MPZL3 is a nuclear‐encoded, mitochondrially localized, immunoglobulin‐like V‐type protein that functions as a key regulator of epithelial cell differentiation, lipid metabolism, ROS production, glycemic control, and energy expenditure. Recently, MPZL3 has surfaced as an important modulator of sebaceous gland function and of hair follicle cycling, an organ transformation process that is also governed by peripheral clock gene activity and PPARγ. Given the phenotype similarities and differences between Mpzl3 and Pparγ knockout mice, we propose that MPZL3 serves as a signaling hub (...) that is regulated by core clock gene products and/or PPARγ to translate signals from these nuclear transcription factors to the mitochondria to modulate circadian and metabolic regulation. Conservation between murine and human MPZL3 suggests that human MPZL3 may have similarly complex functions in health and disease. We summarize current knowledge and discuss future directions to elucidate the full spectrum of MPZL3 functions in mammalian physiology. (shrink)

Hume considers the extent to which the Deity might be held responsible for resultant sin, given that he is responsible for the necessary chain of events leading thereto. Were we to place the responsibility with God, it would not, seemingly, be placed upon ourselves. If we countenance a necessary chain of events, and a perfect Deity, so the argument goes, we lack culpability. Hume rejects this line of reasoning, maintaining that the mind of man is by nature formed to attribute (...) praise and blame to action. Surprisingly, Hume accepts what appears to be the contraposition of the claim he has just rejected. He seems to think that the presence of criminality presents a problem for those who would attribute perfection to the Deity. I argue that the conditionals in questions are subjunctive, thus Hume is not committed to the rejection of a claim and the acceptance of its contraposition. (shrink)

This book offers a distinctive treatment of Hayek's ideas as a "research program". It presents a detailed account of aspects of Hayek's intellectual development and of problems that arise within his work, and then offers some broad suggestions as to ways in which the program initiated in his work might be developed further. The book discusses how Popper and Lakatos' ideas about "research programs" might be applied within political theory. There then follows a distinctive presentation of Hayek's intellectual development up (...) to The Road to Serfdom, together with critical engagement with his later ideas. The discussion draws on a full range of his writings, makes use of some neglected earlier work on social theory and law, and also draws on archival material. This book should appeal to anyone with an interest in Hayek's work, as well as to those with a concern for twentieth century intellectual history. (shrink)

An enduring theme of Western philosophy is that we are all one another’s equals. Yet the principle of basic equality is woefully under-explored in modern moral and political philosophy. What does it mean to say we are all one another’s equals? Jeremy Waldron confronts this question fully and unflinchingly in a major new multifaceted account.

Foucault and Religion seeks to unearth a new dimension of Foucault scholarship. Renowned Foucault scholar Jeremy Carrette reveals not simply how Foucault's work can be applied to religion but how a religious question at the heart of Foucault's own work offers a radical challenge to religious ideas. Carrette argues that Foucault offers a twofold critique of Christianity by bringing the body and sexuality into religious practice and exploring a political spirituality of the self. This first major commentary on Foucault and (...) religion opens up the diverse religious questions the philosopher raises in his work, and sheds new light on how Foucault challenges religious thinking and transforms religious understanding. (shrink)

I have two main aims. The first is general, and more philosophical. The second is specific, and more closely related to physics. The first aim is to state my general views about laws and causation at different ”levels’. The main task is to understand how the higher levels sustain notions of law and causation that ”ride free’ of reductions to the lower level or levels. I endeavour to relate my views to those of other symposiasts. The second aim is to (...) give a framework for describing dynamics at different levels, emphasizing how the various levels’ dynamics can mesh or fail to mesh. This framework is essentially that of elementary dynamical systems theory. The main idea will be, for simplicity, to work with just two levels, dubbed ”micro’ and ”macro’, which are related by coarse-graining. I use this framework to describe, in part, the first four of Ellis’ five types of top-down causation. (shrink)

The Negation Problem states that expressivism has insufficient structure to account for the various ways in which a moral sentence can be negated. We argue that the Negation Problem does not arise for expressivist accounts of all normative language but arises only for the specific examples on which expressivists usually focus. In support of this claim, we argue for the following three theses: 1) a problem that is structurally identical to the Negation Problem arises in non-normative cases, and this problem (...) is solved once the hidden quantificational structure involved in such cases is uncovered; 2) the terms ‘required’, ‘permissible’, and ‘forbidden’ can also be analyzed in terms of hidden quantificational structure, and the Negation Problem disappears once this hidden structure is uncovered; 3) the Negation Problem does not arise for normative language that has no hidden quantificational structure. We conclude that the Negation Problem is not really a problem about expressivism at all but is rather a feature of the quantificational structure of the required, permitted, and forbidden. (shrink)

Many contemporary proponents of hylomorphism, the view that at least some material objects are comprised of both matter and form, endorse a version of hylomorphism according to which the form of a material object is a certain complex relation or structure. In this paper, I introduce three sorts of concerns for this “structural” approach. First, I argue that, in countenancing an abundance of overlapping yet numerically distinct material objects, “structural hylomorphists” are committed to a certain sort of systematic causal overdetermination. (...) Second, I argue that, because of its relatively thin conception of form, the view risks collapsing into some already well-entrenched metaphysical account of material objects. Finally, I argue that because the view emphasizes the more static structural features of composite material objects, structural hylomorphists seem unable to explain how it is that those objects might be said to persist over time through changes in such features. (shrink)

Abstract: This paper assesses the Everettian approach to the measurement problem, especially the version of that approach advocated by Simon Saunders and David Wallace. I emphasise conceptual, indeed metaphysical, aspects rather than technical ones; but I include an introductory exposition of decoherence. In particular, I discuss whether---as these authors maintain---it is acceptable to have no precise definition of 'branch' (in the Everettian kind of sense). (A version of this paper will appear in a CTNS/Vatican Observatory volume on Quantum Theory and (...) Divine Action, ed. Robert Russell et al.). (shrink)

The concept of minimal risk has been used to regulate and limit participation by adolescents in clinical trials. It can be understood as setting an absolute standard of what risks are considered minimal or it can be interpreted as relative to the actual risks faced by members of the host community for the trial. While commentators have almost universally opposed a relative interpretation of the environmental risks faced by potential adolescent trial participants, we argue that the ethical concerns against the (...) relative standard may not be as convincing as these commentators believe. Our aim is to present the case for a relative standard of environmental risk in order to open a debate on this subject. We conclude by discussing how a relative standard of environmental risk could be defended in the specific case of an HIV vaccine trial among adolescents in South Africa. (shrink)

Although workplace bullying is common and has universally harmful effects on employees’ outcomes, little is known about workplace bullies. To address this gap in knowledge, we draw from the tenets of social exchange and displaced aggression theories in order to develop and test a model of workplace bullying that incorporates the effects of employees’ individual differences, perceptions of their work environments, and perceptions of supervisory treatment on their tendencies to bully coworkers. The results of mediated moderation analyses that examine responses (...) from two samples of working adults support our hypotheses. Specifically, we find evidence of an indirect relationship between entitlement and coworker bullying through perceptions of abusive supervision that is stronger for employees who report lower levels of felt accountability than employees who report higher levels of felt accountability. This study makes important theoretical and practical contributions to abusive supervision research, bullying research, and organizational efforts to promote ethical work environments devoid of interpersonal mistreatment by providing novel insight into how employees’ entitlement and felt accountability combine to influence their tendencies to perceive themselves as victims of abusive supervision and culprits of coworker bullying. (shrink)

This paper expounds the modern theory of symplectic reduction in finite-dimensional Hamiltonian mechanics. This theory generalizes the well-known connection between continuous symmetries and conserved quantities, i.e. Noether's theorem. It also illustrates one of mechanics' grand themes: exploiting a symmetry so as to reduce the number of variables needed to treat a problem. The exposition emphasises how the theory provides insights about the rotation group and the rigid body. The theory's device of quotienting a state space also casts light on philosophical (...) issues about whether two apparently distinct but utterly indiscernible possibilities should be ruled to be one and the same. These issues are illustrated using ``relationist'' mechanics. (shrink)

Recent defenders of the divine command theory like Adams and Alston have confronted the Euthyphro dilemma by arguing that although God’s commands make right actions right, God is morally perfect and hence would never issue unjust or immoral commandments. On their view, God’s nature is the standard of moral goodness, and God’s commands are the source of all obligation. I argue that this view of divine goodness fails because it strips God’s nature of any features that would make His goodness (...) intelligible. An adequate solution to the Euthyphro dilemma may require that God be constrained by a standard of goodness that is external to Himself -- itself a problematic proposal for many theists. (shrink)

This is a discussion of some themes in Max Tegmark’s recent book, Our Mathematical Universe. It was written as a review for Plus Magazine, the online magazine of the UK’s national mathematics education and outreach project, the Mathematics Millennium Project. Since some of the discussion---about symmetry breaking, and Pythagoreanism in the philosophy of mathematics---went beyond reviewing Tegmark’s book, the material was divided into three online articles. This version combines those three articles, and adds some other material, in particular a brief (...) defence of quidditism about properties. It also adds some references, to other Plus articles as well as academic articles. But it retains the informal style of Plus. (shrink)

Relationism claims that our physical theory does not commit us to spacetime points. I consider how a relationist might rewrite physical theories without referring to spacetime points, by appealing to possible objects and possible configurations of objects. I argue that a number of difficulties confront this project. I also argue that a relationist need not be Machian in the sense of claiming that objects' spatiotemporal relations determine whether any object is accelerating.

This paper is about the metaphysical debate whether objects persist over time by the selfsame object existing at different times (nowadays called “endurance” by metaphysicians), or by different temporal parts, or stages, existing at different times (called “perdurance”). I aim to illuminate the debate by using some elementary kinematics and real analysis: resources which metaphysicians have, surprisingly, not availed themselves of. There are two main results, which are of interest to both endurantists and perdurantists. (1) I describe a precise formal (...) equivalence between the way that the two metaphysical positions represent the motion of the objects of classical mechanics (both point-particles and continua). (2) I make precise, and prove a result about, the idea that the persistence of objects moving in a void is to be analysed in terms of tracking the continuous curves in spacetime that connect points occupied by matter. The result is entirely elementary: it is a corollary of the Heine–Borel theorem. (shrink)

In some games, the products of the probabilities times the payouts result in a series that is conditionally convergent, which means that the sum can vary based on the order in which the products are summed. The purpose of this paper is to address the question: How should such games be valued? We first show that, contrary to widespread belief, summing in the order determined by the mechanism of the game does not lead to the correct value. We then consider (...) other attempts to value such games. We suggest that games with conditionally convergent series are properly valued by summing the products in increasing order of the absolute values of the game’s payouts. (shrink)

Time, along with concepts as space and matter, is bound to be a central concept of any physical theory. The chapter first discusses how time is treated similarly in quantum and classical theories. It then provides a few references on time‐reversal. The chapter discusses three chosen authors' (Paul Busch, Jan Hilgevoord and Jos Uffink) clarifications of uncertainty principles in general. Next, the chapter follows Busch in distinguishing three roles for time in quantum physics. They are external time, intrinsic time and (...) observable time. It also provides a brief discussion on time operators, in particular Pauli's influential proof. Finally, the chapter talks about time‐energy uncertainty principles with intrinsic times. (shrink)

I reject Norton and Earman's hole argument that spacetime substantivalism is incompatible with determinism. I reconcile these both technically and philosophically. There is a technical definition of determinism that is not violated by pairs of models of the kind used in the hole argument. And technicalities aside, the basic idea of determinism is not violated if we claim that at most one of the two models represents a possible world. This claim can be justified either by metrical essentialism, or by (...) denying transworld identity for points: I prefer the latter. (shrink)

This paper offers a new critical evaluation of the Rawlsian model of global public reason (‘GPR’), focusing on its ability to serve as a normative standard for guiding international diplomacy and deliberation in matters of war. My thesis is that, where war is concerned, the model manifests two fatal weaknesses. First, because it demands extensive neutrality over the moral status of persons – and in particular over whether they possess equal basic worth or value – out of respect for the (...) beliefs of inegalitarian yet ‘decent’ societies, or ‘peoples’, Rawlsian GPR renders calculations of proportionality in war impossible. Second, because its content is provided by a conception of global justice (the so-called ‘Law of Peoples’) whose injunctions are addressed exclusively to peoples, as corporate agents, Rawlsian GPR pushes the moral evaluation of the independent wartime choices of individuals off the agenda of the global public forum altogether. (shrink)

Mathematicians use the word ‘deep’ to convey a high appreciation of a concept, theorem, or proof. This paper investigates the extent to which the term can be said to have an objective character by examining its first use in mathematics. It was a consequence of Gauss's work on number theory and the agreement among his successors that specific parts of Gauss's work were deep, on grounds that indicate that depth was a structural feature of mathematics for them. In contrast, French (...) mathematicians had a less structural, more problem-oriented approach to mathematics and did not speak of depth so readily. (shrink)

In a previous paper, we have proposed assigning as the value of a physical quantity in quantum theory, a certain kind of set (a sieve) of quantities that are functions of the given quantity. The motivation was in part physical---such a valuation illuminates the Kochen-Specker theorem; and in part mathematical---the valuation arises naturally in the topos theory of presheaves. This paper discusses the conceptual aspects of this proposal. We also undertake two other tasks. First, we explain how the proposed valuations (...) could arise much more generally than just in quantum physics; in particular, they arise as naturally in classical physics. Second, we give another motivation for such valuations (that applies equally to classical and quantum physics). This arises from applying to propositions about the values of physical quantities some general axioms governing partial truth for any kind of proposition. (shrink)

This paper discusses some of the modal involvements of analytical mechanics. I first review the elementary aspects of the Lagrangian, Hamiltonian and Hamilton-Jacobi approaches. I then discuss two modal involvements; both are related to David Lewis' work on modality, especially on counterfactuals. The first is the way Hamilton-Jacobi theory uses ensembles, i.e. sets of possible initial conditions. The structure of this set of ensembles remains to be explored by philosophers. The second is the way the Lagrangian and Hamiltonian approaches' variational (...) principles state the law of motion by mentioning contralegal dynamical evolutions. This threatens to contravene the principle that any actual truth, in particular an actual law, is made true by actual facts. Though this threat can be avoided, at least for simple mechanical systems, it repays scrutiny; not least because it leads to some open questions. (shrink)

This paper gives a philosophical assessment of the Montevideo interpretation of quantum theory, advocated by Gambini, Pullin and co-authors. This interpretation has the merit of linking its proposal about how to solve the measurement problem to the search for quantum gravity: namely by suggesting that quantum gravity makes for fundamental limitations on the accuracy of clocks, which imply a type of decoherence that “collapses the wave-packet”. I begin by sketching the topics of decoherence, and quantum clocks, on which the interpretation (...) depends. Then I expound the interpretation, from a philosopher's perspective. Finally, in Section 6, I argue that the interpretation, at least as developed so far, is best seen as a form of the Everett interpretation: namely with an effective or approximate branching, that is induced by environmental decoherence of the familiar kind, and by the Montevideans’ “temporal decoherence”. (shrink)

I extract some philosophical morals from some aspects of Lagrangian mechanics. One main moral concerns methodology: Lagrangian mechanics provides a level of description of phenomena which has been largely ignored by philosophers, since it falls between their accustomed levels---``laws of nature'' and ``models''. Another main moral concerns ontology: the ontology of Lagrangian mechanics is both more subtle and more problematic than philosophers often realize. The treatment of Lagrangian mechanics provides an introduction to the subject for philosophers, and is technically elementary. (...) In particular, it is confined to systems with a finite number of degrees of freedom, and for the most part eschews modern geometry. (shrink)

The building of the transcontinental railroad in the US Central West in the late 1860s greatly improved access to this region and led to the expansion of scientific field work. The relationships between science and the railroad spanned a diverse spectrum, ranging from its practical advantages to more complex interactions such as the transformation of nature along railway corridors and the reciprocal exchange of favours between scientists and railway companies. The dominance of science along the railroad in the second half (...) of the nineteenth century continued into the early twentieth century, with a gradual shift to automobile travel beginning in the 1910s. By stimulating and shaping field research both on and off the railway corridor, the laying of iron tracks across the continent helped guide US science, just as it influenced so many other aspects of US life. (shrink)

In standard models of decision making, participation in violent political action is understood as the product of instrumentally rational reasoning. According to this line of thinking, instrumentally rational individuals will participate in violent political action only if there are selective incentives that are limited to participants. We argue in favor of an alternate model of political violence where participants are motivated by moral commitments to collective sacred values. Correlative and experimental empirical evidence in the context of the Israeli–Palestinian conflict strongly (...) supports this alternate view. (shrink)

We investigate the entrepreneurial opportunities and ethical dilemmas presented by technological turbulence. More specifically we investigate the line between Baumol’s [J. Polit. Econ. 98 (1990) 893] productive (e.g. innovation), unproductive (e.g. rent seeking) and destructive (e.g. criminal) entrepreneurship through three examples of Internet innovation – spam (destructive), music file sharing (unproductive), and Internet pharmacies (potentially productive). The emergence of accessible Internet technologies, under present norms, has created the potential for all three entrepreneurial activities. Because of the propensity for self-serving biases (...) and for bending the rules, the need for creativity in overcoming obstacles and overall liabilities of newness, entrepreneurs are likely to challenge established industrial morals and laws. Unlike new entrants, incumbents must abide by the currently accepted norms, and thus suffer from “liabilities of oldness”. The challenge for new entrants is to change sociopolitical legitimacy, whereas incumbents need to defend the established norms. We discuss competitive and other issues that result from technological turbulence and innovation. (shrink)

In ’The Coherence of Theism’ Richard Swinburne writes that a person cannot be omniscient and perfectly free. In ’The Existence of God’ Swinburne writes that God is a person who is omniscient and perfectly free. There is a straightforward reason why the two passages are not in tension, but recognition of this reason raises a problem for Swinburne’s argument in ’The Existence of God’ (the conclusion of which is that God likely exists). In this paper I present the problem for (...) Swinburne’s argument. I then consider two potential responses and suggest that neither succeeds. (shrink)

Recent analyses of food sharing in small-scale societies indicate that reciprocal altruism maintains interhousehold food transfers, even among close kin. In this study, matrix-based regression methods are used to test the explanatory power of reciprocal altruism, kin selection, and tolerated scrounging. In a network of 35 households in Nicaragua’s Bosawas Reserve, the significant predictors of food sharing include kinship, interhousehold distance, and reciprocity. In particular, resources tend to flow from households with relatively more meat to closely related households with little, (...) as predicted by kin selection. This generalization is especially true of household dyads with mother-offspring relationships, which suggests that studies of food sharing may benefit from distinctions between lineal and collateral kin. Overall, this analysis suggests that exchanges among kin are primarily associated with differences in need, not reciprocity. Finally, although large game is distributed widely, qualitative observations indicate that hunters typically do not relinquish control of the distribution in ways predicted by costly signaling theory. (shrink)

Les sociétés démocratiques sont confrontées à l'émergence d'enjeux environnementaux décisifs qui concernent tant les modes de production, d'échange et de consommation que l'habitat, les transports, l'agriculture, l'industrie et même nos modes de vie. La prise en charge de ces enjeux ne saurait s'opérer simplement par des mesures ponctuelles ou locales. Elle doit aujourd'hui être repensée la temporalité de l'action politique, confrontée à une urgence qui ne cessera de s'accroître dans les prochaines années.