The Committee on Common Problems of Genetics, Paleontology, and Systematics (United States National Research Council) marks part of a critical transition in American evolutionary studies. Launched in 1942 to facilitate cross-training between genetics and paleontology, the Committee was also designed to amplify paleontologist voices in modern studies of evolutionary processes. During coincidental absences of founders George Gaylord Simpson and Theodosius Dobzhansky, an opportunistic Ernst Mayr moved into the project's leadership. Mayr used the opportunity for programmatic reforms he had been pursuing (...) elsewhere for more than a decade. These are evident in the Bulletins he distributed under Committee auspices. In his brief tenure as Committee leader, Mayr gained his first substantial foothold within the coalescing community infrastructure of evolutionary studies. Carrying this momentum forward led Mayr directly into the project to launch the journal Evolution. The sociology of interdisciplinary activity provides useful tools for understanding the Committee's value in the broad sweep of change in evolutionary studies during the synthesis period. (shrink)

This paper is interested in the interdisciplinary characteristics of European integration studies. It explores how the institutional and intellectual, internal and external boundaries of this interdisciplinary field are shaped. For this purpose, it discusses two interlocking dynamics that are most important: on the one hand, the European Union actively attempts to mobilise European integration studies to contribute to building a united Europe by providing specific spaces, resources, and infrastructures for academic research and the public dissemination of results. On the (...) other hand, the external and internal boundaries of this interdisciplinary field are shaped by the movements and interactions of scholars from different academic backgrounds. Together, the different academic strands and policies coproduce the interdisciplinary field of European integration studies. Suggesting avenues for future research, the conclusion recommends analysing key debates in the context of European integration in terms of boundary objects around which academics, policy-makers, and publics can engage with each other and points to specific sites for further observations of these processes of coproduction. (shrink)

A naturalistic impulse has taken speculative analytic metaphysics in its critical sights. Importantly, the claim that it is desirable or requisite to give metaphysics scientific moorings rests on underlying epistemological assumptions or principles. If the naturalistic impulse toward metaphysics is to be well-founded and its prescriptions to have normative force, those assumptions or principles should be spelled out and justified. In short, advocates of naturalized or scientific metaphysics require epistemic infrastructure. This paper begins to supply it. The author first sketches (...) her conception of suitably naturalized or scientific metaphysics. She then lays out a number of candidate epistemic principles centring around the notion of theoretical constraint. The author offers several arguments for the principles, based on statistical likeliness, agreement, falsity avoidance, and methodological efficiency and inefficiency. Finally, she shows how scientific metaphysics satisfies the epistemic principles and is therefore preferable to its traditional rivals. (shrink)

Proponents of engineering and design approaches to biology aim to make interdisciplinary bioscience research faster and more reproducible. This paper outlines and deploys a practice-based approach to analyses of infrastructure that focuses on the routine epistemic activities and charts how two such routines are unsettled and resettled in the background of epistemic culture. This paper describes attempts to bring about new research infrastructures in synthetic biology using robotics and software-enabled design. A focus on the skills of pipetting shows how (...) established manual labor has to be reconfigured to fit with novel robotic automations. An analysis of curating frozen materials shows that automated design presents new problems for the established activities of storing and retrieving biological materials. These movements, while transient, have implications for organizing interdisciplinary collaboration, research productivity, and enabling greater reproducibility. This paper explores the idea of infrastructure as practice and shows how this has important implications for studies of research infrastructures. This article discusses the main contributions of this approach for analysts of infrastructure in terms of movements, temporalities, and ethics and offers suggestions for what the research implies for synthetic biology. (shrink)

ArgumentIn the United States, scientific knowledge is brought before the courts by way of testimony – the testimony of scientific experts. We argue that this expertise is best understoodfirstas related to the quality of the underlying scienceand thenin terms of who delivers it. Bloodstain pattern analysis (BPA), a contemporary forensic science, serves as the vaulting point for our exploration of objectivity as a metric for the quality of a science in judicial contexts. We argue that BPA fails to meet the (...) minimal standard set by Helen Longino’s social-procedural account of objectivity (1990, 2002). In light of some pressing issues for social-procedural accounts, we offer an infrastructural account of objectivity. This account offers what amounts to a friendly amendment to Longino’s account and adds to the ways in which we might analyze social-procedural objectivity. Finally, we address an issue that is pressing in the legal context: given that scientific knowledge is delivered by individuals, not communities, at least in U.S. courts, we (may) need a way to evaluate individual scientific and epistemic agents. We suggest a means for making this evaluation that is derived from our infrastructural account of objectivity. (shrink)

Markets allow for the processing of decentralized information through the price mechanism. But in addition, many markets rely on other mechanisms in markets, or non-market institutions, that provide and manage other forms of knowledge. Within national economies, these institutions form an ‘epistemic infrastructure’ for markets. In global markets, in contrast, this epistemic infrastructure is very patchy, undermining the preconditions for morally responsible agency. New technologies might help to improve the epistemic infrastructure of global markets, but they require conceptualizing knowledge not (...) only as a tradable good, but also as a precondition of morally responsible agency. (shrink)

The agencies of the government of the United States of America, such as the Food and Drug Administration or the Environmental Protection Agency, intervene in American society through the collection, processing, and diffusion of information. The Presidency of Barack Obama was notable for updating and redesigning the US government’s information infrastructure. The White House enhanced mass consultation through open government and big data initiatives to evaluate policy effectiveness, and it launched new ways of communicating with the citizenry. In this essay (...) we argue that these programs spelled out an emergent epistemology based on two assumptions: dispersed knowledge and a critique of judgment. These programs have redefined the evidence required to justify and design regulatory policy and conferred authority to a new kind of expert, which we call epistemic consultants. (shrink)

Statistics circulate with ambivalence in governance settings and mass publics—both extolled as authoritative knowledge and the object of distrustful scrutiny. In the field of human rights activism, where the means to create authoritative knowledge operates asymmetrically between activists, organizations, and state actors, this makes statistical production and circulation subject to an intense politics of knowledge. LGBTI human rights actors in Brazil, for instance, constantly produce numbers that endeavor to make homophobia and transphobia epistemically and affectively real to various audiences. From (...) community surveys of personal experiences of violence or discrimination, to civil society reports of homicides, to federal government reports from human rights hotline complaints, LGBTI activists are awash in figures where they find themselves the producers, consumers, and subject material of such data. This article documents how activists and civil servants count violence, constructing homophobia and transphobia as knowable objects. These counting practices emerge from activists’ counterpublic circulations of knowledge about objects as well as epistemic infrastructures (police, journalistic coverage, hotlines) through which LGBTI peoples’ experience becomes refracted. Aware of these complications, activists deploy epistemic doubt and affective certainty to the field of statistics—utilizing the knowledge they offer while questioning whether violence can be measured at all. (shrink)

In this paper, we tell the story of efforts currently underway, on diverse fronts, to build digital knowledge repositories to support research in the life sciences. If successful, knowledge bases will be part of a new knowledge infrastructure—capable of facilitating ever-more comprehensive, computational models of biological systems. Such an infrastructure would, however, represent a sea-change in the technological management and manipulation of complex data, inducing a generational shift in how questions are asked and answered and results published and circulated. Integrating (...) such knowledge bases into the daily workflow of the lab thus destabilizes a number of well-established habits which biologists rely on to ensure the quality of the knowledge they produce, evaluate, communicate and exploit. As the story we tell here shows, such destabilization introduces a situation of unfamiliarity, one that carries with it epistemic risks. It should elicit—to use Niklas Luhmann’s terms—the question of trust: a shared recognition that the reliability of research practices is being risked, but that such a risk is worth taking in view of what may be gained. And yet, the problem of trust is being unexpectedly silenced. How that silencing has come about, why it matters, and what might yet be done forms the heart of this paper. (shrink)

The status of laws of nature has been the locus of a lively debate in recent philosophy. Most participants have assumed laws play an important role in science and metaphysics while seeking their objective ground in the natural world, though some skeptics have questioned this assumption. So-called Humeans look to base laws on actual, particular facts such as those specified in David Lewis’s Humean mosaic. Their opponents argue that such a basis is neither necessary nor sufficient to support the independent (...) existence of scientific laws. This essentially metaphysical debate has paid scant attention to the details of scientific practice. It has mostly focused on so-called fundamental laws, assumed to take a particular form. I propose a pragmatist alternative—not as another position in the debate but as an alternative to the debate itself. This pragmatist alternative offers a view that questions the representational conception of truth presupposed by participants to the debate as well as the metaphysical import of fundamental laws. Statements of law serve many different purposes in science: I’ll look at some. But their central role is in inference, primarily to improve the epistemic state of a scientist with limited access to information. To play this role, a scientific law statement need be neither necessary, unconditionally universal nor even true. It must merely be sufficiently reliable within its domain of application. The use of laws in astrophysics and metrology will help to illustrate these points. (shrink)

When infrastructural technology is functioning correctly, it is often considered to recede from view and become invisible. According to this perspective, visibility is restored in cases of breakdown and malfunction, which for this reason, are often understood to represent important epistemic opportunities for grasping previously hidden aspects of infrastructure. This article seeks to outline the limitations of the idea that infrastructural failure has a positive epistemic function by distinguishing between two fundamentally different ways in which the nature of technological function (...) can be conceptualised; the first understands function as stemming primarily from the way a technology was designed and produced, the second as a process sustained by constant human activities of maintenance and repair. After illustrating how a number of recent studies of infrastructure build upon insights granted by the latter process perspective, this article aims to demonstrate how the experience of breakdown itself does little to facilitate a shift towards understanding infrastructure in this way. For this reason, this article ends with a suggestion for a shift in emphasis in studies of infrastructure, away from breakdown and towards a sustained examination of everyday practices of maintenance, repair and modification of infrastructural technologies. (shrink)

Traditionally, the field of science and technology studies (STS) considered the scientific laboratory as the central site of knowledge production and technological development. While providing rich analyses of the social construction of scientific knowledge and the role of non-human actors, STS scholars have often neglected the university – the very context in which laboratories themselves are embedded – as a relevant object of research. In this paper, we argue for re-introducing the university as a relevant category and object of analysis (...) by using the notion of epistemic virtues to link epistemic culture – traditionally the focus of STS – and epistemic structure – traditionally the focus of higher education studies. Advancing this line of argumentation, we make three analytical moves. First, we explore academic freedom as a specific version of negative liberty that extends beyond disciplinary boundaries. We suggest that academics continuously negotiate academic freedom considering culturally and socially situated epistemic virtues such as objectivity and neutrality. Second, we introduce the notion of humility to revisit scientific knowledge production more generally and academic freedom in particular. Finally, we argue that practicing humility leads to enacting the university as an infrastructure of becoming otherwise, thereby enriching our understanding of universities as distinct and highly complex social spaces with a logic of their own. (shrink)

Well before the COVID-19 pandemic, proponents of digital psychiatry were touting the promise of various digital tools and techniques to revolutionize mental healthcare. As social distancing and its knock-on effects have strained existing mental health infrastructures, calls have grown louder for implementing various digital mental health solutions at scale. Decisions made today will shape the future of mental healthcare for the foreseeable future. We argue that bioethicists are uniquely positioned to cut through the hype surrounding digital mental health, which (...) can obscure crucial ethical and epistemic gaps that ought to be considered by policymakers before committing to a digital psychiatric future. Here, we describe four such gaps: The evidence gap, the inequality gap, the prediction-intervention gap, and the safety gap. (shrink)

In this chapter I offer a critique of the received way of thinking about responsibility for collective inaction and propose an alternative approach that takes as its point of departure the epistemic agency exhibited by people navigating impossible situations together. One such situation is becoming increasingly common in the context of climate change: so-called “natural” disasters wreaking havoc on communities—flooding homes, collapsing infrastructures, and straining the capacities of existing organizations to safeguard lives and livelihoods. What happens when philosophical reflection (...) begins here—in places where the institutions and practices that have emerged over the last century seem incapable of addressing the problems communities face now, and where people find themselves turning to one another for the sake of their own survival? (shrink)

This paper is divided into two parts. In Section 1, I explore and defend a “regulative view” of folk-psychology as against the “standard view”. On the regulative view, folk-psychology is conceptualized in fundamentally interpersonal terms as a “mind-making” practice through which we come to form and regulate our minds in accordance with a rich array of socially shared and socially maintained sense-making norms. It is not, as the standard view maintains, simply an epistemic capacity for coming to know about the (...) mental states and dispositions already there. Importantly, the regulative view can meet and beat the standard at its own epistemic game. But it also does more. In Section 2, I show how the regulative view makes progress on two other problems that remain puzzling on the standard view: the problem of “first-person authority” – accounting for the special features of self-knowledge; and the problem of “reactive.. (shrink)

In 1864, the first living Mexican axolotls were brought from Mexico to Paris. On arrival, the 34 animals were divided up between the two zoos in Paris, the Ménagerie of the Muséum d'Histoire naturelle and the Jardin d'acclimatation. From there, the animals and their descendants spread around the world as zoo and laboratory specimens, as well as pets. Today, a population of hundreds of thousands of axolotls live in aquariums, zoos, and laboratories around the globe. The fate of the axolotls (...) in the Ménagerie and their subsequent proliferation open a unique window into the culture and practices of keeping unknown animals in Europe in the 19th century, and their relation to experimental zoology. During the early years, the challenges were to keep the axolotls alive and to bring them to reproduction. The surprising transformation of some of these normally aquatic animals into a land-dwelling form prompted further investigations of their living conditions and mode of reproduction. The example of the axolotl offers a detailed look into the practices of handling unknown species, the ways in which this handling became research, and the kinds of knowledge produced in this context. I pay particular attention to the role of the animal keepers and the infrastructures, and the ways in which practical knowledge about the animals' living conditions triggered experimental research. (shrink)

In this article, we discuss the practice of conducting research in one's own field, in this case, from a position as a researcher with a nursing background doing fieldwork in a hospital and in one's own organization, an orthopedic surgical department. We show how an “insider” researcher position paves the way for analytical insights about sleep as an institutional phenomenon in the orthopedic surgical infrastructure and how acute and elective patient trajectories differ but build on the same logic, creating the (...) same dynamics of inclusion and exclusion. Through a situated and sociomaterial perspective, we analyze different clinical interactions in which we follow the hospital bed as an example of a central relational element that co‐creates sleep as an institutional phenomenon. Inspired by Karen Barad, we demonstrate how to move diffractively when doing and analyzing fieldwork and argue how moving diffractively as a researcher doing fieldwork “at home” is productive and challenges the concept and demand of “distance” as the phenomenological exercise in fieldwork. (shrink)

Drug discovery traditionally has occurred behind closed doors in for-profit corporations hoping to develop best-selling medicines that recoup initial research investment, sustain marketing infrastructures, and pass on healthy returns to shareholders. Only corporate Pharma has the man- and purchasing-power to synthesize the thousands of molecules needed to find a new drug and to conduct the clinical trials that will make the drug legal. Against this view, individual physician-scientists have suggested that the promise of applied genomics work calls for a (...) new form of social organization in order to speed the generation and understanding of new therapeutics. Recent successes in open source drug discovery show it is possible to produce valuable, empirically adequate, and sustainable collective beliefs without secrecy, proprietary attitudes, initial cooperation from Pharma, or outsized monetary incentives. After reviewing and differentiating these successes, I diagnose the source of this healthy new epistemic strategy. (shrink)

In recent years, we have witnessed increased interest in alternatives to the dominant corporate social media sites, such as Facebook, Twitter (now X), and TikTok. Tired of disinformation, harassment, privacy violations, and the general degradation of platforms, users and technologists have looked for non-corporate alternatives. Not-for-profit social media platforms emerging from free/libre and open-source software (FLOSS) communities based on non-centralized infrastructure have emerged as promising alternatives. For applied epistemology of the internet, these alternative social media platforms present an opportunity to (...) study different ways of producing knowledge together online. This paper evaluates the epistemic potential for such alternative, non-corporate social media. I present an epistemological framework for analyzing the epistemic promises and perils of alternative social media. Then I apply this framework to the case of Mastodon, a federated, open-source microblogging platform. Mastodon’s structure and culture of openness present opportunities to avoid many of the epistemic perils of biased and untrustworthy large corporate platforms. However, Mastodon’s risks include techno-elitism, white ignorance, and isolated, epistemically toxic communities. (shrink)

In this third paper in a series of four, we explore some ways of doing education differently. An education that moves beyond the persistent failures and irredeemable injustices of modern mass schooling episteme. The episteme for education we adumbrate – an episteme of life continuance – begins with a recognition of interdependency and the value of diversity, diverse knowledges and relations of tolerance. We propose an escape from the extinction ethics which modern schools perpetuate and a new grammar of living (...) in which education and politics are processes of re-learning, co-learning, decision taking, limit testing, and conflict resolution in relation to an uncertain future. To achieve this, we outline a set of open and ‘unplanned’ commoning activities that would take place within local social infrastructures focused on re-politising learning itself and practicing the care of oneself, others, community and the environment. The proposal for a different education as common(ing) activities undertaken within social infrastructures, is about reimagining political and environmental relations, and co-creating a sense of collective ownership of and responsibility for the environment. A form of community that it is practical, rather than utopian, and that would be both the means and ends for such an education. (shrink)

in a nervous system of a given species. This chapter provides a critical perspective on the role of connectomes in neuroscientific practice and asks how the connectomic approach fits into a larger context in which network thinking permeates technology, infrastructure, social life, and the economy. In the first part of this chapter, we argue that, seen from the perspective of ongoing research, the notion of connectomes as “complete descriptions” is misguided. Our argument combines Rachel Ankeny’s analysis of neuroanatomical wiring diagrams (...) as “descriptive models” with Hans-Joerg Rheinberger’s notion of “epistemic objects,” i.e., targets of research that are still partially unknown. Combining these aspects we conclude that connectomes are constitutively epistemic objects: there just is no way to turn them into permanent and complete technical standards because the possibilities to map connection properties under different modeling assumptions are potentially inexhaustible. In the second part of the chapter, we use this understanding of connectomes as constitutively epistemic objects in order to critically assess the historical and political dimensions of current neuroscientific research. We argue that connectomics shows how the notion of the “brain as a network” has become the dominant metaphor of contemporary brain research. We further point out that this metaphor shares (potentially problematic) affinities to the form of contemporary “network societies.” We close by pointing out how the relation between connectomes and networks in society could be used in a more fruitful manner. (shrink)

Dominant forms of contemporary big-data based digital citizen science do not question the institutional divide between qualified experts and lay-persons. In our paper, we turn to the historical case of a large-scale amateur project on biogeographical birdwatching in the late nineteenth and early twentieth century to show that networked amateur research can operate in a more autonomous mode. This mode depends on certain cultural values, the constitution of specific knowledge objects, and the design of self-governed infrastructures. We conclude by (...) arguing that the contemporary quest for autonomous citizen science is part of a broader discourse on the autonomy of scientific research in general. Just as the actors in our historical case positioned themselves against the elitism of gentlemen scientists, avant-garde groups of the twenty first century like biohackers and civic tech enthusiasts position themselves against the system of professional science—while “digital citizen science” remains to oscillate between claims for autonomy and realities of heteronomy, constantly reaffirming the classic lay-expert divide. (shrink)

There Are No Facts examines the uncommon ground we share in a post-truth world. It unpacks how attentive algorithms and extractive data practices are shaping space, influencing behavior and colonizing everyday life. Articulating post-truth territory as an architectural and infrastructural condition, it shows how these spatial architectures of attention and datamining are in turn situated within broader histories of empiricism, objectivity, science, colonialism and perception. These entanglements of people and data, code and space, knowledge and power are considered across scales (...) ranging from the trans-locality of the home to the planetary extent of the COVID-19 pandemic, with stops along the way at the corner bodega, a neighborhood for the proverbial 1%, a waterfront district in Toronto, and a national election. Through an introduction, nine chapters and a coda, the book addresses the erosion of a common ground on which truth claims were once negotiated and the epistemic fragmentation that results. It probes how these socio-technical systems bracket what we know about the world, how they construe our agency to act within it, and how they shape these spaces that, in turn, shape us. (shrink)

Integrity is often conceived as a moral virtue that pertains to the coherence between one’s moral convictions and actions, as well as consistency in convictions over time. By contrast, I argue that integrity is primarily an epistemic virtue. To act with integrity, an individual or organisation must engage in responsible inquiry; that is, the collection, processing, sharing, and storage of information in ways that promote truth. Organisational structures such as division of labour and hierarchy present challenges to responsible inquiry, thereby (...) making epistemic integrity in organisations inherently vulnerable and increasing the risk of unintentional unethical behaviour. This epistemic perspective on organisational integrity emphasises the importance of developing virtuous epistemic infrastructure and an ethical epistemic culture. By aligning their beliefs with facts, organisations can also improve moral behaviour and reduce the risk of culpable ignorance. (shrink)

Evidence-based medicine has been studied as a rich and diverse set of epistemic and infrastructural practices that relate imperfect medical knowledges to complex clinical practices. We examine instances of medical decision-making where medical professionals relate recommendations from clinical practice guidelines to individual patient characteristics when deciding to prescribe implantable cardioverter defibrillators to treat heart failure. When connecting evidence-based recommendations to decisions about individual patients, we find that clinical deliberations invoke different times, such as linear, chronological time, and biological aging, as (...) well as different futures, such as individual future risks and the future sustainability of health systems. Such different “temporalities of evidence” are integral parts of clinicians’ considerations concerning economy, suffering, risks, and hopes in making decisions on individual patients. In line with calls to anchor science and technology studies scholarship studying EBM in the concerns that matter most to patients and health care providers, we argue that the social study of EBM needs to attend to such temporalities to understand how evidence is weighed, which outcomes are considered important, and hence which clinical action is proposed. However, since different ways of “doing time” lead to different appreciations of the clinical outcomes, the notion of clinical “anchoring” becomes rather elusive. (shrink)

This paper offers an analysis of the relation between political populism and mass media, and how this relation becomes problematic for democratic societies. It focuses on the fact that mass media, due to their purpose and infrastructure, can unintentionally reinforce populist messages. Research findings from communication science and political psychology are used to illustrate how, for example, a combination of mass media agenda setting and motivated reasoning can influence citizens’ political decisions and impair their political autonomy. This poses a particular (...) normative challenge for modern democracies: how to counter these populism-supporting effects within the constraints of democratic legitimacy? After showing how severely limited legal measures to curb populist media effects would be, the paper argues in favour of media competence education as a way of providing future citizens with an epistemic toolkit to navigate the media environment and strengthen their political autonomy. (shrink)

This paper discusses the interpersonal dimension of self-tracking technologies from the standpoint of Dewey’s pragmatist ethics. Users of self-tracking routinely exchange data with others, interact through social features embedded in their tools, and form communities focused on the sharing and discussion of data. I employ Dewey’s notion of transaction to discuss how self-quantification impacts users’ perception of others and how it mediates interpersonal relations. In Dewey’s ethics engagement with others is a fundamental part of moral life and individual flourishing can (...) only be achieved in social contexts and through the extension of care towards other people. The ethical ideals and epistemic concepts present in pragmatism allow me to argue that despite claims that self-tracking technologies lead to the formation of communities, pro-social instincts exist prior to the adoption of the devices and self-tracking actually inhibits the formation of mutually uplifting social bonds. In my discussion, I focus on the degree of epistemic distance that makes genuine engagement with others difficult, limits to transactional agency that prohibits users from deciding how they are perceived by others, and the reductive and instrumental nature of interactions embedded in the social features of self-tracking technologies. Moreover, I also analyse some political aspects of community-formation in the context of self-quantification and criticise the ownership structures of data and infrastructure that limit communities’ political agency. (shrink)

Large scale experiments at CERN’s Large Hadron Collider rely heavily on computer simulations, a fact that has recently caught philosophers’ attention. CSs obviously require appropriate modeling, and it is a common assumption among philosophers that the relevant models can be ordered into hierarchical structures. Focusing on LHC’s ATLAS experiment, we will establish three central results here: with some distinct modifications, individual components of ATLAS’ overall simulation infrastructure can be ordered into hierarchical structures. Hence, to a good degree of approximation, hierarchical (...) accounts remain valid at least as descriptive accounts of initial modeling steps. In order to perform the epistemic function Winsberg Model-based reasoning in scientific discovery. Kluwer Academic/plenum Publishers, New York, pp 255–269, 1999) assigns to models in simulation—generate knowledge through a sequence of skillful but non-deductive transformations—ATLAS’ simulation models have to be considered part of a network rather than a hierarchy, in turn making the associated simulation modeling messy rather than motley. Deriving knowledge-claims from this ‘mess’ requires two sources of justification: holistic validation :253–262, 2010; in Carrier M, Nordmann A Science in the context of application. Springer, Berlin, pp 115–130, 2011), and model coherence. As it turns out, the degree of model coherence sets HEP apart from other messy, simulation-intensive disciplines such as climate science, and the reasons for this are to be sought in the historical, empirical and theoretical foundations of the respective discipline. (shrink)

This paper explores the political import of Husserl’s critical discussion of the epistemic effects of the formalization of rational thinking. More specifically, it argues that this discussion is of direct relevance to make sense of the pervasive processes of ‘technization’, that is, of a mechanistic and superficial generation and use of knowledge, to be observed in current contexts of governance. Building upon Husserl’s understanding of formalization as a symbolic technique for abstraction in the thinking with and about numbers, I argue (...) that processes of technization, while being necessary and legitimate procedures for the reduction of complexities, also may give rise to politically unresponsive and ultimately dysfunctional ‘economies of thinking.’ This paper is structured in three parts. In the first part I outline Husserl’s account of the formalization and technization of thought and knowledge. In the second part I make my case for the political import of this account, departing in this context from positions that (a) regard Husserl’s discussions of formalization and its effects as merely epistemological, or that (b) try to mobilize Husserl for a one-sided critique of instrumental reason. In the final part I address a major shortcoming of Husserl’s account, namely its neglect of the concrete and historically evolving technological infrastructures of processes of formalization/technization. (shrink)

My aim in this paper is fairly modest. I obviously do not claim that there has never been or could never be an instance of irrational or fallacious appeals to quotations from canonical sources in the marxist tradition. Instead, I claim that the practice of using quotations from canonical sources is not, as such, irrational. If we understand the epistemological infrastructure of the practice -- the rational underpinnings of it -- we can grasp how these citations appeal to the presumptive (...) authoritativeness of formulations that condense or concisely convey the core of insights that emerged from learning processes that the intellectual tradition of marxism has already traversed. The rational underpinnings of the practice include, first, the neo-Hegelian idea that we can justify a view we now hold by rationally reconstructing the insight-motivated learning process from which it emerged, and second, the convention that these rational reconstructions do not have to be elaborated in each insistence, but can be invoked in a short-form way, such as by citing the name of a decision or a concise statement of it (like a short quotation), as is common in the epistemologically similar practice of precedential reasoning in common law juridical justification. No claim is true just because of who made it; but a claim might be presumptively authoritative in cases where it was made at the end of a learning process, which has not been overtaken by a change in the circumstances or further learning. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Violent Inheritance: Sexuality, Land, and Energy in Making the North American West by E. CramNathan StormerViolent Inheritance: Sexuality, Land, and Energy in Making the North American West. By E. Cram. Oakland: University of California Press, 2022. 292 pp. Cloth $85.00, paper $34.95. ISBN: 0520379470.E. Cram’s Violent Inheritance is an exceptional work that presents a distinctive synthesis of queer, decolonial, and mixed-method scholarship. The goal of the book, Cram (...) states, is to both “reimagine the place of racialized sexualities in contemporary conversations about environment, energy, and systems of violence” and “anchor these questions in contested memories of the North American West” (5). The book does just that, drawing from many contemporary streams of thought in rhetoric as well as the environmental and energy humanities to fashion a new and subtle analytic of infrastructures of feeling, which is supported by a range of conceptual innovations. For readers of this journal, Cram’s choice to ground theory quite literally in the land will be, I suspect, highly rewarding for those with interests crossing a wide range of topics: queer studies, violence, affect, Indigenous thought, sexuality and modernity, memory studies, rhetoric and materialism, ecological thought, ambience, regionalism. The breadth of scholarly dialogues that Cram harmonizes is simply impressive, reflecting the many years and the care they have devoted to this project.The book is composed of five chapters including a conceptual first chapter followed by four separate yet reinforcing studies. These are framed by a tidy introduction that prepares the reader admirably for the synergistic work to follow and a conclusion that stresses the bonds between the chapters without compromising the particularity of each study. In that regard, Violent Inheritance is both a single work guided by several cross-cutting ideas and questions and an anthology of sorts that prompts a series of discrete, rich conversations. The careful writing is evident in every paragraph, often presenting the reader with elegant, thought-provoking formulations [End Page 199] of deep onto-epistemological problems that never feel weighted down by the complexity of dwelling on “onto-epistemic” matters.The introduction sets out the question of the book in engaging fashion. Cram asks, in the first sentence, “What does it mean to route ‘sexuality’ through modernity’s relationship to energy?” They use nineteenth-century eugenic physician John Harvey Kellogg’s Rocky Mountain climatic therapeutics to exemplify how “climate and the environment” became crucial to “the production of theories of sexuality” (3). Cram proposes energy to be “perhaps the dominant relationship between humans and the environment” and points to the ways that “racial and sexual value” have been assigned to a broad range of practices of “revitalization and exhaustion,” such that “racial and sexual vitality converge in extractivism” (3, 5, 4). In this way, the “bodily vitality” of the “normative sexual subject” demands privileged access to land and the energy that can be taken from it, be it affective or petrochemical. The emergence of sexual modernity, Cram thus contends, is inextricably tied to the regime of energy extraction. Through selected cases, Cram follows “nonlinear traces of this regime’s enduring materiality and sedimentation: the ecological, energetic, and affective inheritance that I call ‘land lines’” (6). The term “land lines” refers to how “political and economic actions tether, or forge connections, between domains of sexuality and land use,” and “names the aggregation of layers of cultural sediment or the violent inheritance of any given place.... As method, to trace land lines asks in earnest how places of memory and memorialization mediate these relationships” (6,7, emphasis original). The choice of the North American West follows from Cram having grown up there and the particular land lines that bind them to its violent inheritance, as well as the West’s stature as a colonial reservoir of myth and abundant energy.The separate chapters are saturated with meticulous detail, studied reflection, and constant insight that reward slow reading, making a synoptic view misleading. Nevertheless, chapter 1 travels through the 1893 journal of author Owen Wister (who helped create the myth of the West) to map a rhetoric of reinvigorated, masculinized settler sexuality by way of access to the West and the healing energy... (shrink)

With focus on the development and use of artificial intelligence (AI) systems in the digital health context, we consider the following questions: How does the European Union (EU) seek to facilitate the development and uptake of trustworthy AI systems through the AI Act? What does trustworthiness and trust mean in the AI Act, and how are they linked to some of the ongoing discussions of these terms in bioethics, law, and philosophy? What are the normative components of trustworthiness? And how (...) do the requirements of the AI Act relate to these components? We first explain how the EU seeks to create an epistemic environment of trust through the AI Act to facilitate the development and uptake of trustworthy AI systems. The legislation establishes a governance regime that operates as a socio-epistemological infrastructure of trust which enables a performative framing of trust and trustworthiness. The degree of success that performative acts of trust and trustworthiness have achieved in realising the legislative goals may then be assessed in terms of statutorily defined proxies of trustworthiness. We show that to be trustworthy, these performative acts should be consistent with the ethical principles endorsed by the legislation; these principles are also manifested in at least four key features of the governance regime. However, specified proxies of trustworthiness are not expected to be adequate for applications of AI systems within a regulatory sandbox or in real-world testing. We explain why different proxies of trustworthiness for these applications may be regarded as ‘special’ trust domains and why the nature of trust should be understood as participatory. (shrink)

The outbreak of SARS-CoV-2 has exposed a shared condition of vulnerability on a global scale. How can we use vulnerability as an effective paradigm in order to foster collective political initiatives? This essay claims that the idea of care is key to understand the vulnerability framework as being both an epistemic and a political resource to address ethical issues. The first half of the essay recollects several arguments in Adriana Cavarero’s and Judith Butler’s most recent works, insofar as both theorists (...) have insisted on the notion of vulnerability in order to interpret contemporary political mobilizations. The second part of the essay retraces a constellation of practices of care in the works of several Black and decolonial feminist thinkers situated in different socio-political contexts. Whereas for Christina Sharpe and Saidiya Hartman the focus is on the matter of Blackness and Black lives in their constitutive vulnerability, both Cristina Rivera Garza’s and Sayak Valencia’s works remarkably insist on the specific socio-political context of today’s Mexico. These authors urge the readers to adopt a critical posture when encountering official narratives, also because in their texts they exhibit their own vulnerability. For them, writing, their writing is an ethical demand to imagine alternatives and to foster new entanglements between bodies persisting on the margins, at the limits of the norms that regulate legibility. (shrink)

We explore multi-scale relations in artificial intelligence (AI) use in order to identify difficulties with coordinating relations between users, machine learning (ML) processes, and “sociobuilt contexts”—specifically in terms of their applications to medical technologies and decisions. We begin by analyzing a recent COVID-19 machine learning case study in order to present the difficulty of traversing the detailed causal topography of “sociobuilt contexts.” We propose that the adequate representation of the interactions between social and built processes that occur on many scales (...) ought to drive interdisciplinary approaches for ML modification. Next, we describe ML algorithm development as a process that is partly dependent on methodological stabilization for reliability and partly on coordinating relations. In the coordination between user, ML process, and sociobuilt contexts, we propose that new methods can be explored that promote the inclusion of patients and communities for the purpose of cross-checking portions of the ML process. Finally, we suggest that the advantages of responsible innovation emerge through the iterative entanglement of ethical, methodological, and ontological considerations within the broader conceptual infrastructure of epistemic responsibility. (shrink)

ArgumentGlass vessels such as flasks and test tubes play an ambiguous role in the historiography of modern laboratory research. In spite of the strong focus on the role of materiality in the last decades, the scientific glass vessel – while being symbolically omnipresent – has remained curiously neglected in regard to its materiality. The popular image ortoposof the transparent, neutral, and quasi-immaterial glass container obstructs the view of the physico-chemical functionality of this constitutive inner boundary in modern laboratory environments and (...) its material historicity. In order to understand how glass vessels were able to provide a stable epistemic containment of spatially enclosed experimental phenomena in the new laboratory ecologies emerging in the nineteenth and early twentieth century, I will focus on the history of thematerialstandardization of laboratory glassware. I will follow the rise of a new awareness for measurement errors due to the chemical agency of experimental glass vessels, then I will sketch the emergence of a whole techno-scientific infrastructure for the improvement of glass container quality in late nineteenth-century Germany. In the last part of my argument, I will return to the laboratory by looking at the implementation of this glass reform that created a newoikosfor the inner experimental milieus of modern laboratory research. (shrink)

Oral history is more than an epistemology of the subaltern who do not have any other avenues of narrating and preserving their ontologies. It transcends the academic domain and ventures into the field of therapy as it heals the broken hearted, the subjugated, the bereaved and in the process oscillating to an archive of memory and feelings. It is an epistemology that offers therapeutic healing not only to the downtrodden of the earth but also to the affluent members of the (...) community. In this era of COVID-19 where people have suffered untold and unbearable pain, oral history comes handy as an epistemic memorialisation tool that can be used to offer therapeutic healing to the survivors, the affected, the infected and the nations. The article is based on the author’s views on how South Africa may memorialise COVID-19 through oral history and memorials among others. The article reviews literature on the world’s intentions in memorialising the pandemic and how South Africa can learn or unlearn from the proffered examples. The article also interrogates how oral history approaches, such as crowdsourcing of COVID-19 stories, can be manipulated so that it accommodates the pandemic’s narratives of the commoners found in the locations of South Africa. Research findings reveal that South Africa can learn a lot from the countries that have started to memorialise the pandemic in the sense that it has the experience, skills and infrastructure to do so. Contribution: The study contributes to the ongoing debate about how to memorialise the COVID-19 pandemic taking into consideration the memory politics of inclusion and exclusion. The study is linked to the scope of the journal in the sense that it touches on the national memorialisation of the COVID-19 pandemic through oral history and memorials among others. (shrink)

Intense interspecies engagements are central to the work of ecologists, as they seek to understand our rapidly changing world. To explore researcher-bird engagements in ecological fieldwork, we use a lens of care. Taking as a starting point the widely shared photos of bird-in-the-hand that portray situations where individual birds become sources of data about populations, we show the significance of complex care work in ethically and epistemically loaded moments. Crucial knowledge about survival, biodiversity loss and animal welfare emerges at the (...) intersection of multispecies care for individuals, for populations and for knowledge infrastructures. We put forth the concept of intermittent care to explain the changing concerns for individual birds here-and-now or for populations of the future. Attention to care therefore helps unravel how ecological knowing depends on entanglements between humans, nature, and technologies that take shape through a constant negotiation of different strands and matters of multispecies care. (shrink)

In response to the attractive moral and politicalmodel of cosmopolitanism, this paper offers anoverview of some of the conceptual limitations to thatmodel arising from computer-mediated, interest-basedsocial interaction. I discuss James Bohman''sdefinition of the global and cosmopolitan spheres andhow computer-mediated communication might impact thedevelopment of those spheres. Additionally, I questionthe commitment to purely rational models of socialcooperation when theorizing a computer-mediated globalpublic sphere, exploring recent alternatives. Andfinally, I discuss a few of the political andepistemic constraints on participation in thecomputer-mediated public sphere (...) that threaten thecosmopolitan ideal.``Nature should be thanked for fostering socialincompatibility, enviously competitive vanity, andinsatiable desires for possessions and even power.Without these desires, all man''s excellent naturalcapacities would never be roused to develop.'''' Theultimate destiny for mankind, according to Kant whowrote these words in 1784, is to achieve through theuse of reason a `cosmopolitan existence'' or ``thematrix within which all the original capacities of thehuman race may develop.'''' Ironically, however, as Habermas andothers have realized, Kant''s carefully developedvision for `perpetual peace'' among nations and `worldcitizenship'' is now murky even as the electronicallymediated infrastructure of that matrix is rapidlydeveloping. Globalization as a process has intensifiedto the point where a new social, political, andeconomic condition has taken hold in the global arena.Recently this condition has been termed ``globality'''' –a term denoting a networked world characterized byspeed, mobility, risk, insecurity, andflexibility. And a debate is forming around thequestion of whether we are still in late modernity andexperiencing the culmination of modernity''s inherentlyglobalizing tendency or instead we have entered thenetworked age, in which the tension between collectiveand transformative identities and the networking logicof dominant institutions and organizations heralds theend of civil society. Inthis paper assume the latter but wish to explorefurther the political and epistemic constraints onparticipation in the computer-mediated public sphere.These constraints seem certain to impact the viabilityof a cosmopolitan public sphere. In the first sectionI shall discuss James Bohman''s definition of theglobal and cosmopolitan spheres and howcomputer-mediated communication (hereafter CMC) mightimpact the development of those spheres. In the secondsection, I question the commitment to purely rationalmodels of social cooperation when theorizing a globalpublic sphere. I explore recently proposed alternativeways of thinking about this issue in section three.And finally, I discuss a few of the political andepistemic constraints on participation in thecomputer-mediated public sphere that threaten thecosmopolitan ideal. (shrink)

This paper discusses the phenomenon of misleading about “the game you are in.” Individuals who mislead others in this way draw on the fact that we rely on social norms for regulating the levels of alertness, openness, and trust we use in different epistemic situations. By pretending to be in a certain game with a certain epistemic situation, they can entice others to reveal information or to exhibit low levels of alertness, thereby acting against their own interests. I delineate this (...) phenomenon from direct lies and acts of misleading by implication, and discuss some variations of it. I then ask why and under what conditions it is morally wrong to mislead others about the game they are in. I distinguish three normative angles for understanding the phenomenon: deontological constraints, free-riding on a shared cultural infrastructure, and implicit discrimination against outsiders and atypical candidates. I conclude by briefly discussing some practical implications. (shrink)

This book paints a comprehensive portrait of Mexico’s system of assisted reproduction first from a historical perspective, then from a more contemporary viewpoint. Based on a detailed analysis of books and articles published between the 1950s and 1980s, the first section tells the story of how the epistemic, normative, and material infrastructure of the assisted reproduction system was built. It traces the professionalization process of assisted reproduction as a medical field and the establishment of its professional association. Drawing on ethnographic (...) material, the second part looks at how this system developed and flourished from the 1980s up to 2010, its commercialization process, how the expansion of reproductive services took place, and the messages regarding reproductive technologies that circulated within a wide discursive landscape. Given its scope and methods, this book will appeal to scholars interested in science and technology studies, reproduction studies, history of medicine, medical anthropology, and sociology. (shrink)

This paper reconstructs the history of the trigonometrical surveying of Kashmir from 1855 to 1865. It highlights the strategies through which surveyors had to justify the employment of high-precision instruments and methods in Himalayan terrain. Only by tediously manipulating their institutional environment in India and Britain did the staff of the Kashmir survey manage to complete its operations in light of constant financial and physical hardship. To sustain their measurements, surveyors aligned themselves with various political projects, entertaining and shifting allegiances (...) with local rulers, scientific societies, and colonial institutions. After suffering severe cuts to instruments and assistance staff, the party was entirely stripped of funds by the East India Company in 1857 and relied on the material support of Maharaja Gulab Singh. Subsequently, surveyors adopted an expansionist rhetoric to gather the support of the Royal Geographical Society. In doing so, they framed precision as an essential contribution to imperial expansion, effective colonial rule, and intervention in ‘backward’ Kashmiri society and infrastructure. The Kashmir survey illustrates that rendering precision valuable requires an ongoing performative effort of justification to align epistemic with political and institutional interests. (shrink)

The low commitment and meaning of life can be caused by many, but they potentially occur because people in an institution do not know what they get from their work other than just money; people become unhappy with their work, then get bored and uncomfortable at work, apathetic, and ultimately unproductive. An institution that implements workplace spirituality will make people feel connected and meaningful at work. The purpose of this study is to explain how the values of WS can increase (...) staff’s commitment and meaning of life at the institutions. The results of this study indicate that the WS can increase the commitment and meaning of the life of employees in the institution's through several things. First, the value which can increase work commitment is value of togetherness, responsibility, justice, trust, sincerity, integrity, innovative, and professional. Second, the meaning of work for them is a moral call, a form of gratitude, fulfillment, worship, self-actualization, the command of Allahswt, and doing the main duty. Third, the efforts made by the staff are: to build a working atmosphere with workplace culture and climate, improve the quality of institutions by making research and recruiting qualified lecturers,conducting useful activities, adding infrastructure to support activities, friendly communication, social media as means of socialization, religious or coaching and motivation training, oblige Zuhur prayers in congregation, and cooperate with others. Fourth, the impact of workplace spirituality for employees is to feel proud of their institution, to feel comfortable and to have intimacy, to have well self-actualization, to be more productive in their work, to maintain altitude, leadership that refers to the pattern of politics alone will decrease the quality of the institution, mutual visit and sharing information or giving advise, positive activities coloring each institution, and adding enthusiasm to work. (shrink)

The underreporting of suspected adverse drug reactions hinders pharmacovigilance. Solutions to underreporting are oftentimes directed at clinicians and health care professionals. However, given the recent rise of public inclusion in medical science, solutions may soon begin more actively involving patients. I aim to offer an evaluative framework for future possible proposals that would engage patients with the aim of mitigating underreporting. The framework may also have value in evaluating current reporting practices. The offered framework is composed of three criteria that (...) are bioethical, social-epistemic, and pragmatic: (i) patients should not be exposed to undue harms, e.g., nocebo effects; (ii) data should be collected, analyzed, and communicated prioritizing pharmacovigilance’s aims, i.e., free from industry bias; and (iii) proposals should account for existing and foreseeable pragmatic constraints like clinician ‘buy in’ and existing reporting infrastructure. Proposals to engage patients in pharmacovigilance that fulfil or address these criteria are preferable to those that do not. (shrink)

ABSTRACT I argue that this examination and appreciation for the shift to abductive reasoning should be extended to the intersection of neuroscience and novel brain-computer interfaces too. This paper highlights the implications of applying abductive reasoning to personalized implantable neurotechnologies. Then, it explores whether abductive reasoning is sufficient to justify insurance coverage for devices absent widespread clinical trials, which are better applied to one-size-fits-all treatments. INTRODUCTION In contrast to the classic model of randomized-control trials, often with a large number of (...) subjects enrolled, precision medicine attempts to optimize therapeutic outcomes by focusing on the individual.[i] A recent publication highlights the strengths and weakness of both traditional evidence-based medicine and precision medicine.[ii] Plus, it outlines a tension in the shift from evidence-based medicine’s inductive reasoning style (the collection of data to postulate general theories) to precision medicine’s abductive reasoning style (the generation of an idea from the limited data available).[iii] The paper’s main example is the application of precision medicine for the treatment of cancer.[iv] I argue that this examination and appreciation for the shift to abductive reasoning should be extended to the intersection of neuroscience and novel brain-computer interfaces too. As the name suggests, brain-computer interfaces are a significant advancement in neurotechnology that directly connects someone’s brain to external or implanted devices.[v] Among the various kinds of brain-computer interfaces, adaptive deep brain stimulation devices require numerous personalized adjustments to their settings during the implantation and computation stages in order to provide adequate relief to patients with treatment-resistant disorders. What makes these devices unique is how adaptive deep brain stimulation integrates a sensory component to initiate the stimulation. While not commonly at the level of sophistication as self-supervising or generative large language models,[vi] they currently allow for a semi-autonomous form of neuromodulation. This paper highlights the implications of applying abductive reasoning to personalized implantable neurotechnologies. Then, it explores whether abductive reasoning is sufficient to justify insurance coverage for devices absent widespread clinical trials, which are better applied to one-size-fits-all treatments.[vii] ANALYSIS I. The State of Precision Medicine in Oncology and the Epistemological Shift While a thorough overview of precision medicine for the treatment of cancer is beyond the scope of this article, its practice can be roughly summarized as identifying clinically significant characteristics a patient possesses (e.g., genetic traits) to land on a specialized treatment option that, theoretically, should benefit the patient the most.[viii] However, in such a practice of stratification patients fall into smaller and smaller populations and the quality of evidence that can be applied to anyone outside these decreases in turn.[ix] As inductive logic helps to articulate, the greater the number of patients that respond to a particular therapy the higher the probability of its efficacy. By straying from this logical framework, precision medicine opens the treatment of cancer to more uncertainty about the validity of these approaches to the resulting disease subcategories.[x] Thus, while contemporary medical practices explicitly describe some treatments as “personalized”, they ought not be viewed as inherently better founded than other therapies.[xi] A relevant contemporary case of precision medicine out of Norway focuses on the care of a patient with cancer between the ventricles of the heart and esophagus, which had failed to respond to the standard regimen of therapies over four years.[xii] In a last-ditch effort, the patient elected to pay out-of-pocket for an experimental immunotherapy (nivolumab) at a private hospital. He experienced marked improvements and a reduction in the size of the tumor. Understandably, the patient tried to pursue further rounds of nivolumab at a public hospital. However, the hospital initially declined to pay for it given the “lack of evidence from randomised clinical trials for this drug relating to this [patient’s] condition.”[xiii] In rebuttal to this claim, the patient countered that he was actually similar to a subpopulation of patients who responded in “open‐label, single arm, phase 2 studies on another immune therapy drug” (pembrolizumab).[xiv] Given this interpretation of the prior studies and the patient’s response, further rounds of nivolumab were approved. Had the patient not had improvements in the tumor’s size following a round of nivolumab, then pembrolizumab’s prior empirical evidence in isolation would have been insufficient, inductively speaking, to justify his continued use of nivolumab.[xv] The case demonstrates a shift in reasoning from the traditional induction to abduction. The phenomenon of ‘cancer improvement’ is considered causally linked to nivolumab and its underlying physiological mechanisms.[xvi] However, “the weakness of abductions is that there may always be some other better, unknown explanation for an effect. The patient may for example belong to a special subgroup that spontaneously improves, or the change may be a placebo effect. This does not mean, however, that abductive inferences cannot be strong or reasonable, in the sense that they can make a conclusion probable.”[xvii] To demonstrate the limitations of relying on the abductive standard in isolation, commentators have pointed out that side effects in precision medicine are hard to rule out as being related to the initial intervention itself unless trends from a group of patients are taken into consideration.[xviii] As artificial intelligence (AI) assists the development of precision medicine for oncology, this uncertainty ought to be taken into consideration. The implementation of AI has been crucial to the development of precision medicine by providing a way to combine large patient datasets or a single patient with a large number of unique variables with machine learning to recommend matches based on statistics and probability of success upon which practitioners can base medical recommendations.[xix] The AI is usually not establishing a causal relationship[xx] – it is predicting. So, as AI bleeds into medical devices, like brain-computer interfaces, the same cautions about using abductive reasoning alone should be carried over. II. Responsive Neurostimulation, AI, and Personalized Medicine Like precision medicine in cancer treatment, computer-brain interface technology similarly focuses on the individual patient through personalized settings. In order to properly expose the intersection of AI, precision medicine, abductive reasoning, and implantable neurotechnologies, the descriptions of adaptive deep brain stimulation systems need to deepen.[xxi] As a broad summary of adaptive deep brain stimulation, to provide a patient with the therapeutic stimulation, a neural signal, typically referred to as a local field potential,[xxii] must first be detected and then interpreted by the device. The main adaptive deep brain stimulation device with premarket approval, the NeuroPace Responsive Neurostimulation system, is used to treat epilepsy by detecting and storing “programmer-defined phenomena.”[xxiii] Providers can optimize the detection settings of the device to align with the patient’s unique electrographic seizures as well as personalize the reacting stimulation’s parameters.[xxiv] The provider adjusts the technology based on trial and error. One day machine learning algorithms will be able to regularly aid this process in myriad ways, such as by identifying the specific stimulation settings a patient may respond to ahead of time based on their electrophysiological signatures.[xxv] Either way, with AI or programmers, adaptive neurostimulation technologies are individualized and therefore operate in line with precision medicine rather than standard treatments based on large clinical trials. Contemporary neurostimulation devices are not usually sophisticated enough to be prominent in AI discussions where the topics of neural networks, deep learning, generative models, and self-attention dominate the conversation. However, implantable high-density electrocorticography arrays (a much more sensitive version than adaptive deep brain stimulation systems use) have been used in combination with neural networks to help patients with neurologic deficits from a prior stroke “speak” through a virtual avatar.[xxvi] In some experimental situations, algorithms are optimizing stimulation parameters with increasing levels of independence.[xxvii] An example of neurostimulation that is analogous to the use of nivolumab in Norway surrounds a patient in the United States who was experiencing both treatment-resistant OCD and temporal lobe epilepsy.[xxviii]Given the refractory nature of her epilepsy, implantation of an adaptive deep brain stimulation system was indicated. As a form of experimental therapy, her treatment-resistant OCD was also indicated for the off-label use of an adaptive deep brain stimulation set-up. Another deep brain stimulation lead, other than the one implanted for epilepsy, was placed in the patient’s right nucleus accumbens and ventral pallidum region given the correlation these nuclei had with OCD symptoms in prior research. Following this, the patient underwent “1) ambulatory, patient-initiated magnet-swipe storage of data during moments of obsessive thoughts; (2) lab-based, naturalistic provocation of OCD-related distress (naturalistic provocation task); and (3) lab-based, VR [virtual reality] provocation of OCD-related distress (VR provocation task).”[xxix] Such signals were used to identify when to deliver the therapeutic stimulation in order to counter the OCD symptoms. Thankfully, following the procedure and calibration the patient exhibited marked improvements in their OCD symptoms and recently shared her results publicly.[xxx] In both cases, there is a similar level of abductive justification for the efficacy of the delivered therapy. In the case study in which the patient was treated with adaptive deep brain stimulation, they at least had their neural activity tested in various settings to determine the optimum parameters for treatment to avoid them being based on guesswork. Additionally, the adaptive deep brain stimulation lead was already placed before the calibration trials were conducted, meaning that the patient had already taken on the bulk of the procedural risk before the efficacy could be determined. Such an efficacy test could have been replicated in the first patient’s cancer treatment, had it been biopsied and tested against the remaining immunotherapies in vitro. Yet, in the case of cancer with few options, one previous dose of a drug that appeared to work on the patient may justify further doses. However, as the Norwegian case presents, corroboration with known responses to a similar drug (from a clinical trial) could be helpful to validate the treatment strategy. (It should be noted that both patients were resigned to these last resort options regardless of the efficacy of treatment.) There are some elements of inductive logic seen with adaptive deep brain stimulation research in general. For example, abductively the focus could be that patient X’s stimulation parameters are different from patient Y’s and patient Z’s. In contrast, when grouped as subjects who obtained personalized stimulation, patients X, Y, and Z demonstrate an inductive aspect to this approach’s safety and/or efficacy. The OCD case holds plenty of abductive characteristics in line with precision medicine’s approach to treating cancer and as more individuals try the method, there will be additional data. With the gradual integration of AI into brain-computer interfaces in the name of efficacy, this reliance on abduction will continue, if not grow, over time. Moving forward, if a responsive deep brain stimulation treatment is novel and individualized (like the dose of nivolumab) and there is some other suggestion of efficacy (like clinical similarities to other patients in the literature), then it may justify insurance coverage for the investigative intervention, absent other unrelated reasons to deny it. III. Ethical Implications and Next Steps While AI’s use in oncology and neurology is not yet as prominent as its use in other fields (e.g., radiology), it appears to be on the horizon for both.[xxxi] AI can be found in both the functioning of the neurotechnologies as well as the implementation of precision medicine. The increasing use of AI may serve to further individualize both oncologic and neurological therapies. Given these implications and the handful of publications cited in this article, it is important to have a nuanced evaluation of how these treatments, which heavily rely on abductive justification, ought to be managed. The just use an abductive approach may be difficult as AI infused precision medicine is further pursued. At baseline, such technology relies on a level of advanced technology literacy among the general public and could exclude populations who lack access to basic technological infrastructure or know-how from participation.[xxxii] Even among nations with adequate infrastructure, as more patients seek out implantable neurotechnologies, which require robust healthcare resources, the market will favor patient populations that can afford this complex care.[xxxiii] If patients already have the means to pay for an initial dose/use of a precision medicine product out of pocket, should insurance providers be required to cover subsequent treatments?[xxxiv] That is, if a first dose of a cancer drug or a deep brain stimulator over its initial battery life is successful, patients may feel justified in having the costs of further treatments covered. The Norwegian patient’s experience implies there is a precedent for the idea that some public insurance companies ought to cover successful cancer therapies, however, insurance companies may not all see themselves as obligated to cover neurotechnologies that rely on personalized settings or that are based on precision/abductive research more than on clinical trials. CONCLUSION The fact that the cases outlined above rely on abductive style of reasoning implies that there may not be as strong a justification for coverage by insurance, as they are both experimental and individualized, when compared to the more traditional large clinical trials in which groups have the same or a standardized protocol (settings/doses). If a study is examining the efficacy of a treatment with a large cohort of patients or with different experimental groups/phases, insurance companies may conclude that the resulting symptom improvements are more likely to be coming from the devices themselves. A preference for inductive justification may take priority when ruling in favor of funding someone’s continued use of an implantable neurostimulator. There are further nuances to this discussion surrounding the classifications of these interventions as research versus clinical care that warrant future exploration, since such a distinction is more of a scale[xxxv] than binary and could have significant impacts on the “right-to-try” approach to experimental therapies in the United States.[xxxvi] Namely, given the inherent limitations of conducting large cohort trials for deep brain stimulation interventions on patients with neuropsychiatric disorders, surgically innovative frameworks that blend abductive and inductive methodologies, like with sham stimulation phases, have traditionally been used.[xxxvii] Similarly, for adaptive brain-computer interface systems, if there are no large clinical trials and instead only publications that demonstrate that something similar worked for someone else, then, in addition to the evidence that the first treatment/dose worked for the patient in question, the balance of reasoning would be valid and arguably justify insurance coverage. As precision approaches to neurotechnology become more common, frameworks for evaluating efficacy will be crucial both for insurance coverage and for clinical decision making. ACKNOWLEDGEMENT This article was originally written as an assignment for Dr. Francis Shen’s “Bioethics & AI” course at Harvard’s Center for Bioethics. I would like to thank Dr. Shen for his comments as well as my colleagues in the Lázaro-Muñoz Lab for their feedback. - [i] Jonathan Kimmelman and Ian Tannock, “The Paradox of Precision Medicine,” Nature Reviews. Clinical Oncology 15, no. 6 (June 2018): 341–42, https://doi.org/10.1038/s41571-018-0016-0. [ii] Henrik Vogt and Bjørn Hofmann, “How Precision Medicine Changes Medical Epistemology: A Formative Case from Norway,” Journal of Evaluation in Clinical Practice 28, no. 6 (December 2022): 1205–12, https://doi.org/10.1111/jep.13649. [iii] David Barrett and Ahtisham Younas, “Induction, Deduction and Abduction,” Evidence-Based Nursing 27, no. 1 (January 1, 2024): 6–7, https://doi.org/10.1136/ebnurs-2023-103873. [iv] Vogt and Hofmann, “How Precision Medicine Changes Medical Epistemology,” 1208. [v] Wireko Andrew Awuah et al., “Bridging Minds and Machines: The Recent Advances of Brain-Computer Interfaces in Neurological and Neurosurgical Applications,” World Neurosurgery, May 22, 2024, S1878-8750(24)00867-2, https://doi.org/10.1016/j.wneu.2024.05.104. [vi] Mark Riedl, “A Very Gentle Introduction to Large Language Models without the Hype,” Medium (blog), May 25, 2023, https://mark-riedl.medium.com/a-very-gentle-introduction-to-large-language-models-without-the-hype-5 f67941fa59e. [vii] David E. Burdette and Barbara E. Swartz, “Chapter 4 - Responsive Neurostimulation,” in Neurostimulation for Epilepsy, ed. Vikram R. Rao (Academic Press, 2023), 97–132, https://doi.org/10.1016/B978-0-323-91702-5.00002-5. [viii] Kimmelman and Tannock, 2018. [ix] Kimmelman and Tannock, 2018. [x] Simon Lohse, “Mapping Uncertainty in Precision Medicine: A Systematic Scoping Review,” Journal of Evaluation in Clinical Practice 29, no. 3 (April 2023): 554–64, https://doi.org/10.1111/jep.13789. [xi] Kimmelman and Tannock, “The Paradox of Precision Medicine.” [xii] Vogt and Hofmann, 1206. [xiii] Vogt and Hofmann, 1206. [xiv] Vogt and Hofmann, 1206. [xv] Vogt and Hofmann, 1207. [xvi] Vogt and Hofmann, 1207. [xvii] Vogt and Hofmann, 1207. [xviii] Vogt and Hofmann, 1210. [xix] Mehar Sahu et al., “Chapter Three - Artificial Intelligence and Machine Learning in Precision Medicine: A Paradigm Shift in Big Data Analysis,” in Progress in Molecular Biology and Translational Science, ed. David B. Teplow, vol. 190, 1 vols., Precision Medicine (Academic Press, 2022), 57–100, https://doi.org/10.1016/bs.pmbts.2022.03.002. [xx] Stefan Feuerriegel et al., “Causal Machine Learning for Predicting Treatment Outcomes,” Nature Medicine 30, no. 4 (April 2024): 958–68, https://doi.org/10.1038/s41591-024-02902-1. [xxi] Sunderland Baker et al., “Ethical Considerations in Closed Loop Deep Brain Stimulation,” Deep Brain Stimulation 3 (October 1, 2023): 8–15, https://doi.org/10.1016/j.jdbs.2023.11.001. [xxii] David Haslacher et al., “AI for Brain-Computer Interfaces,” 2024, 7, https://doi.org/10.1016/bs.dnb.2024.02.003. [xxiii] Burdette and Swartz, “Chapter 4 - Responsive Neurostimulation,” 103–4; “Premarket Approval (PMA),” https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpma/pma.cfm?id=P100026. [xxiv] Burdette and Swartz, “Chapter 4 - Responsive Neurostimulation,” 104. [xxv] Burdette and Swartz, 126. [xxvi] Sean L. Metzger et al., “A High-Performance Neuroprosthesis for Speech Decoding and Avatar Control,” Nature 620, no. 7976 (August 2023): 1037–46, https://doi.org/10.1038/s41586-023-06443-4. [xxvii] Hao Fang and Yuxiao Yang, “Predictive Neuromodulation of Cingulo-Frontal Neural Dynamics in Major Depressive Disorder Using a Brain-Computer Interface System: A Simulation Study,” Frontiers in Computational Neuroscience 17 (March 6, 2023), https://doi.org/10.3389/fncom.2023.1119685; Mahsa Malekmohammadi et al., “Kinematic Adaptive Deep Brain Stimulation for Resting Tremor in Parkinson’s Disease,” Movement Disorders 31, no. 3 (2016): 426–28, https://doi.org/10.1002/mds.26482. [xxviii] Young-Hoon Nho et al., “Responsive Deep Brain Stimulation Guided by Ventral Striatal Electrophysiology of Obsession Durably Ameliorates Compulsion,” Neuron 0, no. 0 (October 20, 2023), https://doi.org/10.1016/j.neuron.2023.09.034. [xxix] Nho et al. [xxx] Nho et al.; Erik Robinson, “Brain Implant at OHSU Successfully Controls Both Seizures and OCD,” OHSU News, accessed March 3, 2024, https://news.ohsu.edu/2023/10/25/brain-implant-at-ohsu-successfully-controls-both-seizures-and-ocd. [xxxi] Awuah et al., “Bridging Minds and Machines”; Haslacher et al., “AI for Brain-Computer Interfaces.” [xxxii] Awuah et al., “Bridging Minds and Machines.” [xxxiii] Sara Green, Barbara Prainsack, and Maya Sabatello, “The Roots of (in)Equity in Precision Medicine: Gaps in the Discourse,” Personalized Medicine 21, no. 1 (January 2024): 5–9, https://doi.org/10.2217/pme-2023-0097. [xxxiv] Green, Prainsack, and Sabatello, 7. [xxxv] Robyn Bluhm and Kirstin Borgerson, “An Epistemic Argument for Research-Practice Integration in Medicine,” The Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of Medicine 43, no. 4 (July 9, 2018): 469–84, https://doi.org/10.1093/jmp/jhy009. [xxxvi] Vijay Mahant, “‘Right-to-Try’ Experimental Drugs: An Overview,” Journal of Translational Medicine 18 (June 23, 2020): 253, https://doi.org/10.1186/s12967-020-02427-4. [xxxvii] Michael S. Okun et al., “Deep Brain Stimulation in the Internal Capsule and Nucleus Accumbens Region: Responses Observed during Active and Sham Programming,” Journal of Neurology, Neurosurgery & Psychiatry 78, no. 3 (March 1, 2007): 310–14, https://doi.org/10.1136/jnnp.2006.095315. (shrink)

Each chapter of this dissertation develops a standard with which to evaluate and guide the improvement of a different node of a democratic system. In the first chapter, I consider the relationship between citizens, their environment, and the formal infrastructure of democracy. The standard for this node is democratic health, which is a feature of the social epistemic environment in which citizens operate. I argue that a democratically healthy environment is one that is conducive to the development of citizens’ epistemic (...) capacities to reason and communicate about their interests. I then demonstrate how political phenomena such as polarization pose social epistemic challenges to democratic health and argue that an epistemic conception of civic virtue can guide efforts to improve it. In the second chapter, I consider the relationship between representatives and their constituents under non-ideal conditions. The key standard for this node is systemic interest-responsiveness. I argue that observed public opinion and citizens’ values, commitments, and goals can stand in tension, and that representative democracies must be responsive to both factors. On this basis, I argue in favor of pairing independent administrative agencies with expanded forms of public input. In the third chapter, I consider how civic education can promote epistemic civic virtue. The key standard I develop here is the social epistemic public good. I argue that civic education can provide social epistemic benefits through its civic exchange function, which enables citizens to learn about the views and traditions of other citizens, and prepares them to effectively communicate with diverse others. Furthermore, I argue that this function can be pursued in the absence of widespread agreement about which values civic education should promote. (shrink)

This paper is about how epistemic and practical reasons for belief can be compared against one another when they conflict. It provides a model for determining what one ought to believe, all-things-considered, when there are conflicting epistemic and practical reasons. The model is meant to supplement a form of pluralism about doxastic normativity that I call ‘Inclusivism’. According to Inclusivism, both epistemic and practical considerations can provide genuine normative reasons for belief, and both types of consideration can contribute to metaphysically (...) determining what beliefs one ought, all-things-considered, to have. (shrink)

Epistemic and moral certainities like ' This is a hand' or 'Killing people is evil' will be interpreted as constitutive rules of language games, such that they are unjustifiable, undeniable and serving as obliging standards of truth, goodness and rationality for members of a community engaging in the respective practices.

Scientists regularly make possibility claims. While philosophers of science are well aware of the distinction between epistemic and objective notions of possibility, we believe that they often fail to apply this distinction in their analyses of scientific practices that employ modal concepts. We argue that heeding this distinction will help further progress in current debates in the philosophy of science, as it shows that the debaters talk about different things, rather than disagree on the same issue. We first discuss how (...) the two notions differ with respect to their epistemology and show that these differences are sometimes ignored in the philosophy of science. We then revisit four current philosophy of science debates about modelling, that are framed in modal terms, to showcase how the distinction significantly clarifies these debates and thereby helps advance them. (shrink)

A number of scholars have recently drawn attention to the importance of iteration in scientific research. This paper builds on these previous discussions by drawing a distinction between epistemic and methodological forms of iteration and by clarifying the relationships between them. As defined here, epistemic iteration involves progressive alterations to scientific knowledge claims, whereas methodological iteration refers to an interplay between different modes of research practice. While distinct, these two forms of iteration are related in important ways. Contemporary research on (...) the biological effects of nanomaterials illustrates that methodological iteration can help to “initiate,” “equip,” and “stimulate” epistemic iteration. (shrink)