Maternal opioid use during pregnancy is a growing national problem and can lead to newborns developing neonatal opioid withdrawal syndrome soon after birth. Recent data demonstrates that nearly every 15 min a baby is born in the United States suffering from NOWS. The primary treatment for NOWS is opioid replacement therapy, commonly oral morphine, which has neurotoxic effects on the developing brain. There is an urgent need for non-opioid treatments for NOWS. Transcutaneous auricular neurostimulation, a novel and non-invasive form of (...) electrostimulation, may serve as a promising alternative to morphine. tAN is delivered via a multichannel earpiece electrode worn on and around the left ear, targeting two cranial nerves—the vagus and trigeminal nerves. Prior research suggests that auricular neurostimulation exerts an anxiolytic effect on the body by releasing endogenous opioids and reduces withdrawal symptoms in adults actively withdrawing from opioids. In this first-in-human prospective, open-label trial, we investigated tAN as an adjuvant to morphine therapy in eight infants >33 weeks gestational age suffering from NOWS and receiving oral morphine treatment. Infants received tAN for 30 min 1 h before receiving a morphine dose. tAN was delivered at 0.1 mA below perception intensity at two different nerve targets on the ear: Region 1, the auricular branch of the vagus nerve; and Region 2, the auriculotemporal nerve. tAN was delivered up to four times daily for a maximum of 12 days. The primary outcome measures were safety [heart rate monitoring, Neonatal Infant Pain Scale, and skin irritation] and morphine length of treatment. tAN was well-tolerated and resulted in no unanticipated adverse events. Comparing to the national average of 23 days, the average oral morphine LOT was 13.3 days and the average LOT after tAN initiation was 7 days. These preliminary data suggest that tAN is safe and may serve as a promising alternative adjuvant for treating NOWS and reducing the amount of time an infant receives oral morphine. (shrink)

In "Machiavelli’s Art of Politics" Alejandro Bárcenas offers a reexamination of Niccolò Machiavelli’s political thought in order to propose a concise and historically accurate portrayal of his ideas and intellectual context. -/- This study provides a nuanced view of the complexities of Machiavelli’s thought by analyzing his classical background, taking into particular consideration the influence of Xenophon, and his view of the ideal ruler as someone who creates the conditions for a flourishing human life. In addition, Bárcenas explains why (...) Machiavelli defends a republican political order that encourages citizens to live according to their own laws while serving a common good and revises his legacy through the writings of Leo Strauss, Eric Voegelin and Maurizio Viroli. (shrink)

[v. 1]. Escritos filosóficos y políticos I -- v. 2. Escritos filosóficos y políticos II. Escritos sobre la universidad.

Este artigo discute a teoria do reflexo desenvolvida por Lenin em seu confronto com a filosofia hegeliana nos comentários que escreveu a The Science of Logic em 1915. Nesses comentários, Lenin apresenta a reflexão no contexto de uma relação reflexiva adaptativa entre o movimento da o conhecimento e o movimento da realidade; a dinâmica do conhecimento segue o movimento da realidade e a influencia. Para Lenin desses comentários, a reflexão é um momento (mental) do processo de objetificação humana que transforma (...) a realidade e origina o ser humano. (shrink)

The following study shows the main qualitative results obtained by means of a two follow up study with a group of telephone interpreters who previously participated in an ad hoc emotional regulation program designed according to their specific needs.The study aimed to evaluate the impact of the intervention program in the long term.The results demonstrated the positive effect of the program on the interpreters’ lives and on their emotional management.The need of verifying the effect of this kind of programs in (...) order to totally measure their impact through the time is discussed. (shrink)

¿Necesitamos representaciones del cuerpo para llevar a cabo actividades como cruzar la calle, montar en bicicleta o salir por la puerta? En este trabajo se defiende la idea de que la ejecución de este tipo de acciones involucra representaciones del cuerpo con contenido no conceptual. Primero se discuten los argumentos en contra de la noción de representación del cuerpo en la acción, para extraer sus principales consecuencias. Se propone una versión delcontenido de las representaciones del cuerpo involucradas en la acción (...) cotidiana, y se finaliza con una discusión acerca de una objeción potencial, y con una reflexión sobre la relación entre contenido conceptual y contenido no conceptual. (shrink)

In the last hundred years -from "Diseaster" of 1898- Spanish philosophy enters in a peculiar crisis. The military defeat and the economic depression do not lead to the Spanish thinkers towards the modernity. They reject the scheme "subject-object" and they looks for the encounter between a radical subjectivity and a transobjetive reality. These common characteristics are in Unamuno, Ortega y Gasset, Zubiri, Millán-Puelles and L. Polo.

From the fifties on, the region of middle Magdalena (Colombia), is going to live some specitic circunstantes that will provide their people with mecanisms in order to resolve a chain of vital contlicts they were involved in. Their voices will sound and will lead us, through their personal stories, to the widest scerie in their region and country. The human experiences that will be exposed here can be considered as "lives in straist". They will be existentes marked by suffering, extreme (...) violente, frighteness in short, but also by generousness and the wish of living with dignity. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Résumé L'article vise à montrer que le langage est intimement lié au monde social et que la clarification d'une telle relation dépend du fait de considérer sur un même plan les énoncés et les actions, ce qui conduit à considérer l'énonciation par le langage comme un type de comportement partagé. Cela signifie que la langue ne sert pas seulement les besoins de la vie sociale en tant que moyen d'intercompréhension. De façon relativement autonome, le langage fonctionne dans des conditions de (...) réalisation qui sont des relations sociales très segmentées et hiérarchisées. L'hypothèse est qu'il est nécessaire, comme point de départ de l'analyse du caractère social du langage, de reconnaître la valeur performative qu'ont les énoncés, du fait qu'ils contiennent, dans le domaine des actes de langage, un certain pouvoir effectif ajusté aux conditions sociales qui détermine leur énonciation. Resumen El artículo tiene el objetivo de mostrar que el lenguaje está íntimamente vinculado con el mundo social y que aclarar tal relación depende de considerar en un mismo plano de dependencia a los enunciados y a las acciones - lo que lleva a considerar al lenguaje como un tipo de comportamiento compartido. Eso quiere decir que el lenguaje no solo sirve a las necesidades de la vida social como medio de intercomprensión. Sobre un fondo relativamente autónomo -caracterizable en las consideraciones sobre los matices semánticos introducidos por las significaciones implícitas- el lenguaje funciona en condiciones de realización que son relaciones sociales altamente segmentadas y jerarquizadas. La hipótesis es que el lenguaje se realiza socialmente en la medida en que facilita a los individuos una forma de contacto. Pero también insistimos en que como punto de partida para el análisis del carácter social del lenguaje es necesario reconocer el valor performativo que tienen los enunciados en cuanto comportan, en el ámbito de los hechos del habla, un cierto poder realizativo ajustado a condiciones sociales que determinan los caminos de tal realización. (shrink)

El artículo busca profundizar en las elaboraciones de Freud respecto de la agresividad y la inconvertibilidad de la violencia, con el objeto de indagar en los posibles aportes que la perspectiva psicoanalítica puede realizar frente a los problemas sociopolíticos contemporáneos. Este trabajo se detiene en las problemáticas referidas a la naturalización de las identidades, la radicalización de las retóricas comunitarias y los escenarios de exclusión. Sostiene, en este sentido, la importancia de los procesos sublimatorios en el trabajo de diferimiento frente (...) al empuje pulsional. (shrink)

Se busca rastrear la imagen que Platón tiene de Heráclito y articularla con la estructura argumentativa del Cratilo, para comprender las necesidades textuales a las que responde la doctrina del flujo perpetuo, es decir, la discusión sobre la corrección (ὀρθότης) del nombre. Gracias a la inclusión del testimonio heraclíteo, resulta posible rastrear la presunta consolidación de la tesis sobre los nombres primarios y los secundarios como el eje de la separación entre dos planos de realidad (uno estable y uno móvil) (...) y de la teoría de las Ideas -es decir, como la base de la epistemología platónica presente en los diálogos de madurez-. The article seeks to trace the image Plato has of Heraclitus and connect it with the argumentative structure of the Cratylus in order to understand the textual needs that give rise to the doctrine of perpetual flux, that is, the discussion regarding the correctness (ὀρθότης) of names. The inclusion of Heraclitus's testimony makes it possible to trace the alleged consolidation of the thesis regarding primary and secondary names as the axis of separation between two levels of reality (one stable, the other, changing) and the theory of Ideas -that is, as the basis of Plato's epistemology as set forth in the late dialogues-. (shrink)

En las últimas décadas, la tendencia a pensar la estética a partir del carácter autónomo de su objeto ha sido dominante en la discusión filosófica alemana. Sin embargo, la crítica a la estética de la autonomía ha cobrado recientemente un nuevo aliento. Uno de los intentos más ambiciosos por destronar la centralidad de este paradigma en la estética actual corresponde al filósofo Georg W. Bertram. El propósito de este artículo es reconstruir la teoría estética de Bertram y exponer cómo ella (...) se inserta en la disciplina estética. Paralelamente, se mostrarán algunas dificultades de la revitalización de una ontología del arte basada en la continuidad entre praxis artística y vida cotidiana. (shrink)

Nota crítica sobre PornoXplotación: la explosión de la gran adicción de nuestros tiempos, de Mabel Lozano y Pablo J. Conellie, Barcelona, Editorial Alrevés, 2020, 286 pp.

Emotional regulation, understood as the skills and strategies needed to influence and/or modify the emotional experiences, has a very remarkable implication within numerous emotional and behavioral disorders in childhood and adolescence. In recent years there has been a significant increase in research on emotional regulation, however, the results are still divergent in terms of differences in emotional regulation in relation to age and gender. This study aimed to assess emotional regulation in adolescents in relation to their age and gender. Two (...) hundred and fifty-four adolescents from eight schools in the Valencian Community and aged between 9 and 16 years participated in the study. The adolescents completed the Cognitive Emotion Regulation Questionnaire and the FEEL-KJ questionnaire. We analyzed the differences in emotional regulation strategies and a latent emotional regulation variable in two age groups (9 to 12 years and 13 to 16 years) and by gender. The results suggested that children and pre-adolescents in the 9-12 year group obtained lower scores in the emotional regulation strategies than the 13-16 year group. Girls reported higher scores on the use of emotional regulation strategies when experiencing sadness, anxiety and anger than boys, and on the overall average of regulation according to these specific emotions. Age, but not gender, had a major effect on scores for the latent variable of emotion regulation. An interaction effect between age and gender was identified in the latent emotion regulation scores. Girls tended to have higher scores than boys when they were younger and lower scores than boys when they were older. These results could be relevant for designing prevention and intervention programs for adolescents and at different ages. (shrink)

La filosofía de la historia de Kant se fundamenta en el concepto de una intención de la naturaleza [ Naturabsicht ]. En este ensayo, presento los diferentes conceptos que Kant tiene de naturaleza para explicar el modo específico en que el individuo participa del desarrollo histórico del género humano. En este sentido intento probar, acudiendo a los opúsculos jurídico políticos de Kant, que el cumplimiento plenode la intención de la naturaleza es posible gracias a los conceptos de antagonismo e Ilustración (...) [ Aufklärung ], y también a la distinción que propongo entre el caráctery la extensiónde esta última. (shrink)

Jon Elster suele considerar su primer libro Leibniz et la formation de l¿esprit capitaliste como algo profundamente vergonzoso. Aquí intentaremos hacer una relectura de él que, a partir de desnudar sus debilidades, haga lucir sus bondades, especialmente para comprender tanto el lugar clave que el libro ocupa dentro de la obra del filósofo noruego, como los elementos del sistema de Leibniz que hicieron posible las conexiones que nos presenta. Dentro de nuestro análisis tendrá un lugar especial la consideración del elemento (...) metodológico central de su texto: la analogía. (shrink)

Atran conjectures that a triggering algorithm for a living- kind module could involve inputs from other modules that detect animacy and intentionality. Here we further speculate about how algorithms for detecting specific intentions could be used to trigger between- or within-species categorization. Such categorization may be adaptively important in Eldredge's energy and information realms.

During the last few months, several pioneer genome‐wide transcriptomic, proteomic and metabolomic studies have revolutionised the understanding of bacterial biological processes, leading to a picture that resembles eukaryotic complexity. Technological advances such as next‐generation high‐throughput sequencing and high‐density oligonucleotide microarrays have allowed the determination, in several bacteria, of the entire boundaries of all expressed transcripts. Consequently, novel RNA‐mediated regulatory mechanisms have been discovered including multifunctional RNAs. Moreover, resolution of bacterial proteome organisation (interactome) and global protein localisation (localizome) have unveiled an (...) unanticipated complexity that highlights the significance of protein multifunctionality and localisation in the cell. Also, analysis of a complete bacterial metabolic network has again revealed a high fraction of multifunctional enzymes and an unexpectedly high level of metabolic responses and adaptation. Altogether, these novel approaches have permitted the deciphering of the entire physiological landscape of one of the smallest bacteria, Mycoplasma pneumoniae. Here, we summarise and discuss recent findings aimed at defining the blueprint of any prokaryote. (shrink)

El presente artículo busca presentar los resultados de un estudio desarrollado entre los años 2011 y 2012 sobre las representaciones sociales y percepciones de los migrantes peruanos acerca de su proceso de integración en Santiago de Chile, particularmente respecto del acceso a los servicios públicos de educación, salud y vivienda. A partir de una metodología cualitativa, estos servicios son puestos bajo la mirada de los discursos de los migrantes peruanos, develando la discriminación de la que son objeto debido a su (...) procedencia nacional, así como otras formas de exclusión derivadas de su origen popular, y retratando a la ciudad de Santiago como un escenario receptor de flujos migratorios internacionales. (shrink)

The possible linkages among liberty and power is a philosophical issue that gets to special important inside to contemporary political philosophy’s context. During this stage, a notion of legitimacy began to develop on which both freedom and power would be sustained, without being justified in a supposed statalist originin. Neither the legitimate power no the legitime freedom come to be backing by the juristic order up in the first instance, inasmuch up its source would be prior. From Foucault and Marcuse (...) outlooks on this issue, it will treat to inquire on the disquisitions that both their ever speeches propose. (shrink)