The ongoing COVID-19 pandemic and resulting health and economic crisis has caused major disruptions in the functioning of food systems and revived the discussion on what forms balanced, effective and responsible crisis management. As part of its thought leadership and its social responsibility in times of crisis, WUR is uniquely placed to contribute to the scientific knowledge base and data collection mechanisms required for early recognition and rapid response. In addition, WUR takes on the challenge to generate timely insights into (...) the possible scenarios for the prevention of a crisis and during and after emergencies to enable our clients and stakeholders to make informed decisions. Lastly, WUR can provide a better understanding of the mechanisms of spillover, and tangible and practical tools to help reduce the risk of spillover events from occurring, prevent pathogen spread, or mitigate the impacts of a future pandemic. In its research institutes and university, WUR brings together expertise in human, animal, plant and environmental health, the global agri-food system, economics, social sciences, food safety and security, ethics, and policy. Here, in the knowledge that COVID-19 will not be the last pandemic, we present WUR’s ambition and capabilities towards an integrated global multi-stakeholder approach to the prevention and management of potentially pandemic diseases, across the four phases of crisis management; prevention, preparedness, response, and recovery and learning. (shrink)

Three philosophical perspectives on the relation between technology and society are distinguished and discussed: 1) technology as an autonomous force that determines society; 2) technology as a human construct that can be shaped by human values, and 3) a co-evolutionary perspective on technology and society where neither of them determines the other. The historical evolution of the three perspectives is discussed and it is argued that all three are still present in current debates about technological change and how it may (...) affect society. This is illustrated for the case of Artificial Intelligence (AI). It is argued that each of the three perspectives contributes to the debate of AI but that the third has the strongest potential to uncover blind spots in the current debate. (shrink)

How are we to appraise new technological developments that may bring revolutionary social changes? Currently this is often done by trying to predict or anticipate social consequences and to use these as a basis for moral and regulatory appraisal. Such an approach can, however, not deal with the uncertainties and unknowns that are inherent in social changes induced by technological development. An alternative approach is proposed that conceives of the introduction of new technologies into society as a social experiment. An (...) ethical framework for the acceptability of such experiments is developed based on the bioethical principles for experiments with human subjects: non-maleficence, beneficence, respect for autonomy, and justice. This provides a handle for the moral and regulatory assessment of new technologies and their impact on society. (shrink)

The participation of minors in clinical trials is essential to provide safe and effective medical care to children. Because few drugs have been tested in children, pediatricians are forced to prescribe medications off-label with uncertain efficacy and safety. In this article, we analyze how the enrollment of minors in clinical trials is negotiated within relationships of mutual trust between clinicians, minors, and their parents. After a brief description of the problems associated with involving minors in clinical research, we consider how (...) existing “relationships of trust” can be used as a place where the concerns of research subjects can be more fully discussed and addressed. Building on the tacit recognition of trust found in The European Clinical Trials Directive we make policy recommendations that allow for clearer, more ethically informed guidelines for enrolling minors in clinical research. (shrink)

The condition of explicit theoretically discursive cognitive performance, as it culminates in scientific activity, is, I claim, the life world. I contrast life world and scientific world and argue that the latter arises from the first and that contrary to the prevailing views the scientific world (actually, worlds, since the classical world is substantially different from the quantum world) finds its completion in the life world and not the other way around. In other words: the closure we used to search (...) in a complete and comprehensive scientific description of all aspects of experience by referring it back to underlying atoms, genes and other scientific objects and the covering laws ruling them, should be sought in a reintegrating and occasionally dissolving of the abstract scientific model in the self-organizational fluidity and superposition-like indeterminateness and non-locality of the life world: “We have to acknowledge the indeterminate as a positive phenomenon” (Merleau-Ponty in his The Phenomenology of Perception). (shrink)

Gedurende 2017 herdenk Lutherse en Calvinistiese kerke die Kerkhervorming wat 500 jaar gelede plaasgevind het. Hierdie hoofstuk fokus op Johannes Calvyn se eerste publikasies, dit wil sê publikasies wat verskyn het voordat hy met sy bediening in Genève begin het. Die fokus val op die drie belangrikste publikasies in hierdie periode, te wete sy 'Kommentaar op Seneca se De Clementia', die 'De Psychopannychia' en die eerste uitgawe van sy 'Christianae Religionis Institutio'. In hierdie eerste drie publikasies is 'n jeugdige Calvyn (...) aan die woord. Ten spyte daarvan is die publikasies omvangryk en is dit duidelik dat Calvyn vroeg in sy lewe oor omvangryke kennis en insig beskik het. Die vroegste publikasies word somtyds as van minder belang geag. In hierdie bydrae word die stelling gemaak dat die publikasies van groot belang is omdat Calvyn talle van die gedagtes wat later in sy werke na vore kom, reeds in sy vroeë werke aan die orde gestel het. (shrink)

Rosenberg has rightly argued that fitness is supervenient. But he has wrongly assumed that this makes The fittest survive nontautologous. Supervenience makes strict reduction impossible. It sheds light on disputes concerning the testability of evolutionary theory.

Periodic attacks of uncertain origin, where the clinical presentationresembles epilepsy but there is no evidence of a somatic disease, arecalled Pseudo-Epilepsy or Pseudo-Epileptic Attack Disorder (PEAD). PEADmay be called a `non-disease', i.e. a disorder on the fringes ofestablished disease patterns, because it lacks a rationalpathophysiological explanation. The first aim of this article is tocriticize the idea, common in medical science, that diseases are realentities which exist separately from the patient, waiting to bediscovered by the doctor. We argue that doctor and (...) patient construct adisease, and that the construction of the disease PEAD includes manynormative evaluations. The second aim is to provide insight into thesuffering of patients with PEAD. We focus on three aspects of thepatient, identity, autonomy and responsibility. We present somecharacteristic descriptions of (pseudo-)epileptic attacks by FjodorDostoevsky, Gustave Flaubert and Thomas Mann. We argue that diagnosingPEAD reduces a meaningful life event into an insignificant, thoughintriguing, medical phenomenon, and that the patient will not benefitfrom being diagnosed as having PEAD. (shrink)

In his 1939 Cambridge Lectures on the Foundations of Mathematics, Wittgenstein proclaims that he is not out to persuade anyone to change their opinions. I seek to further our understanding of this point by investigating an exchange between Wittgenstein and Turing on contradictions. In defending the claim that contradictory calculi are mathematically defective, Turing suggests that applying such a calculus would lead to disasters such as bridges falling down. In the ensuing discussion, it can seem as if Wittgenstein challenges Turing's (...) claim that such disasters would occur. I argue that this is not what Wittgenstein is doing. Rather, he is scrutinizing the meaning and philosophical import of Turing's claim—showing how Turing is wavering between making an empirical prediction and a logical observation, and that it is only through this wavering that Turing can believe that he has provided a proper explanation of why contradictory calculi are mathematically defective. (shrink)

This paper aims at contributing to a research agenda in engineering ethics by exploring the ethical aspects of engineering design processes. A number of ethically relevant topics with respect to design processes are identified. These topics could be a subject for further research in the field of engineering ethics. In addition, it is argued that the way design processes are now organised and should be organised from a normative point of view is an important topic for research.

The notion of responsible innovation suggests that innovators carry additional responsibilities beyond those commonly suggested. In this paper, we will discuss the meaning of these novel responsibilities focusing on two philosophical problems of attributing such responsibilities to innovators. The first is the allocation of responsibilities to innovators. Innovation is a process that involves a multiplicity of agents and unpredictable, far-reaching causal chains from innovation to social impacts, which creates great uncertainty. A second problem is constituted by possible trade-offs between different (...) kinds of responsibility. It is evident that attributing backward-looking responsibility for product failures diminishes the willingness to learn about such defects and to take forward-looking responsibility. We will argue that these problems can be overcome by elaborating what it is exactly that innovators are responsible for. In this manner, we will distinguish more clearly between holding responsible and taking responsibility. This opens a space for ‘supererogatory’ responsibilities. Second, we will argue that both innovation processes and outcomes can be objects of innovators’ responsibility. Third, we will analyze different kinds of responsibility and show that the functions of their attribution are not necessarily contradictory. Based on this conceptual refinement, we will argue that accountability, responsibility-as-virtue and the willingness to take responsibility are crucial for responsible innovation. (shrink)

The iCat is a user-interface robot with the ability to express a range of emotions through its facial features. This article summarizes our research to see whether we can increase the believability and likability of the iCat for its human partners through the application of gaze behaviour. Gaze behaviour serves several functions during social interaction such as mediating conversation flow, communicating emotional information and avoiding distraction by restricting visual input. There are several types of eye and head movements that are (...) necessary for realizing these functions. We designed and evaluated a gaze behaviour system for the iCat robot that implements realistic models of the major types of eye and head movements found in living beings: vergence, vestibulo ocular reflexive, smooth pursuit movements and gaze shifts. We discuss how these models are integrated into the software environment of the iCat and can be used to create complex interaction scenarios. We report about some user tests and draw conclusions for future evaluation scenarios. (shrink)

(1996). Georges Sorel in North America. The European Legacy: Vol. 1, Fourth International Conference of the International Society for the Study of European Ideas, pp. 1459-1464.

Pendant les années 1968-1977, l'héritage culturel et politique de Mai 68 se diffuse dans la société française. Dans cet ensemble d'idées le maoïsme et le féminisme constituent les courants les plus importants. L'objectif de cette étude qui se veut une contribution à l'histoire des idées, est d'analyser comment le maoïsme et le féminisme ont été accueillis par trois revues intellectuelles prestigieuses : Tel Quel, Les Temps modernes et Esprit. Cette approche permet également d'évoquer le lien qui relie Sartre aux maoïstes (...) et la relation qui s'est établie entre les militantes du Mouvement des femmes et Simone de Beauvoir. De même, le quatrième chapitre traite l'influence du maoïsme sur la théorie de texte de Tel Quel, tandis que le chapitre neuf se termine par une analyse du rapport qui existe entre l'écriture de Julia Kristeva et les prémisses féministes du groupe Psych et Po. La description chronologique du corpus permet de mieux saisir l'évolution de certaines idées qui ont dominé l'histoire intellectuelle de l'après-Mai 68, comme celle d'une " révolution de la pensée ". Le matériel fourni par l'histoire sert aussi de pont de départ à une analyse sociologique de la rivalité qui existe entre les revues féministes d'une part, et entre Tel Quel et le surréalisme d'autre part. (shrink)

The impact of philosophy of science on biology is slight. Evolutionary biology, however, is nowadays an exception. The status of the neo-Darwinian (synthetic) theory of evolution is seriously challenged from a methodological perspective. However, the methodology used in the relevant discussions is plainly defective. A correct application of methodology to evolutionary theory leads to the following conclusions. (a) The theory of natural selection (the core of neo-Darwinism) is unfalsifiable in a strict sense of the term. This, however, does not militate (...) against the theory, because no scientific theory whatever is testable in this way. Under a more liberal testability criterion, the theory is surely testable. None the less, certain (not all) research programs may tend to make the theory untestable in practice. (b) It has often been argued that the tautologous character of the principle of natural selection, allegedly the focus of evolutionary theory, makes the theory untestable through circular reasoning. Actually, the principle is only a tautology if fitness is wrongly defined in terms of actual survival. But even then circular reasoning need not ensue. (c) Evolutionary principles do not permit, without additional information, the derivation of statements about evolutionary events concerning particular species or populations. If this were a reason to criticize the theory (as has been argued in the literature), any other scientific theory would be inadequate by the same token. (shrink)

The Safe-by-Design approach in synthetic biology holds the promise of designing the building blocks of life in an organism guided by the value of safety. This paves a new way for using biotechnologies safely. However, the Safe-by-Design approach moves the bulk of the responsibility for safety to the actors in the research and development phase. Also, it assumes that safety can be defined and understood by all stakeholders in the same way. These assumptions are problematic and might actually undermine safety. (...) This research explores these assumptions through the use of a Group Decision Room. In this set up, anonymous and non-anonymous deliberation methods are used for different stakeholders to exchange views. During the session, a potential synthetic biology application is used as a case for investigation: the Food Warden, a biosensor contained in meat packaging for indicating the freshness of meat. Participants discuss what potential issues might arise, how responsibilities should be distributed in a forward-looking way, who is to blame if something would go wrong. They are also asked what safety and responsibility mean at different phases, and for different stakeholders. The results of the session are not generalizable, but provide valuable insights. Issues of safety cannot all be taken care of in the R&D phase. Also, when things go wrong, there are proximal and distal causes to consider. In addition, capacities of actors play an important role in defining their responsibilities. Last but not least, this research provides a new perspective on the role of instruction manuals in achieving safety. (shrink)

This is a book review of Postcritical Management Studies, by Ghislain Deslandes, published in 2023 by Springer.

I argue that discussions of Frege’s conception of elucidation have suffered from a conflation of two distinct issues: elucidation of primitive scientific terms, and elucidation of the logical categories. The former seeks to bring us to grasp the Bedeutung of terms that stand at the beginning of the chain of definitions of a scientific system. The latter cannot be understood on the model of securing agreement in Bedeutung at all. I show how existing discussions of Fregean elucidation insufficiently take this (...) difference into account. I adumbrate what I take to be a more accurate understanding of Fregean elucidation of the logical categories, starting from the observation that Frege, when engaged in such elucidation, consistently reverts to talking about signs. Frege, I argue, takes signs to possess logical features, and it is these logical features which his elucidations are meant to help us to grasp. For Frege, the nature of the logical categories lies in the signs. In this way, I argue, Frege’s approach to elucidating the logical categories is incompatible with a realist conception according to which there is a logical order of reality that is prior to the logical order of language. (shrink)

Value Sensitive Design (VSD) is an established method for integrating values into technical design. It has been applied to different technologies and, more recently, to artificial intelligence (AI). We argue that AI poses a number of challenges specific to VSD that require a somewhat modified VSD approach. Machine learning (ML), in particular, poses two challenges. First, humans may not understand how an AI system learns certain things. This requires paying attention to values such as transparency, explicability, and accountability. Second, ML (...) may lead to AI systems adapting in ways that ‘disembody’ the values embedded in them. To address this, we propose a threefold modified VSD approach: 1) integrating a known set of VSD principles (AI4SG) as design norms from which more specific design requirements can be derived; 2) distinguishing between values that are promoted and respected by the design to ensure outcomes that not only do no harm but also contribute to good; and 3) extending the VSD process to encompass the whole life cycle of an AI technology in order to monitor unintended value consequences and redesign as needed. We illustrate our VSD for AI approach with an example use case of a SARS-CoV-2 contact tracing app. (shrink)

During the 16th century, Europe underwent fundamental sociopolitical changes, which challenged theologians and the church to respond theologically. In light of the celebration of the Reformation and the theme of this conference, this contribution presents Calvin as a ‘public theologian’. To this purpose it is necessary to define ‘public theology’, describe the sociopolitical changes which challenged theologians during the 16th century, and lastly to focus on Calvin’s contribution to the discourse. Because of the vast amount of material that is available, (...) this contribution is limited to Calvin’s first publication, his ‘Commentary on Seneca’s De Clementia’. Calvin’s fundamental understanding of law and justice, as well as his theological engagement with sociopolitical issues, made him a public theologian par excellence. Calvin’s legal training surfaced whenever he addressed the authorities, for instance, when pleading the case of persecuted Protestants. He had a fundamental understanding of issues such as justice and freedom. The rights, responsibilities and obligations of government and people should always remain in balance. Sociopolitical transformation, as experienced in South Africa during the last three decades, requires of theologians to engage theologically with relevant issues. In this, Calvin set a remarkable example. (shrink)

'Marginalia' are notes made in the margins of a book. It could be general comments, glosses or scholia. For centuries marginalia was considered an important scholarly activity, almost as important as the original text. The famous marginalia on the text of Homer's Iliad dates back to the 5th century before Christ. Some of the most important theologians in history kept themselves busy by adding marginalia to texts. Luther's marginalia on the text of Paul's Letter to the Romans is a good (...) example of this type of scholarly endeavour. Writing about the life and work of a fellow theologian could at best be a few marginal notes - sometimes it is a mere scribble, sometimes an interpretation of a text and sometimes commentary is necessary. This contribution reflects on the life and work of I.W.C. van Wyk, a theologian who dedicated his life to the church, mission and reformed theology. (shrink)

El artículo trata de las huellas que el agustinismo del siglo XVI dejó en la exégesis bíblica de la facultad de teología de Lovaina. Como un ejemplo de esto, se abordan las obras de Cornelio Jansenio de Gante, subrayando su doble propósito académico y pastoral-litúrgico. Se estudian también las obras de Thomas Stapleton, Promptuaria y Antidota, señalando su intención de contrarrestar las interpretaciones bíblicas de Calvino, Beza y otros reformadores.

In this article, we describe the various steps that led to the digitization of the dialectological records compiled by Gaston Dulong based on surveys conducted throughout Québec since the late 1940s. Due to their heritage value and scientific interest, these records are currently added to the Fonds de données linguistiques du Québec (FDLQ). However, preparing this corpus poses significant challenges due to the large number of documents to be processed, their physical condition as well as the nature of the data (...) they contain. To ensure data quality, we have favoured an approach that allows for a reasoned way of dealing with the noise caused by computerization. (shrink)

The polymath Michel de Certeau is traditionally seen as one of a group of French poststructuralist thinkers who reject constructs in the social sciences in favor of the diversity of the everyday or the past. However, in this paper I will show that, as a historian, Certeau did not discard these constructs, but rather valued them as a means of doing justice to the “strangeness” of the past. The position that Certeau adopts can be seen most clearly from his theoretical (...) debate with Paul Veyne, which is the starting point of this article. I then show how Certeau’s first major historical work, The Possession at Loudun, exemplifies his theoretical position. An analysis of this work demonstrates how the historian’s active reconstruction of interactions between exorcists, medical doctors, state officers, and possessed nuns helps us to perceive the complexity of the past in a way that can be seen as a microhistory avant la lettre. I will suggest that during his writing of the history of Loudun, Certeau implicitly raises more theoretical and epistemological problems, and in so doing he “practices” a theory of history. The most elusive aspect of the story at Loudun turns out to be the drama around the priest Grandier. This article demonstrates how Certeau pays tribute to Grandier by using “scientific” methods, thus showing the “limits of representation” through disciplinary means. Finally, the article explores the implications of Certeau’s theory and practice of the writing of history for understanding historiography at large. The historian not only appears as a tramp who looks for remains that are forever lost to us, but is also a “scientist” who uses both models and concepts in order to put them to the test. (shrink)

This is the editorial for Vol 19 Issue 2 of Philosophy of Management. A reflection is made on COVID-19 measures and a call for papers is made to explore the crisis through philosophical inquiry on 1) disaster management and 2) existentialist views of work. Guidance is given based on papers published previously in the journal, and on Camus’ La Peste / The Plague.

In lieu of an abstract, here is a brief excerpt of the content:A Vindication Wim Klever Comparing Hume with Spinoza I am accused ofhaving misread both, at least in certain respects; I would have gone too far in considering Spinoza as an influential root of Hume's thought. On occasion of Dr. Leavitt's criticism I would like to stress the following points: 1. In spite ofWolfson'sendeavourtoreduceSpinozatoAristotelian, scholastic and Jewish sources ofthe Middle Ages, many texts—in fact all texts in which Aristotle ismentioned—constitute (...) aconvincingproof that Spinoza not only rejected,just like Hume, all sorts ofAristotelian and scholastic speculation, buteven showedmuch contemptfor them.1 In the same way there cannot be any doubt that he rejected Maimonides' Jewish Aristotelianism.2 In the TTP he defines his position in sharp contrast to Maimonides. 2.Nominalism means that names may be used for the indication of many items whereas ideas are essentially ideas of particulars. According to Spinoza everything is reflected in its own specific idea,3 whereas names like 'ens', 'aliquid', 'man', etc. may be the sign, sometimes ambiguously but often also without confusion, of more things, which are vaguely conceived. This confused idea, then, is nevertheless the properideaofaparticularblurredimageinthebrains. Some eminent scholars like Stuart Hampshire and Martial Gueroult (I confess: not all ofthem) pretend that Spinoza is a true nominalist. I think the texts (and the whole structure of the system) enforce us to confess that they are right. 3.In the case of common things, that is, (elementary) things common to all beings, the human body included, the ideas of these things are, though particular, common too.4 In spite ofand in line with Hume's agreement with Spinoza's nominalism he does not deny, as Leavitt pretends, the existence of common notions. In "Of the Passions," part 1, section 10, he writes that "according to common notions a man has no power, where very considerable motives Ue betwixt him and the satisfaction of his desires, and determine him to forbearwhathe wishes toperform."5Thispassageis notatallinconflict with Treatise 1.1.7 in which the real existence ofabstract ideas in our mind is refuted. The ideas of things we have in common with other natural beings, may not be called abstract for that reason. This section (T 17-25) is perfectly congruous with Spinoza's position. 4.I keep to my claim that there is a striking parallel between Spinoza's famous distinction between three kinds of knowledge Volume XVII Number 2 209 WIM KLEVER (2 Ethics 40s2) and some statements ofHume. Additional evidence for this claim (compared with what I gave already) is to find in Treatise 1.3.11, where Hume marks "several degrees of evidence,... distinguishing] human reason into three kinds, viz. that from knowledge, from proofs, and from probabilities" (T 124, first emphasis added); and in the Enquiry, where all objects of human reason are dividedinto three (!)kinds as well, namely"Relations ofIdeas... either intuitively or demonstratively certain" and "Matters ofFact."6 Put into a diagram the resemblance becomes even more apparent: Spinoza Ethics opinio/imaginatio ratio intuitio Hume TreatiseEnquiry probabilityMatters of Fact proofdemonstratively knowledgeintuitively Careful comparison ofthe texts shows that the functions attributed to the various kinds ofknowledge are exactly the same in Spinoza as in Hume, contrary to what is suggested by Leavitt. I only need to remind him ofthe 'Spinozistic' opening ofTreatise 1.3.3: "Tis a general maxim in philosophy, that whatever begins to exist, must have a cause of existence... Tis suppos'd to be founded on intuition,... All certainty arises from the comparison of ideas, and from the discovery of such relations as are unalterable" (T 78-79). Both philosophers locate the highest kind of knowledge in the evidence of mathematics and the common properties of nature, explained in physics. Let us not forget that both are fully naturalists, for whom the understanding of things "sub specie aeternitatis" (Spinoza's description of the third kind of knowledge) means in fact the intuition of the particular essence of things in a scientific way. 5.In the TractatusTheologico-Politicus itiscertainly not Spinoza's intention to show that the third kind of knowledge is identical with prophecy. On the contrary, in the first two chapters he clearly demonstrates, in his scientific hermeneutics, that prophecy is... (shrink)

Organizations such as the EU High-Level Expert Group on AI and the IEEE have recently formulated ethical principles and (moral) values that should be adhered to in the design and deployment of artificial intelligence (AI). These include respect for autonomy, non-maleficence, fairness, transparency, explainability, and accountability. But how can we ensure and verify that an AI system actually respects these values? To help answer this question, I propose an account for determining when an AI system can be said to embody (...) certain values. This account understands embodied values as the result of design activities intended to embed those values in such systems. AI systems are here understood as a special kind of sociotechnical system that, like traditional sociotechnical systems, are composed of technical artifacts, human agents, and institutions but—in addition—contain artificial agents and certain technical norms that regulate interactions between artificial agents and other elements of the system. The specific challenges and opportunities of embedding values in AI systems are discussed, and some lessons for better embedding values in AI systems are drawn. (shrink)

Liberalist thinking argues that moral agents have a right to pursue an ordinary life. It also insists that moral agent can be bystanders. A bystander is involved with morally bad states of affairs in the sense that they are bound by moral duty, but for a non-blameworthy reason. A common view on the morality of commercial life argues that commercial agents cannot and ought not to assume the status of bystander, when confronted with child labor, pollution, or other overwhelmingly big (...) morally bad states of affairs. According to the common view, the agent will get overdemanded. In this paper, the overdemandingness charge is interpreted as a criticism of the liberalist position. According to this charge, bystander status must be given up in the market because otherwise the right to pursue a personal life is crushed. In this paper, we demonstrate that the overdemandingness charge fails. It does not make sense if bystander status is grounded in the duty of beneficence. It would make sense if the status were grounded in the duty of rescue but that duty does not apply in relation to oMBS. The condition of ‘subjective urgency’ is not fulfilled. Hence, liberalist thinking can withstand the charge of overdemandingness and commercial agents cannot assume a right never to acknowledge bystander status. (shrink)

Editors’ Overview: Moral Responsibility in Technology and Engineering Content Type Journal Article Category Original Paper Pages 1-11 DOI 10.1007/s11948-011-9285-z Authors Neelke Doorn, Department of Technology, Policy and Management, Delft University of Technology, P.O. Box 5015, 2600 GA Delft, The Netherlands Ibo van de Poel, Department of Technology, Policy and Management, Delft University of Technology, P.O. Box 5015, 2600 GA Delft, The Netherlands Journal Science and Engineering Ethics Online ISSN 1471-5546 Print ISSN 1353-3452 Journal Volume Volume 18 Journal Issue Volume (...) 18, Number 1. (shrink)

This article deals with the question of how self-organization in living organisms is realized. Self-organization may be observed in open systems that are out of equilibrium. Many disequilibria-conversion phenomena exist where free energy conversion occurs by spontaneously formed engines. However, how is self-organization realized in living entities? Living cells turn out to be self-organizing disequilibria-converting systems of a special kind. Disequilibrium conversion is realized in a typical way, through employing information specifying protein complexes acting as nano engines. The genetic code (...) enables processing of information—derived from coding DNA—to produce these molecular machines. Hence, information is at the core of living systems. Two promising approaches to explaining living cells containing sequences carrying information are mentioned. Also discussed is the question of whether a second concept of self-organization—namely, the Kantian concept—applies. (shrink)