Polycystic kidney disease (PKD) is one of the most prevalent causes of heritable renal failure. The disease is characterized by the occurrence of numerous fluid‐filled cysts within the parenchyma of kidney. The cysts are epithelial in origin and expand in size, leading to crowding of normal kidney tissue. Ultimately, there is gross enlargement of the kidneys with loss of normal functions, and death usually occurs because of complications related to renal failure. Animal models of polycystic kidney disease are proving to (...) be extremely useful for studying the molecular basis of renal cyst formation and for the isolation of genes carrying the mutations. This article describes the various animal models of polycystic kidney disease, spontaneously and experimentally derived, that have recently been identified. (shrink)

The COVID-19 pandemic has deeply influenced the tourism and hospitality industry, and it has also reshaped people’s travel preferences and related behaviors. As a result, how prospective travelers perceive travel constraints and their effects on future travel behaviors may have changed to some extent. Besides, such perception arguably varies across gender. Therefore, this research examines the interplay between travel constraints, gender, and travel intentions for facilitating robust tourism recovery by revisiting the Leisure Constraints Model from a gender perspective. Data were (...) collected through a survey from 357 Malaysian prospective travelers. By conducting path analysis and multigroup analysis, it is found that structural and interpersonal constraints impose indirect effects on travel intentions, and gender moderating the effect of structural cost on intrapersonal constraints and effect of intrapersonal constraints on travel intentions. Based on these findings, this research provides theoretical and practical implications into how to adjust their marketing strategies and travel products during the era of “new normal” for tourism policy makers, destination marketers, and related businesses. (shrink)

Youth ministry as a sub-discipline of practical theology has traditionally always had an ecclesial focus. The focus was often based on the practices of proselytisation and discipleship, a sort of ‘reach and teach’ model whereby Christian believers would do the ‘reaching and teaching’ of the ‘lost’ youth. This is most true in an evangelical context and is further undergirded by a Western concept of personal salvation nearly devoid of any communal responsibilities and context. The traditional model, therefore, in evangelical churches (...) was reaching the ‘lost’ with the Gospel of Jesus Christ, with the aim of personal salvation for the individual who would eventually become a member of the faith community through a discipleship programme. Thus, the beginning and end of the entire process were the focus on personal salvation devoid of any contextual consideration. Youth ministry as practical theology must move into the area of public theology to engage the practices inherited from the western model by engaging with the public (youths) as public theologians (those who influence the theologies of the youth), and the public faiths and spiritualities (the expression of the youth’s theologies) to be relevant to the majority and developing world.Contribution: In this study, the author suggests that this ‘reach and teach’ paradigm with an ecclesial focus in the context of the majority and developing world is no longer suitable to meet the needs of youth. In addition, the author recommends a more appropriate framework with youth ministry as public practical theology for consideration. (shrink)

Jesper Ryberg and Julian Roberts teach ethics and criminology at Roskilde University and the University of Oxford respectively. In Sentencing and Artificial Intelligence, they have curated a powerf...

Wittgenstein’s mature philosophy offers a therapeutic way out of some conundrums stemming from taxonomic expectations regarding philosophical description of experience in general. The paper asks if this is also true of the facts of aesthetic experience. This possibility is hinted at by examining an application of the notion of certainty to aesthetic experience. Some traits of possible uses of central concepts of the mature Wittgenstein to a philosophical aesthetics inspired by the “new method” are also canvassed.

The anthropologist James Frazer investigates the ritual gesture in search of be- liefs about the physical world by the native. Wittgenstein considers this a case of aspect- blindness, one that is disruptive of the conditions for understanding the native’s most triv- ial gestures. Unable to cast his glance from within the native situation, this methodological view from nowhere has an arresting effect on experience – in particular, the experience of speaking. This interruption is to be examined by means of a (...) thought experiment. Then, through the interplay of the concepts of Spirit and Aspect, a philosophical tool is described to assess the problem that can also serve as practical guide back to ordinary experience. The next step is to examine this way out in a particularly sensitive kind of experience of meaning: the aesthetic experience, also seen as a ritual. We conclude by alluding to a pos- sibly mutual illumination between aesthetic experience, translation studies and a Cavellian take on ordinary language. (shrink)

A mudança da concepção do critério geral da significação que tinha Wittgenstein no seu período intermediário para a concepção dos critérios de significação do seu período posterior justifica que se fale numa correlativa mudança na aplicabilidade do conceito de ‘uso’. Acompanhar esta mudança é importante para se caracterizar o âmbito do pragmático tal como Wittgenstein o concebe, e bem assim o tipo de investigação sobre os fundamentos do simbolismo linguístico e sobre a ligação entre linguagem e mundo que esse filósofo (...) advoga como adequada. Este artigo pretende circunscrever algumas das novas questões que, no período intermediário de Wittgenstein , conduziriam a tal mudança conceptual. (shrink)

As with many other countries, Malaysia is also developing and promoting biomedical research to increase the understanding of human diseases and possible interventions. To facilitate this development, there is a significant growth of biobanks in the country to ensure continuous collection of biological samples for future research, which contain extremely important personal information and health data of the participants involved. Given the vast amount of samples and data accumulated by biobanks, they can be considered as reservoirs of precious biomedical big (...) data. It is therefore imperative for biobanks to have in place regulatory measures to ensure ethical use of the biomedical big data. Malaysia has yet to introduce specific legislation for the field of biobanking. However, it can be argued that its existing Personal Data Protection Act 2010 has laid down legal principles that can be enforced to protect biomedical big data generated by the biobanks. Consent is a mechanism to enable data subjects to exercise their autonomy by determining how their data can be used and ensure compliance with legal principles. However, there are two main concerns surrounding the current practice of consent in biomedical big data in Malaysia. First, it is uncertain that the current practice would be able to respect the underlying notion of autonomy, and second, it is not in accordance with the legal principles of the PDPA. Scholars have deliberated on different strategies of informed consent, and a more interactive approach has recently been introduced: dynamic consent. It is argued that a dynamic consent approach would be able to address these concerns. (shrink)

This study aims to determine the paradigm shift of scientists who use inner reason to external reason (mind), a concept initiated by Aristotle. The change allegedly occurred because of the strict laws of science. Philosophers basically talk about a topic broadly and deeply about inner reason, while scientists are more focused and narrower (outer reason). Data are obtained from six articles closely related to reason, mind, and brain, then explored and presented by six expert panels for data analysis using the (...) N Vivo 12 QSR tool. The study shows a very strong correlation between the philosophical factor and reason. The results of the cluster analysis describe various comprehensive topics discussed by philosophers regarding reason which are correlated with inner reason and God, while the scientific discussion shows a very strong correlation between the brain and the alpha band. The alpha band is a condition that exists in brain waves. The cluster analysis results illustrate that scientists' discussions are focused and narrow on the brain. Thus, there has been a paradigm shift, where scientists now use outer reason to solve problems in life rather than applying inner reason. An interesting finding from this paper is that philosophers refer to reason as a noun, which means that reason is matter. This information is helpful because until now, based on a literature search, there have been no articles from scientists explaining that reason is a matter. (shrink)

A modified version of the SEIR model with the effects of vaccination and inter-state movement is proposed to simulate the spread of COVID-19 in Malaysia. A mathematical analysis of the proposed model was performed to derive the basic reproduction number. To enhance the model’s forecasting capabilities, the model parameters were estimated using the Nelder–Mead simplex method by fitting the model outputs to the observed data. Our results showed a good fit between the model outputs and available data, where the model (...) was then able to perform short-term predictions. In line with the rapid vaccination program, our model predicted that the COVID-19 cases in the country would decrease by the end of August. Furthermore, our findings indicated that relaxing travel restrictions from a highly vaccinated region to a low vaccinated region would result in an epidemic outbreak. (shrink)

The past decade has seen major movements and mobilizations against the new crop of bilateral free trade and investment agreements being pursued by governments in the wake of the failure of global (World Trade Organization) and regional (e.g. Free Trade Area of the Americas) negotiations, and the defeat of an attempted Multilateral Agreement on Investment in the 1990s. However, in spite of much scholarly, non-governmental organization (NGO) and activist focus on transnational global justice activism, many of these movements, such as (...) the major multi-sectoral popular struggle over the recently-concluded US-Korea Free Trade Agreement, are hardly acknowledged in North America and Europe. With a shift in emphasis pushing liberalization and deregulation of trade and investment increasingly favouring lower-profile bilateral agreements, this article maps the resistance movements to these latest shifts in global free market capitalist relations and discusses the disconnect between these (mainly Southern) struggles and dominant scholarly and NGO conceptions of global justice and the global justice movement as well as questions of knowledge production arising from these movements. (shrink)

Sanayi devrimi sonrası Avrupa Devletleri’nde üretimin artması, yeni pazar ve hammadde ihtiyacını da beraberinde getirmiştir. Bu ihtiyacın giderilebilmesi için sanayi ürünlerinin ve üretim araçlarının tanıtılması amacı ile uluslararası sergiler düzenlenmeye başlanmıştır. Ayrıca bu sergilerle ülkelerin bilim, sanayi, teknoloji ve tarım alanındaki gelişme ve yeniliklerinin herkese duyurulması amaçlanmıştır. Öncülüğünü Fransa ve İngiltere’nin yaptığı sanayi sergileri, ilgili ülkelerin sömürgelerinden gelen hammadde ve bu hammaddelerden üretilen sanayi ürünlerinin pazarlanmasına yönelik olarak yapılmıştır. Başlangıçta sanayi ve ticari amaçla başlatılan sergiler, Avrupa ile Avrupa dışında bulunan (...) devletlerin kültür ve yerel sanatları arasında, etkileşime de sebep olmuştur. 18. yüzyılın sonlarından itibaren Fransa'da ulusal düzeyde ve 19. yüzyılın ilk yarısında çeşitli Avrupa ülkelerinde düzenlenen benzer olayların doruk noktası olan Londra sergisi ilk uluslararası sergi olarak kayda geçmiştir. 1851 yılında Londra’da açılan sergi bundan sonra düzenlenen diğer uluslararası sergilere de ilham kaynağı olmuştur. (shrink)

Throughout the realm of aesthetics there is the general sentiment that kitsch is inherently immoral. Although kitsch itself is a relatively ambiguous term, objects falling into this category are charged with a negative ethical stigma due to their being sentimental and manipulative. In this paper, I articulate the shakiness of the claim that kitsch _is_ immoral by first comparing three accounts of kitsch to demonstrate how the term “kitsch” can be applied (or denied) to various aesthetic objects. I then argue (...) that the charges of sentimentality and manipulation create further ambiguities regarding kitsch. I conclude that although certain objects can be kitsch, to categorically denounce kitsch on an ethical basis is too strong a claim. (shrink)

Na investigação acadêmica/científica, o vago é usualmente tratado como desvio do exato. Na teoria da tradução, isso toma corpo no conceito tradicional de ‘equivalência’ como igualdade a priori e no nível do sistema linguístico. Contra essa visão, retomamos aqui uma aproximação entre o conceito de ‘normas tradutórias’ de Gideon Toury e a concepção de linguagem do Wittgen­stein tardio, orientando-nos também pelos comentários do filósofo brasileiro Arley Moreno. Defendemos que o vago tem precedência lógica ante o preciso, na linguagem tout court (...) e na tradução de modo específico. Isso se aplica particularmente aos vetores ‘adequação’ e ‘aceitabilidade’ que Toury apresenta em seu “kit do tradutor” — a partir do conceito de ‘semelhança de família’ do Wittgenstein tardio. (shrink)

The Farm to Fork (F2F) Strategy at the heart of the European Union’s Green Deal set out to create a “just transition” towards a sustainable food system, with benefits for all actors. We conducted a critical discourse analysis (CDA) to explore discourses around power in the food system and farmers’ position in the communication and implementation of the Farm to Fork Strategy. Discourse analysis encapsulates various scientific methodologies for deciphering the meaning behind the creation and communication of different forms of (...) language and identify power dynamics, amongst other aspects. We identified two prior discourses in one of the objectives of the European Union’s new Common Agricultural Policy (2023-27). Our analysis found that the discourses, namely “rebalance power in food system” and “strengthening farmers’ position in value chains,” are marginalized in favour of an innovation-investment discourse, indicative of greater financialization and technologization based on techno-finances fixes in transforming the European Union agri-food system. We argue that entities representing agri-business interests have been influential in the policymaking process and voices representing smallholder and medium-sized farmers’ transformational discourses have been excluded. (shrink)

Pervez Musharraf was the thirteenth Chief of the Army staff and tenth president of Pakistan. In October 1999, he took over as a Chief Executive of Pakistan by dismissing then Prime Minister Nawaz Sharif. Military takeover was savored by the people of Pakistan due to bad governance of democratic Governments. Unlike the former dictator Gen Zia ul Haq, Gen. Pervez Musharraf gave the impression of being secular and liberal. He was an ardent admirer of Mustafa Kamal Ataturk and wanted to (...) establish Turkish Model of democracy in Pakistan. To delink Islam from extremism and fundamentalism, he introduced the strategy of “enlightened moderation” which has been discussed in this paper. Many Pakistanis welcomed his policy of “enlightened moderation” and even OIC acknowledged his approach. He worked sincerely to uplift the status of women in the society. He also led the army in the war against terrorism and launched operation against militants who were challenging the writ of the Government. The economy of Pakistan was at its peak and poverty graph was declining in Pakistan during his period when many sociological changes in the country took place. (shrink)

The main concern of this paper is to study the dynamic of a predator–prey system with diffusion. It incorporates the Holling-type-II and a modified Leslie–Gower functional responses under Robin boundary conditions. More concretely, we study the dissipativeness of the system by using the comparison principle, and we derive a criteria for permanence and for predator extinction.

PORTUGUESE: A experiência conceptualizada colhe os seus critérios de dizibilidade pública no contexto da experiência sentida de pessoas, e a noção de prática marca o âmbito desses limites, em conexão tensa com a autonomia do simbolismo linguístico. Tal é a hipótese deste livro, que se junta assim a um debate sobre o sentido da objetividade. O livro articula uma leitura das Investigações filosóficas (1953) como uma expansão do espaço lógico de possibilidades de sentido ou do significado proposicional do Tractatus Logico-Philosophicus (...) (1922) para considerar a lógica da experiência sentida do significado em geral. Essa lógica é então ainda pensada nas suas condições de possibilidade, mas vistas como “impuras”, ancoradas em gestos contingentes e contextuais, ou em acordos no nível de uma forma de vida, não apenas em regras de uso da linguagem. A tática dessa estratégia foi tomar um dito anotado nos Cadernos (1916), “A lógica deve cuidar de si própria”, e transformá-lo numa função, “x deve cuidar de si própria”, trocando x por linguagem nos anos 1930 e prática nos anos 1940. Assim buscou Wittgenstein “fazer justiça aos fatos” (Remarks on Frazer’s Golden Bough) da experiência sentida do significado, a um tempo ancorada na vida humana e ligada a relações modais. Não se trata aqui de um argumento propriamente dito mas, antes, do desenho de um pano de fundo para o exame de alguns dos conceitos operatórios do Wittgenstein tardio, tais como ‘relações intermediárias’, ‘regras/prática’, ‘espírito/objetividade’, ‘certeza/prática’, etc.; e também para o exame de perspectivas de leitura, tais como a dialógica e a do ‘álbum de família’. // ENGLISH: Conceptualized experience gathers its criteria for public meaning in the context of the felt experience of persons, and the notion of praxis marks the scope of these limits, in tense connection with the autonomy of linguistic symbolism. This is the hypothesis with which this book joins the debate on the meaning of objectivity. The book articulates a reading of the Philosophical Investigations (1953) as an expansion of the logical space of possibilities of sense or propositional meaning of the Tractatus Logico-Philosophicus (1922) to consider the logic of the felt experience of meaning in general. This logic is then still thought of in its conditions of possibility, but seen as “impure”, anchored in contingent and contextual gestures, or agreements at the level of a form of life, not just in rules of language usage. The tactic of this strategy was to take a saying from the Notebooks (1916), “Logic must take care of itself”, and turn it into a function, “x must take care of itself”, switching x for language in the 1930s and practice in the 1940s. Thus, Wittgenstein sought to “do justice to the facts” (Remarks on Frazer's Golden Bough) of the felt experience of meaning, as this experience is at once grounded in human life and yet bound by modal relations. This is not intended as an argument per se but rather as a background against which to examine some of Wittgenstein's operative concepts (such as aspect, intermediate relations, rules/practice, spirit/objectivity, certainty/practice, etc.) and reading perspectives (such as the dialogical and “family album” readings). -/- . (shrink)

This chapter contains sections titled: Defining the Subject The Scope of Philosophy in the Islamic Context Sources and Legacy The Political Orientation of Islamic Philosophy Some Salient Themes The Great Debate Alternative Traditions Concluding Comment Works cited.

Researchers on gender and ethical decision-making have recently emphasized the differences between men's and women's ethical perceptions. This study is concerned with the perceptions of salespeople working in clothing and medical equipment sectors in Turkey. It regards the perceptions of colleagues of opposing genders in ethically questionable situations. The evaluation of salespeople's responses for 14 ethical scenarios indicates that there is no significant difference in ethical perception based on gender. Each gender predicted that their counterpart's response would be the same (...) as their own. The study also examined the effects of some demographic factors as well as the firm's sector on the salespeople's ethical perceptions and found that there are both differences and similarities in detail between genders of salespeople within ethically questionable situations. (shrink)

Leadership and areas of influence are often reserved for the adult community. The youth are mostly regarded as developing beings, with insufficient knowledge and experience to take on leadership roles where influence can be exercised. It is often considered – especially in the context of the church – that the youth do not have the capacity to lead, while evidence from society and research studies points to the contrary. The author of this article argues that the ability to influence does (...) not depend on age or in an accumulation of experience. Instead, the ability of the youth to make a difference is attributed to their desire to do so. The author draws attention to why we need to focus on the youth and their ability to make a difference. The article presents an argument based on scriptural evidence and a theology of childhood as to why it is indeed possible and beneficial for the youth to exert their influence across various sectors of society. (shrink)

If we are to escape reification—a sort of cogni- tive neutrality of basic, gnosic apprehension of the world plus a fundamental disrespect of the other as free agent—we should recognize our mode of existence as always already one of existential engagement with and within experience, aiming at articulating and expressing this engagement. One way of fully inhabiting this, let’s call it the proper human stance, is through recognizing a pendular space between the basic attitudes of acknowledging lived, shared interests and (...) values and avoiding being bound to and dependent on the values of others. Both philosophy as radical critical re- flection, and art, or artistic processes of production and re- ception, can be seen as invitations to inhabit this pendular space of human experience, by way of continually opening up our habits of sensibility to new engagements in thought and life, and successfully articulating and expressing these engagements in public forms. I take Cavell’s reading of Wittgenstein’s mature philosophy as an attuning to an apt attitude towards this invitation. Is this attitude one possible, non-procedural meaning of “liberalism”? (shrink)

There has been an increase of discussion and focus on matters of theological significance in the area of youth ministry. An area that remains neglected concerns the professional youth worker in Southern Africa. This focus on professional youth work has gained a great amount of urgency from the office of the presidency of Southern Africa, who in collaboration with the Commonwealth desk have prioritised the focus on youth work in South Africa. Unfortunately, the focus on the professional youth worker, the (...) career youth pastor, within the church in Southern Africa fails to receive a similar amount of attention. The article will highlight the need to pursue a theological articulation around the office of the career youth pastor by building a practical theological argument for the office of career youth pastor. The article will address a case study of a mainline evangelical denomination regarding its theological articulation of the career youth pastor. (shrink)