In some situations a number of agents each have the ability to undertake an initiative that would have significant effects on the others. Suppose that each of these agents is purely motivated by an altruistic concern for the common good. We show that if each agent acts on her own personal judgment as to whether the initiative should be undertaken, then the initiative will be undertaken more often than is optimal. We suggest that this phenomenon, which we call the unilateralist’s (...) curse, arises in many contexts, including some that are important for public policy. To lift the curse, we propose a principle of conformity, which would discourage unilateralist action. We consider three different models for how this principle could be implemented, and respond to an objection that could be raised against it. (shrink)

Why do the two sexes have different lifespans and rates of aging? Two hypotheses based on asymmetric inheritance of sex chromosomes (“unguarded X”) or mitochondrial genomes (“mother's curse”) explain sex differences in lifespan as sex‐specific maladaptation leading to increased mortality in the shorter‐lived sex. While asymmetric inheritance hypotheses equate long life with high fitness, considerable empirical evidence suggests that sexes resolve the fundamental tradeoff between reproduction and survival differently resulting in sex‐specific optima for lifespan. However, selection for sex‐specific values (...) in life‐history traits is constrained by intersexual genetic correlations resulting in intra‐locus sexual conflict over optimal lifespan. The available data suggest that the evolution of sexual dimorphism only partially resolves these conflicts. Sexual conflict over optimal trait values, which has been demonstrated in model organisms and in humans, is likely to play a key role in shaping the evolution of lifespan, as well as in maintaining genetic variation for sex‐specific diseases. (shrink)

The AGI alignment problem has a bimodal distribution of outcomes with most outcomes clustering around the poles of total success and existential, catastrophic failure. Consequently, attempts to solve AGI alignment should, all else equal, prefer false negatives (ignoring research programs that would have been successful) to false positives (pursuing research programs that will unexpectedly fail). Thus, we propose adopting a policy of responding to points of philosophical and practical uncertainty associated with the alignment problem by limiting and choosing necessary assumptions (...) to reduce the risk of false positives. Herein we explore in detail two relevant points of uncertainty that AGI alignment research hinges on---meta-ethical uncertainty and uncertainty about mental phenomena---and show how to reduce false positives in response to them. (shrink)

Brahmā’s Curse: Facets of Political and Social Violence in Premodern Kashmir. By Walter Slaje. Studia Indologica Universitatis Halensis, vol. 13. Halle an der Saale: Universitätsverlag Halle-Wittenberg, 2019. Pp. viii + 53. €48.

In lieu of an abstract, here is a brief excerpt of the content:David Michael Levin ROUSSEAU'S CURSE Pretext Rousseau is the author of a text he called his Confessions. ' But neither a text nor a confession can exist without a reader, or an other. Like it or not, we readers are participants in the rite of Rousseau's confessions. Do we have anything to confess? When the reading of a confession uncovers the spelling of a curse, so that (...) the self-accused author appears to accuse his readers, the discoverers of the curse can no longer pretend their neutrality and innocence. In fact, the detectives must assume the identity of the accused. In such a special case, then, the inevitable work of textual interpretation magically doubles as the story of a mysteriously elusive "crime" and its final, or anyway presumed detection. But, as in the very best of such stories, neither the skillfully executed crime nor its invisible author—if indeed these terms denote anything at all—need be what they seem. So perhaps the only thing we can say for sure here is that the spelling of the curse is the curse of spelling. And this puts us on the track of a mystery as ancient as the art of writing itself—a mystery whose story the scholars of hermeneutics have thus far preferred to ignore. The mystery I have in mind is the secret affinity between writing and death. A careful hermeneutic approach to Plato's critique of writing, however, may give us a crucial clue. For what binds written language to the power of death is its role in mourning, its incarnation in the form of shadows: black configurations of shadows placed for visibility against the white of the paper. In Plato's Myth of the Cave, the crime of writing is dimly adumbrated. Writing is idolatry, worship of false images, shadows. Rousseau's Confessions, written near the end of his life in the shadow of death, does not escape the shadows of doubt and suspicion which we, his readers, having discovered our own selves inscribed into the darkness of the text, cannot easily refrain from casting. But as soon as we recognize in the shapes of these shadows a suspicion for which 76 David Michael Levin77 we are responsible, we must confess our fatal complicity in the closing of the hermeneutical circle. Commentary on the Text If Rousseau's Confessions does not read like the typical memoir, neither does it read like the typical confession. A final twist awaits us. We read with a certain innocence, or faith, not prepared for the transitive conclusion: the text, as it happens, will bequeath a monstrous and impossible burden. What is the reader to do? How could it be that this man, who seemed to honor us, and won our trust with the candor of his revelations, should so boldly, by one cross conceit, vanish, only to leave us double-crossed and within a labyrinth which, as he would have us believe, we ourselves have wrought? What are we to make of his work? At first, the Confessions appears to be a work of light: with dazzling clarity of mind and courage no less prismatic, Rousseau proposes to take his readers into the gloomy chasms of his soul. "My purpose," he declares, "is to display to my kind a portrait in every way true to nature, and the man I shall portray is myself" (p. 17). That this, however, is not the whole of his intention, we learn through a neighboring sentence. For he says: "Let the last trumpet sound when it will, I shall come forward with this work in my hand, to present myself before my Sovereign Judge, and proclaim aloud: 'Here is what I have done'..." (p. 17). And yet, even this does not fully disclose his design, since he concedes, somewhat later, that "it is as if, feeling my life escaping from me, I were trying to recapture it at its beginnings" (p. 31). But in the end, as in the beginning, darkness and light are one. And indeed, deep into the Seventh Book, we see that the author's light does begin to dim, and that he no longer speaks with much assurance. Nor is... (shrink)

This paper explores background features in the development of Nietzsche’s criticism of Christianity by following him through what I have termed his conventional stage, his critical stage, and his stage of outrage. Next to examining some of his various criticisms during those stages, I also ask what the challenges were to which these criticisms responded and why Nietzsche eventually responded to these challenges with outrage. Outrage towards Christianity is unmistakably expressed in Nietzsche’s late work The Antichrist: A Curse on (...) Christianity. To understand Nietzsche’s outrage better we need to explore the role of ‘Antichrist’ in the title of that work and the meaning of ‘curse’ in its subtitle. (shrink)

We set out to find ways to help decision makers overcome the “winner’s curse,” a phenomenon commonly observed in asymmetric information bargaining situations, and instead found strong support for its robustness. In a series of manipulations of the “Acquiring a Company Task,” we tried to enhance decision makers’ cognitive understanding of the task. We did so by presenting them with different parameters of the task, having them compare and contrast these different parameters, giving them full feedback on their history (...) of choices and resulting outcomes, and allowing them to interact with a human opponent instead of a computer program. Much to our surprise, none of these manipulations led to a better understanding of the task. Our results demonstrate and emphasize the robustness of the winner’s curse phenomenon. (shrink)

In this paper, I revisit the question of how and in what sense can individuals comprising a group be held responsible for morally reprehensible behaviour by that group. The question is tackled by posing a counterfactual: what would happen if selfish individuals became moral creatures? A game called the Samaritan’s Curse is developed, which sheds light on the dilemma of group moral responsibility, and raises new questions concerning ‘conferred morality’ and self-fulfilling morals, and also forces us to question some (...) implicit assumptions of game-theory. (shrink)

A lot of philosophy taught to science students consists of scientific methodology. But many philosophy of science textbooks have a fraught relationship with methodology, presenting it either a system of universal principles or entirely permeated by contingent factors not subject to normative assessment. In this paper, I argue for an alternative, heuristic perspective for teaching methodology: as fallible, purpose- and context-dependent, subject to cost-effectiveness considerations and systematically biased, but nevertheless subject to normative assessment. My pedagogical conclusion from this perspective is (...) that philosophers should aim to teach science students heuristic reasoning: strategies of normative method choice appraisal that are sensitive to purposes, contexts, biases and cost-effectiveness considerations; and that we should do so by teaching them exemplars of such reasoning. I illustrate this proposal at the hand of three such exemplars, showing how they help students to appreciate the heuristic nature of both methods and methodology, and to normatively assess method choice in such circumstances. (shrink)

The winner’s curse in auctions might emerge from asymmetric information and/or from some willingness to pay for winning. This article is based on a sealed-bid common value first price auction, with a net loss for the subject with the second highest bid. The results show the existence of a trade-off between the magnitude of the potential loss and the willingness to pay for the victory. In the context of public procurement these results suggest that companies are willing to overpay (...) small contracts to gain a sort of ‘free advertising’, whereas this is not the case when the contracts are large. (shrink)

This article discusses the causes of Lev Shestov’s psychological and worldview crises that he experienced in 1895, forcing the thinker to abandon his idealist philosophy and to embark on a path of...

David Gauthier in his article, Maximization constrained: the rationality of cooperation, tries to defend of the joint strategy in situations which no outcome is both equilibrium and optimal. Prisoner’s Dilemma is the most familiar example of these situations. He first starts with some quotes by Hobbes in Leviathan; Hobbes, in chapter 15 discusses an objection by someone is called Foole, and then will reject his view. In response to Foole, Hobbes presents two strategies (i.e. joint and individual) and two kinds (...) of agents in such problems including Prisoner’s Dilemma – i.e. straightforward maximizer (SM) and constrained maximizer(CM). Then he considers two arguments respectively for SM and CM, and he will show that why in an ideal and transparent situation, the first argument fails and the second one would be the only valid argument. likewise, in the following part of his article, he considers more realistic situations with translucency and he concludes that under some conditions, joint strategy would be still the rational decision. (shrink)

My aim in this paper is to show how the problem of inflated effect sizes corrupts the severity measure of evidence. This has never been done. In fact, the Winner’s Curse is barely mentioned in the philosophical literature. Since the severity score is the predominant measure of evidence for frequentist tests in the philosophical literature, it is important to underscore its flaws. It is also crucial to bring the philosophical literature up to speed with the limits of classical testing. (...) The Winner’s Curse is one of them. The problem is that when a significant result is obtained by using an underpowered test, the severity score becomes particularly high for large discrepancies from the null-hypothesis. This means that such discrepancies are very well supported by the evidence according to that measure. However, it is now well documented that significant tests with low power display inflated effect sizes. They systematically show departures from the null hypothesis H0 that are much greater than they really are. From an epistemological point of view this means that a significant result produced by an underpowered test does not provide evidence for large discrepancies from H0. Therefore, the severity score is an inadequate measure of evidence. Given that we are now aware of the phenomenon of inflated effect sizes, it would be irresponsible to rely on the severity score to measure the strength of the evidence against the null. Instead, one must take appropriate measures to try and avoid using underpowered tests by setting a threshold for the sample size or by replicating the results of the experiment. (shrink)

In cloud security, intrusion detection system (IDS) is one of the challenging research areas. In a cloud environment, security incidents such as denial of service, scanning, malware code injection, virus, worm, and password cracking are getting usual. These attacks surely affect the company and may develop a financial loss if not distinguished in time. Therefore, securing the cloud from these types of attack is very much needed. To discover the problem, this paper suggests a novel IDS established on a combination (...) of a leader-based k-means clustering (LKM), optimal fuzzy logic system. Here, at first, the input dataset is grouped into clusters with the use of LKM. Then, cluster data are afforded to the fuzzy logic system (FLS). Here, normal and abnormal data are inquired by the FLS, while FLS training is done by the grey wolf optimization algorithm through maximizing the rules. The clouds simulator and NSL-Knowledge Discovery and DataBase (KDD) Cup 99 dataset are applied to inquire about the suggested method. Precision, recall, and F-measure are conceived as evaluation criteria. The obtained results have denoted the superiority of the suggested method in comparison with other methods. (shrink)

This book is the third in a series based on conferences sponsored by the Metroplex Institute for Neural Dynamics, an interdisciplinary organization of neural ...

Two reports have shown that mammalian artificial chromosomes (MAC) can be constructed from cloned human centromere DNA and telomere repeats, proving the principle that chromosomes can form from naked DNA molecules transfected into human cells. The MACs were mitotically stable, low copy number and bound antibodies associated with active centromeres. As a step toward second-generation MACs, yeast and bacterial cloning systems will have to be adapted to achieve large MAC constructs having a centromere, two telomeres, and genomic copies of mammalian (...) genes. Available construction techniques are discussed along with a new P1 artificial chromosome (PAC)-derived telomere vector (pTAT) that can be joined to other PACs in vitro, avoiding a cloning step during which large repetitive arrays often rearrange. The PAC system can be used as a route to further define the optimal DNA elements required for efficient MAC formation, to investigate the expression of genes on MACs, and possibly to develop efficient MAC-delivery protocols. BioEssays 1999;21:76–83. © 1999 John Wiley & Sons, Inc. (shrink)

This article is guided by principles and practices of bioethics and public health ethics focused on health care reform within the context of promoting Optimal Health. The Tuskegee University National Center for Bioethics in Research and Health Care is moving beyond the traditions of bioethics to incorporate public health ethics and Optimal Health. It is imperative to remember the legacy of the ill-fated research entitled Tuskegee Study of Untreated Syphilis in the Negro Male. Human participant research and health care must (...) be connected to principles of bioethics and public health ethics if the Affordable Care Act is expected to positively impact on the health of people living in the United States. Optimal Health describes a strategy to achieve individual and population health. Health care reform offers an opportunity to shift from the traditional pathology focus of managing diseases to target disease prevention and health promotion with a new set of tools. Transformational change is possible if the lessons learned from the U.S. Public Health Service Syphilis Study at Tuskegee are considered and strategies in bioethics and public heath ethics are employed. (shrink)

Amitav Ghosh’s The Nutmeg’s Curse (2021) is an insightful deliberation on the layered inequities and asymmetries created by the intersection of colonialism and anthropogenic activities. In The Nutmeg’s Curse, Ghosh conceives the present-day climate and ecological crisis as fallouts of colonial thinking and its manifestations in dominant epistemic and ethical constructions. This article underscores Ghosh’s critique of the Eurocentric discourses for their instrumentality in producing the totalitarian binaries of human and non-human, in which the ‘human’ was always the (...) whites and the ‘non-human’ comprised all ‘others’—the non-whites, indigenous people, nature and ecology. In attributing agency and signifying authority to the white capitalist, this dualistic thinking has always conceived of the ‘others’ as non-humans—those who could be objectified, commodified and tampered with. This article explores how Ghosh repudiates this colonialist monolithic demarcation, which, in compliance with the discourse of the Anthropocene, had annihilated non-Western forms of signification, knowledge and ethics. The article focuses on how the systemic othering of Western modernity’s episteme had been incremental, leading to occurrences of ‘testimonial injustices’ and ‘hermeneutical injustices’—which had culminated in severe forms of epistemicide and unleashed, what Boaventura de Sousa Santos terms ‘cognitive injustice’—relegating indigeneity and ecology to precarious conditions. In accordance with this, this article argues that Ghosh envisages a critical necessity to dismantle the matrix of Western capitalist modernity and its associated narrative of the Anthropocene and claims for a conceptualization of decolonial ecological ethics that would prioritize an encompassing of the episteme produced by the ‘other’. An engagement with the indigenous voices and a restoration of non-Western modes of knowledge production are crucial, as they can offer new ethical dimensions to envision ecology and life with its multiplicities and facilitate ‘cognitive justice’ for the oppressed and unrepresented ‘other’. (shrink)

There is evidence that bidders fall prey to the winner’s curse because they fail to extract information from hypothetical events—like winning an auction. This paper investigates experimentally whether bidders in a common value auction perform better when the requirements for this cognitive issue—also denoted by contingent reasoning—are relaxed, leaving all other parameters unchanged. For my underlying research question, I used a lab experiment with two stages. In stage I, the subjects participate in a non-standard common value auction, called the (...) wallet game, in which a naïve bidding strategy can lead to both winner’s curse and loser’s curse. In stage II, the subjects in the treatment group learn whether their initial bid was the winning bid or not and they get the opportunity to change this bid. In this sense, the bidders face the same decision problems as in stage I again, but the need for hypothetical thinking is reduced in stage II. The overall pattern of the data suggests that the problem of irrational over- and underbidding can be weakened by giving the subjects ex ante feedback about their bid, but unlike related studies I also find negative effects of additional information. (shrink)

PurposeSocial media has increased as a marketing channel, and Facebook is the biggest social media company globally. Facebook contains both positive and negative information about companies; therefore, it is important for companies to manage their Facebook page to best serve their own interests. Although most users are familiar with business and marketing activities on Facebook, they use it primarily for fun and personal purposes. The most effective methods for companies to use Facebook have not been clear. The personal nature of (...) Facebook presents unique challenges for companies by raising ethical and social responsibility issues that are important to users. The purpose of this paper is to discover how companies can optimize their use of Facebook as a marketing channel.Design/methodology/approachA survey was conducted. The respondents were 158 users of Facebook in Sweden; complete answers were provided by all respondents. In a series of specific questions and comments, the respondents were asked to describe an optimal marketing solution on Facebook for companies. They rated different functions, which were illustrated with pictures, to help in the cognitive process and to avoid misunderstandings.FindingsMost users who have an opinion on the issue accept marketing on Facebook, but only in the right amount. There are basically two groups: those who think that companies have no place on Facebook and those who want companies to be active on Facebook. The latter group emphasizes the importance of meaningful posts without unsolicited sales messages, and would prefer to search for the companies themselves rather than being bombarded by company messages. By far, status updates and pictures/images were found to be the most important functions to respondents.Research limitations/implicationsThe sample consisted of only Swedish users. Another limitation was that, since many Facebook users do not normally think about the implications of being exposed to marketing on Facebook, they have difficulty taking a position on many issues related to the service.Practical implicationsThe results give companies a clear idea of how to effectively use Facebook in their marketing efforts.Originality/valueA large number of companies are currently asking themselves, “How can we use Facebook in an optimal way?” The results in this study answer this question and lead directly to saving time and resources for these companies. (shrink)

Management and performance are interdisciplinary, spanning diverse fields such as business, industry, government, sports, arts, health and education. In four studies, world-class performers in a variety of fields, for example, management, sports and classical music, have been found to display higher mind–brain development than matched average-performing control groups, including more frequent peak experiences. In this article, we will use a selection of clearly articulated peak experiences reported by these world-class performers to illustrate the subjective or inner nature of optimal performance. (...) Such performance seems to be characterized by inner calmness and happiness amidst dynamic activity, maximum wakefulness, effortlessness and ease of functioning, and a sense of perfection. In order to provide an adequate theoretical framework for understanding peak experiences, we combine Western developmental psychology with the advanced growth range of higher consciousness, as outlined in the ancient Vedic knowledge of India. (shrink)

We formulate and analyze the dynamics of an influenza pandemic model with vaccination and treatment using two preventive scenarios: increase and decrease in vaccine uptake. Due to the seasonality of the influenza pandemic, the dynamics is studied in a finite time interval. We focus primarily on controlling the disease with a possible minimal cost and side effects using control theory which is therefore applied via the Pontryagin’s maximum principle, and it is observed that full treatment effort should be given while (...) increasing vaccination at the onset of the outbreak. Next, sensitivity analysis and simulations (using the fourth order Runge-Kutta scheme) are carried out in order to determine the relative importance of different factors responsible for disease transmission and prevalence. The most sensitive parameter of the various reproductive numbers apart from the death rate is the inflow rate, while the proportion of new recruits and the vaccine efficacy are the most sensitive parameters for the endemic equilibrium point. (shrink)

The COVID-19 pandemic has resulted in more than 524 million cases and 6 million deaths worldwide. Various drug interventions targeting multiple stages of COVID-19 pathogenesis can significantly reduce infection-related mortality. The current within-host mathematical modeling study addresses the optimal drug regimen and efficacy of combination therapies in the treatment of COVID-19. The drugs/interventions considered include Arbidol, Remdesivir, Interferon and Lopinavir/ritonavir. It is concluded that these drugs, when administered singly or in combination, reduce the number of infected cells and viral load. (...) Four scenarios dealing with the administration of a single drug, two drugs, three drugs and all four are discussed. In all these scenarios, the optimal drug regimen is proposed based on two methods. In the first method, these medical interventions are modeled as control interventions and a corresponding objective function and optimal control problem are formulated. In this framework, the optimal drug regimen is derived. Later, using the comparative effectiveness method, the optimal drug regimen is derived based on the basic reproduction number and viral load. The average number of infected cells and viral load decreased the most when all four drugs were used together. On the other hand, the average number of susceptible cells decreased the most when Arbidol was administered alone. The basic reproduction number and viral load decreased the most when all four interventions were used together, confirming the previously obtained finding of the optimal control problem. The results of this study can help physicians make decisions about the treatment of the life-threatening COVID-19 infection. (shrink)

Journals regulate a significant portion of the communication between scientists. This paper devises an agent-based model of scientific practice and uses it to compare various strategies for selecting publications by journals. Surprisingly, it appears that the best selection method for journals is to publish relatively few papers and to select those papers it publishes at random from the available “above threshold” papers it receives. This strategy is most effective at maintaining an appropriate type of diversity that is needed to solve (...) a particular type of scientific problem. This problem and the limitation of the model is discussed in detail. (shrink)

Purpose ‐ The purpose of this paper is to explore the "resource curse" problem as a counter-example of creative performance and innovation by examining reliance on capital and physical resources, showing the gap between expectations and ex-post actual performance that became clearer under conditions of economic turmoil. Design/methodology/approach ‐ The analysis uses logistic regressions with dichotomous response and predictor variables on structured tables of count data, representing firm performance as an outcome of capital resources, physical resources and innovation where (...) appropriate. Findings ‐ Key findings relevant to economic and business practice follow. First, a typical characteristic of successful Vietnamese firms in the transition period is their reliance on either capital resources or physical asset endowments. Second, poor performers exhibit evidence of over-reliance on both capital and physical assets. Third, firms that relied on both types of resources tended to downplay creative performance. Some evidence suggests that firms face more acute problem caused by the law of diminishing returns in troubled times. Fourth, the "innovation factor" has not been tapped as a source of economic growth. Research limitations/implications ‐ This study has some limitations. The size of the survey sample is approximately 150 firms, while the potential sample of > 300 should be possible in the future. When the size increases, the research could be expanded to include further variables that will help investigate more deeply into the related issues and business implications. With regard to the implications of the study, the absence of innovations has made the notion of "resource curse" identical to "destructive creation" implemented by ex-ante resource-rich firms, and worsened the problem of resource misallocation in transition turmoil. The Vietnamese corporate sector's addiction to resources may contribute to economic deterioration, through a downward spiral of lower efficiency leading to consumption of more resources. Practical implications ‐ Insights obtained from this study could save transition economies' resources which have almost always been considered sine qua non before any critical major policymaking, while this is not necessarily true, and in many cases, even counterproductive. Originality/value ‐ Original data set on Vietnam stock market are collected, processed, prepared and used by the authors. Original design by the authors for regression equations with dichotomous predictor variables: dependence on endowed physical assets, reliance on capital resources and significant signs of creative performance/innovations. Original idea of viewing "resource curse" as absence of innovation and due to uncreative "destructive creation" of poor-performing commercial operations by resource-rich firms is used in the paper. We have searched the literature in business research and found that the empirical results have not been previously reported. (shrink)

Broad focus (or informational integration or nonautonomy) is lexically and contextually constrained, but these constraints are not well understood. On a standard theory of focus interpretation, the presupposition of a broad focus is verified whenever those of two narrow foci are. I argue that to account for cases where two narrow foci are preferred, it is necessary to assume that broad focus competes with two narrow foci and implicates the opposite of what they presuppose. Central constraints on thetic statements are (...) thus accounted for in an Optimality Theory (OT) enriched Alternative Semantics. (shrink)