MPZL3 is a nuclear‐encoded, mitochondrially localized, immunoglobulin‐like V‐type protein that functions as a key regulator of epithelial cell differentiation, lipid metabolism, ROS production, glycemic control, and energy expenditure. Recently, MPZL3 has surfaced as an important modulator of sebaceous gland function and of hair follicle cycling, an organ transformation process that is also governed by peripheral clock gene activity and PPARγ. Given the phenotype similarities and differences between Mpzl3 and Pparγ knockout mice, we propose that MPZL3 serves as a signaling hub (...) that is regulated by core clock gene products and/or PPARγ to translate signals from these nuclear transcription factors to the mitochondria to modulate circadian and metabolic regulation. Conservation between murine and human MPZL3 suggests that human MPZL3 may have similarly complex functions in health and disease. We summarize current knowledge and discuss future directions to elucidate the full spectrum of MPZL3 functions in mammalian physiology. (shrink)

Introduction -- Fallibilism -- Contextualism -- Knowledge and reasons -- Justification -- Belief -- The value and importance of knowledge -- Infallibilism or pragmatic encroachment? -- Appendix I: Conflicts with bayesian decision theory? -- Appendix II: Does KJ entail infallibilism?

When should you engage with difficult arguments against your cherished controversial beliefs? The primary conclusion of this book is that your obligations to engage with counterarguments are more limited than is often thought. In some standard situations, you shouldn't engage with difficult counterarguments and, if you do, you shouldn't engage with them open-mindedly. This conclusion runs counter to aspects of the Millian political tradition and political liberalism, as well as what people working in informal logic tend to say about argumentation. (...) -/- Not all misleading arguments wear their flaws on their sleeve. Each step of a misleading argument might seem compelling and you might not be able to figure out what's wrong with it. Still, even if you can't figure out what's wrong with an argument, you can know that it's misleading. One way to know that an argument is misleading is, counterintuitively, to lack expertise in the methods and evidence-types employed by the argument. When you know that a counterargument is misleading, you shouldn't engage with it open-mindedly and sometimes shouldn't engage with it at all. You shouldn't engage open-mindedly because you shouldn't be willing to reduce your confidence in response to arguments you know are misleading. And you sometimes shouldn't engage closed-mindedly, because to do so can be manipulative or ineffective. -/- In making this case, Jeremy Fantl discusses echo chambers and group polarization, the importance in academic writing of a sympathetic case for the opposition, the epistemology of disagreement, the account of open-mindedness, and invitations to problematic academic speakers. (shrink)

Evidentialism is the thesis that epistemic justification for belief supervenes on evidential support. However, we claim there are cases in which, even though two subjects have the same evidential support for a proposition, only one of them is justified. What make the difference are pragmatic factors, factors having to do with our cares and concerns. Our argument against evidentialism is not based on intuitions about particular cases. Rather, we aim to provide a theoretical basis for rejecting evidentialism by defending a (...) “pragmatic” necessary condition on epistemic justification. We argue for the following necessary condition for justification: S is justified in believing that p only if S is rational to prefer (and, hence, act) as if p. In light of this necessary condition, the price of evidentialism is skepticism, or something close to it. (shrink)

Consider the sentence “Lois knows that Superman flies, but she doesn’t know that Clark flies”. In this paper we defend a Millian contextualist semantics for propositional attitude ascriptions, according to which ordinary uses of this sentence are true but involve a mid-sentence shift in context. Absent any constraints on the relevant parameters of context sensitivity, such a semantics would be untenable: it would undermine the good standing of systematic theorizing about the propositional attitudes, trivializing many of the central questions of (...) epistemology, the philosophy of mind, and the philosophy of action. In response to this problem, we prove a series of tenability results. We show that, given certain constraints on the parameters of context sensitivity, there is a broad class of principles of propositional attitude psychology whose good standing follows from corresponding claims about people’s mental representations. But these constraints also have some surprising consequences: they are jointly incompatible with coarse-grained theories of propositions, and they are in tension with a natural picture of how speakers and hearers coordinate on the interpretation of attitude ascriptions. In light of these consequences we explore different ways in which the contextualist picture might be developed, and argue that our preferred way compares favorably with Fregeanism and neo-Russellianism. (shrink)

Modest Infinitism -/- Jeremy Fantl -/- Abstract -/- Infinitism, a theory of justification most recently developed and defended by Peter Klein, is the view that justification is a matter of having an infinite series of non-repeating reasons for a proposition. I argue that infinitism is preferable to other theories (like foundationalism) in that only infinitism can plausibly account for two important features of justification: 1) that it admits of degrees and 2) that a concept of complete justification makes sense.

I argue that there is a prima facie tension between solutions to the problem of fake news and solutions to the problem presented by various cognitive biases that dispose us to dismiss evidence against our prior beliefs (what might seem to be the driving force behind echo chambers). We can guard against fake news by strengthening belief. But we can exit echo chambers by becoming more sensitive to counterevidence, which seems to require weakening our beliefs. I resolve the tension by (...) arguing against an injunction to weaken belief in the required ways. In particular, there is no injunction to be open-minded in all circumstances toward various counterarguments, even those whose premises seem compelling and in which we can’t expose a flaw. On the contrary, there are circumstances in which you should, in the relevant sense, be closed-minded toward such counterarguments. (shrink)

You know that George W. Bush is the U.S. president, but you know how to ride a bicycle. What's the difference? According to intellectualists, not much: either knowing how to do something is a matter of knowing that something is the case or, at the very least, know-how requires a prior bit of theoretical knowledge. Anti-intellectualists deny this order of priority: either knowing-how and knowing-that are independent or, at the very least, knowing that something is the case requires a prior (...) bit of know-how. Much of the dispute centers on the relationship between knowing how to do something and having an ability to do it. If having an ability is necessary and sufficient for knowing-how, this is thought to provide comfort for anti-intellectualists. This paper traces the place of ability in the know-how/know-that debate from Ryle's seminal statement of anti-intellectualism through Stanley and Williamson's more recent defense of intellectualism. (shrink)

Lady Mary Shepherd’s critique of Hume’s account of causation, his worries about knowledge of matters of fact, and the contention that it is possible for the course of nature to spontaneously change relies primarily on three premises, two of which – that objects are merely bundles of qualities and that the qualities of an object are individuated by the causal powers contributed by those qualities – anticipate contemporary metaphysical views in ways that she should be getting credit for. The remaining (...) premise – that it is impossible for an object to begin to exist uncaused – seems more old fashioned. I argue that Shepherd can do without her old-fashioned premise and that she provides the materials for arguing that her remaining premises demonstrate a stronger anti-Humeanism than is maintained even by the contemporary representatives of those views, even though she may have to concede more to Humeanism than she would like. (shrink)

Some things, but only some things, are by nature subject to standards. Why? I explain and develop what I call nature-first constitutivism, which says that what something is determines what it should be. Nature is the basis of normativity. I explain this view in terms of a unique type of property which particulars of a genus can lack even though those properties partially determines the nature of the genus. Such properties partially describe the nature of a genus and are thereby (...) normative for the particulars of that genus. Particulars of genera with such essential properties are by nature subject to standards with respect to those properties. Particulars of genera without such properties are not by nature subject to standards. (shrink)

This chapter addresses concerns that pragmatic encroachers are committed to problematic knowledge variance. It first replies to Charity Anderson and John Hawthorne’s new putative problem cases, which purport to show that pragmatic encroachment is committed to problematic variations in knowledge depending on what choices are available to the potential knower. It argues that the new cases do not provide any new reasons to be concerned about the pragmatic encroacher’s commitment to knowledge-variance. The chapter further argues that concerns about knowledge-variance are (...) not limited to the pragmatic encroacher, but come up for traditional purist invariantism as well. (shrink)

There is pragmatic encroachment on some epistemic status just in case whether a proposition has that status for a subject depends not only on the subject's epistemic position with respect to the proposition, but also on features of the subject's non-epistemic, practical environment. Discussions of pragmatic encroachment usually focus on knowledge. Here we argue that, barring infallibilism, there is pragmatic encroachment on what is arguably a more fundamental epistemic status – the status a proposition has when it is warranted enough (...) to be a reason one has for believing other things. (shrink)

An enduring theme of Western philosophy is that we are all one another’s equals. Yet the principle of basic equality is woefully under-explored in modern moral and political philosophy. What does it mean to say we are all one another’s equals? Jeremy Waldron confronts this question fully and unflinchingly in a major new multifaceted account.

The possibility of error conditions the possibility of normative principles. I argue that extant interpretations of this condition undermine the possibility of normative principles for our action because they implicitly treat error as a perfection of an action. I then explain how a constitutivist metaphysics of capacities explains why error is an imperfection of an action. Finally, I describe and defend the interpretation of the error condition which follows.

Foucault and Religion seeks to unearth a new dimension of Foucault scholarship. Renowned Foucault scholar Jeremy Carrette reveals not simply how Foucault's work can be applied to religion but how a religious question at the heart of Foucault's own work offers a radical challenge to religious ideas. Carrette argues that Foucault offers a twofold critique of Christianity by bringing the body and sexuality into religious practice and exploring a political spirituality of the self. This first major commentary on Foucault and (...) religion opens up the diverse religious questions the philosopher raises in his work, and sheds new light on how Foucault challenges religious thinking and transforms religious understanding. (shrink)

[COMMENTARY on Walter Veit's "A Philosophy for the Science of Animal Consciousness"] The framework Veit introduces for animal consciousness turns on finding and articulating its evolutionary origins. Veit argues that consciousness first evolved as affective experience in the Cambrian period. His argument centers around the plausible need of organisms in the Cambrian for a common currency of subjective valuation. I argue that such an adaptive pressure is unlikely to result in affective experience. I review other processes that instantiate common currencies (...) of subjective valuation: unconscious (non-experiential) affect and the reward learning system and argue that each is likely to have evolved prior to affective experience. (shrink)

Shearmur draws on his years as Popper's assistant, on unpublished material in the Hoover archive, and on wider themes within Popper's philosophy to offer striking critical re-interpretations of his ethical and social theory. This title available in eBook format. Click here for more information . Visit our eBookstore at: www.ebookstore.tandf.co.uk.

According to one prominent critique of mainstream epistemology, discoveries about what it takes to know or justifiedly believe that p can’t provide the right kind of intellectual guidance. As Mark Webb puts it, “the kinds of principles that are developed in this tradition are of no use in helping people in their ordinary epistemic practices.” In this paper I defend a certain form of traditional epistemology against this “regulative” critique. Traditional epistemology can provide—and, indeed, can be essential for—intellectual guidance. The (...) reason is that, in many cases, how you should proceed intellectually depends on what you already know or justifiedly believe: how you should treat counterevidence to your beliefs, for example, can depend on whether those beliefs count as knowledge. Therefore, to get guidance on how to proceed intellectually, it will often be essential to be able to figure out what you know or justifiedly believe. And to do that it will often be helpful to try to figure out what it takes to count as knowledge or justified belief in the first place. To do this is precisely to engage in mainstream epistemology. (shrink)

Unlike its friendly cousin the placebo effect, the nocebo effect (the effect of expecting a negative outcome) has been almost ignored. Epistemic and ethical confusions related to its existence have gone all but unnoticed. Contrary to what is often asserted, adverse events following from taking placebo interventions are not necessarily nocebo effects; they could have arisen due to natural history. Meanwhile, ethical informed consent (in clinical trials and clinical practice) has centred almost exclusively on the need to inform patients about (...) intervention risks with patients to preserve their autonomy. Researchers have failed to consider the harm caused by the way in which the information is conveyed. In this paper, I argue that the magnitude of nocebo effects must be measured using control groups consisting of untreated patients. And, because the nocebo effect can produce harm, the principle of non-maleficence must be taken into account alongside autonomy when obtaining (ethical) informed consent and communicating intervention risks with patients. (shrink)

Contribution to a symposium on Keith DeRose's book, The Case for Contextualism: Knowledge, Skepticism, and Context.

We begin by asking what fallibilism about knowledge is, distinguishing several conceptions of fallibilism and giving reason to accept what we call strong epistemic fallibilism, the view that one can know that something is the case even if there remains an epistemic chance, for one, that it is not the case. The task of the paper, then, concerns how best to defend this sort of fallibilism from the objection that it is “mad,” that it licenses absurd claims such as “I (...) know that p but there’s a chance that not p ” and “ p but it there’s a chance that not p .” We argue that the best defense of fallibilism against this objection—a “pragmatist” defense—makes the following claims. First, while knowledge that p is compatible with an epistemic chance that not- p , it is compatible only with an insignificant such chance. Second, the insignificance of the chance that not- p is plausibly understood in terms of the irrelevance of that chance to p ’s serving as a ‘justifier’, for action as well as belief. In other words, if you know that p , then any chance for you that not p doesn’t stand in the way of p ’s being properly put to work as a basis for action and belief. (shrink)

This book offers a distinctive treatment of Hayek's ideas as a "research program". It presents a detailed account of aspects of Hayek's intellectual development and of problems that arise within his work, and then offers some broad suggestions as to ways in which the program initiated in his work might be developed further. The book discusses how Popper and Lakatos' ideas about "research programs" might be applied within political theory. There then follows a distinctive presentation of Hayek's intellectual development up (...) to The Road to Serfdom, together with critical engagement with his later ideas. The discussion draws on a full range of his writings, makes use of some neglected earlier work on social theory and law, and also draws on archival material. This book should appeal to anyone with an interest in Hayek's work, as well as to those with a concern for twentieth century intellectual history. (shrink)

Creepiness and the emotion of the creeps have been overlooked in the moral philosophy and moral psychology literatures. We argue that the creeps is a morally significant emotion in its own right, and not simply a type of fear, disgust, or anger (though it shares features with those emotions). Reflecting on cases, we defend a novel account of the creeps as felt in response to creepy people. According to our moral insensitivity account, the creeps is fitting just when its object (...) is agential activity that is insensitive to basic moral considerations. When, only when, and insofar as someone is disposed to such insensitivity, they are a creep. Such insensitivity, especially in extreme forms, raises doubts about creeps’ moral agency. We distinguish multiple types of insensitivity, respond to concerns that feeling the creeps is itself objectionable, and conclude with a discussion of epistemic issues relating to the creeps. (shrink)

Animalism, the view that human persons are human animals in the most straightforward, non-derivative sense, is typically taken to conflict with the intuition that a human person would follow her functioning cerebrum were it to be transplanted into another living human body. Some animalists, however, have recently called into question the incompatibility between animalism and this “Transplant Intuition,” arguing that a human animal would be relocated with her transplanted cerebrum. In this paper, we consider the prospects for this cerebrum transplant-compatible (...) variant of animalism, which we call “Transplanimalism.” After presenting its account of three related thought experiments, and outlining its key advantages over Standard Animalism, we raise two concerns for Transplanimalism. First, we argue that Transplanimalism, like other closest-continuer accounts of the human person, encounters difficulties with symmetrical fission cases. Second, we introduce a new thought experiment that pushes Transplanimalism into surprisingly counterintuitive results. As a result of these concerns, we conclude that, despite its attractiveness, animalists should not endorse Transplanimalism. (shrink)

In this article I discuss what I am calling “ally aesthetics.” I suggest a set of necessary, though not necessarily sufficient, considerations for the creation of successful instances of ally art. Focusing on three case studies, I propose some key characteristics of ally aesthetics, such as its contextual/temporal nature and how that relates to success and the importance of understanding the place of the ally aesthetic within the larger movements they are allying with.

We use the normality framework of Goodman and Salow (2018, 2021, 2023b) to investigate of dynamics of rational belief. The guiding idea is that people are entitled to believe that their circumstances aren’t especially abnormal. More precisely, a rational agent’s beliefs rule out all and only those possibilities that are either (i) ruled out by their evidence or (ii) sufficiently less normal than some other possibility not ruled out by their evidence. Working within this framework, we argue that the logic (...) of rational belief revision is much weaker than is usually supposed. We do so by isolating a natural family of orthodox principles about belief revision, describing realistic cases in which these principles seem to fail, and showing how these counterexamples are predicted by independently motivated models of the cases in question. In these models, whether one evidential possibility counts as sufficiently less normal than another is determined by underlying probabilities (together with a contextually determined question). We argue that the resulting probabilistic account of belief compares favorably with other such accounts, including Lockeanism (Foley, 1993), a ‘stability’ account inspired by Leitgeb (2017), the ‘tracking theory’ of Lin and Kelly (2012), and the influential precursor of Levi (1967). We show that all of these accounts yield subtly different but similarly heterodox logics of belief revision. (shrink)

I argue, contra Dreier, Blackburn, and others, that there are no morally neutral metaethical positions. Every metaethical position commits you to the denial of some moral statement. So, for example, the metaethical position that there are no moral properties commits you to the denial of the moral conjunction of 1) it is right to interfere violently when someone is wrongly causing massive suffering and 2) it is wrong to interfere violently when only non-moral properties are at stake. The argument generalizes (...) to all metaethical positions. (shrink)

This paper provides a framework for understanding how non-ideal constitutions are better or worse imitations of the ideal constitution. My suggestion is that the non-ideal constitutions imitate the skill of the political expert, which includes an epistemic component (their political knowledge) and two teleological components (the benefit to the citizens on the one hand, and the unity of the city on the other). I then show how some constitutions better imitate the political expert’s skill across these dimensions, as higher-ranked constitutions (...) are in a better epistemic condition, better benefit the citizens, and better foster unity in the city than lower-ranked constitutions. A major upshot of my reading will be to show that Plato recognizes the value of some non-ideal constitutions while making clear how they still fall short of the ideal. (shrink)

The first detailed study of the effect of provocation on culpability in morality and law, this book traces the fascinating history of the legal doctrine of provocation, right up to present-day controversies over the scope of the doctrine's application in murder cases.

Dogmatism is the view that it is often legitimate to flatly dismiss counterarguments to a belief: your belief can count as knowledge even if you can’t figure out what’s wrong with the counterargument. Hume defended a version of dogmatism restricted to testimony in favor of miracles. Moore defended a dogmatism restricted to arguments for skepticism. In this paper it is argued that Hume’s and Moore’s dogmatisms should be generalized to all controversial matters. Dogmatism about controversial matters is true if you (...) can have knowledge about controversial matters. That’s because, when it comes to a belief about a controversial matter, there could easily be an apparently sound argument that the belief is false. But, often, if your knowledge can withstand this fact (which it can, the literature on disagreement notwithstanding), then it can withstand your discovering the apparently sound argument and finding it apparently sound. (shrink)

Drawing on Frederick Douglass’s arguments about racial pride, I develop and defend an account of feeling racial pride that centers on resisting racialized oppression. Such pride is racially ecumenical in that it does not imply partiality towards one’s own racial group. I argue that it can both accurately represent its intentional object and be intrinsically and extrinsically valuable to experience. It follows, I argue, that there is, under certain conditions, a morally unproblematic, and plausibly valuable, kind of racial pride available (...) to white people, though one that could hardly differ more from what is generally meant by “white pride.”. (shrink)

The standard conception of misleading evidence has it that e is misleading evidence that p iff e is evidence that p and p is false. I argue that this conception yields incorrect verdicts when we consider what it is for evidence to be misleading with respect to questions like whether p. Instead, we should adopt a conception of misleading evidence according to which e is misleading with respect to a question only if e is in-fact irrelevant to that question – (...) a relation that requires that e fail to be both explanatorily connected to and evidence for any truth that answers the question. This modified conception allows e to be non-misleading evidence with respect to a question even if e is evidence for the false answer to that question. It also points toward a new argument for and explanation of the truth of a central premise – what Maria Lasonen-Aarnio dubs “Entitlement” – that generates the infamous dogmatism puzzle. (shrink)

In this excellent and well-argued book, Michael Hannon defends two primary claims: first, the function of knowledge-attributions is primarily that of flagging reliable informants; second, proper ep...

Les sociétés démocratiques sont confrontées à l'émergence d'enjeux environnementaux décisifs qui concernent tant les modes de production, d'échange et de consommation que l'habitat, les transports, l'agriculture, l'industrie et même nos modes de vie. La prise en charge de ces enjeux ne saurait s'opérer simplement par des mesures ponctuelles ou locales. Elle doit aujourd'hui être repensée la temporalité de l'action politique, confrontée à une urgence qui ne cessera de s'accroître dans les prochaines années.

The purpose of this paper is to point the way to the money tree. Currently, almost all investment professionals think that outperformance requires an “edge,” that is, the ability to predict the future to some degree. In this paper, I suggest that money can be made in a 0, or even slightly negative, expected value environment by carefully choosing investment/bet sizes. Philosophical considerations are found mainly in Section 4.

Cognitivism about the emotions is the view that emotions involve judgments (or quasi-judgmental cognitive states) that we could, in principle, articulate without reference to the emotions themselves. D’Arms and Jacobson (2003) argue that no such articulation is available in the case of “possessive” emotions, such as pride and guilt, and, so, cognitivism (in regard to such emotions, at least) is false. This article proposes and defends a cognitivist account of our partiality to the objects of our pride. I argue that (...) taking pride in something requires judging that your relation to that thing indicates that your life accords with some of your personal ideals. This cognitivist account eschews glossing pride in terms of one’s “possession” of what one is proud of and, so, escapes D’Arms and Jacobson’s critique. I motivate this account by critically assessing the most sophisticated possession-based account of pride in the literature, found in Gabriele Taylor (1985). (shrink)

Explores how the emotional experience of gratitude has been enlisted in neoliberal governance through the language of debt. In The Art of Gratitude, Jeremy David Engels sketches a genealogy of gratitude from the ancient Greeks to the contemporary self-help movement. One of the most striking things about gratitude, Engels finds, is how consistently it is described using the language of indebtedness. A chief purpose of this, he contends, is to make us more comfortable living lives in debt, with the nefarious (...) effect of pacifying the citizenry so we are less likely to speak out about social and economic injustice. To counteract this, he proposes an alternative art of gratitude-as-thanksgiving that is inspired by Indian philosophy, particularly the yoga philosophy of the Bhagavad Gita and Patanjali’s Yoga-Sutras. He argues that this art of gratitude can challenge neoliberalism by reorienting our politics away from resentment, anger, and guilt and toward a democratic ethic of thanksgiving and the common good. Jeremy David Engels is the Sherwin Early Career Professor in the Rock Ethics Institute and Associate Professor of Communication Arts and Sciences at Penn State University. He is the author of The Politics of Resentment: A Genealogy and Enemyship: Democracy and Counter-Revolution in the Early Republic. (shrink)

We argue that knowledge doesn‘t require any of truth, justification, or belief. This is so for four primary reasons. First, each of the three conditions has been subject to convincing counterexamples. In addition, the resultant account explains the value of knowledge, manifests important theoretical virtues (in particular, simplicity), and avoids commitment to skepticism.

According to time-slice epistemology, what attitudes you should have at a time supervenes on features of you—like your evidence or mental states—at that time. Evidentialism is commonly assumed to b...

Four classes of naturally rare vascular plant species are described and classified, based on parameters of spatial distribution and longevity. Properties intrinsic to these time/space parameters are explored and an importance hierarchy of causes of rarity is proposed for each class. These hierarchies serve as the basis for a predictive classification. Human causes of rarity such as habitat destruction and taxonomic difficulties are not considered in detail here but are discussed as confounding factors in the elucidation of rarity in vascular (...) plants. Several examples are provided to illustrate this classification and provide testable hypotheses concerning the origins of natural rarity in plant species. (shrink)