Emotions differ strongly where these patterns of features are concerned, while their essential functional roles are the same. We argue that emotions form a unified ontological category that is coherent and can be well defined by their characteristic functional roles. Our account of emotions is supported by data from developmental psychology, neurobiology, evolutionary biology and sociology. (shrink)

The ministerial recruitment strategies in Communist Romania are a symmetric replica of the elite selection patterns in parliamentary democracies. Starting with the mid-60s, all the major traditional pathways to power formally mirror mechanisms of the elite selection and differentiation, which are commonly encountered in Western democracies. During the Communist regime, “atypical” credentials such as education, academia, and the economic experiences also increased the likelihood of a promotion in public office. Starting from the notable differences between the Romanian elites and those (...) in other Communist countries in the region, the paper argues that intertwined patterns of “Westernisation” and patrimonial-type credentials contributed to the consolidation of the Romanian Communist Party and hindered, in the aftermath of the regime change, the first attempts at elite renewal and democratisation. (shrink)

Post-war Japan has seen profound and rapid social change and transformation. One of the most visible areas of change in Japan has been medicine, and particularly the ethical practices and policies that guide medical decision-making. The formal discipline of bioethics, Seimei Rinri in Japanese, has grown by leaps and bounds since the late 1970s, when it began to appear in the curriculum and professional activities of Japanese medical schools and philosophy departments. The introduction of bioethics to Japan was timely, as (...) innovation in medicine and technology was evolving in ways that revealed that the intersection of medicine, traditional Japanese values, and new cultural trends was an area of great moral complexity. In its infancy, bioethics in Japan was more or less an import from the United States, where the discipline took its roots. Quickly, however, it became clear that Japan's history and tradition would call for a different approach, and the engagement of slightly different ethical issues. Organ transplantation, for example, sparked much greater controversy in Japan than it ever did in the United States. Today, Japan has one of the most dynamic bioethics programs in the world, and it is one that reflects both traditional Japanese culture and the need for inter-cultural engagement in an increasingly global world. Through a series of original chapters written by bioethicists and covering a range of ethical issues, this anthology shows that, in contrast to previous assumptions, Japanese bioethics has, in fact, taken on an identity that is undoubtedly separate from its American origins. Rich philosophical questions raised by medicine, human subjects research, and psychiatric care are being posed by scholars in a way that reflect Japanese tradition and is no longer simply reflective of, or shaped by, American traditions and philosophical problems. The book highlights and showcases these trends through a series of chapters written by some of the leading scholars in contemporary Japanese bioethics, many of whom were pioneers of the field when it began and are now nearing retirement. (shrink)

It is frequently claimed that the human mind is organized in a modular fashion, a hypothesis linked historically, though not inevitably, to the claim that many aspects of the human mind are innately specified. A specific instance of this line of thought is the proposal of an innately specified geometric module for human reorientation. From a massive modularity position, the reorientation module would be one of a large number that organized the mind. From the core knowledge position, the reorientation module (...) is one of five innate and encapsulated modules that can later be supplemented by use of human language. In this paper, we marshall five lines of evidence that cast doubt on the geometric module hypothesis, unfolded in a series of reasons: (1) Language does not play a necessary role in the integration of feature and geometric cues, although it can be helpful. (2) A model of reorientation requires flexibility to explain variable phenomena. (3) Experience matters over short and long periods. (4) Features are used for true reorientation. (5) The nature of geometric information is not as yet clearly specified. In the final section, we review recent theoretical approaches to the known reorientation phenomena. (shrink)

Over the last twenty years, wildlife biologists and transportation planners have worked with environmental groups and state and tribal governments to mitigate the effects of human transportation arteries on animal habitats and movements. This paper draws connections between this growing field of road ecology and feminist science studies in order to accomplish two things. First, it aims to highlight the often unacknowledged roots that the interdisciplinary field of animal studies has in feminist theory. Second, it seeks to contribute to conversations (...) in the humanities and social sciences on roadkill and on wildlife biology by steering us into a world of practice that foregrounds mundane details. I approach this topic through interdisciplinary methods, including interviews with tribal and state wildlife biologists and participation in fieldwork on a western painted turtle tagging project. Although engaging in science and formulating policy are often understandably regarded by nonspecialists as practices that distance observers from their topic, in the world of roadkill prevention, I argue that the opposite is the case. What I call “intimate bureaucracies” are formed: arrangements of papers, policies, and people that bring a world of counting, and accountability, into being. (shrink)

ObjectiveOur research aim is to enrich the conceptualization of high conflict post-divorce co-parenting by understanding the dynamic process involved.BackgroundThe studied phenomena were explored by linking previous scientific knowledge to practice.MethodWe cross-referenced the previous study results with the experiences reported by eight professionals and tried to answer the following research question: how professionals’ experience and previous scientific knowledge contribute to a better understanding of HC post-divorce co-parenting? Individual face to face interviews were conducted and analyzed regarding the qualitative theoretical reasoning of (...) thematic analysis.ResultsAnalysis allowed us to highlight how four main axes are related to HC post-divorce co-parenting: Parents for life, Acting in the child’s best interests, Managing disagreements, and Healing the separation.ConclusionOur findings capture high conflict post-divorce co-parenting as a multidimensional dynamic process. As such, dealing with co-parenting disagreements must be understood as a moment in a process that is influenced by, and influences, other dimensions.ImplicationsInterventions must consider the four dimensions and their reciprocal interactions. The essential elements underlying parents’ difficulties may reside at a multiplicity of levels: inter-relational, contextual, and intrapsychic. Each level contains key potential factors in understanding these families, and in formulating intervention guidelines. (shrink)

The paper develops an inductive extension of AGM-style belief base revision theory with the aim of formally implementing Freitag’s :254–267, 2015, Dialectica 70:185–200, 2016) solution to Goodman’s paradox. It shows that the paradox dissolves once belief revision takes place on inductively closed belief bases, rather than on belief sets.

Cet article a déjà paru dans Techniques & Culture en ligne, 48-49 | 2007 Résumé : L'œuvre d'André Leroi-Gourhan est traversée par une anthropologie du rythme. Celle-ci ne part pas d'une socialité constituée, de rythmes dits « sociaux », mais inscrit au contraire l'analyse de la rythmicité dans une approche de l'homme comme être vivant, comme totalité indivise. Elle pose en des termes renouvelés le problème classique du groupement des hommes et des liens entre l'individu et son milieu. Avec la (...) question - Anthropologie. (shrink)

Drug discovery traditionally has occurred behind closed doors in for-profit corporations hoping to develop best-selling medicines that recoup initial research investment, sustain marketing infrastructures, and pass on healthy returns to shareholders. Only corporate Pharma has the man- and purchasing-power to synthesize the thousands of molecules needed to find a new drug and to conduct the clinical trials that will make the drug legal. Against this view, individual physician-scientists have suggested that the promise of applied genomics work calls for a new (...) form of social organization in order to speed the generation and understanding of new therapeutics. Recent successes in open source drug discovery show it is possible to produce valuable, empirically adequate, and sustainable collective beliefs without secrecy, proprietary attitudes, initial cooperation from Pharma, or outsized monetary incentives. After reviewing and differentiating these successes, I diagnose the source of this healthy new epistemic strategy. (shrink)

Despite our interests in conceptual schemes, paradigms, styles of reasoning, levels of explanation, and populationist modes of theorizing, many philosophers ignore the fact that instruction occurs in situ. This paper highlights the importance of cultural location by reflecting upon the author’s experience as an instructor of modernity at Marshall University, a regional state institution in Huntington, West Virginia. For many Appalachian students, issues barely tolerated by others (as part of their required history sequence) are uniquely resonant. At the same time, (...) existing power structures—and the very real limits established by those structures—discourage Appalachian students from embracing or even entertaining the canonical themes of modernity. Immersing oneself in the regional culture, instead of bemoaning it, enables a philosophy instructor to examine modernity from both the pre- and postmodern perspectives, while also conveying to students that their education matters a great deal to the fate of the region. (shrink)

It has been alleged that Carolus Linnaeus practised Eurocentrism, sexism and racism in naming plant genera after famous botanists, and excluding ‘barbarous names’. He has therefore been said to practise ‘linguistic imperialism’. This paper examines whether Linnaeus applied ‘linguistic imperialism’ to the naming of Chinese plants. On the basis of examples such as Thea (¼Camellia), Urena, Basella, Annona, Sapindus (¼Koelreuteria), and Panax, I conclude that Linnaeus used generic names of diverse origins. However, he misidentified Chinese plants’ habitats, and acted on (...) these misapprehensions. (shrink)