The ring‐shaped ATPase machine, cohesin, regulates sister chromatid cohesion, transcription, and DNA repair by topologically entrapping DNA. Here, we propose a rigid scaffold model to explain how the cohesin regulators Pds5 and Wapl release cohesin from chromosomes. Recent studies have established the Smc3‐Scc1 interface as the DNA exit gate of cohesin, revealed a requirement for ATP hydrolysis in ring opening, suggested regulation of the cohesin ATPase activity by DNA and Smc3 acetylation, and provided insights into how Pds5 and Wapl open (...) this exit gate. We hypothesize that Pds5, Wapl, and SA1/2 form a rigid scaffold that docks on Scc1 and anchors the N‐terminal domain of Scc1 (Scc1N) to the Smc1 ATPase head. Relative movements between the Smc1‐3 ATPase heads driven by ATP and Wapl disrupt the Smc3‐Scc1 interface. Pds5 binds the dissociated Scc1N and prolongs this open state of cohesin, releasing DNA. We review the evidence supporting this model and suggest experiments that can further test its key principles. (shrink)

Much recent work in applied legal and political theory has been preoccupied with the problem of the moral status of business organizations and corporations, and of the nature of their agency and personality. On the one hand, moral rights, such as rights to freedom and autonomy, are paradigmatically ascribed to natural, human persons; moral responsibility analogously seems therefore paradigmatically applicable to individuals. Organizations seemingly have no will or mind, no human feelings such as pleasure, pain, shame, and remorse. How can (...) the language of rights and responsibility be applicable to them? On the other hand, it seems to be a fact that business organizations often do things that we human beings do—make deals, sign contracts, cause harm, and issue apologies. In ordinary and in legal discourse all the time we hear such things as, “Miller's Pulp Mill is responsible for its corrupt environmental practice”; “Philip Cosmetics Ltd. has the right to advertise its products”; and “Sunligt Co. is accountable for its irresponsible behavior.” How then are we to understand the attributions of organizational agency, personality, and responsibility that these statements presuppose? Are the predicates in these statements to be taken as having the same intension, or the same force, as similar ones predicated on natural persons? Or are the predications to be seen as extensions of meaning, justified or not? Or as exotic metaphors with no factual implications? (shrink)

According to Shelly Kagan, the moral status of an individual is determined by the extent to which the individual has (has now, might/will have, or could have had) certain psychological capacities. Roughly speaking, the greater one's relevant psychological capacities, the higher their moral status. In this paper, I offer a twofold critique of Kagan's hierarchicalism. On the one hand, I argue against the primary argument in favor of Kagan's view (the argument from distribution) by challenging the key intuition on which (...) the argument relies, thereby reducing the appeal of Kagan's position. On the other hand, using Kagan's general methodology, I argue that a good reason to reject Kagan's account of moral status is that he fails to explain away the counterintuitive result of his theory in the case of normal variation. (shrink)

Social Information Science (or Social Informatics) is a new and interdiscipline branch subject in China. This paper probe the emergence and the research outline of social information science. 1. The proposal of the social information science. We set up the research from an extension from the theoretical informatics to the concrete informatics; a internal bond of integrating various subjects in humane and social sciences; an intersection and mutual permeation between the social science and the natural science; a the intersection and (...) interaction among humane and social sciences, modern information science and information technology; a strengthening to the research into Social Epistemology. Ⅱ. On the concept of social information. Social information directly is different with selfexistent and natural information, and more related to human’s autonomous creative activities, to society’s culture inheritance, to social value, to human’s spiritual interaction and to human’s emotions. Ⅲ.On the theoretical orientation of the social information science. Social Information Science is a concrete branch of informatics, a generation of sub-disciplines of social information, a kind of traversing and comprehensive research on individual social science from the angle of information, a kind of exchange and interaction between social theoretical research and the modern information technology. Ⅳ. The research focus of the social information science. The paper lists 10 main focus in the research of social information science. Ⅴ.The system and frame of the social information science. In general, there should be four levels of researches if the social information science is to be viewed as a relatively independent subject: the philosophical level, the scientific theoretical level, concrete apply level, social information technology and methods. (shrink)

Purpose: Discuss the relationship among college students’ media internalized pressure, social physique anxiety, weight control self-efficacy, and sports participation in providing a reference for promoting college students to develop healthy and confident living habits.Methods: Take Southwest University in China as the object, select the subjects by stratified random sampling, and process the data with SPSS19.0 and AMOS21.0 statistical software.Results: Media internalized pressure is positively correlated with social physique anxiety, weight control self-efficacy, and sports participation; social physique anxiety is significantly positively (...) correlated with weight control self-efficacy and sports participation, and weight control self-efficacy is significantly positively correlated with sports participation; media internalized pressure has a direct effect on sports participation, and social physique anxiety and weight control self-efficacy play significant mediating roles in the relationship between media internalized pressure and sports participation, respectively; the chained mediating force of social physique anxiety and weight control self-efficacy also reaches a significant level.Conclusion: Media internalized pressure can influence college students’ sports participation through the direct path as well as indirect paths such as social physique anxiety, the intermediary effect of weight control self-efficacy, and chained intermediary effect of social physique anxiety–weight control self-efficacy, and social physique anxiety is another key factor affecting college students’ sports participation except media internalized pressure. (shrink)

In this paper, I shall argue that philosophy proper is a Western cultural practice and cannot refer to traditional Chinese thinking unless in an analogical or metaphorical sense. Likewise, the Chinese idiom ‘Zhongguo zhexue’ has evolved its independent cultural meaning and has no need to be considered as philosophy in the Western academic sense. For the purpose of elucidating the culturally autonomous status of Zhongguo zhexue, as well as the possible counterparts of Western philosophy in other cultures, I contend that (...) Davidsonian anomalous monism may provide a proper explanatory framework for the intercultural relationships between different ‘sophias’ from various traditions. As for the equivocal English term ‘Chinese philosophy’, I suggest replacing it with a more precise new word: ‘sinosophy’. (shrink)

Business Ethics, the Environment & Responsibility, Volume 31, Issue 2, Page 577-588, April 2022.

PurposesThis paper aims to discuss the relationship between college students’ sports participation, school bullying, emotional intelligence and self-esteem. At the same time, it explores the intrinsic mechanisms of school bullying, in order to provide a reference for reducing bullying phenomenon among college students, and pave the way for college students to lead happy, healthy and confident lives.MethodsA total of 1,317 students from four universities in Southwest China were selected as subjects for this survey. They were selected by stratified random sampling, (...) and the data needed was obtained using a structured questionnaire. The data was subsequently processed with statistical software SPSS19.0 and AMOS21.0.Results Sports participation has a significant and positive correlation with emotional intelligence and self-esteem, likewise, it has a significant negative correlation with school bullying. Emotional intelligence has a marked positive correlation with self-esteem, at the same time it has a significant negative correlation with school bullying. In addition, self-esteem is strongly negative correlated with school bullying. Sports participation has a direct effect on school bullying. Emotional intelligence and self-esteem also play a significant mediating role between sports participation and school bullying, and the chain mediating force of emotional intelligence—self-esteem also reaches a significant level.ConclusionSports participation affects school bullying among college students not only directly but also indirectly, such as through emotional intelligence, the mediating role of self-esteem, and the chain mediating role of emotional intelligence to self-esteem. Apart from sports participation, emotional intelligence is another key factor that affects college students’ school bullying. Therefore, while attaching great importance to college students’ sport participation, schools should also provide courses aimed at developing students’ emotional intelligence. (shrink)

Computational models have shown that purely statistical knowledge about words’ linguistic contexts is sufficient to learn many properties of words, including syntactic and semantic category. For example, models can infer that “postman” and “mailman” are semantically similar because they have quantitatively similar patterns of association with other words. In contrast to these computational results, artificial language learning experiments suggest that distributional statistics alone do not facilitate learning of linguistic categories. However, experiments in this paradigm expose participants to entirely novel words, (...) whereas real language learners encounter input that contains some known words that are semantically organized. In three experiments, we show that the presence of familiar semantic reference points facilitates distributional learning and this effect crucially depends both on the presence of known words and the adherence of these known words to some semantic organization. (shrink)

Kant’s coining of «reflective judgment» in the third Critique by a conceptual clarification of the third higher cognitive faculty has long been criticized as redundant for his philosophical system and deemed a typical Kantian architectonic failure. Zhu Xi’s vital development of the doctrine «gewu» in his commentary on The Great Learning has been attacked for centuries for committing a hermeneutic fallacy. I argue that a comparative study shows that both conceptions steered a metaphysical transition towards «the supersensible» in each philosophy, (...) leading to a similar construction of moral teleology. Zhu Xi’s «li» is comparable to Kant’s «purpose» as a moral teleological property. The Neo-Confucian li-qi dichotomy provides a counterpart of the Kantian double causality. Nevertheless, Neo-Confucian moral teleology does not rely on a Kantian-type rationalistic deduction concerning the idea of highest good (as final purpose) nor on the so-called intellectual intuition. Gewu looks outwards for the moral coherence between humans and things, while Kant ultimately rejects the natural world for the sake of moral certainty in terms of freedom and identifies what is unique within us. (shrink)

Ralph Weber's reply to my comment, as we have come to expect from his writing, is both well articulated and instructive. His clarification has helped me to further grasp the consideration that underpins his methodological criticism. I am also encouraged to find agreement on the worth of a historical study of comparative philosophy as an established sub-discipline. In addition, Weber's attitude toward "disagreement" is thought-provoking. However, I would like to suggest that disagreement is positive and meaningful if and only if (...) it is not based on misunderstanding, and moreover if disagreement itself should not be regarded as the purpose. The ideal intellec tual exchange should be able to encompass both... (shrink)

ABSTRACTTo assess the strength of Lloyd's conception of analogy, in particular, his innovative conceptual apparatus ‘the multidimensionality of reality’ and ‘the semantic stretch’, I propose the notion of hermeneutic mechanism as a rival tool of investigation. Hermeneutic mechanism manifests in the interaction of negative and positive hermeneutic forces, the dynamic interdependence between ideal universality and contextualized individuality, and the organism-like ‘hermeneutic circle’. I argue that hermeneutic mechanism not only offers a meta-methodological perspective for appreciating Lloyd's methodological development of analogy for (...) cross-cultural studies, but also incorporates both Lloyd's quest for diversity and his critique of logical dichotomy, and moreover overcomes the explicatory flaw in his ‘multidimensionality of reality’ and colour metaphor. (shrink)

Marketers often use a visual line to divide the product information on an advertisement into left-right segments for aesthetic or categorization purposes. The present research examined the effect of the dividing line on the consumer memory. Across three studies, we showed that the presence of a dividing line enhances consumers’ memory about the products displayed on the left/top of an advertisement. This effect occurs because the dividing line orients participants’ first eye fixation to the left/top area of the advertisement, such (...) that their visual attention is largely restricted to that area and they could better remember the contents displayed on that area. The theoretical contributions and implications for marketers and consumers are discussed. (shrink)

Stressful life events and subjective well-being are negatively related, but there is little research in the current literature exploring the mediating and moderating mechanisms underlying this association, especially for female adolescents in vocational schools who are subjected to undesirable life events. In the present study, we examined the mediating role of depression in the association between stressful life events and female adolescents’ subjective well-being, as well as the moderating role of perceived social support in the direct and indirect relations involved. (...) The participants were 1,096 vocational school female adolescents, who completed the questionnaires regarding stressful life events, subjective well-being, depression, and perceived social support. The results showed that depression partially mediated the relation between stressful life events and subjective well-being. Importantly, perceived social support moderated the direct link between stressful life events and subjective well-being, and the indirect link between stressful life events and depression, but not the indirect link between depression and subjective well-being. Especially, female adolescents high in perceived social support displayed higher levels of subjective well-being and lower levels of depression in facing with stressful life events than those low in perceived social support. These findings highlight the mechanisms underlying the relationship between stressful life events and subjective well-being in vocational school female adolescents. (shrink)

Ralph Weber’s recent criticism sheds light on the methodological predicament of comparative philosophy. I examine Weber’s analytical tool and argue that its general applicability and potential unbridled use can lead to a conflict between its own legitimacy and the legitimacy of comparative philosophy as an established sui generis sub-discipline of philosophy which largely functions as “intercultural” or “trans-cultural philosophy”. I defend the cultural approach, and argue that comparative philosophy should be viewed as philosophical data analysis from different spatiotemporal origins, in (...) order to achieve better explanatory power for philosophical study. I point out that philosophy in China has its own peculiar methodological predicament. The comparative study of philosophy is a joint project of inter-cultural dialogue that rests on the collective effort of global participants. (shrink)