Cellular reprogramming can manipulate the identity of cells to generate the desired cell types1– 3. The use of cell intrinsic components, including oocyte cytoplasm and transcription factors, can enforce somatic cell reprogramming to pluripotent stem cells4– 7. By contrast, chemical stimulation by exposure to small molecules offers an alternative approach that can manipulate cell fate in a simple and highly controllable manner8– 10. However, human somatic cells are refractory to chemical stimulation owing to their stable epigenome2,11,12 and reduced plasticity13,14; it (...) is therefore challenging to induce human pluripotent stem cells by chemical reprogramming. Here we demonstrate, by creating an intermediate plastic state, the chemical reprogramming of human somatic cells to human chemically induced pluripotent stem cells that exhibit key features of embryonic stem cells. The whole chemical reprogramming trajectory analysis delineated the induction of the intermediate plastic state at the early stage, during which chemical-induced dedifferentiation occurred, and this process was similar to the dedifferentiation process that occurs in axolotl limb regeneration. Moreover, we identified the JNK pathway as a major barrier to chemical reprogramming, the inhibition of which was indispensable for inducing cell plasticity and a regeneration-like program by suppressing pro-inflammatory pathways. Our chemical approach provides a platform for the generation and application of human pluripotent stem cells in biomedicine. This study lays foundations for developing regenerative therapeutic strategies that use well-defined chemicals to change cell fates in humans. (shrink)

近年來關於賽伯格與後人類主義的論述在西方世界方興未艾，論者紛紛從科學、醫學、宗教、哲學、倫理學、社會學、文學與文化研究等各個不同面向思考人們正在經歷的後人類世界。但對一般中文讀者而言，這兩個新詞彙所指 涉的意義仍相當模糊。本書收錄了國內外關於賽伯格與後人類主義的重要論文，嘗試探討人與科技、身體與環境、精神與物質兩者界線逐漸消弭的後人類社會裡的危機與轉機。本書討論之內容相當廣泛，除了探討大眾文化所透露 出的哲學內涵，也從生態文學談到科幻小說，本身即為一部賽伯格文本，不但充斥著許多有意思的矛盾或裂縫，也跨越了各個不同的學門界線，多元豐富的內容相信能夠給予中文讀者提供一個從文學、文化研究角度思索賽伯格與 後人類的獨特視野。.

Drawing on social exchange theory, we argue that family-supportive supervisor behavior (FSSB) inhibits employees’ unethical pro-family behavior (UPFB) via the mediation of felt obligation. We further propose that employees’ positive reciprocity beliefs strengthen the hypothesized relationships. Using a sample consisting of 345 full-time employees from an Internet service company located in China, we found that felt obligation partially mediated the negative relationship between FSSB and UPFB and that the FSSB-felt obligation relationship and the mediation relationship were stronger for employees with (...) higher positive reciprocity beliefs. Theoretical and practical implications, limitations, and future directions are discussed. (shrink)

Business Ethics, the Environment & Responsibility, EarlyView.

Previous studies have confirmed that individual waste management behavior is influenced by both rational-based and altruistic-oriented beliefs and attitudes. Scholars incorporated personal norms in Ajzen’s theory of planned behavior and confirmed its usefulness in predicting waste management behavior. However, limited attention has been paid to the interactions between the variables in the model. Scholars also commented that the cognitive dimension was largely neglected in the current socio-psychological framework of waste management behavior. This study intends to address this issue by incorporating (...) environmental concern and environmental knowledge in the model and examining the psychological paths linking these variables to waste management behavior within the expanded model of planned behavior. Based on a cross-sectional survey among 434 university students in China, the results showed that subjective norms, perceived behavioral control, personal norms, and environmental knowledge were essential predictors of waste management behavior, whereas the direct effect of attitude was not statistically significant. Environmental concern and subjective norms could influence waste management behavior through personal norms. Environmental knowledge could influence waste management behavior indirectly through environmental concern, personal norms, and perceived behavioral control. Moreover, perceived behavioral control served as a mediator between the relationship of personal norms and waste management behavior. (shrink)

This article examines one of the most crucial yet often-overlooked links in global film processes: piracy. It does so within the context of a changing digital media environment that calls for a reassessment of key dimensions: networks, globalization, technology, space and the state. More specifically, it focuses on the operation of film piracy networks in Greater China that includes the Mainland, Hong Kong and Taiwan. By zooming in on `Greater China', this article presents empirical accounts of specific links and connections (...) on and between the intersecting distribution and piracy networks. In sum, distribution and piracy in China highlight some of the most interesting and intricate insights into issues of power, control, technology, network, speed, global-regional-national dynamics, subjectivities and reflexivity. Given the complexity of the issues, this study argues for a spatial, network and process-oriented theoretical framework. (shrink)

Global warming and other climate issues seriously threaten global sustainable development. As citizen environmental behavior can have a positive impact on the environment, it is of great theoretical significance and practical reference value to study the impact of psychological distance theory on citizen environmental behavior. This study obtained 2,633 related studies from 1980 to 2020 from the Web of Science as research objects, and used CiteSpace, VOSviewer, Netdraw, and other software programs to perform a bibliometric analysis, which can show the (...) complex relationship implied in the citation, intuitively grasp the development context and hot frontier in this field, and help scholars better study citizen environmental behavior. The results and conclusions are as follows. The related research covered three periods: infancy, growth, and outbreak. Chronologically, the relevant research evolved from building models to analyze the impact of environmental enrichment on human environmental behavior, to studying the motivation behind citizen environmental behavior, and finally to paying attention to sustainable development. A cluster analysis of high-frequency keywords identified three research hotspots: “drivers of psychological distance of environmental change perception on citizen environmental behavior,” “impact of social distance on adolescents’ behavior,” and “construal level theory and citizen green behavior.” Based on these findings, possible future research directions were identified, including changing from a single theory to a combination of multiple theories to comprehensively study citizen environmental protection behavior; analyzing the motivation of citizen environmental behavior and summarizing the general motivation of environmental behavior according to its internal relationship; and determining how to narrow the global psychological distance, strengthen the awareness of the community of human destiny, and explore the establishment of an efficient global climate cooperation mechanism. (shrink)

Substantial evidence from experimental studies has shown that mating motivation increases men’s financial risk-taking behaviors. The present study proposed a new moderator, men’s past relationship experience, for this well-accepted link between mating motivation and financial risk-taking tendency. Heterosexual young men were randomly assigned to the mating condition and control condition, and they completed a set of financial risk-taking tasks and reported their past relationship experience. A significant main effect of mating motivation and a significant interaction effect between experimental conditions and (...) relationship experience emerged, suggesting that mating motivation increased financial risk-taking tendency only among men who have never been committed in a romantic relationship, rather than those who have had such experience. This moderating effect was replicated in two experiments. The present study contributed to the understanding of individual differences in the relationship between mating motivation and male financial risk-taking. The present findings also have important implications for financial industry and gambling companies to better target clients and advertise their high-risk products. (shrink)

Problematic smartphone use in college students has been a major public health concern in modern society, which may also lead to adverse health outcomes. Using a three-wave longitudinal study design, the current study aimed to examine the prevalence and psychosocial factors of PSU in a large sample of Chinese college students. The data used in this study was obtained from an ongoing longitudinal study in Guangdong, China. In the current study, a total of 7,434 freshmen and sophomores who completed the (...) first three surveys were included. Self-administered questionnaires were used to assess PSU, possible social anxiety disorders, depressive symptoms, loneliness, family conflicts, academic stress, and some demographic characteristics. Generalized estimating equation models were performed to determine the risk factors associated with PSU. The results showed that 65.8, 58.1, and 52.8% of college students reported PSU at three waves, with an apparent downward trend. Female students reported higher prevalence rates of PSU than males. Depressive symptoms, possible social anxiety disorders, loneliness, family conflicts, and high academic pressure were important risk factors for PSU. Early intervention and identification of those who show signs of PSU may prevent the development of maladaptive coping responses and addictive behaviors, so as to prevent future negative psychosocial consequences. (shrink)

Fourteen subjects were tape‐recorded while they undertook to find a law to summarize numerical data they were given. The source of the data was not identified, nor were the variables labeled semantically. Unknown to the subjects, the data were measurements of the distances of the planets from the sun and the periods of their revolutions about it—equivalent to the data used by Johannes Kepler to discover his third law of planetary motion.Four of the 14 subjects discovered the same law as (...) Kepler did (the period varies as the 3/2 power of the distance), and a fifth came very close to the answer. The subiects' protocols provide a detailed picture of the problem‐solving searches they engaged in, which were mainly, but not exclusively, in the space of possible functions for fitting the data, and provide explanations as to why some succeeded and the others failed.The search heuristics used by the subjects are similar to those embodied in the BACON program, computer simulation of certain scientific discovery processes. The experiment demonstrates the feasibility of examining some of the processes of scientific discovery by recreating, in the laboratory, discovery situations of substantial historical relevance. It demonstrates also, that under conditions rather similar to those of the original discoverer, a law can be rediscovered by persons of ordinary intelligence (i.e., the intelligence needed for academic success in a good university). The data for the successful subjects reveal no “creative” processes in this kind of a discovery situation different from those that are regularly observed in all kinds of problem‐solving settings. (shrink)

As an intercultural modern art form, web-based ink and wash cartoons are significant tools to communicate cultural identities in the Chinese context because of their entertaining form, thought-provoking content, and profound cultural connotation. Against this background, the present study investigates the multimodal appraisal systems of 96 web-based ink and wash cartoons, focusing on attitudinal meanings and explicating how the attitudinal resources contribute to the communication of Chinese cultural identities. The analysis of 96 web-based ink and wash cartoons shows that the (...) cultural identities of the Chinese dream, Confucianism, collectivism, and optimism are communicated through the interplay between visual and verbal semiotic resources. The analytical results reveal a series of generic features of the web-based ink and wash cartoons that contribute to the promotion of cultural identities, including the popular theme, minimalist style, positive attitude prosody, and the use of culture-specific metaphor and ideation. These features underpin the strategies for promoting Chinese cultural identities and the shift in national branding policy. The study hopes to provide clues for government, social institutions, and individuals to promote cultural identities effectively through social media. (shrink)

本书第一章介绍王船山的生平及其著述。第二章概述王船山研究情况。第三章至第八章依次介绍清代、民国与中华人民共和国成立后的王船山研究论文与著作情况。第九章介绍香港、台湾地区的王船山研究著作。.

Zhu Xi is the most important of the twelfth-century neo-Confucianists. Some consider him second only to Confucius himself in his importance to Chinese philosophy as a whole, since it is his interpretation of Confucius that has been canonical since his lifetime. This short book, modeled after the Burton Watson "Basic Writings" volumes for Zhuangzi, Xunzi, and Han Feizi, is an accessible, one-volume introduction to Zhu Xi's influential philosophical system designed especially for course use. In "classifying" Zhu Xi's conversations in the (...) Classified Conversations of Master Zhu, Li Jingde dedicated the first thirteen chapters to conversations explaining his general philosophical system. Readers are introduced to his metaphysics of principle (li), psychophysical stuff (qi), spiritual beings (guishen), human nature (xing), mind-heart (xin), and emotions (qing); and to his program of self-cultivation-that is, the curriculum that Confucians should follow to attain moral perfection. Gardner argues that these chapters constitute the best overview of Zhu Xi's basic philosophical teachings, and selections from them form the basis of his volume. Occasionally, they are supplemented with passages from the Collected Literary Writings of Master Zhu and from Zhu's commentaries on the Classics. (shrink)

本书是研究马克思主义哲学的成果汇集。这些成果从马克思主义哲学的视域,对当代重大现实问题和理论问题进行了认真的研究.

Evidences are important proofs to support judicial trials. Automatically extracting evidences from judgement documents can be used to assess the trial quality and support “Intelligent Court”. Current evidence extraction is primarily depended on sequence labelling models. Despite their success, they can only assign a label to a token, which is difficult to recognize nested evidence entities in judgment documents, where a token may belong to several evidences at the same time. In this paper, we present a novel evidence extraction architecture (...) called ATT-MRC, in which extracting evidence entities is formalized as a question answer problem, where all evidence spans are screened out as possible correct answers. Furthermore, to address the data imbalance problem in the judgement documents, we revised the loss function and combined it with a data enhancement technique. Experimental results demonstrate that our model has better performance than related works in evidence extraction. (shrink)

本书通过比较研究揭示出,在生存主义哲学和道家思想对人之生存结构的理解方面,存在着深层的共识,这是二者之间展开深度对话的"客观基础".本书分为两大部分,第一部分,包括本研究的第一章和第二章,分别对海德格 尔存在与时间和萨特存在与虚无中的生存主义思想加以呈现,诠释,以期读者能够对生存主义哲学的"标本式"理论有所了解,并为后文的比较研究提供一定的理论铺垫.第三到八章,对道家思想与生存主义思想展开多维比较. 主要围绕"无"在生存结构中的地位和作用来展开,并努力揭示出,生存主义哲学和道家思想在人的"带无生存"这一点上,有着极为醒目的相通之处.然而,在此基础上产生的价值导向,却表现出同样醒目的分梳.通过分析道 家与生存主义哲学思想上重叠性与互补性,可能为融合东西方智慧,尤其是吸收中国传统道家智慧的现代生存哲学理论体系的建立提供一定的思想素材和理论参考.

马克思主义哲学是对人类以往科学和哲学发展的科学总结,是人类思想史上的革命,是整个马克思主义学说的重要组成部分和理论基础,是无产阶级争取自身解放的科学世界观和方法论.

As the labeling costs in legal artificial intelligence tasks are expensive. Therefore, it becomes a challenge to utilize low cost to train a robust model. In this paper, we propose a LAIAugment approach, which aims to enhance the few-shot learning capability in legal artificial intelligence tasks. Specifically, we first use the self-training approach to label the amount of unlabelled data to enhance the feature learning capability of the model. Moreover, we also search for datasets that are similar to the training (...) set by improving the text similarity function. We conducted experimental analyses for three legal artificial intelligence tasks, including evidence extraction, legal element extraction, and case multi-label prediction, which composed of 3500 judgement documents. The experimental results show that the proposed LAIAugment method has an average F1-score of 72.3% on the three legal AI tasks, which is 1.93% higher than the baseline model. At the same time, it shows a huge improvement in few-shot learning. (shrink)