One of the major developments in cancer research in recent years has been the construction of models that treat cancer as a cellular population subject to natural selection. We expand on this idea, drawing upon multilevel selection theory. Cancer is best understood in our view from a multilevel perspective, as both a by-product of selection at other levels of organization, and as subject to selection at several levels of organization. Cancer is a by-product in two senses. First, cancer cells co-opt (...) signaling pathways that are otherwise adaptive at the organismic level. Second, cancer is also a by-product of features distinctive to the metazoan lineage: cellular plasticity and modularity. Applying the multilevel perspective in this way permits one to explain transitions in complexity and individuality in cancer progression. Our argument is a reply to Germain’s scepticism towards the explanatory relevance of natural selection for cancer. The extent to which cancer fulfills the conditions for being a paradigmatic Darwinian population depends on the scale of analysis, and the details of the purported selective scenario. Taking a multilevel perspective clarifies some of the complexities surrounding how to best understand the relevance of evolutionary thinking in cancer progression. (shrink)

The mammalian placenta exhibits elevated expression of endogenous retroviruses (ERVs), but the evolutionary significance of this feature remains unclear. I propose that ERV‐mediated regulatory evolution was, and continues to be, an important mechanism underlying the evolution of placental development. Many recent studies have focused on the co‐option of ERV‐derived genes for specific functional adaptations in the placenta. However, the co‐option of ERV‐derived regulatory elements could potentially lead to the incorporation of entire gene regulatory networks, which, I argue, would (...) facilitate relatively rapid developmental evolution of the placenta. I suggest a model in which an ancient retroviral infection led to the establishment of the ancestral placental developmental gene network through the co‐option of ERV‐derived regulatory elements. Consequently, placental development would require elevated tolerance to ERV activity. This in turn would expose a continuous stream of novel ERV mutations that may have catalyzed the developmental diversification of the mammalian placenta. (shrink)

Why have theories of evolution become now a matter of concern for critically rethinking sex and sexual difference? Why after years of deconstructing the ontologies of sex rooted in biological discourses and metaphysics of identity has critical thought turned to biology, physics, and mathematics? One way to tackle this new turn toward scientific thought may be derived from the reaction against an overused method of textual critique, which has come short of engaging with the reality of matter. If sexuality (...) and sex are material forms of irreducible difference, then one needs a window into the material processes that lead to such forms. (shrink)

The climate of epistemological opinion is rapidly changing in the direction of an increasing concern with the substantive results of the empirical sciences of man, such as psychology and biology. This change is of a comparatively recent date: as late as in 1964, Chauncey Wright’s seminal speculations on the biology of knowledge-processes were shrugged off by one commentator as “nineteenth-century impedimenta and paraphernalia”. Today, such a judgment seems strangely out of date. Our knowledge of man as an animal has been (...) broadened and deepened, both by the dramatic advances of molecular biology and by the recent appearance of the ‘sociobiology’ represented by Edward O. Wilson. To the philosopher, the question inevitably arises of how far this knowledge extends and, in particular, to what extent it can account for peculiarly human intellectual phenomena, such as the growth of scientific knowledge. The study of man as an animal and the study of man as a knower can no longer be simply assumed to be two distinct and separate departments of thought. (shrink)

The Homo naledi discovery introduced questions that had not been previously posed regarding fossil finds. This is because, apart from their fascinating physiology, they seemingly deliberately disposed of their dead in a ritualised way. Although this theory may still be disproved in future, the present article provisionally accepts it. This evokes religious questions because it suggests the possibility of causal thinking, wilful and cooperative behaviour, and the possibility that this behaviour entails traces of proto-religious ideas. This poses the challenge to (...) develop a hominin hermeneutics that endeavours to reconstruct the possible motivation behind this action. The relatively larger brain with its enlarged Broca's area suggests the possibility of a sophisticated communication system and an enhanced way of dealing with emotion. We know that almost all life forms have some form of awareness and that more sophisticated degrees of consciousness may be present in the higher primates. Various 'clues' are investigated to try and understand the H. naledi phenomenon: lessons from chimpanzee studies, the implications of tool making for hominin development, the possibility of a proto-language and the role symbol formation may have played. The H. naledi case also indicates on a theological level that religion is natural. Some attention is given to this thesis. Biological and environmental factors come into play to illuminate biological factors like emotion and higher cognition without which religion would not be possible. Sophisticated cognition is coloured by affect and this makes some form of reflection on the fate of loved ones who have died a strong possibility. (shrink)

Conspicuous consumption associated with status reinforcement behavior can be explained in terms of costly signaling, or strategic handicap theory, first articulated by Zahavi and later formalized by Grafen. A theory is introduced which suggests that the evolutionary raison d’être of status reinforcement behavior lies not only in its effects on lifetime reproductive success, but in its positive effects on the probability of survival through infrequent, unpredictable demographic bottlenecks. Under some circumstances, such “wasteful” displays may take the form of displays of (...) altruistic behavior and generosity on the part of high status individuals, in that is signals the ability to bear the short-term costs of being generous or “cooperative,” while at the same time reinforcing the long-term benefits of higher status. (shrink)

I provide an exposition and critique of the ecological ethics of Murray Bookchin. First, I show how Bookchin draws on ecology and evolutionary biology to produce a mutually constraining cluster of ethical guidelines to underpin and justify his vision of a nonhierarchical, ecological society. I then critically examine Bookchin’s method of justification and the normative consequences that flow from his position. I argue that Bookchin’s enticing promise that his ecological ethics offers the widest realm of freedom to all life forms (...) is undermined by the way in which he distinguishes and privileges second nature over first nature. I conclude that Bookchin’s promise can only be delivered by a biocentric philosophy rather than by his own ecological ethics. (shrink)

In A Million Years of Music, Gary Tomlinson develops an extensive evolutionary narrative that emphasises several important components of human musicality and proposes a theory of the coalescence of these components. In this essay I tie some of Tomlinson’s ideas to five constraints on theories of music’s evolution. This provides the framework for organising my reconstruction of his model. Thereafter I focus on Tomlinson’s description of ‘entraining’ Acheulean toolmakers and offer several criticisms. I close with some tentative proposals for (...) further theorising. (shrink)

Hayek’s social theory of evolution suggests that market liberal morality is adaptive for social groups. He justified the evolutionary superiority of market liberalism by asserting that groups operating under a market liberal morality would have a higher capacity to expand and reproduce than groups with alternative tribal moralities. Thus, market liberal groups would be favoured through cultural and genetic group selection. But in fact, market liberal morality reveals maladaptive tendencies and remains insufficiently powerful to create adaptive social groups. Hayek’s (...) dismissal of moral tribalism in favour of market liberal morality is found to underestimate the importance of tribal goals in the evolutionary system. (shrink)

Abstract This paper argues that a genuine engagement of Christianity with evolution needs to include a discussion of Christology. Further, it develops a particular approach to Christology through a theo-dramatic account of incarnation. The somewhat static post-Chalcedon theological categories of divine and human natures are hard to square with contemporary evolutionary accounts of human origins. Once the divine Logos is portrayed in the active categories of Wisdom it becomes easier to envisage divine and creaturely wisdom coexisting in the person (...) of Christ. I argue, in particular, that a focus on God's agency through a modified version of Hans Urs von Balthasar's account of theo-drama invites participation and affirms human agency in a way that grand narratives do not. More particularly, drawing on examples from hominid evolution, contemporary discussion of paleontology and cooperative evolutionary theories, I suggest that the most convincing accounts of evolutionary biology fit into this theo-dramatic account more readily than alternatives. As such, in the spirit of Robert Boyle, this paper deliberately blurs the categories of revealed and natural theology by arguing that we can make sense of the former through concentration on the latter. (shrink)

One of the particular problems in the debate between science and theology regarding human origins seems to be an apparent controversy between the continuous character of evolutionary processes leading to the origin of Homo sapiens and the punctual understanding of the act of creation of man seen as taking place in a moment in time. The paper elaborates scientific arguments for continuity or discontinuity of evolution, and what follows, for the existence or nonexistence of a clear borderline between our (...) species and the rest of the living world. It is argued that, due to the conventional character of the notion of species, anthropology is unable to point to a moment in time or a place on Earth when or where Homo sapiens came into existence as a ‘really new’ species. The argument of the non˗specificity of humans is reinforced by considering emotional homologies between man and apes, “cultural” transmission of the patterns of behaviour in animals, or their mental and communicational abilities. All this is in line with a more general philosophical view of ontological continuity of the world. However, the argument is counterbalanced by pointing to such human characteristics as the ability to use abstract notions, or those forms of human behaviour which do not seem to have their animal analogues. In turn, various possibilities of theological interpretations of the act of creation of man are pointed out and a question is considered as to what extent theology is interested in a "momentary" account of this act. By pointing to theological accounts proposed as early as the 2nd century, it is argued that a vision of God – the craftsman who ‘builds’ its creation step by step, or even less restrictive forms of divine interventionism, are theologically inadequate. The original opposition between the continuity of evolutionary processes and ‘punctual’ character of creation is thus weakened and, from that perspective, a solution to the controversy in question is sought. One of such solutions, an “evolutionary model of creation”, a form of evolutionary creationism, proposed by a Polish philosopher Kazimierz Kloskowski, is presented. This model is based on two assumptions, stemming from process philosophy and evolutionary epistemology. The need to apply them in constructing a coherent view on evolution and creation is critically considered in the paper. (shrink)

Glowacki's work meshes well with our view of human nature as having evolved to use culture to improve survival and reproduction. Peace is a cultural achievement, requiring advances in social organization and control, including leaders who can implement policies to benefit the group, third-party mediation, and intergroup cooperation. Cultural advances shift intergroup interactions from negative-sum (war) to positive-sum (trade).

Embryos and microscopes share a long, remarkable history and biologists have always been intrigued to watch how embryos develop under the microscope. Here we discuss the advances in microscopy which have greatly influenced our current understanding of embryogenesis. We highlight the evolution of microscopes and the optical technologies that have been instrumental in studying various developmental processes. These imaging modalities provide mechanistic insights into the dynamic cellular and molecular events which drive lineage commitment and morphogenetic changes in the developing (...) embryo. We begin the journey with a brief history of microscopy to study embryos. First, we review the principles and optics of light, fluorescence, confocal, and electron microscopy which have been key techniques for imaging cellular and molecular events during embryonic development. Next, we discuss recent key imaging modalities such as light‐sheet microscopy, which are suitable for whole embryo imaging. Further, we highlight imaging techniques like multiphoton and super resolution microscopy for beyond light diffraction limit, high resolution imaging. Lastly, we review some of the scattering‐based imaging methods and techniques used for imaging human embryos. (shrink)

The traditional role of evolutionary theory in the social sciences has been to explain the existence of an object in terms of the survival of the fittest. In economics this approach has acted as a justification for hypotheses such as profit maximisation, or the existence of institutions in terms of their overall efficiency. This volume challenges that view and argues that one of the first tasks of economic theory should be to explain the enormous diversity of institutional arrangements that has (...) characterised human societies. (shrink)

Intelligent design, though unnecessary in the study of biological evolution, is essential to the study of cultural evolution. However, the intelligent designers in question are not deities or aliens but rather humans going about their lives. The role of intentionality in cultural evolution can be elucidated through the addition of signaling theory to the framework outlined in the target article. (Published Online November 9 2006).