Conserved upstream open reading frames (uORFs) are found within many eukaryotic transcripts and are known to regulate protein translation. Evidence from genetic and bioinformatic studies implicates disturbed uORF‐mediated translational control in the etiology of human diseases. A genetic mouse model has recently provided proof‐of‐principle support for the physiological relevance of uORF‐mediated translational control in mammals. The targeted disruption of the uORF initiation codon within the transcription factor CCAAT/enhancer binding protein β (C/EBPβ) gene resulted in deregulated C/EBPβ protein isoform expression, associated (...) with defective liver regeneration and impaired osteoclast differentiation. The high prevalence of uORFs in the human transcriptome suggests that intensified search for mutations within 5′ RNA leader regions may reveal a multitude of alterations affecting uORFs, causing pathogenic deregulation of protein expression. (shrink)

The emerging consensus in the philosophy of cognition is that cognition is situated, i.e., dependent upon or co-constituted by the body, the environment, and/or the embodied interaction with it. But what about emotions? If the brain alone cannot do much thinking, can the brain alone do some emoting? If not, what else is needed? Do (some) emotions (sometimes) cross an individual's boundary? If so, what kinds of supra-individual systems can be bearers of affective states, and why? And does that make (...) emotions ?embedded? or ?extended? in the sense cognition is said to be embedded and extended? Section 2 shows why it is important to understand in which sense body, environment, and our embodied interaction with the world contribute to our affective life. Section 3 introduces some key concepts of the debate about situated cognition. Section 4 draws attention to an important disanalogy between cognition and emotion with regard to the role of the body. Section 5 shows under which conditions a contribution by the environment results in non-trivial cases of ?embedded? emotions. Section 6 is concerned with affective phenomena that seem to cross the organismic boundaries of an individual, in particular with the idea that emotions are ?extended? or ?distributed.? (shrink)

Nach einem weit verbreiteten Urteil gibt Kant der Ökonomie in seinem Werk keinen nennenswerten Raum. Die vorliegende Studie widerlegt dies, indem sie Kants Äußerungen zu ökonomischen Themen systematisiert: zur Selbstständigkeit, zum Kaufmann, zum Handel, zum Geld, zur „Staatswirthschaft" sowie zum technischen Fortschritt. Sie erschließt Kants Ökonomie aus der Ergänzung rechtlicher und ethischer Pflichten durch deren anthropologische Ausführungsbedingungen. Dabei geht sie aus von einem zeitgenössischen Verständnis der Ökonomie als Wissenschaft vom Wohlstand. Im deutschsprachigen Raum des 18. Jahrhunderts konkurrieren hier drei Paradigmen (...) miteinander: das aristotelische, das smithianische und das kameralistische. Sie identifizieren jeweils das Haus, den Markt oder den Staat als zentrale Handlungssphäre der Ökonomie. Die Studie kommt zu dem Schluss, dass Kants praktische Philosophie für Ergänzungen aus jeder dieser ökonomischen Handlungssphären offen ist, solange diese freiheitliche Prinzipien erfüllen; sie ist damit nicht, wie gelegentlich behauptet, auf eine einzige Wirtschaftsordnung festgelegt, etwa auf eine rein marktliberale. Relevant ist dies für die Kant-Forschung, für die Wirtschaftsphilosophie sowie für die Ideengeschichte. (shrink)

This article examines for the first time the jihadist global hegemonic masculinity of Osama bin Laden. Based on Bin Laden’s public statements translated into English, the authors examine how in the process of constructing a rationale for violent attacks primarily against the United States, he simultaneously and discursively formulates a jihadist global hegemonic masculinity. The research adds to the growing interest in discursive global hegemonic masculinities, as well as jihadist masculinities in the Middle East, by scrutinizing how Bin Laden’s jihadist (...) global hegemonic masculinity is produced in and through his public statements. The authors close their discussion by demonstrating how Bin Laden’s discursive practices are embedded in a clash of competing global hegemonic masculinities on the world stage. (shrink)

Zusammenfassung Eine Karriere im Hochleistungssport ist mit hohen zeitlichen Belastungen verbunden. Da die Spitzensport- Karriere lebenszeitlich beschränkt ist und in der Regel in der vierten Lebensdekade beendet wird, stellt sich die Frage nach den Auswirkungen eines Engagements im Hochleistungssport auf die Berufskarriere. Hierzu wurden im Rahmen einer quantitativ orientierten Kohortenanalyse ehemalige Spitzensportler zu ihrem beruflichen Werdegang und möglichen Einflussfaktoren des Hochleistungssports retrospektiv befragt. Die Befunde der beiden Teiluntersuchungen zeigen, dass die hohen zeitlichen Anforderungen des Spitzensports den beruflichen Werdegang nur zum (...) Teil beeinträchtigen. Dies gilt nicht nur für sehr erfolgreiche Sportler, sondern auch für Hochleistungssportler, die weniger erfolgreich sind, sowie für Profisportler, die besonders intensiv in das System Hochleistungssport eingebunden sind. Dabei wirken sich Faktoren, wie institutionelle Unterstützungsmaßnahmen, Bekanntheit und soziale Kontakte sowie die Chance im Berufsfeld Spitzensport zu arbeiten, positiv auf die Berufskarriere aus. Allerdings haben sich aufgrund der Professionalisierung des Hochleistungssports die Risiken im kohortenspezifischen Vergleich vergrößert. (shrink)

Das Stichwort der?Narben des Geistes? aus der Phänomenologie des Geistes nutzt die Untersuchung zu einer Kritik Hegels, die ihren Ausgang vom Verhältnis von Geist und Sprache, von Literatur und Philosophie nimmt.Hegels Phänomenologie des Geistes stellt bis heute den umfassendsten Versuch dar, einen für die Moderne gültigen Begriff der Erfahrung zu begründen. Unter dem Stichwort?Narben des Geistes? greift die Untersuchung Hegels Ansatz auf, um ihn zunächst mit literarischen Texten von Sophokles, Diderot und Goethe und in einem zweiten Schritt mit alternativen philosophischen (...) Modellen von Benjamin bis zu Foucault zu konfrontieren. Den Abschluss bildet die Frage nach Erfahrungsbegriffen vor (Montaigne), parallel zu (Hölderlin) und nach Hegels Zeit (Nietzsche). Das Ziel der Untersuchung besteht in einer Kritik des Hegelschen Erfahrungsbegriffs im Blick auf den ästhetischen Diskurs der Moderne. (shrink)

Certification is a crucial part of the organic farming system to protect the integrity of the whole organic sector. Process-oriented on-site auditing by skilled inspectors is the central element of the certification procedure to protect the organic sector against fraud. However, little is known about the role of the inspectors in the certification scheme. In recent years, the requirements and challenges for the organic certification system have changed significantly. The aim of the present study is to get insights into strategies (...) and action patterns used by organic inspectors and thus to better understand their behaviour. Due to the exploratory character of the study, a qualitative approach was chosen. Twenty narrative expert interviews with organic inspectors were conducted. The evaluation was carried out with the narration analysis, which was basis for a typology analysis. The results of the study show that all organic inspectors develop strategies and behavioural patterns, which can be structured in two levels: an interpersonal and a professional level. On the interpersonal level, the results indicate that the inspectors’ behaviour patterns lie between goodwill and demonstration of power. At the professional level, the organic inspectors work with a risk or a checklist-oriented control approach. A risk-oriented control is characterised by the intrinsic motivation of the organic inspector to maintain the integrity of the organic sector. Risk-oriented inspectors set a control focus on the detection of fraud. The aspect of personal ethical involvement and interpersonal actions in control systems should be included when considering improvements in the organic sector. (shrink)

We generalise the concept of clique width to structures of arbitrary signature and cardinality. We present characterisations of clique width in terms of decompositions of a structure and via interpretations in trees. Several model-theoretic properties of clique width are investigated including VC-dimension and preservation of finite clique width under elementary extensions and compactness.

The concept of emergence is widely used in both the philosophy of mind and in cognitive science. In the philosophy of mind it serves to refer to seemingly irreducible phenomena, in cognitive science it is often used to refer to phenomena not explicitly programmed. There is no unique concept of emergence available that serves both purposes.

Several theories of emergence will be distinguished. In particular, these are synchronic, diachronic, and weak versions of emergence. While the weaker theories are compatible with property reductionism, synchronic emergentism and strong versions of diachronic emergentism are not. Synchronice mergentism is of particular interest for the discussion of downward causation. For such a theory, a system's property is taken to be emergent if it is irreducible, i.e., if it is not reductively explainable. Furthermore, we have to distinguish two different types of (...) irreducibility with quite different consequences: If, on the one hand, a system's property is irreducible because of the irreducibility of the system's parts' behavior on which the property supervenes, we seem to have a case of "downward causation". This kind of downward causation does not violate the principle of the causal closure of the physical domain. If, on the other hand, a systemic property is irreducible because it is not exhaustively analyzable in terms of its causal role, downward causation is not implied. Rather, it is dubitable how unanalyzable properties might play any causal role at all. Thus, epiphenomenalism seems to be implied. The failure to keep apart the two kinds of irreducibility has muddled recent debate about the emergence of properties considerably. (shrink)

Two of Heidegger’s most fundamental distinctions, authenticity and inauthenticity, the existential and the existentiell, are motivated by Aristotle’s δύναμισ/ένέργεια distinction. Even the basic concept of truth must be understood in terms of δύναμισj and ένέργεια. Moreover, Heidegger’s existential imperative only becomes fully comprehensible within the Aristotelian context, revealing the intrinsic interrelation of Heidegger’s two distinctions with one another.

A central problem for the international governance of heritable germline gene editing is that there are important differences in attitudes and values as well as ethical and health care considerations around the world. These differences are reflected in a complicated and diverse regulatory landscape. Several publications have discussed whether reproductive uses would be legally permissible in individual countries and whether clinical applications could emerge in the context of regulatory gaps and gray areas. Systematic comparative studies that explore issues related to (...) the governance of this technology from different national and international perspectives are needed to address the lack of knowledge in this area. In this research report, we contribute to filling this gap by presenting views of stakeholders in the United Kingdom on challenges to the governance of heritable genome editing. We present findings from a multistakeholder study conducted in the United Kingdom between October 2016 and January 2018 and funded by the Wellcome Trust. This research included interviews, literature analysis, and a workshop. We involved leading U.K. scientists, in vitro fertilization clinicians, and representatives from regulatory bodies, patient organizations, and other civil societal organizations, as well as fertility companies. Part one of this article explores stakeholder perceptions of possible global developments in heritable genome editing and associated risks and governance challenges. Part two presents a range of policy options that were generated during the workshop in relation to the challenges discussed in part one. (shrink)

Bioethical debates on the use of human embryos and oocytes for stem cell research have often been criticized for the lack of empirical insights into the perceptions and experiences of the women and couples who are asked to donate these tissues in the IVF clinic. Empirical studies that have investigated the attitudes of IVF patients and citizens on the donation of their embryos and oocytes have been scarce and have focused predominantly on the situation in Europe and Australia. This article (...) examines the viewpoints on the donation of embryos for stem cell research among IVF patients and students in China. Research into the perceptions of patients is based on in-depth interviews with IVF patients and IVF clinicians. Research into the attitudes of students is based on a quantitative survey study. The empirical findings in this paper indicate that perceptions of the donation of human embryos for stem cell research in China are far more diverse and complex than has commonly been suggested. Claims that ethical concerns regarding the donation and use of embryos and oocytes for stem cell research are typical for Western societies but absent in China cannot be upheld. The article shows that research into the situated perceptions and cultural specificities of human tissue donation can play a crucial role in the deconstruction of politicized bioethical argumentation and the assumptions about “others” that underlie socio-ethical debates on the moral dilemmas of technology developments in the life sciences. (shrink)

Review by: Achim Blumensath The Bulletin of Symbolic Logic, Volume 19, Issue 3, Page 394-396, September 2013.

The goal of this paper is to examine moods, mostly in comparison to emotions. Nearly all of the features that allegedly distinguish moods from emotions are disputed though. In a first section I comment on duration, intentionality, and cause in more detail, and develop intentionality as the most promising distinguishing characteristic. In a second section I will consider the huge variety of moods, ranging from shallow environmentally triggered transient moods to deep existential moods that last much longer. I will explore (...) what their sources are, and how they impact one another, other affective processes, and our being in the world. I follow several eminent emotion researchers and try to carve out their insights, many seemingly mutually excluding each other. As it will turn out, most of them are, in fact, not excluding each other, but contribute to a layered picture of moods that fits well in between emotions and personality traits. Eventually, I will shortly discuss what we can do with our moods. (shrink)

There is widespread belief among realists that it is consistent to think of the world as a totality of absolute facts and of our representation of the world as perspectival. As a pluralist Michael Lynch has challenged this view by arguing that relativism about representational content en tails relativism about facts. Lynch's 'T-argument' is presented and discussed in detail. It is argued not only that the 'T-argument' fails and that content relativism and fact absolutism are compatible, but also that content (...) absolutism entails fact absolutism. These two points add up to a serious challenge of pluralists in committing them to the view that there are many actual worlds. (shrink)

This book offers a faithful and meticulous reading of Heidegger's magnum opus , Being and Time .

In the second half of the 19th century, pre-Hispanic jade artifacts from Mexico—especially jade celts and votive axes—stood at the center of scholarly debates on the origins of American civilizations. The contradiction between the prevalence of carved jades, on the one hand, and the apparent absence of jade mineral deposits in the Americas, on the other, resuscitated centuries-old theories that placed the beginnings of pre-Hispanic civilizations in China. The increasing availability of Chinese and Mexican jades in the same spaces of (...) commercial exchange, collection, display, and study—following French imperialist interventions in China and Mexico in the 1860s, which resulted in the plunder of a massive number of antiquities; and in a broader context of interest in jade that brought together artifacts from the South Pacific and from Neolithic contexts in Europe—contributed material proof to these theories. The so-called “jade question” was mostly dismissed by the 20th century, but the debates surrounding jade's mineralogical identity and provenance provide insight into the kinds of epistemological configurations, material limitations, and geopolitical arrangements that bore upon the emergence of new disciplines, including mineralogy, archaeology, and prehistory, as well as the new sciences of the pre-Hispanic past. This essay explores these processes and reconstructs the dense networks of private and public institutions, scholars, collectors, dealers, and connoisseurs, that made jade artifacts from Mexico—and Central America—into a scientific, aesthetic, and commercial category. (shrink)

Often, the behavior of animals can be better explained and predicted, it seems, if we ascribe the capacity to have beliefs, intentions, and concepts to them. Whether we really can do so, however, is a debated issue. Particularly, Donald Davidson maintains that there is no basis in fact for ascribing propositional attitudes or concepts to animals. I will consider his and rival views, such as Colin Allen's three-part approach, for determining whether animals possess concepts. To avoid pure theoretical debate, however, (...) I will test these criteria using characteristic examples from ethology that depict a broad range of animal behavior. This will allow us to detect a series of gradations in animals' capacities, in the course of which we can think over what would count for or against an attribution of concepts and propositional attitudes to them in each single case. Self-conceit is our natural hereditary disease. Of all creatures man is the most wretched and fragile, and at once the most supercilious. ... It is by this conceit that man arrogates to himself ... divine properties, that he segregates himself from the mass of other creatures and raises himself above them .. (shrink)

In this paper, we argue that the concept of environmental scaffolding can contribute to a better understanding of our affective life and the complex manners in which it is shaped by environmental entities. In particular, the concept of environmental scaffolding offers a more comprehensive and less controversial framework than the notions of embeddedness and extendedness. We contribute to the literature on situated affectivity by embracing and systematizing the diversity of affective scaffolding. In doing so, we introduce several distinctions that provide (...) classifications of different types of environmentally scaffolded affectivity. Furthermore, we differentiate eight dimensions that allow us to evaluate the quality and effectivity of scaffolds in particular applications. On that basis, we develop a taxonomy using paradigmatic examples of affective scaffolding. This taxonomy enriches the current debate by emphasizing distinctions that are often conflated and by identifying fields of application that are commonly overlooked. (shrink)

According to Kant, the moral worth of an action depends on its maxim. As he explains, particularly in the Groundwork, moral worth accrues to an action when the action rests on a maxim selected for its accordance with the moral law. With respect to Religion, however, Kant modifies his understanding of the moral worth of actions. He now expresses the view that an agent acts morally worthy only if he possesses a moral Gesinnung as a character trait. According to this (...) opinion, only such persons can act in a manner that has moral worth who own a good Gesinnung and seek to express it in their actions. But to be in possession of a good Gesinnung depends, according to Kant, on strict conditions that ordinary actors will not realistically be able to fulfil. This accords with Kant's verdict that moral progress has not yet taken place because the conversion in Gesinnung that it would require is still outstanding. (shrink)

Der Beitrag widmet sich der Bedeutung der Objektwahl in der Literatur. Ausgehend von antiken Bestimmungen der Funktion des Eros bei Hesiod und Platon wendet sich der Aufsatz Freuds Begriff der »Objektwahl« zu, um auf dieser Grundlage drei literarische Texte unterschiedlicher Epochen in den Blick zu nehmen. Shakespeares Komödie »A midsummer night’s dream« liest der Autor als Ausdruck einer verunsichernden Erfahrung von Kontingenz, die das Thema der Liebe zugleich in eine Spannung von Tragödie und Komödie verortet. Goethes Gedicht »Willkommen und Abschied« (...) überführt diese Kontingenz in eine Dialektik von Vereinigung und Trennung, die von narzisstischen Bestimmungen nicht frei bleibt. Michel Houellebecqs Romane stehen dagegen für die resigna­tive Einsicht in das geschichtliche Ende der Objektwahl in Zeiten ein, die wesentlich von ökonomischen Tauschmechanismen bestimmt sind. Inwiefern die spätkapitalistische Ökonomie der Liebe noch mit der Begrifflichkeit Freuds zu fassen ist, muss vor diesem Hintergrund offenbleiben. (shrink)

The invention in 1986 of scanning force microscopy (SFM) provided a new and powerful tool for the investigation of biological structures. SFM yields a three‐dimensional view at nanometer resolution of the surface topography associated with biological objects. The potential for imaging either macromolecules or biomolecules and cells under native (physiological) conditions is currently being exploited to obtain functional information at the molecular level. In addition, the forces involved in individual bimolecular interactions are being assessed under static and dynamic conditions. In (...) this report we focus on the imaging capability of the SFM. The rather broad spectrum of applications represented is intended to orient the prospective user of biological SFM. (shrink)

The concept of self-legislation or autonomy is one of the outstanding innovations of Kant’s ethics. Nevertheless, it should not be ignored that it also builds on previous positions. Even if Kant in the Groundwork classifies all other moral principles as heteronomous, it is important to recognize that Kant incorporates elements of Wolff’s theory of self-legislation and Crusius’ theory of obligation into his theory of autonomy. In this essay, I present the relevant themes in Wolff and Crusius and discuss how they (...) were taken up by Kant in the mid-1780s. (shrink)

Während es im moralisch-politischen Diskurs geradezu unkontrovers ist, dass Toleranz eine eminent wichtige Rolle für ein friedliches Zusammenleben von Menschen in pluralistischen Gesellschaften spielt, ist es alles andere als klar, was Toleranz überhaupt ist. Insbesondere die häufig anzutreffende Auffassung, dass es ‚Paradoxien‘ der Toleranz gäbe, sowie die in der Literatur immer von Neuem auftauchende Vexierfrage, ob Toleranz auch den Feinden der Toleranz gelten kann oder muss, sind deutliche Anzeichen dafür, dass es kein stabiles Verständnis der Natur dieser Einstellung gibt. Das (...) Problem ist nicht zuletzt ein methodologisches. Ich stelle zunächst einige Adäquatheitsbedingungen für eine Theorie der Toleranz auf, und argumentiere dann, dass eine Theorie der Toleranz als eine moralpsychologische Theorie vom normativen Begriff der Tolerierbarkeit frei zu halten ist. Nach der hier vorgeschlagenen Theorie besteht das Herzstück der Toleranz in einer verhaltenswirksamen Kontrolle moralischer Aversionen. Diese Theorie erfüllt die Adäquatheitsbedingungen für Theorien der Toleranz und wird von ihnen sogar erzwungen. Auf der Grundlage der erzielten Ergebnisse, erläutere ich dann Sinn und Rechtfertigung der Toleranzforderung und skizziere ihren Ort innerhalb der Ethik. (shrink)

Aiming for applications in monadic second-order model theory, we study first-order theories without definable pairing functions. Our main results concern forking-properties of sequences of indiscernibles. These turn out to be very well-behaved for the theories under consideration.

This paper revisits the often debated question Can machines think? It is argued that the usual identification of machines with the notion of algorithm has been both counter-intuitive and counter-productive. This is based on the fact that the notion of algorithm just requires an algorithm to contain a finite but arbitrary number of rules. It is argued that intuitively people tend to think of an algorithm to have a rather limited number of rules. The paper will further propose a modification (...) of the above mentioned explication of the notion of machines by quantifying the length of an algorithm. Based on that it appears possible to reconcile the opposing views on the topic, which people have been arguing about for more than half a century. (shrink)