This paper is truly a joint effort and it could not have been written without the contribution of both authors. Garson, though, deserves credit (or blame) for first seeing the need for two kinds of quantifier scope, and also for devising essentials of the positive theory.

DBS Think Tank IX was held on August 25–27, 2021 in Orlando FL with US based participants largely in person and overseas participants joining by video conferencing technology. The DBS Think Tank was founded in 2012 and provides an open platform where clinicians, engineers and researchers can freely discuss current and emerging deep brain stimulation technologies as well as the logistical and ethical issues facing the field. The consensus among the DBS Think Tank IX speakers was that DBS expanded in (...) its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. After collectively sharing our experiences, it was estimated that globally more than 230,000 DBS devices have been implanted for neurological and neuropsychiatric disorders. As such, this year’s meeting was focused on advances in the following areas: neuromodulation in Europe, Asia and Australia; cutting-edge technologies, neuroethics, interventional psychiatry, adaptive DBS, neuromodulation for pain, network neuromodulation for epilepsy and neuromodulation for traumatic brain injury. (shrink)

The notions of “narrated time” and “narrative identity” have become, in less than three decades, commonplaces, not only for philosophers, but also for psychologists and ethicists. This would be welcomed, if only it were not used nowadays in what must be called a new dogmatic way. Now, Paul Ricœur indeed asserted, in various ways, the wealth of the notion of narrative; but he also readily acknowleged its limits – aren’t these limits those of hermeneutics itself? Normal 0 false false false (...) EN-US JA X-NONE. (shrink)

L’ontologie heideggérienne de l’être-pour-la-mort a souvent servi de référence négative à Paul Ricœur. Il lui a très tôt opposé trois thèses qu’il n’aurait peut-être pas formulées s’il n’avait pas croisé la philosophie de Jaspers : a) « La naissance signifie plus que la mort » ; b) « la rencontre décisive avec la mort est la mort de l’être aimé » ; c) « la mortalité elle-même doit être pensée sub specie vitae et non sub specie mortis ». La première (...) thèse conditionne les deux suivantes. Elle introduit une phénoménologie de l’ « être-en-vie » qui en appelle de la vie reçue à la vie transmise. On objectera peut-être que la phénoménologie de l’être-en-vie suppose l’ontologie de l’être-pour-la-mort. Mais, même si c’était le cas, elle n’en transformerait pas moins profondément la signification. La compréhension de l’existence est affectée elle-même par les phénomènes de la vie reçue et transmise. C’est ce que veut dire cette expression : « exister vivant ». L’angoisse de la fin n’annule pas la joie des commencements. Peut-être même reçoit-elle de celle-ci son sens.Paul Ricoeur has often referred to Heidegger’s ontology of being-towards-death to oppose it. He early set against it three thesis that he might have formulated differently had he not studied Jasper’s philosophy : a) « birth means more than death » ; b) « the decisive encounter with death is the death of the loved one » ; c) « mortality itself must be thought sub specie vitae, not sub specie mortis ». From the first thesis, can be inferred the two others. It brings in a phenomenology of being-alive. One may raise the objection that the phenomenology of being-alive presupposes the ontology of being-towards-death. But even so it would be necessarily transform its meaning. The understanding of existence is itself affected by the phenomena of life as given and received. Such is the meaning of the phrase : « existing alive ». The distress of the end never cancels the joy of the beginnings. It may even get its sense from it. (shrink)

The double membrane of the nuclear envelope is a formidable barrier separating the nucleus and cytoplasm of eukaryotic cells. However, movement of specific macromolecules across the nuclear envelope is critical for embryonic development, cell growth and differentiation. Transfer of molecules between the nucleus and cytoplasm occurs through the aqueous channel formed by the nuclear pore complex (NPC)Abbreviations: NPC, nuclear pore complex; GlcNac, N‐acetylglucosamine; WGA, wheat germ agglutinin. Although small molecules may simply diffuse across the NPC, transport of large proteins and (...) RNA requires specific transport signals and is energy dependent. A family of pore glycoproteins modified by O‐linked N‐acetylglucosamine moieties are essential for transport through the NPC. Recent evidence suggests that the regulation of nuclear transport may also involve the inteaction of RNA and nuclear proteins with specific binding proteins that recognize these transport signals. Are these nuclear pore glycoproteins and signal binding proteins the ‘gatekeepers’ that control access to the genetic material? Recent evidence obtained from a combination of biochemical and genetic approaches suggests – perhaps. (shrink)

The pore‐forming BCL‐2 family proteins are effectors of mitochondrial poration in apoptosis initiation. Two atypical effectors—BOK and truncated BID (tBID)—join the canonical effectors BAK and BAX. Gene knockout revealed developmental phenotypes in the absence the effectors, supporting their roles in vivo. During apoptosis effectors are activated and change shape from dormant monomers to dynamic oligomers that associate with and permeabilize mitochondria. BID is activated by proteolysis, BOK accumulates on inhibition of its degradation by the E3 ligase gp78, while BAK and (...) BAX undergo direct activation by BH3‐only initiators, autoactivation, and crossactivation. Except tBID, effector oligomers on the mitochondria appear as arcs and rings in super‐resolution microscopy images. The BH3‐in‐groove dimers of BAK and BAX, the tBID monomers, and uncharacterized BOK species are the putative building blocks of apoptotic pores. Effectors interact with lipids and bilayers but the mechanism of membrane poration remains elusive. I discuss effector‐mediated mitochondrial poration. (shrink)

The relationship between kinetochores and nuclear pore complexes (NPCs) is intimate but poorly understood. Several NPC components and associated proteins are relocated to mitotic kinetochores to assist in different activities that ensure faithful chromosome segregation. Such is the case of the Mad1‐c‐Mad2 complex, the catalytic core of the spindle assembly checkpoint (SAC), a surveillance pathway that delays anaphase until all kinetochores are attached to spindle microtubules. Mad1‐c‐Mad2 is recruited to discrete domains of unattached kinetochores from where it promotes the rate‐limiting (...) step in the assembly of anaphase‐inhibitory complexes. SAC proficiency further requires Mad1‐c‐Mad2 to be anchored at NPCs during interphase. However, the mechanistic relevance of this arrangement for SAC function remains ill‐defined. Recent studies uncover the molecular underpinnings that coordinate the release of Mad1‐c‐Mad2 from NPCs with its prompt recruitment to kinetochores. Here, current knowledge on Mad1‐c‐Mad2 function and spatiotemporal regulation is reviewed and the critical questions that remain unanswered are highlighted. (shrink)

In most of the more lively fields of physical enquiry in the first three decades of the seventeenth century, a striking contrast may be observed between the antiquity of the problems attacked, and the innovatory procedures applied to solve them. None of these questions, inherited from a past now remote, seemed more pressing than the time-honoured controversy of the plenum versus the vacuum, especially as the concept of the atomic structure of matter was so closely associated with the existence of (...) the void. The more one studies the arguments produced at that time, the more one will be impressed with the value and importance, for the vacuists and the atomists, of the Pneumatics of Hero of Alexandria. When we read Galileo's explanation of combustion, “the extremely fine particles of fire, penetrating the narrow pores of the metal would fill the minute intervening vacuum, and would set free these minute particles from the forced attraction which these same vacua exert’, we can hear clear echoes of Hero's account of disseminated micro-vacua. Now Hero's work is clearly divided into two sections: a theoretical preface and a collection of 78 “pneumatic devices”. One might be tempted to claim that he, rather than his fellow-atomist Lucretius, inspired the first tentative syntheses of seventeenth-century atomism but it would still be necessary to agree that his chief contributions to the achievements of that generation lie in the experimental techniques which they derived from his instrumentation. Were it not for the popularity of his pneumatic demonstrations, he could never have won such a great reputation as a natural philosopher. Without that reputation, his opinions on this topic would not have been valued as almost equal to those of the mighty Aristotle, especially since he was so decidedly in the minority. (shrink)

In a number of membrane-bound viruses, ion channels are formed by integral membrane proteins. These channel proteins include M2 from influenza A, NB from influenza B, and, possibly, Vpu from HIV-1. M2 is important in facilitating uncoating of the influenza A viral genome and is the target of amantadine, an anti-influenza drug. The biological roles of NB and Vpu are less certain. In all cases, the protein contains a single transmembrane α-helix close to its N-terminus. Channels can be formed by (...) homo-oligomerization of these proteins, yielding bundles of transmembrane helices that span the membrane and surround a central ion-permeable pore. Molecular modeling may be used to integrate and interpret available experimental data concerning the structure of such transmembrane pores. This has proved successful for the M2 channel domain, where two independently derived models are in agreement with one another, and with solid-state nuclear magnetic resonance (NMR) data. Simulations based on channel models may yield insights into possible ion conduction and selectivity mechanisms. BioEssays 20:992–1000, 1998. © 1998 John Wiley & Sons, Inc. (shrink)

This specimen of a forthcoming book on the void in ancient natural philosophy by using an example illustrates the problems that confront the scholar. The term εὐτονία, used by Chrysippus, occurs in the Pneumatics of Hero of Alexandria in connection with empty pores. Has he borrowed the notion from Stoic philosophy, or was Strato of Lampsacus, older than Chrysippus, the first to use it? In all probability it was Ctesibius who independently of Stoic philosophy applied the term to account for (...) the kinetic qualities of the material used for his inventions, and Philo Byzantius took over the notion from him. Hero may have derived it from Ctesibius either directly or via Philo. (shrink)

Many pigmented heterokonts are able to synthesize elements of their cell walls (the frustules) of dense biogenic silica. These include diatom algae, which occupy a significant place in the biosphere. The siliceous frustules of diatoms have species‐specific patterns of surface structures between 10 and a few hundred nanometers. The present review considers possible mechanisms of uptake of silicic acid from the aquatic environment, its transport across the plasmalemma, and intracellular transport and deposition of silica inside the specialized Silica Deposition Vesicle (...) (SDV) where elements of the new frustule are formed. It is proposed that a complex of silicic acid with positively charged proteins silaffins and polypropylamines remains a homogeneous solution during the intracellular transport to SDV, where biogenic silica precipitates. The high density of the deposited biogenic silica may be due to removal of water from the SDV by aquaporins followed by syneresis—a process during which pore water is expelled from the network of the contracting gel. The pattern of aquaporins in the silicalemma, the membrane embracing the SDV, can determine the pattern of species‐specific siliceous nanostructures. BioEssays 30:328–337, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Abstract This paper examines a fundamental, though relatively understudied, aspect of the physical theory of the physician Asclepiades of Bithynia, namely his doctrine of pores. My principal thesis is that this doctrine is dependent on a conception of void taken directly from Epicurean physics. The paper falls into two parts: the first half addresses the evidence for the presence of void in Asclepiades' theory, and concludes that his conception of void was basically that of Epicurus; the second half focuses on (...) the precise nature of Asclepiadean pores, and seeks to show that they represent void interstices between the primary particles of matter which are the constituents of the human body, and are thus exactly analogous to the void interstices between atoms within solid objects in Epicurus' theory. (shrink)

Mit diesem Band legt Ernst A. Schmidt seine Forschungen über 'das Leere' in Antike und Früher Neuzeit vor. Schmidt behandelt zunächst die Atomistik von Leukipp bis Lukrez, die Porentheorie von Empedokles bis Heron von Alexandria sowie die Theorie des Philoponos. Dem schliesst sich eine Untersuchung zur Rezeption der antiken Konzepte in der fru·hneuzeitlichen Physik (Galilei, Gassendi, Henry More) an. Im Anhang bringt Schmidt eine kritische Darstellung des antiken Atomismus in drei Texten des 18. Jahrhunderts, bei Polignac, Wieland und Le Sage. (...) Es gibt bislang keine vergleichbar umfassende und quellengesättigte Arbeit zum Thema. Wer sich für 'das Leere' interessiert oder nach Quellen sucht, wird von Schmidt bestens versorgt. In this book Ernst A. Schmidt, emeritus of Classical Philology at Tübingen University, presents his research on the subject of "the void" in antiquity and early modern times. Schmidt first deals with atomistics from Leucipp to Lucretius, the pore theory from Empedocles to Heron of Alexandria, and the theory of Philoponos. This is followed by an investigation of the reception of ancient concepts in early modern physics (Galileo, Gassendi, Henry More). In an appendix the author offers a critical account of ancient atomism in three texts from the 18th century by Polignac, Wieland and Le Sage. There is no comparably comprehensive and source-saturated work on the subject to date. Anyone interested in "the void" or looking for sources will be well served by Schmidt. (shrink)

The crystal δ‐endotoxins of Bacillus thuringiensis (Bt) are a family of insecticidal proteins which have been known for some time to kill insects by lysing their gut epithelial cells, but the precise molecular mechanism of toxicity has remained elusive. The recent publication of the crystal structure of a Bt δ‐endotoxin has made it possible for us to model the molecular events that occur as the toxin binds to its receptor and inserts into the membrane to form a pore. Using our (...) knowledge of insect gut physiology, we can also predict the effect on the insect of the formation of a toxic pore. We present a new model to explain the events that occur in the insect gut during toxin action. (shrink)

The human immune system can directly lyse invading micro‐organisms and aberrant host cells by generating pores in the cell envelope, called membrane attack complexes (MACs). Recent studies using single‐particle cryoelectron microscopy have revealed that the MAC is an asymmetric, flexible pore and have provided a structural basis on how the MAC ruptures single lipid membranes. Despite these insights, it remains unclear how the MAC ruptures the composite cell envelope of Gram‐negative bacteria. Recent functional studies on Gram‐negative bacteria elucidate that local (...) assembly of MAC pores by surface‐bound C5 convertase enzymes is essential to stably insert these pores into the bacterial outer membrane (OM). These convertase‐generated MAC pores can subsequently efficiently damage the bacterial inner membrane (IM), which is essential for bacterial killing. This review summarizes these recent insights of MAC assembly and discusses how MAC pores kill Gram‐negative bacteria. Furthermore, this review elaborates on how MAC‐dependent OM damage could lead to IM destabilization, which is currently not well understood. A better understanding on how MAC pores kill bacteria could facilitate the future development of novel strategies to treat infections with Gram‐negative bacteria. (shrink)

SummaryMuch excitement surrounded the proposal that a family of endo‐lysosomal channels, the two‐pore channels (TPCs) were the long sought after targets of the Ca2+‐mobilising messenger, nicotinic acid adenine dinucleotide phosphate (NAADP). However, the role of TPCs in NAADP signalling may be more complex than originally envisaged. First, NAADP may not bind directly to TPCs but via an accessory protein. Second, two papers recently challenged the notion that TPCs are NAADP‐regulated Ca2+ channels by suggesting that they are highly selective Na+ channels (...) regulated by the lipid phosphatidylinositol 3,5‐bisphosphate and by ATP. This paper aims critically to evaluate the evidence for TPCs as NAADP targets and to discuss how the new findings fit in with what we know about endo‐lysosomal Ca2+ stores. (shrink)

Transport through the nuclear pore complex (NPC), a keystone of the eukaryotic building plan, is known to involve a large channel and an abundance of phenylalanine–glycine (FG) protein domains serving as binding sites for soluble nuclear transport receptors and their cargo complexes. However, the conformation of the FG domains in vivo, their arrangement in relation to the transport channel and their function(s) in transport are still vividly debated. Here, we revisit a number of representative transport models—specifically Brownian affinity gating, selective (...) phase gating, reversible FG domain collapse, and reduction of dimensionality (ROD)—in the light of new data obtained by optical single transporter recording, optical superresolution microscopy, artificial nanopores, and many other techniques. The analysis suggests that a properly adapted, simplified version of the ROD model accounts well for the available data. This has implications for nucleocytoplasmic transport in general. (shrink)

The nuclear pore complex (NPC) is emerging as a center for recruitment of a class of “difficult to repair” lesions such as double‐strand breaks without a repair template and eroded telomeres in telomerase‐deficient cells. In addition to such pathological situations, a recent study by Su and colleagues shows that also physiological threats to genome integrity such as DNA secondary structure‐forming triplet repeat sequences relocalize to the NPC during DNA replication. Mutants that fail to reposition the triplet repeat locus to the (...) NPC cause repeat instability. Here, we review the types of DNA lesions that relocalize to the NPC, the putative mechanisms of relocalization, and the types of recombinational repair that are stimulated by the NPC, and present a model for NPC‐facilitated repair. (shrink)

Membrane damage induced by haemolytic agents does not necessarily lead to lysis: the pores that are formed at low concentration of agent are formed at low concentration of agent are not large enough to allow leakage of cytoplasmic proteins, and in many instances the lesions become repaired with time. Quite different agents induce a similar type of lesion: in each case leakage is reduced at low ionic strenth, and is prevented by divalent cations such as Ca2+ or Zn2+, suggesting a (...) possible therapeutic approach to the containment of several membrane‐damaging diseases. (shrink)

Ion channels are transport proteins present in the lipid bilayers of biological membranes. They are involved in many physiological processes, such as the generation of nerve impulses, hormonal secretion, and heartbeat. Conformational changes in the ion channel-forming protein allow the opening or closing of pores to control the ionic flux through the cell membranes. The opening and closing of the ion channel have been classically treated as a random kinetic process, known as a Markov process. Here the time the channel (...) remains in a given state is assumed to be independent of the condition it had in the previous state. More recently, however, several studies have shown that this process is not random but a deterministic one, where both the open and closed dwell-times and the ionic current flowing through the channel are history-dependent. This property is called long memory or long-range correlation. However, there is still much controversy regarding how this memory originates, which region of the channel is responsible for this property, and which models could best reproduce the memory effect. In this article, we provide a review of what is, where it is, its possible origin, and the mathematical methods used to analyze the long-term memory present in the kinetic process of ion channels. (shrink)

Six years ago, the Singer lab published a landmark paper which described how individual mRNA particles cross the nuclear pore complex in mammalian tissue culture cells. This involved the simultaneous imaging of mRNAs, each labeled by a large number of tethered fluorescent proteins and fluorescently tagged nuclear pore components. Now two groups have applied this technique to the budding yeast Saccharomyces cerevisiae. Their results indicate that in the course of nuclear export, mRNAs likely engage complexes that are present on either (...) side of the pore and that these interactions are modulated by proteins present in the messenger ribonucleoprotein (mRNP) complex. These findings lend support to the notion that just before and/or after the completion of nuclear export, mRNPs undergo one or more maturation steps that prepare the packaged mRNAs for translation. These results represent new and exciting insights into the mechanism of mRNA nuclear export. (shrink)

The nuclear export of mRNA through the nuclear pore complex (NPC) is a process required for the healthy functioning of human cells, making it a critical area of research. However, the geometries of mRNA and the NPC are well below the diffraction limit of light microscopy, thereby presenting significant challenges in evaluating the discrete interactions and dynamics involved in mRNA nuclear export through the native NPC. Recent advances in biotechnology and single‐molecule super‐resolution light microscopy have enabled researchers to gain granular (...) insight into the specific contributions made by discrete nucleoporins in the nuclear basket of the NPC to the export of mRNA. Specifically, by expanding upon the docking step facilitated by the protein TPR in the nuclear basket as well as identifying NUP153 as being the primary nuclear basket protein initiating export through the central channel of the NPC. (shrink)

In eukaryotic cells the nucleus and its contents are separated from the cytoplasm by the nuclear envelope. Macromolecules, as well as smaller molecules and ions, can cross the nuclear envelope through the nuclear pore complex. Molecules greater than approx. 60 kDa and containing a nuclear localization signal are actively transported across the nuclear membranes, but there has been little evidence for regulatory mechanisms for smaller molecules and ions. Recently, diffusion across the nuclear envelope has been observed to be regulated by (...) nuclear cisternal Ca2+ concentrations. Following depletion of Ca2+ from the nuclear store by inositol 1,4,5‐trisphosphate or Ca2+ chelators, a fluorescent 10 kDa marker molecule was no longer able to enter the nucleus. Distinct conformational states of the nuclear pore complexes depended on the Ca2+ filling state of the nuclear envelope, supporting the assumption that a switch in the conformation of the nuclear pore complex may control the transport of intermediate‐sized molecules across the nuclear envelope. Thus nuclear Ca2+ stores may regulate the conformational state of the nuclear pore complex, and thereby passive diffusion of molecules between the cytosol and the nucleoplasm. The physiological significance of this finding is currently unknown. (shrink)

Este artigo explora a dialogicidade do objeto da Estética Peirciana. Seguindo Herbart, o pragmaticista americano, em seu relato mais maduro (1911), concebe a Estética como uma ciência que lida com os dois tipos de τὸ καλόν, a saber, com a nobreza da conduta (realizada na ação) e com a beleza sensual (experimentada na arte natureza), embora predilete sistematicamente pela primeira, isto é, pelo estudo das condições da imaginação de um fim último admirável em si mesmo (considerando assim o fim esteticamente (...) em sua primeiridade, como uma qualidade possível) e que é pressuposto no estudo das condições de sua atualização como summum bonum (considerando assim o fim eticamente em sua segundidade, como norma que fundamenta relações diádicas de conformidade de conduta autocontrolada a ele). Como a (des)aprovação estética dos fins revela o fundamento último de imaginar a unidade de uma possível identidade prática, a Estética revela as condições de uma liberdade interior que torna a conduta autogovernada possível em primeiro lugar; não, porém, como dado transcendental, mas como resultado de práticas pedagógicas (Seção I). Em seguida, analisamos como a dialogicidade estética se origina da postura de primeira pessoa da questão fundamental que ela faz: “[O] que estou procurando?” (II.1); diferenciamos os partidos, fases e pressupostos dessa dialogicidade (II.2), e analisamos o papel de um ideal – em sua concretização metodológica como hábito de se sentir “crescido sob a influência de um curso de autocrítica e de heterocríticas” – joga pela causalidade semiótica envolvida na formação da conduta (II.3). (shrink)

Ductin is the highest conserved membrane protein yet found in eukaryotes. It is multifunctional, being the subunit c or proteolipid component of the vacuolar H+‐ATPase and at the same time the protein component of a form of gap junction in metazoan animals. Analysis of its structure shows it to be a tandem repeat of two 8‐kDa domains derived from the subunit c of the F0 proton pore from the F1F0 ATPase. Each domain contains two transmembrane α‐helices, which together may form (...) a four‐helix bundle. In both the V‐ATPase and gap junction channel, ductin is probably arranged as a hexamer of subunits forming a central channel of gap junction‐like proportions. The two functions appear to be seggregated by ductin having two orientations in the bilayer. Ductin is also the major component of the mediatophore, a protein complex which may aid in the release of neurotransmitters across the pre‐synaptic membrane. It is also a target for a class of poorly understood viral polypeptides. These polypeptides are small and highly hydrophobic and some have oncogenic activity. Ductin thus appears to be at the crossroads of a number of biological processes. (shrink)

Resumo: O artigo apresenta os traços fundamentais que permeiam as categorias Trabalho e Formação Humana na Ontologia do ser social de Lukács. Para alcançar tal objetivo, é necessário debruçar-se sobre os nódulos internos que permeiam a atividade sensível do ser, que, ao longo da história, acumula na prática as condições que possibilitam o ser orgânico realizar o salto ontológico em direção a constituir-se como ser social. Verifica-se, ainda, que a capacidade teleológica dos indivíduos sociais está subordinada ao trabalho humano. No (...) desenvolvimento social, é possível apreender a teleologia de segunda ordem, que pese, a capacidade de um ou mais indivíduos sociais influenciarem a maioria ou parte do ser social em desempenhar pores teleológicos não elaborados por eles. Os elementos práticos remetem à ampliação do trabalho como ontogênese de toda a práxis social. Por fim, pretende-se expor o processo de autoconstituição material e histórica do ser social e sua gênese no trabalho. Palavras-chave: Trabalho; Ontologia do ser social; Formação humana; Teleologia; Práxis social. Ontological priority of labor in György Lukács Abstract: The article presents the fundamental characteristics that permeate the categories Labor and Human Formation in Lukács’ Ontology of the social being. In order to do this, it is necessary to focus on the internal nodes pervading the human being’s sensitive activity which, throughout history, in practice provides the conditions that allow the organic being to make the ontological leap toward becoming a social being. It is also noted that the teleological capacity of social individuals is subordinated to human work. In social development, it is possible to understand secondary teleology, that measures the ability of one or more social individuals to influence most or part of the social being to carry out teleological positings they have not produced themselves. The practical elements refer to the expansion of labor as ontogenesis of social praxis as a whole. Finally, the article will discuss the process of material and historical self-constitution of the social being and its genesis in labour. Verifica-se, ainda, que a capacidade teleológica dos indivíduos sociais está subordinada ao trabalho humano Key-words: Labor; Ontology of the social being; Human formation; Teleology; Social praxis. La prioridad ontológica del trabajo en György Lukács Resumen: El artículo presenta los raResumosgos fundamentales que impregnan las categorías Trabajo y Formación humana en la ontología del ser social de Lukács. Para lograr este objetivo, es necesario centrarse en los nodos internos que impregnan la actividad sensible del ser, que, a lo largo de la historia, acumula en la práctica, las condiciones que permiten al ser orgánico dar el salto ontológico para constituirse, cómo ser social. También se verifica, parece que la capacidad teleológica de los individuos sociales está subordinada al trabajo humano. En el desarrollo social, es posible aprehender la teleología de segundo orden, a pesar de la capacidad de uno o más individuos sociales para influir en la mayoría o parte del ser social para realizar poros teleológicos no elaborados por ellos. Los elementos prácticos se refieren a la expansión del trabajo como ontogénesis de toda praxis social. Finalmente, se pretende exponer el proceso de autoconstitución material e histórica del ser social y su génesis en el trabajo. Palabras clave: Trabajo; Ontología del ser social; Formación humana; Teleología; Praxis social. Data de registro: 23/03/2023 Data de aceite: 10/07/2023. (shrink)

Língua : "majestosamente bela, porém sempre imperfeita" -- Tradução : atravessando abismos -- Pós-história : articular o inarticulável -- A tradução na sociedade pós-histórica.

In lieu of an abstract, here is a brief excerpt of the content: -/- I gathered it in my hands as it fell from my hair-brush, too saturated to hold anymore. It felt as if I were inside a movie and waiting for someone to yell “Cut!” but no call came. It continued to fall, feather-like onto the ground, individual strands glinting in the light of the bathroom window. My hair, nearly all of it, was gone. Between the time of (...) my heart transplant and the moment my hair began to fall out, I arguably had suffered enough. Transplant brought four open-heart surgeries, ten days on ECMO, an intra-aortic balloon pump, delirium, necrotizing pneumonia, and so much muscular atrophy that I had to re-learn how to walk. CPR, broken ribs, and the scar of a tricuspid clip from a botched biopsy: it was not the miracle I was hoping for. The internal trauma had certainly taken its toll. I no longer knew how I really felt, thanks to copious pain meds that altered my mind and body. Each limb was foreign as I re-acclimated to how one grabs hold of a cup, signs their name, touches their legs. Externally, I was a mess: covered in deep purple bruises across my torso from the diabetes treatments, dead skin pooling in unwashed pores, my ankles swollen and indiscernible from my legs. But lacking a good mirror (or the desire to find one), I still felt like “myself” during my forty-five day hospital stay. I could feel my cheekbones protruding from thinning skin, saw through unfocused eyes from the tempestuous blood sugars, and my hair sat in a rat’s nest atop my head; but I was still me. -/- Arriving home, I felt like a newborn being brought into the real world for the first time. I needed help with everything—showers, sitting up, putting on shoes, even going to the bathroom. At age twenty-four, I felt I had regressed to the point of no return as I relied on others to do the simplest tasks. In addition, I was quarantined inside for three months, due to the risk of obtaining a fungal infection from the outside. Caged, and alone in my body, I a trapped and wounded tiger: angry, hurting, and scared. [End Page 109]When I had been prepared for transplant—and I use “prepared” loosely because the information packet I was handed was insulting at best—I knew to expect the scars. I had no issue with that, having been cut open at my throat and chest for previous surgeries. I knew to expect a 12-inch line from neck to navel: the most evident sign I would now carry that I was disabled. -/- What I did not expect were the bullet holes— the sealed entrances of thick chest tubes that now dotted my lower torso. I did not anticipate the bruises on my arms and groin from arterial pokes. I felt violated as if I had walked into some kind of abduction and was rolled out, beaten, bruised, and, worst, touched. But it wasn’t the physical trauma that hurt the most. It was that no one seemed surprised. Immediately after transplant, the team’s focus is purely on survival. Survive the 30 days post-surgery. Survive the year. Metrics, uncomfortably tied to transplant center success statistics, funding, and clout have little to do with the patients themselves. What did I care to only survive a year? I wanted years. I wanted decades. It felt I wanted more than anyone was willing to pay attention to. -/- The conversation was narrowed to high-risk issues: infection, rejection, or other life-threatening conditions. While this makes sense on a clinical level, what constitutes a major event for a clinician may not be of the same emotional value to the patient. In my case, I was less occupied by how the steroids were working and more obsessed with their side effects, such as how much weight I was rapidly gaining. I walked into the clinic one day with the beginnings of stretch marks and a week later had claw-like ripples down my sides. My mood swings were explosive... (shrink)

Diverse micro‐organisms populate a global deep biosphere hosted by rocks and sediments beneath land and sea, containing more biomass than any other biome except forests. This paper reviews an emerging palaeobiological archive of these dark habitats: microfossils preserved in ancient pores and fractures in the crust. This archive, seemingly dominated by mineralized filaments (although rods and coccoids are also reported), is presently far too sparsely sampled and poorly understood to reveal trends in the abundance, distribution, or diversity of deep life (...) through time. New research is called for to establish the nature and extent of the fossil record of Earth's deep biosphere by combining systematic exploration, rigorous microanalysis, and experimental studies of both microbial preservation and the formation of abiotic pseudofossils within the crust. It is concluded that the fossil record of Earth's largest microbial habitat may still have much to tell us about the history of life, the evolution of biogeochemical cycles, and the search for life on Mars. (shrink)

Pretende-se nesse artigo confrontar as posições de Theodor Adorno e Friedrich Hegel acerca da concepção de progresso, inferidas do rearranjo adorniano das categorias de particular e universal, que depreendem da filosofia hegeliana. O propósito é expor a crítica de Adorno, formulada na Dialética negativa, à noção de Hegel de que o curso da história universal é a realização efetiva do progresso do espírito do mundo em suas figuras particulares. Para tanto, o particular e o universal serão tomados como categorias explicativas (...) da crítica adorniana à totalidade e à sistematicidade, no intuito de realocar o particular no interior da dialética, enfatizando seu caráter não identitário e resistente à sistematicidade e às formas de totalidade com pretensões universalizantes; em seguida, evocar-se-á os elementos da filosofia da história de Walter Benjamin presentes no pensamento de Adorno, para que, por fim, se sustente a hipótese de que a marcha do espírito condiz menos com o progresso, porém, muito mais com a regressão, o que ocorre na medida em que o progresso se serve de uma narrativa que oblitera a violência e a dominação do universal sobre o particular, ao ocultar as contradições deflagradas no contexto da marcha da história do espírito do mundo. (shrink)

Although the capacity to infect non-dividing cells is a hallmark of lentiviruses, nuclear import is still barely understood. More than 100 research papers have been dedicated to this topic during the last 15 years, yet, more questions have been raised than answers. The signal-facilitating translocation of the viral preintegration complex (PIC) through the nuclear pore complex (NPC) remains unknown. It is clear, however, that nuclear import is the result of a complex interplay between viral and cellular components. In this review, (...) we discuss the current knowledge on nuclear import. We focus on the controversies and pitfalls and discuss the interplay between virus and host. (shrink)

A curious irony hangs over the two similes of the lantern and the clepsydra which Empedocles used to describe his theories of seeing and breathing. Similes were a feature of Empedocles' style, and it is clear that on these two in particular he has lavished considerable care. They have been preserved in their entirety, as almost the longest continuous quotations which Aristotle makes from any author. Despite such auspicious beginnings, these two similes have proved peculiarly resistant to modern attempts at (...) interpretation. The reason for this, I shall try to show, is that certain features in the two similes took on a spurious significance as a result of Plato's remodelling of Empedocles' theories. Difficulties of interpretation have been caused by trying to read back these innovations of Platonic theory into details of the similes that in their original context were fortuitous and inessential.In Plato vision occurs when fire leaves the eye and joins fire outside to form a single compacted body, along which movements from the visible object are communicated as sensations to the eye.According to Theophrastus, Empedocles explained vision as the result of effluences which are given off from objects and enter the appropriate pores of the eye. Dark effluences enter the watery pores of the eyes, and bright effluences enter the fiery pores of the eye. As I have tried to show in an earlier article, Empedocles distinguished good and bad vision, by day and by night, for eyes with a predominance of fire and for eyes with a predominance of water. Good vision results when the dark and light elements which enter the eye are equally balanced. Poor vision results either when there is too much fire in the eye, so that we are dazzled, or when there is too much water in the eye, so that our vision is dimmed. In the whole of his detailed and one would have thought exhaustive account, Theophrastus says nothing about fire leaving the eye as a factor in the act of vision. (shrink)

A marked feature of eukaryotic programmed cell death is an early drop in mitochondrial transmembrane potential. This results from the opening of permeability transition pores, which are composed of adenine nucleotide translocators and mitochondrial porins. The latter share striking similarites with bacterial porins, (including down‐regulation of their pore size by purine nucleotides), suggesting a common origin. The porins of some invasive bacteria play a crucial role during their accommodation inside the host cell and this co‐existence resembles the endosymbiotic origin of (...) mitochondria. The above observations suggest that early in eukaryotic evolution, former invaders may have used porin‐type channels to enter their host and to induce its death when the levels of its cytoplasmic purine nucleotides were dropped. The appearance of adenosine nucleotide translocators in the primitive eukaryotes, which permitted usage of the oxidative metabolism of the invaders, provided the basis for the permeability transition phenomena, now linked to the apoptotic process. Bcl‐2‐type molecules, being able to modulate the permeability transition pores by interaction with adenosine nucleotide translocators, may have played an essential role in conferring a means of controlling apoptosis. (shrink)

The immediacy of daily encounters with gender roles, as well as the specific features of authoritarian mediation in their social shaping, make an analysis of gendered social interaction indispensable. In this paper the analysis is centered on the concept of social character, with special emphasis on authoritarianism as a continuous determinant of the transformation of natural sex into social construct of gender. It is precisely the authoritarian personality type that is the basis for alienated gender, dominated by sexism, a?natural? belonging (...) to the private or the public sphere of social life, suppression of individual human capacities, and reduction of choice. After a review of the theoretical conceptions of social character and authoritarianism, a historical-comparative analysis of authoritarianism is offered, where the latter is seen as an element of the social character within the perspective of the typology traditional - modern - postmodern society. It is argued in conclusion that, in spite of certain emancipatory achievements, men and women still tend to escape into the security of authoritarian alienation. Feminist theory remains a basic source for reflecting on these processes; therefore the author pleads for a wider acceptance of feminist insights as contributions to establishing a postmodern, interpretive?sociology in a new key?. Analiza drustvene interakcije medju polovima nametnuta je neposrednoscu svakodnevnog susretanja sa polnim ulogama, kao i specificnostima autoritarnog posredovanja u drustvenom uoblicavanju tih uloga. U ovom radu, analiza je organizovana oko pojma drustvenog karaktera, pri cemu se poseban naglasak stavlja na autoritarnost kao kontinuiranu determinantu preobrazaja prirodnog pola u drustveno konstruisanu kategoriju roda. Upravo je autoritarni tip licnosti podloga za otudjenu polnost, u kojoj dominiraju seksizam,?prirodno? pripadanje privatnoj ili javnoj sferi drustvenog zivota, suzbijanje individualnih ljudskih potencijala i suzavanje mogucnosti izbora. Posle pregleda teorijskih koncepcija drustvenog karaktera i pojma autoritarnosti, nudi se istorijsko-uporedna analiza prisustva autoritarnosti kao elementa drustvenog karaktera iz perspektive tipologije tradicionalno - moderno - postmoderno drustvo. Zakljucuje se da, i pored izvesnog ostvarenog emancipacijskog hoda, muskarci i zene jos uvek teze bekstvu u sigurnost autoritarne otudjenosti. Feministicka teorija ostaje nezaobilazna osnova za promisljanje ovih procesa, te se pledira za sire usvajanje feministickih uvida kao doprinosa oblikovanju jedne postmoderne, razumevajuce?sociologije u novome kljucu?. (shrink)

The paper pores over the recent conceptions of normative judgement developed against the background of advances in psychology and neuroscience. It begins by analyzing what normative claim of morality and law consists of before presenting and criticizing the Social Intuitionist Model of normative judgement developed by Jonathan Haidt. The model poses serious challenges for well-established normative concepts, and the concept of normativity as objective reason for action in particular. A question is asked of what the relationship between philosophical conceptions and (...) the findings of neuroscience should be. The conclusion is that, in the face of new scientific facts, philosophers have no choice but to carefully revise their conceptual schemes. (shrink)

Joaquim de Fiore acusou Pedro Lombardo da heresia quaternarista e não muito tempo depois foi condenado por triteísmo no IV Concílio Lateranense de 1215. O erro do abade foi o de ter afirmado a unidade trinitária por colectividade. A historiografia mantém ainda a hipótese de que esse erro possa ter tido origem na doutrina herética de Gilberto de la Porée. Porém, ao relacionar o Abade de Fiore e o Abade de Claraval torna-se difícil manter tal hipótese. Difícil será também (...) continuar a aceitar como equivocada a afirmação de tal tipo de unidade trinitária. Não obstante, ainda que parte do problema se resolva na relação entre os dois abades, é preciso ter presente que a via mística proposta por eles é diferente. Um segue a via do conhecimento e da ascensão espiritual colectiva. O outro segue a via da vontade e do êxtase individual. /// Joachim of Fiore accused Peter Lombard of the "quaternary" heresy only to be later himself condemned for tritheism at the Fourth Lateran Council (1215 A. D.). The Abbot's error was to affirm the trinitary unity by means of the collective. The historiography still sustains the hypothesis that this error originated in the heretical doctrine of Gilbert de la Poree. However, it is difficult to keep such hypothesis when we relate the Abbot of Fiore and the Abbot of Clairvaux. Also difficult will be to persevere accepting as equivocated the affirmation of such Trinitarian unity. What is more, even if part of the problem can be solved by relating both abbots, it is necessary to understand that the mystical way proposed by each of them is quite different. One follows the way of knowledge and of the collective spiritual ascension while the other follows the way of the will and of individual ecstasy. (shrink)

ABSTRACT This article explores the discursive configuration of paid work by Greek employees, shedding light to the symbolic pores they mobilize in order to craft its meaning as well as to the micro- and macrosocial implications of their argumentation strategies. Building upon a social constructionist epistemology, 22 in-depth, semi-structured interviews were conducted and analyzed using tools and techniques provided by critical approaches to discourse analysis. The ‘school’, the ‘journey’, and the ‘slavery’ repertoires, as I named them, were the three discursive (...) patterns identified, each one grounded in different assumptions about the social universe and thus legitimizing or challenging the hegemonic fixations of the meaning of work. (shrink)

The cyclic GMP-gated channel responds to changes in free intracellular cGMP, and as a result, it plays a central role in the phototransduction process in rod and cone photoreceptor cells. Recent biochemical, immunochemical, and molecular biology studies indicate that this channel consists of a complex of two distinct subunits and one or more associated proteins. Primary structural analysis indicates that the a and (3 subunits contain a cGMP-binding domain, an even number of membrane-spanning segments, a voltage sensor motif and a (...) pore region. The latter two features are found in voltage-gated channels and suggest that these two classes of channels have evolved from the same ancestral channel protein. A working model for the membrane topography of the channel subunits is proposed based on immunogold labeling studies and sequence analysis. Recent studies also indicate that calmodulin binds to the 240 kDa protein of the channel complex and modulates the sensitivity of the channel for cGMP in a Ca2+-dependent manner. The molecular properties of the channel complex and the possible role of Ca2+-calmodulin modulation of the channel during photoactivation and photorecovery are discussed in relation to the current mechanism of phototransduction in photoreceptor cells. (shrink)

Nuclear pore complexes mediate and control transport between the cytosol and the nucleus. They form a highly selective and, thus, tight nuclear barrier between these compartments. The nuclear barrier provides the cell with the opportunity to control access to its DNA, a defining feature of eukaryotes. The tightness of the nuclear barrier is therefore physiologically pivotal and any remarkable change in its structure and permeability can prove pathophysiological, e.g. as a result of viral attack. However, there is accumulating evidence that (...) nuclear barrier structure and permeability are highly responsive to hydrophobic cargos of crucial physiological and therapeutic relevance, glucocorticoids (steroid hormones). The present review highlights the glucocorticoid‐induced effects on the nuclear barrier structure and permeability concluding that they are physiologically essential to mediate glucocorticoid action. BioEssays 28: 935–942, 2006. © 2006 Wiley periodicals, Inc. (shrink)

With a profound cultural crystalization, China was one of the first countries to brew wine in the world. As a Cultural carrier, wine ever performed the functions of religion, literature, art, and entertainment. To have a deep understanding of Chinese extensive and profound culture, it is necessary to pore over Chinese ancient wine’s various functions.

In a number of membrane-bound viruses, ion channels are formed by integral membrane proteins. These channel proteins include M2 from influenza A, NB from influenza B, and, possibly, Vpu from HIV-1. M2 is important in facilitating uncoating of the influenza A viral genome and is the target of amantadine, an anti-influenza drug. The biological roles of NB and Vpu are less certain. In all cases, the protein contains a single transmembrane α-helix close to its N-terminus. Channels can be formed by (...) homo-oligomerization of these proteins, yielding bundles of transmembrane helices that span the membrane and surround a central ion-permeable pore. Molecular modeling may be used to integrate and interpret available experimental data concerning the structure of such transmembrane pores. This has proved successful for the M2 channel domain, where two independently derived models are in agreement with one another, and with solid-state nuclear magnetic resonance (NMR) data. Simulations based on channel models may yield insights into possible ion conduction and selectivity mechanisms. BioEssays 20:992–1000, 1998. © 1998 John Wiley & Sons, Inc. (shrink)

Chromosomes are not only carriers of the genetic material, but also actively regulate the assembly of complex intracellular architectures. During mitosis, chromosome‐induced microtubule polymerisation ensures spindle assembly in cells without centrosomes and plays a supportive role in centrosome‐containing cells. Chromosomal signals also mediate post‐mitotic nuclear envelope (NE) re‐formation. Recent studies using novel approaches to manipulate histones in oocytes, where functions can be analysed in the absence of transcription, have established that nucleosomes, but not DNA alone, mediate the chromosomal regulation of (...) spindle assembly and NE formation. Both processes require the generation of RanGTP by RCC1 recruited to nucleosomes but nucleosomes also acquire cell cycle stage specific regulators, Aurora B in mitosis and ELYS, the initiator of nuclear pore complex assembly, at mitotic exit. Here, we review the mechanisms by which nucleosomes control assembly and functions of the spindle and the NE, and discuss their implications for genome maintenance. (shrink)

A partir da segunda metade do século XX, medicina e psiquiatria, em Europa e Estados Unidos, se dedicaram a descobrir a ‘verdade’ da transexualidade. Conceituou-se a transexualidade como uma categoria diagnóstica, em detrimento de um pressuposto ideal de corpo e sexualidade. Assim, a nomeação do corpo ideal se deu alinhada à noção de Eu moderno, natural, pré-discursivo, ao passo que o corpo trans se transformou em Outro. É no sentido da desnaturalização que emerge o conceito de cisgeneridade, fora das academias (...) e a despeito de suas normativas. No Brasil, essa emergência se dá por conta dos movimentos transfeministas. A cisgeneridade se esconde por trás do que Viviane Vergueiro designa como “silêncio descritivo”: enquanto nomeia o Outro, o Eu se camufla por trás desse silêncio como uma natureza não-nomeada, porém continuamente reiterada. Ao ser designada enquanto tal, a cisgeneridade acadêmica comumente se recusa a reconhecer sua própria nomeação. Pretendo, como objetivo geral, relacionar as noções de silêncio descritivo, nomeação e autoridade científica, para sustentar três linhas argumentativas – a saber: que não há pré-discursividade; que a recusa em reconhecer a nomeação da norma denota a fragilidade das dicotomias entre o normal e o patológico; que a linguagem, por uma perspectiva [trans-]anarquista, é uma ferramenta disruptiva no próprio ato de nomear a norma. Como metodologia, mobilizo discussão bibliográfica entre autores anarquistas e críticos da modernidade/colonialidade. (shrink)

A particle of molecular dimensions which can exist in two states is associated with a membrane pore through which molecules of a gas can pass. The gas molecules from two identical phases on either side of the membrane may pass only when the particle is in one particular state. If certain restrictions are imposed on the system, then the particle appears to act like a Maxwell's Demon(1) which “handles” the gas molecules during their passage through the pore.

A case study in historical cognitive science, this paper addresses two claims made by radical proponents of new dynamical approaches. It queries their historical narrative, which sees embodied, situated cognition as correcting an individualist, atemporal framework originating in Descartes. In fact, new Descartes scholarship shows that 17th-century animal spirits neurophysiology realized a recognizably distributed model of memory; explicit representations are patterns of spirit flow, and memory traces are changes left by experience in connections between brain pores. This historical sketch supports (...) the second dynamicist claim, that connectionists' stress on the cognitive importance of pattern-recreation needs supplementing by dynamicists' real-time focus and attention to the active roles of body and environment. Animal spirits theory exhibits just the 'continuous reciprocal causation' between brain, body, and environment which Andy Clark sees as dynamicism's central contribution, and allows for the embedding of brains in culture as well as the physical world. (shrink)

Stomata are microscopic pores on the surface of land plants used for gas and water vapor exchange. A pair of highly specialized guard cells surround the pore and adjust pore size. Studies in Arabidopsis have revealed that cell–cell communication is essential to coordinate the asymmetric cell divisions required for proper stomatal patterning. Initial research in this area identified signaling molecules that negatively regulate stomatal differentiation. However, genes promoting cell‐fate transition leading to mature guard cells remained elusive. Now, three closely related (...) basic helix–loop–helix (bHLH) proteins, SPEECHLESS, MUTE and FAMA have been identified as positive regulators that direct three consecutive cell‐fate decisions during stomatal development. The identification of these genes opens a new direction to investigate the evolution of stomatal development and the conserved functions of bHLH proteins in cell type differentiation adopted by plants and animals. BioEssays 29:861–870, 2007. © 2007 Wiley Periodicals, Inc. (shrink)