Results for 'adipose tissue'

987 found
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  1.  22
    Adipose tissue NAD + biology in obesity and insulin resistance: From mechanism to therapy.Shintaro Yamaguchi & Jun Yoshino - 2017 - Bioessays 39 (5).
    Nicotinamide adenine dinucleotide (NAD+) biosynthetic pathway, mediated by nicotinamide phosphoribosyltransferase (NAMPT), a key NAD+ biosynthetic enzyme, plays a pivotal role in controlling many biological processes, such as metabolism, circadian rhythm, inflammation, and aging. Over the past decade, NAMPT‐mediated NAD+ biosynthesis, together with its key downstream mediator, namely the NAD+‐dependent protein deacetylase SIRT1, has been demonstrated to regulate glucose and lipid metabolism in a tissue‐dependent manner. These discoveries have provided novel mechanistic and therapeutic insights into obesity and its metabolic complications, (...)
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  2. Mechanisms of Lipid‐Associated Macrophage Accrual in Metabolically Stressed Adipose Tissue.Isabel Reinisch, Sarah Enzenhofer & Andreas Prokesch - forthcoming - Bioessays:e202400203.
    Adipose tissue (AT) inflammation, a hallmark of the metabolic syndrome, is triggered by overburdened adipocytes sending out immune cell recruitment signals during obesity development. An AT immune landscape persistent throughout weight loss and regain constitutes an immune‐obesogenic memory that hinders long‐term weight loss management. Lipid‐associated macrophages (LAMs) are emerging as major players in diseased, inflamed metabolic tissues and may be key contributors to an obesogenic memory in AT. Our previous study found that LAM abundance increases with weight loss (...)
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  3.  23
    Diversity of Adipose Tissue Immune Cells: Are All Eosinophils Created Equal?W. Reid Bolus - 2018 - Bioessays 40 (10):1800150.
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  4.  6
    Vibrational and structural investigations on adipose tissues.M. Giarola, G. Guella, G. Mariotto, F. Monti, B. Rossi, A. Sanson & A. Sbarbati - 2008 - Philosophical Magazine 88 (33-35):3953-3959.
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  5.  13
    Effects of surgical removal of interscapular brown adipose tissue on food intake and amphetamine anorexia.Paul J. Wellman & Patricia A. Watkins - 1984 - Bulletin of the Psychonomic Society 22 (5):472-473.
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  6.  2
    The LAM Is Not Enough–An Idea to Watch Regarding Adipose Tissue Macrophages and Their Disease Relevance.Lorenz Adlung - forthcoming - Bioessays:e202500020.
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  7.  31
    Defining Eosinophil Function in Adiposity and Weight Loss.Alexander J. Knights, Emily J. Vohralik, Kyle L. Hoehn, Merlin Crossley & Kate G. R. Quinlan - 2018 - Bioessays 40 (10):1800098.
    Despite promising early work into the role of immune cells such as eosinophils in adipose tissue (AT) homeostasis, recent findings revealed that elevating the number of eosinophils in AT alone is insufficient for improving metabolic impairments in obese mice. Eosinophils are primarily recognized for their role in allergic immunity and defence against parasitic worms. They have also been detected in AT and appear to contribute to adipose homeostasis and drive energy expenditure, but the underlying mechanisms remain elusive. (...)
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  8.  12
    Functional differentiation of white and brown adipocytes.Susanne Klaus - 1997 - Bioessays 19 (3):215-223.
    Adipose tissue plays an important role in mammalian energy equilibrium not only as a lipid‐dissipating, i.e. energy‐storing, tissue (white adipose tissue), but also as an energy‐dissipating one (brown adipose tissue). Brown adipocytes have the ability of facultative heat production due to a unique mitochondrial protein, the uncoupling protein (UCP). Differentiation of white and (to a lesser extent) brown adipocytes has been studied in different cell culture systems, which has led to the identification of (...)
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  9.  50
    Hunger and Satiety Signaling: Modeling Two Hypothalamomedullary Pathways for Energy Homeostasis.Kazuhiro Nakamura & Yoshiko Nakamura - 2018 - Bioessays 40 (8):1700252.
    The recent discovery of the medullary circuit driving “hunger responses” – reduced thermogenesis and promoted feeding – has greatly expanded our knowledge on the central neural networks for energy homeostasis. However, how hypothalamic hunger and satiety signals generated under fasted and fed conditions, respectively, control the medullary autonomic and somatic motor mechanisms remains unknown. Here, in reviewing this field, we propose two hypothalamomedullary neural pathways for hunger and satiety signaling. To trigger hunger signaling, neuropeptide Y activates a group of neurons (...)
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  10.  20
    Environmental factor reversibly determines cellular identity through opposing Integrators that unify epigenetic and transcriptional pathways.Hiroki Takahashi, Ryo Ito, Yoshihiro Matsumura & Juro Sakai - 2024 - Bioessays 46 (2):2300084.
    Organisms must adapt to environmental stresses to ensure their survival and prosperity. Different types of stresses, including thermal, mechanical, and hypoxic stresses, can alter the cellular state that accompanies changes in gene expression but not the cellular identity determined by a chromatin state that remains stable throughout life. Some tissues, such as adipose tissue, demonstrate remarkable plasticity and adaptability in response to environmental cues, enabling reversible cellular identity changes; however, the mechanisms underlying these changes are not well understood. (...)
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  11.  16
    I am Not Obese. I am Just Fat.Sarah Bramblette - 2014 - Narrative Inquiry in Bioethics 4 (2):85-88.
    In lieu of an abstract, here is a brief excerpt of the content:I am Not Obese. I am Just Fat.Sarah BrambletteMy body mass index classifies me as super morbidly obese, however my overall vital health statistics would indicate otherwise. I celebrated the American Medical Association’s classification of obesity as a disease for several reasons. First, obesity as a disease involves other medical complications of which I have none, so finally perhaps I can say I am not obese, I am just (...)
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  12.  3
    The Art of Chilling Out: How Neurons Regulate Torpor.Akinobu Ohba & Hiroshi Yamaguchi - 2025 - Bioessays 47 (2):e202400190.
    Endothermic animals expend significant energy to maintain high body temperatures, which offers adaptability to varying environmental conditions. However, this high metabolic rate requires increased food intake. In conditions of low environmental temperature and scarce food resources, some endothermic animals enter a hypometabolic state known as torpor to conserve energy. Torpor involves a marked reduction in body temperature, heart rate, respiratory rate, and locomotor activity, enabling energy conservation. Despite their biological significance and potential medical applications, the neuronal mechanisms regulating torpor still (...)
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  13.  14
    Metabolism and chromatin: A dynamic duo that regulates development and ageing.Andromachi Pouikli & Peter Tessarz - 2021 - Bioessays 43 (5):2000273.
    Bone‐marrow mesenchymal stem cell (BM‐MSC) proliferation and lineage commitment are under the coordinated control of metabolism and epigenetics; the MSC niche contains low oxygen, which is an important determinant of the cellular metabolic state. In turn, metabolism drives stem cell fate decisions via alterations of the chromatin landscape. Due to the fundamental role of BM‐MSCs in the development of adipose tissue, bones and cartilage, age‐associated changes in metabolism and the epigenome perturb the balance between stem cell proliferation and (...)
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  14.  26
    Importance of muscular system in breast cancer patients: a science, technology and society approach.Yolexis Prieto Cordovés, Luisa María Serrano González, Iris Susana Bacallao Cabrera & Natacha María Guillemí Álvarez - 2019 - Humanidades Médicas 19 (1):180-200.
    RESUMEN El presente texto es el resultado de un estudio dirigido a demostrar la importancia del sistema muscular en mujeres operadas de cáncer de mama, enfermedad con elevada incidencia en Cuba y el mundo. Se investigó en los principales reportes anatómicos. Se partió de la revisión documental de textos básicos para la carrera de Medicina inherentes a la asignatura Anatomía Humana. Se corroboró que autores como M. Prives, N Lisenkov y V Bushkovich y R. D. Sinelnikov; describen los músculos, pero (...)
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  15.  17
    Mitochondrially localized MPZL3 emerges as a signaling hub of mammalian physiology.Tongyu C. Wikramanayake, Carina Nicu, Jérémy Chéret, Traci A. Czyzyk & Ralf Paus - 2021 - Bioessays 43 (10):2100126.
    MPZL3 is a nuclear‐encoded, mitochondrially localized, immunoglobulin‐like V‐type protein that functions as a key regulator of epithelial cell differentiation, lipid metabolism, ROS production, glycemic control, and energy expenditure. Recently, MPZL3 has surfaced as an important modulator of sebaceous gland function and of hair follicle cycling, an organ transformation process that is also governed by peripheral clock gene activity and PPARγ. Given the phenotype similarities and differences between Mpzl3 and Pparγ knockout mice, we propose that MPZL3 serves as a signaling hub (...)
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  16.  19
    A Influência da Alimentação e Estado Nutricional Do Brasileiro Sob a Inflamação Subclínica Sistêmica – Um Prato Cheio Para o Covid-19.Maria Luisa Bellotto - 2020 - Simbio-Logias Revista Eletrônica de Educação Filosofia e Nutrição 12 (16):20-33.
    Knowledge about eating habits is relevant for understanding the relations between diet, obesity and development of Chronic Non-Communicable Diseases. The storage of calories as body fat, mainly in the visceral subcutaneous adipose tissue, as consequence of hypercaloric diet poor in nutrients, is responsible for increasing sublinic inflammation and overloading the immune system. Diet plays an important role in reducing inflammation. In time of infectious pandemia, of the new corona virus (COVID-19), the food quality and nutritional status of Brazilians (...)
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  17.  24
    Lipophilic Environmental Chemical Mixtures Released During Weight‐Loss: The Need to Consider Dynamics.Duk-Hee Lee, David R. Jacobs, Lars Lind & P. Monica Lind - 2020 - Bioessays 42 (6):1900237.
    Intentional weight loss can increase health risk in the long‐term, despite short‐term benefits, because human adipose tissue is widely contaminated with various lipophilic environmental contaminants, especially persistent organic pollutants (POPs). Recently, chronic exposure to low POPs has emerged as a new risk factor for common metabolic diseases and cardiovascular diseases. The amount of POPs released from adipocytes to the circulation increases during weight loss, thereby increasing POPs exposure of other critical organs. Possible harmful effects due to release of (...)
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  18.  26
    Signaling roles of platelets in skeletal muscle regeneration.Flavia A. Graca, Benjamin A. Minden-Birkenmaier, Anna Stephan, Fabio Demontis & Myriam Labelle - 2023 - Bioessays 45 (12):2300134.
    Platelets have important hemostatic functions in repairing blood vessels upon tissue injury. Cytokines, growth factors, and metabolites stored in platelet α‐granules and dense granules are released upon platelet activation and clotting. Emerging evidence indicates that such platelet‐derived signaling factors are instrumental in guiding tissue regeneration. Here, we discuss the important roles of platelet‐secreted signaling factors in skeletal muscle regeneration. Chemokines secreted by platelets in the early phase after injury are needed to recruit neutrophils to injured muscles, and impeding (...)
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  19.  11
    Time‐restricted feeding regulates lipid metabolism under metabolic challenges.Yiming Guo, Christopher Livelo & Girish C. Melkani - 2023 - Bioessays 45 (12):2300157.
    Dysregulation of lipid metabolism is a commonly observed feature associated with metabolic syndrome and leads to the development of negative health outcomes such as obesity, diabetes mellitus, non‐alcoholic fatty liver disease, or atherosclerosis. Time‐restricted feeding/eating (TRF/TRE), an emerging dietary intervention, has been shown to promote pleiotropic health benefits including the alteration of diurnal expression of genes associated with lipid metabolism, as well as levels of lipid species. Although TRF likely induces a response in multiple organs leading to the modulation of (...)
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  20.  11
    Skin aging: Dermal adipocytes metabolically reprogram dermal fibroblasts.Ilja L. Kruglikov, Zhuzhen Zhang & Philipp E. Scherer - 2022 - Bioessays 44 (1):2100207.
    Emerging data connects the aging process in dermal fibroblasts with metabolic reprogramming, provided by enhanced fatty acid oxidation and reduced glycolysis. This switch may be caused by a significant expansion of the dermal white adipose tissue (dWAT) layer in aged, hair‐covered skin. Dermal adipocytes cycle through de‐differentiation and re‐differentiation. As a result, there is a strongly enhanced release of free fatty acids into the extracellular space during the de‐differentiation of dermal adipocytes in the catagen phase of the hair (...)
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  21.  26
    Anthropometric Indicators as a Tool for Diagnosis of Obesity and Other Health Risk Factors: A Literature Review.Paola Piqueras, Alfredo Ballester, Juan V. Durá-Gil, Sergio Martinez-Hervas, Josep Redón & José T. Real - 2021 - Frontiers in Psychology 12.
    Obesity is characterized by the accumulation of an excessive amount of fat mass in the adipose tissue, subcutaneous, or inside certain organs. The risk does not lie so much in the amount of fat accumulated as in its distribution. Abdominal obesity is an important risk factor for cardiovascular diseases, diabetes, and cancer, having an important role in the so-called metabolic syndrome. Therefore, it is necessary to prevent, detect, and appropriately treat obesity. The diagnosis is based on anthropometric indices (...)
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  22.  17
    Probiotic dairy products and consumption preferences in terms of sweetness sensitivity and the occurrence of childhood obesity.Marek Kardas, Wiktoria Staśkiewicz, Ewa Niewiadomska, Agata Kiciak, Agnieszka Bielaszka & Edyta Fatyga - 2022 - Frontiers in Psychology 13.
    Fermented dairy products such as yogurt contain many bioactive compounds. In addition, probiotic yogurts are an invaluable source of probiotic bacteria and are a group of probiotic products best accepted by children. There is plenty of research indicating an interdependence between yogurt consumption, body mass index, and adipose tissue percentage, which suggests that yogurt consumption may contribute to reducing the risk of becoming overweight or obese. In turn, the occurrence of overweight and obesity may be accompanied by a (...)
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  23.  16
    Obesity genes and the regulation of body fat content.David S. Weigle & Joseph L. Kuijper - 1996 - Bioessays 18 (11):867-874.
    Physiological investigation has demonstrated that the central nervous system monitors body composition and adjusts energy intake and expenditure to stabilize total adipose tissue mass. Genetic variations in the signalling molecules involved in this regulatory system account for the heritable component of body fat content. The application of molecular techniques to rodent models of Mendelian obesity has resulted in the characterization of five loci at which mutations produce an abnormal accumulation of body fat. The genes at these loci include (...)
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  24.  16
    Neuro-Immunity Controls Obesity-Induced Pain.Tuany Eichwald & Sebastien Talbot - 2020 - Frontiers in Human Neuroscience 14:530365.
    The prevalence of obesity skyrocketed over the past decades to become a significant public health problem. Obesity is recognized as a low-grade inflammatory disease and is linked with several comorbidities such as diabetes, circulatory disease, common neurodegenerative diseases, as well as chronic pain. Adipocytes are a major neuroendocrine organ that continually, and systemically, releases pro-inflammatory factors. While the exact mechanisms driving obesity-induced pain remain poorly defined, nociceptors hypersensitivity may result from the systemic state of inflammation characteristic of obesity as well (...)
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  25.  4
    (1 other version)Dialectical Tension Between Gloomy and Rosy Prospects of Behavioral Genetics.Awais Aftab - 2024 - Philosophy Psychiatry and Psychology 31 (4):451-454.
    In lieu of an abstract, here is a brief excerpt of the content:Dialectical Tension Between Gloomy and Rosy Prospects of Behavioral GeneticsAwais Aftab, MD (bio)Turkheimer and Greer’s article “Spit for Science and the Limits of Applied Psychiatric Genetics” (2024) offers a devastating critique of the state of psychiatric genetics, using Spit for Science (S4S) as a case study. I have read the paper many times in the process of writing this commentary, and each time I am left inarticulate. Nonetheless, I (...)
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  26. Some Mechanical Properties of Collagenous Frameworks and Their Functional Significance.Structure of Connective Tissue - 1965 - In Karl W. Linsenmann, Proceedings. St. Louis, Lutheran Academy for Scholarship.
     
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  27. TITLE: Simmons Cancer Institute at Southern Illinois University School of Medicine Tissue Bank Protocol.Tissue Bank Director, Kathy Robinson, James Malone, Randolph Elble, John Godwin & I. N. D. Number - 2008 - IRB: Ethics & Human Research 3:12-10.
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  28.  10
    2 5 Ethics, Public Policy.Human Fetal Tissue - forthcoming - Bioethics: Basic Writings on the Key Ethical Questions That Surround the Major, Modern Biological Possibilities and Problems.
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  29.  18
    Tissue typing for bone marrow transplantation: An ethical examination of some arguments concerning harm to the child.Erica Grundell - 2003 - Monash Bioethics Review 22 (4):45-55.
    Tissue typing (TT) is a recent and controversial scientific advance. Whilst its current applications can easily be described as protherapeutic and within the realms of preventative medicine,1 its specificity and potential are often characterized as the tip of the eugenic iceberg: undermining the very basis of individual autonomy and identity in an inevitable march towards the perfect society:2 In addition to arguments concerning societal harms flowing from TT, significant concerns have also been raised concerning harms to the future child (...)
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  30.  17
    Fetal Tissue Research and the Misread Compromise.Warren Kearney - 1991 - Hastings Center Report 21 (5):7-12.
    The bill to restore federal funding for human fetal tissue research has been passed by the House and awaits Senate approval. But it requires women who are willing to donate fetal tissue to certify that they did not have an abortion with the intent to donate. It further requires researchers to keep the certifications on file and available for government audit. Both requirements spell trouble.
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  31.  13
    Visceral Adiposity Index Is a Measure of the Likelihood of Developing Depression Among Adults in the United States.Jun Lei, Yaoyue Luo, Yude Xie & Xiaoju Wang - 2022 - Frontiers in Psychology 13.
    BackgroundDepression is a serious mental disorder often accompanied by emotional and physiological disorders. Visceral fat index is the current standard method in the evaluation of visceral fat deposition. In this study, we explored the association between VAI and depression in the American population using NHANES data.MethodsA total of 2,577 patients were enrolled for this study. Data were collected through structured questionnaires. Subgroup analysis for the relationship between VAI and depression was evaluated using multivariate regression analysis after adjustment for potential confounding (...)
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  32.  74
    The use of human tissue.Grant Gillett - 2007 - Journal of Bioethical Inquiry 4 (2):119-127.
    The use of human tissue raises ethical issues of great concern to health care professionals, biomedical researchers, ethics committees, tissue banks and policy makers because of the heightened importance given to informed consent and patient autonomy. The debate has been intensified by high profile scandals such as the “baby hearts” debacle and revelations about the retention of human brains in neuropathology laboratories worldwide. Respect for patient’s rights seems, however, to impede research and development of clinical knowledge in contemporary (...)
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  33.  18
    Testicular Tissue Cryopreservation and Ethical Considerations: A Scoping Review.Angel Petropanagos - 2017 - Journal of Bioethical Inquiry 14 (2).
    Testicular tissue cryopreservation aims to preserve the future option of genetic reproduction for prepubescent cancer patients who are at risk of infertility as a result of their cancer therapies. This technology is experimental and currently only offered in the research context. As TTCP moves towards becoming more widely available, it is imperative that healthcare providers recognize the complex ethical issues surrounding this technology. This scoping review study identifies and assesses the range and depth of ethical concerns related to this (...)
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  34.  15
    Adiposity affects emotional information processing.César Romero-Rebollar, Leonor García-Gómez, Mario G. Báez-Yáñez, Ruth Gutiérrez-Aguilar & Gustavo Pacheco-López - 2022 - Frontiers in Psychology 13.
    Obesity is a worldwide epidemic associated with severe health and psychological wellbeing impairments expressed by an increased prevalence of affective disorders. Emotional dysfunction is important due to its effect on social performance. The aim of the present narrative review is to provide a general overview of human research exploring emotional information processing in overweight and obese people. Evidence suggests that obesity is associated with an attenuation of emotional experience, contradictory findings about emotion recognition, and scarce research about automatic emotional information (...)
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  35.  20
    Adiposity Related Brain Plasticity Induced by Bariatric Surgery.Michael Rullmann, Sven Preusser, Sindy Poppitz, Stefanie Heba, Konstantinos Gousias, Jana Hoyer, Tatjana Schütz, Arne Dietrich, Karsten Müller, Mohammed K. Hankir & Burkhard Pleger - 2019 - Frontiers in Human Neuroscience 13.
  36.  30
    Tissue vs Liquid Biopsies for Cancer Detection: Ethical Issues.Chiara Mannelli - 2019 - Journal of Bioethical Inquiry 16 (4):551-557.
    Cancer is the second leading cause of death in developed countries, making it a global public health problem. In this scenario, early detection is the key to successful treatment. Tissue biopsy, the current gold standard for cancer diagnosis, offers reliable results, but it is feasible only when the mass becomes detectable. On the other hand liquid biopsy, a promising experimental system, not yet implemented within clinical practice, allows early detection as its functioning relies on the analysis of body fluids. (...)
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  37.  51
    Is tissue engineering a new paradigm in medicine? Consequences for the ethical evaluation of tissue engineering research.Leen Trommelmans, Joseph Selling & Kris Dierickx - 2009 - Medicine, Health Care and Philosophy 12 (4):459-467.
    Ex-vivo tissue engineering is a quickly developing medical technology aiming to regenerate tissue through the introduction of an ex-vivo created tissue construct instead of restoring the damaged tissue to some level of functionality. Tissue engineering is considered by some as a new medical paradigm. We analyse this claim and identify tissue engineering’s fundamental characteristics, focusing on the aim of the intervention and on the complexity and continuity of the process. We inquire how these features (...)
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  38.  35
    Facial Adiposity, Attractiveness, and Health: A Review.Stefan de Jager, Nicoleen Coetzee & Vinet Coetzee - 2018 - Frontiers in Psychology 9.
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  39.  27
    Maternal Adiposity Influences Neonatal Brain Functional Connectivity.Andrew P. Salzwedel, Wei Gao, Aline Andres, Thomas M. Badger, Charles M. Glasier, Raghu H. Ramakrishnaiah, Amy C. Rowell & Xiawei Ou - 2019 - Frontiers in Human Neuroscience 12.
  40. The tissue organization field theory of cancer: A testable replacement for the somatic mutation theory.Ana M. Soto & Carlos Sonnenschein - 2011 - Bioessays 33 (5):332-340.
    The somatic mutation theory (SMT) of cancer has been and remains the prevalent theory attempting to explain how neoplasms arise and progress. This theory proposes that cancer is a clonal, cell‐based disease, and implicitly assumes that quiescence is the default state of cells in multicellular organisms. The SMT has not been rigorously tested, and several lines of evidence raise questions that are not addressed by this theory. Herein, we propose experimental strategies that may validate the SMT. We also call attention (...)
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  41.  65
    Neural fetal tissue transplants: Old and new issues.Lois Margaret Nora & Mary B. Mahowald - 1996 - Zygon 31 (4):615-632.
    Neural fetal tissue transplantation offers promise as a treatment for devasting neurologic conditions such as Parkinson's disease. Two types of issues arise from this procedure: those associated with the use of fetuses, and those associated with the use of neural tissue. The former issues have been examined in many forums; the latter have not. This paper reviews issues and arguments raised by the use of fetal tissue in general, but focuses on the implications of the use of (...)
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  42.  30
    Tissue‐disruption‐induced cellular stochasticity and epigenetic drift: Common origins of aging and cancer?Jean-Pascal Capp & Frédéric Thomas - 2021 - Bioessays 43 (1):2000140.
    Age‐related and cancer‐related epigenomic modifications have been associated with enhanced cell‐to‐cell gene expression variability that characterizes increased cellular stochasticity. Since gene expression variability appears to be highly reduced by—and epigenetic and phenotypic stability acquired through—direct or long‐range cellular interactions during cell differentiation, we propose a common origin for aging and cancer in the failure to control cellular stochasticity by cell–cell interactions. Tissue‐disruption‐induced cellular stochasticity associated with epigenetic drift would be at the origin of organ dysfunction because of an increase (...)
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  43.  76
    Tissue for transplantation.Tam Dalyell - 1975 - Journal of Medical Ethics 1 (2):61-62.
    In this article Mr Tam Dalyell mp uses extracts from the speech1 he made in the House of Commons on 11 December 1974 to reiterate his reasons for persisting in his attempts to have formulated in law the right of hospitals to take such organs from a dead person as might be useful unless before death potential donors (all of us) had stated that they did not consent. Details of those objecting would be registered on a central computer.
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  44.  62
    Taking tissue seriously means taking communities seriously.Ross EG Upshur, James V. Lavery & Paulina O. Tindana - 2007 - BMC Medical Ethics 8 (1):11.
    Health research is increasingly being conducted on a global scale, particularly in the developing world to address leading causes of morbidity and mortality. While research interest has increased, building scientific capacity in the developing world has not kept pace. This often leads to the export of human tissue (defined broadly) from the developing to the developed world for analysis. These practices raise a number of important ethical issues that require attention.
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  45.  31
    Tissue Culture and Tissue Culture Technologies at the Rockefeller Institute for Medical Research: Roots of Regenerative Medicine, 1910–1950. [REVIEW]Darwin H. Stapleton - 2009 - Medicine Studies 1 (1):77-81.
    Alexis Carrel’s and Keith Porter’s accomplishments at the Rockefeller Institute for Medical Research, 1910–1950, were fundamental to the creation of the field of tissue culture.
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  46.  81
    Human tissue biobanks: the balance between consent and the common good.Zisis Kozlakidis, Robert Js Cason, Christine Mant & John Cason - 2012 - Research Ethics 8 (2):113-123.
    Biobanks are currently archiving human materials for medical research at a hitherto unprecedented rate. These valuable resources will be essential for developing ‘personalized’ medicines and for a better understanding of disease susceptibilities. However, for such scientific advances to benefit everyone, it is crucial that biobanks recruit donations from all sections of the community. Unfortunately, other initiatives, such as transplant programmes, have clearly demonstrated that ethnic minorities are under-represented. Here we suggest that this issue deserves serious consideration to avoid biobanks evolving (...)
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  47.  22
    Biomedicine, tissue transfer and intercorporeality.Catherine Waldby - 2002 - Feminist Theory 3 (3):239-254.
    More and more areas of medicine involve subjects donating tissues to another — blood, organs, bone marrow, sperm, ova and embryos can all be transferred from one person to another. Within the technical frameworks of biomedicine, such fragments are generally treated as detachable things, severed from social identity once they are removed from a particular body. However an abundant anthropological and sociological literature has found that, for donors and patients, human tissues are not impersonal. They retain some of the values (...)
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  48.  20
    Unpacking the Human Tissue Act 2004.Elizabeth Cooke - 2007 - Research Ethics 3 (2):61-63.
    The Human Tissue Act 2004 has generated considerable confusion, and is perhaps not the easiest statute to read. This paper aims to give a short guided tour of its provisions, and to highlight some of the practical issues that have already arisen since it came into operation on 1 September 2006. It does so from the point of view of University researchers, and of University RECs which may have to advise on these issues.
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  49.  55
    Human Tissue and Global Ethics.Donna Dickenson - 2005 - Genomics, Society and Policy 1 (1):1-13.
    One important sense of 'global ethics' concerns the applied ethical issues arising in the context of economic globalisation. This article contends that we are beginning to witness the economic commodification and, concomitantly, the globalisation, of human tissue and the human genome. Policy-makers and local research ethics committees need to be aware that the relevant ethical questions are no longer confined to their old national or subnational context. A shift from questions of personal autonomy and identity can therefore be expected-towards (...)
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  50.  11
    Embryonic Tissue Should.Be Conducted - 2013 - In Arthur L. Caplan & Robert Arp, Contemporary debates in bioethics. Malden, MA: Wiley-Blackwell. pp. 25--237.
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