Clinical mental health researchers may understandably struggle with how to incorporate biological assessments in clinical research. The options are numerous and are described in a vast and complex body of literature. Here we provide guidelines to assist mental health researchers seeking to include biological measures in their studies. Apart from a focus on behavioral outcomes as measured via interviews or questionnaires, we advocate for a focus on biological pathways in clinical trials and epidemiological studies that may help clarify pathophysiology and (...) mechanisms of action, delineate biological subgroups of participants, mediate treatment effects, and inform personalized treatment strategies. With this paper we aim to bridge the gap between clinical and biological mental health research by (1) discussing the clinical relevance, measurement reliability, and feasibility of relevant peripheral biomarkers; (2) addressing five types of biological tissues, namely blood, saliva, urine, stool and hair; and (3) providing information on how to control sources of measurement variability. (shrink)

Yuri Balashov sets out major rival views of persistence--endurance, perdurance, and exdurance--in a spacetime framework and proceeds to investigate the implications of Einstein's theory of relativity for the debate about persistence. His overall conclusion--that relativistic considerations favour four-dimensionalism over three-dimensionalism--is hardly surprising. It is, however, anything but trivial. Contrary to a common misconception, there is no straightforward argument from relativity to four-dimensionalism. The issues involved are complex, and the debate is closely entangled with a number of other philosophical disputes, (...) including those about the nature and ontology of time, parts and wholes, material constitution, causation and properties, and vagueness. (shrink)

This article examines the method of reflective equilibrium (RE) and its role in philosophical inquiry. It begins with an overview of RE before discussing some of the subtleties involved in its interpretation, including challenges to the standard assumption that RE is a form of coherentism. It then evaluates some of the main objections to RE, in particular, the criticism that this method generates unreasonable beliefs. It concludes by considering how RE relates to recent debates about the role of intuitions in (...) philosophy. (shrink)

The structures of everyday life, where religious identity is constructed, are analysed in the article of Boreyko Yuri Grigorovich «The structures of everyday life in the design of religious identity». Determined that the basis of personal and group religious identity are mental structures, symbolic actions, rituals, language.

In two earlier works (Balashov, 2000a: Philosophical Studies 99, 129–166; 2000b: Philosophy of Science 67 (Suppl), S549–S562), I have argued that considerations based on special relativity and the notion of coexistence favor the perdurance view of persistence over its endurance rival. Cody Gilmore (2002: Philosophical Studies 109, 241–263) has subjected my argument to an insightful three fold critique. In the first part of this paper I respond briefly to Gilmore’s first two objections. I then grant his observation that anyone who (...) can resist the first objection is liable to succumb to the third one. This, however, opens a way to other closely related relativistic arguments against endurantism that are immune to all three objections and, in addition, throw new light on a number of important issues in the ontology of persistence. I develop two such novel arguments in the second half of the paper. (shrink)

In this paper I develop three different arguments against the thesis that knowledge-how is a kind of knowledge-that. Knowledge-that is widely thought to be subject to an anti-luck condition, a justified or warranted belief condition, and a belief condition, respectively. The arguments I give suggest that if either of these standard assumptions is correct then knowledge-how is not a kind of knowledge-that. In closing I identify a possible alternative to the standard Rylean and intellectualist accounts of knowledge-how. This alternative view (...) illustrates that even if the arguments given here succeed it might still be reasonable to hold that knowing how to do something is a matter of standing in an intentional relation to a proposition other than the knowledge-that relation. (shrink)

This ambitious book looks into the reasons for the exceptional durability of the Chinese empire, which lasted for more than two millennia (221 B.C.E. - 1911 C.E.). Yuri Pines identifies the roots of the empire's longevity in the activities of thinkers of the Warring States period (453-221 B.C.E.), who, in their search for solutions to an ongoing political crisis, developed ideals, values, and perceptions that would become essential for the future imperial polity. In marked distinction to similar empires worldwide, (...) the Chinese empire was envisioned and to a certain extent 'preplanned' long before it came into being. As a result, it was not only a military and administrative construct, but also an intellectual one. Pines makes the argument that it was precisely its ideological appeal that allowed the survival and regeneration of the empire after repeated periods of turmoil. "Envisioning Eternal Empire" presents a panoptic survey of philosophical and social conflicts in Warring States political culture. By examining the extant corpus of preimperial literature, including transmitted texts and manuscripts uncovered at archaeological sites, Pines locates the common ideas of competing thinkers that underlie their ideological controversies. This bold approach allows him to transcend the once fashionable perspective of competing 'schools of thought' and show that beneath the immense pluralism of Warring States thought one may identify common ideological choices that eventually shaped traditional Chinese political culture. The result is a refreshingly novel look at the foundational period in Chinese intellectual history. (shrink)

in D. Dieks (ed.), The Ontology of Spacetime, Vol. 2. Elsevier, forthcoming.

The series is devoted to the study of scientific and philosophical texts from the Classical and the Islamic world handed down in Arabic. Through critical text editions and monographs, it provides access to ancient scientific inquiry as it developed in a continuous tradition from Antiquity to the modern period. All editions are accompanied by translations and philological and explanatory notes.

Automated classification of legal documents has been the subject of extensive research in recent years. However, this is still a challenging task for long documents, since it is difficult for a model to identify the most relevant information for classification. In this paper, we propose a two-stage supervised learning approach for the classification of petitions, a type of legal document that requests a court order. The proposed approach is based on a word-level encoder–decoder Seq2Seq deep neural network, such as a (...) Bidirectional Long Short-Term Memory (BiLSTM) or a Bidirectional Encoder Representations from Transformers (BERT) model, and a document-level Support Vector Machine classifier. To address the challenges posed by the lengthy legal documents, the approach introduces a human-in-the-loop approach, whose task is to localize and tag relevant segments of text in the word-level training part, which dramatically reduces the dimension of the document classifier input vector. We performed experiments to validate our approach using a real-world dataset comprised of 270 intermediate petitions, which were carefully annotated by specialists from the 15th civil unit of the State of Alagoas, Brazil. Our results revealed that both BiLSTM and BERT-Convolutional Neural Networks variants achieved an accuracy of up to 95.49%, and also outperformed baseline classifiers based on the Term Frequency–Inverse Document Frequency test vectorizer. The proposed approach is currently being utilized to automate the aforementioned justice unit, thereby increasing its efficiency in handling repetitive tasks. (shrink)

I examine the issue of persistence over time in thecontext of the special theory of relativity (SR). Thefour-dimensional ontology of perduring objects isclearly favored by SR. But it is a different questionif and to what extent this ontology is required, andthe rival endurantist ontology ruled out, by thistheory. In addressing this question, I take theessential idea of endurantism, that objects are whollypresent at single moments of time, and argue that itcommits one to unacceptable conclusions regardingcoexistence, in the context of SR. (...) I then propose anddiscuss a plausible account of coexistence forperduring objects, which is free of these defects. This leaves the endurantist room for some maneuvers. I consider them and show that they do not really helpthe endurantist out. She can accommodate the notionof coexistence in the relativistic framework only atthe cost of renouncing central endurantist intuitions. (shrink)

O objetivo deste artigo é apontar e analisar os principais fatores que levaram uma pessoa, ou um grupo de pessoas, a assistir um jogo de futebol da Copa do Mundo 2014 em uma FIFA Fan Fest e não em outros locais. Socialização, afetividade e diversão são aspectos considerados na análise. O papel do esporte enquanto produto de entretenimento e consumo também foi contemplado no estudo. O evento, pela proliferação de imagens que proporciona, é exemplo claro do que Guy Debord definiu (...) como Sociedade do Espetáculo. Foram entrevistadas 79 pessoas em duas FIFA Fan Fests realizadas na cidade de São Paulo, em partidas da seleção brasileira na Copa do Mundo 2014. Os resultados obtidos no estudo comprovam a inserção do esporte mais popular do planeta na lógica das modernas estratégias de consumo. Também evidenciam as relações existentes entre o futebol, e seu universo, e a chamada indústria do entretenimento. (shrink)

Previous work suggests that Asians allocate more attention to configuration information than Caucasian Americans do. Yet this cultural variation has been found only with stimuli such as natural scenes and objects that require both feature- and configuration-based processing. Here, we show that the cultural variation also exists in face perception—a domain that is typically viewed as configural in nature. When asked to identify a prototypic face for a set of disparate exemplars, Japanese were more likely than Caucasian Americans to use (...) overall resemblance rather than feature matching. Moreover, in a speeded identity-matching task, Japanese were more accurate than Americans in identifying the spatial configuration of features (e.g., eyes). Together, these findings underscore the robustness of culture’s influences on cognition. (shrink)

This paper is a reaction to the following remark by grzegorczyk: "the compound sentences are not a product of experiment. they arise from reasoning. this concerns also negations; we see that the lemon is yellow, we do not see that it is not blue." generally, in science the truth is ascertained as indirectly as falsehood. an example: a litmus-paper is used to verify the sentence "the solution is acid." this approach gives rise to a (very intuitionistic indeed) conservative extension of (...) the heyting logic satisfying natural duality laws. (shrink)

The nature of persistence of physical objects over time has been intensely debated in contemporary metaphysics. The two opposite views are widely known as "endurantism" (or "three-dimensionalism") and "perdurantism" ("four-dimensionalism"). According to the former, objects are extended in three spatial dimensions and persist through time by being wholly present at any moment at which they exist. On the rival account, objects are extended both in space and time and persist by having "temporal parts," no part being present at more than (...) one time. Relativistic considerations seem highly relevant to this debate. But they have played little role in it so far. This paper seeks to remedy that situation. I argue that considerations based on the special theory of relativity and the notion of coexistence favor perdurantism over endurantism. (shrink)

The information-hierarchical approach is used to analyze the evolutionary developed organization of mankind. This organization is shown to be hierarchical, from molecular hierarchical levels to the religious ones. Time cycles of each level operation are included in the greater cycle of the next level according to the specific schemes defined by the common information principle of natural system development. Time cycles of levels have duration of 1 second, 6 seconds, 42 seconds, 24 hours, 11 days, 1 years, 33 year, 1,000 (...) years, 3,000 years or 6,000 years and all together make up the mankind clock that is similar to the formerly ascertained biosphere clock. The cycles of duration from 1 second to 33 years form the human biological clock, so the information-hierarchical organization of cell metabolism manifests itself as the key mechanism of the clock. The new scientific field has been characterized. It is the management of sustainable development of the states as evolutionary developed systems with the use of information relationships of their functioning. In the case of Christianity adoption by any large ethnos the next 1,000-year cycle of the Christianity-Judaism system will start. (shrink)

Is there a successful regress argument against intellectualism? In this article I defend the negative answer. I begin by defending Stanley and Williamson's (2001) critique of the contemplation regress against Noë (2005). I then identify a new argument – the employment regress – that is designed to succeed where the contemplation regress fails, and which I take to be the most basic and plausible form of a regress argument against intellectualism. However, I argue that the employment regress still fails. Drawing (...) on the previous discussion, I criticise further regress arguments given by Hetherington (2006) and Noë (2005). (shrink)

The main result of this paper is a probabilistic construction of finite rigid structures. It yields a finitely axiomatizable class of finite rigid structures where no L ω ∞,ω formula with counting quantifiers defines a linear order.

In this paper, the ethical, legal, and social implications of Thailand’s surrogacy regulations from both domestic and global perspectives are explored. Surrogacy tourism in Thailand has expanded since India strengthened its visa regulations in 2012. In 2015, in the wake of a major scandal surrounding the abandonment of a surrogate child by its foreign intended parents, a law prohibiting the practice of surrogacy for commercial purposes was enacted. Consequently, a complete ban on surrogacy tourism was imposed. However, some Thai physicians (...) and surrogate mothers cross into neighboring countries to provide foreign clients with the commercial surrogacy services that are forbidden in Thailand. Under this legislation, the needs of Thai couples who are unable to conceive are accommodated by legally accessible, non-commercial surrogacy services; however, there is currently no provision in place aimed at protecting the rights and interests of surrogate mothers and children. It is widely believed that the abolition of surrogacy tourism, an industry that give rise to several major scandals, and legal access to surrogacy by Thai couples were the Thai government’s primary goal in implementing this legislation. (shrink)

I offer an argument in defense of four-dimensionalism, the view that objects are temporally, as well as spatially extended. The argument is of the inference-to-the-best-explanation variety and is based on relativistic considerations. It deals with the situation in which one and the same object has different three-dimensional shapes at the same time and proceeds by asking what sort of thing it must be in order to present itself in such different ways in various "perspectives" (associated with moving reference frames) without (...) being different from itself. I argue that the best answer is that the object must be four-dimensional. It will then have differing 3D shapes in different perspectives because such shapes are intrinsic properties of its 3D parts. (shrink)

Most four-dimensionalists, including both worm and stage theorists, endorse mereological universalism, the thesis that any class of objects has a fusion. But the marriage of fourdimensionalism and universalism is unfortunate and unprofitable: it creates a recalcitrant problem for stage theory’s account of lingering properties, such as writing ‘War and Piece’ and traveling across the tennis court, which take time to be instantiated. This makes it necessary to impose a natural restriction on diachronic composition.

What follows for the ability hypothesis reply to the knowledge argument if knowledge-how is just a form of knowledge-that? The obvious answer is that the ability hypothesis is false. For the ability hypothesis says that, when Mary sees red for the first time, Frank Jackson’s super-scientist gains only knowledge-how and not knowledge-that. In this paper I argue that this obvious answer is wrong: a version of the ability hypothesis might be true even if knowledge-how is a form of knowledge-that. To (...) establish this conclusion I utilize Jason Stanley and Timothy Williamson’s well-known account of knowledge-how as “simply a species of propositional knowledge” . I demonstrate that we can restate the core claims of the ability hypothesis – that Mary only gains new knowledge-how and not knowledge-that – within their account of knowledge-how as a species of knowledge-that. I examine the implications of this result for both critics and proponents of the ability hypothesis. (shrink)

Malignant cells are characterized by an increased content of endogenous formaldehyde formed as a by‐product of biosynthetic processes. Accumulation of formaldehyde in cancer cells is combined with activation of the processes of cellular formaldehyde clearance. These mechanisms include increased ALDH and suppressed ADH5/FDH activity, which oncologists consider poor and favorable prognostic markers, respectively. Here, the sources and regulation of formaldehyde metabolism in cancer cells are reviewed. The authors also analyze the participation of oncoproteins such as fibulins, FGFR1, HER2/neu, FBI‐1, and (...) MUC1‐C in the control of genes related to formaldehyde metabolism, suggesting the existence of two mutually exclusive processes in cancer cells: 1) production and 2) oxidation and elimination of formaldehyde from the cell. The authors hypothesize that the study of the anticancer properties of disulfiram and alpha lipoic acid – which affect the balance of formaldehyde in the body – may serve as the basis of future anticancer therapy. (shrink)

A growing literature in economics studies ethical behavior and honesty, as it is imperative for functioning societies in a world of incomplete information and contracts. A majority of studies found more pronounced dishonesty among teams compared to individuals. Scholars identified certain nudges as effective and cost-neutral measures to curb individuals' dishonesty, yet little is known about the effectiveness of such nudges for teams. We replicate a seminal nudge treatment effect, signing on the top of a reporting form vs. no signature, (...) with individuals and confirm the original nudge treatment effect. We further ran the same experiment with teams of two that have to make a joint reporting decision. Our results show the effectiveness of the nudge for teams, which provides further confidence in the applicability of the nudge. (shrink)

The author aims at an objective reinterpretation of L.Feuerbach's doctrine and refuting the prejudices that exist in the historical and philosophical tradition in relation to the Feuerbachian philosophical system. Through an analysis of Feuerbach's views on such concepts as the historical and philosophical paradigm, the relation of man to the world, dialectics and religion, the author concludes that these elements of Feuerbach's doctrine were distorted by K. Marx, F. Engels and their followers. The author demonstrates through Feuerbachian responses to 11 (...) theses of Marx by H.M. Sass that some aspects of Feuerbach's philosophy remain relevant to philosophy, and that the founders of Marxism distorted Feuerbach's doctrine in order to distinguish their philosophical system as more modern and true. (shrink)

The author analyses some problems discussed in the article of Vadim Mezhuev. He discusses the ways in which historians deal with their own scientific problems in the light of philosophical problems of sciences. According to Yu. Nikiforov, a philosopher can always talk about the future which is yet to come; a historian sees the future through the present of the processes which she describes. The author argues that a reconstruction of the past is always based on the knowledge of the (...) present. (shrink)

This introduction surveys the biography and major works of Liu Zehua, a leading scholar of China's intellectual history, political thought, and political culture. It explores the impact of Liu Zehua's personal experience, in particular the upheavals of the Cultural Revolution, on his conceptualization of Chinese political culture as subjugated to the overarching principle of monarchism. Liu Zehua's critical engagement with China's past distinguishes him from proponents of revival of traditional values and makes him one of the powerful opponents of cultural (...) conservatives in China. (shrink)

How should intellectualists respond to apparent Gettier-style counterexamples? Stanley offers an orthodox response which rejects the claim that the subjects in such scenarios possess knowledge-how. I argue that intellectualists should embrace a revisionary response according to which knowledge-how is a distinctively practical species of knowledge-that that is compatible with Gettier-style luck.

The theory of trees with additional unary predicates and quantification over nodes and branches embraces a rich branching time logic. This theory was reduced in the companion paper to the first-order theory of binary, bounded, well-founded trees with additional unary predicates. Here we prove the decidability of the latter theory.

A common belief is that evolution generally proceeds towards greater complexity at both the organismal and the genomic level, numerous examples of reductive evolution of parasites and symbionts notwithstanding. However, recent evolutionary reconstructions challenge this notion. Two notable examples are the reconstruction of the complex archaeal ancestor and the intron‐rich ancestor of eukaryotes. In both cases, evolution in most of the lineages was apparently dominated by extensive loss of genes and introns, respectively. These and many other cases of reductive evolution (...) are consistent with a general model composed of two distinct evolutionary phases: the short, explosive, innovation phase that leads to an abrupt increase in genome complexity, followed by a much longer reductive phase, which encompasses either a neutral ratchet of genetic material loss or adaptive genome streamlining. Quantitatively, the evolution of genomes appears to be dominated by reduction and simplification, punctuated by episodes of complexification. (shrink)