Primary progressive multiple sclerosis (PPMS) shows a highly variable disease progression with poor prognosis and a characteristic accumulation of disabilities in patients. These hallmarks of PPMS make it difficult to diagnose and currently impossible to efficiently treat. This study aimed to identify plasma metabolite profiles that allow diagnosis of PPMS and its differentiation from the relapsing-remitting subtype (RRMS), primary neurodegenerative disease (Parkinson’s disease, PD), and healthy controls (HCs) and that significantly change during the disease course and could serve as surrogate (...) markers of multiple sclerosis (MS)-associated neurodegeneration over time. We applied untargeted high-resolution metabolomics to plasma samples to identify PPMS-specific signatures, validated our findings in independent sex- and age-matched PPMS and HC cohorts and built discriminatory models by partial least square discriminant analysis (PLS-DA). This signature was compared to sex- and age-matched RRMS patients, to patients with PD and HC. Finally, we investigated these metabolites in a longitudinal cohort of PPMS patients over a 24-month period. PLS-DA yielded predictive models for classification along with a set of 20 PPMS-specific informative metabolite markers. These metabolites suggest disease-specific alterations in glycerophospholipid and linoleic acid pathways. Notably, the glycerophospholipid LysoPC(20:0) significantly decreased during the observation period. These findings show potential for diagnosis and disease course monitoring, and might serve as biomarkers to assess treatment efficacy in future clinical trials for neuroprotective MS therapies. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Feminist Studies 46, no. 2. © 2020 by Feminist Studies, Inc. 259 Heather Berg Left of #MeToo In her 1949 call to “End the Neglect of the Problems of the Negro Woman!” Claudia Jones tells the story of Dora Jones, a Black domestic worker enslaved for forty years by her employer.1 Elizabeth Ingalls, a wealthy white woman, had traveled to Dora Jones’s Alabama home as a missionary teacher (...) and persuaded the seventeen-year-old Jones to travel to Boston as her housekeeper in 1907. Ingalls would keep Jones captive until 1947. In the intervening years, Ingalls subjected Jones to routine physical abuse and an endless expanse of intensive, unpaid domestic labor. With no days off and permitted to leave only for errands, Jones was allowed no personal relationships or contact with the outside world. Ingalls’s first husband, the bureaucrat Walter Harman, raped Jones over the course of three years, and Jones became pregnant.2 Ingalls would term this an “affair” and, as court documents showed, pushed Jones to “submit” to an abortion.3 Later, when Jones protested her abusive conditions and attempted to escape, Ingalls blackmailed her, threatening 1. Claudia Jones, “An End to the Neglect of the Problems of the Negro Woman!” Political Affairs (June 1949): 11. 2. I am inferring non-consent based on Jones’s captivity. On unfreedom and the politics of consent, see Saidiya Hartman, “Seduction and the Ruses of Power,” Callaloo 19, no. 2 (1996): 537–60. 3. United States v. Ingalls et al., Cr. No. 10568-SD (District Court, S.D. California, July 29, 1947). 260 Heather Berg to “commit Jones to prison” for interracial “adultery” and the abortion she had as a result. Jones finally won her freedom in 1947, a year after Ingalls’s adult daughter reported her mother to the police.4 Claudia Jones offers Dora Jones’s story as evidence of the exceptional precarity of Black women domestic workers. Like others in her cohort of “black left feminists” (to borrow Erik McDuffie’s term), Jones focused on domestic work as a field that epitomized the “triple oppression” at which she took aim.5 Sexual violence at work is not exceptional in Claudia Jones’s telling. Instead, it operates alongside a catalog of abuses at the intersection of capitalism, state terror, the degradation of women, imperialism, and white supremacy. An active member of the Communist Party, Jones insisted on thinking these systems together, maintaining that only through collective struggle against them could justice be won. Women would not be comrades in that struggle in any simple way. Jones was sharply critical of the idea that Black women’s oppression could be explained by “the rotten bourgeois notion about a ‘battle of the sexes.’”6 Instead, she urged working-class Black people to fight “against their common oppressors, the white ruling class.”7 Solidarity among women was illusory, in part, because of white women’s roles as employers of Black women’s domestic work. Against a narrative of sexual violence that describes simple dominance by men over women, Dora Jones’s story highlights the ways that systems of domination work together to enable abuse. Her suffering was not the same as that visited on bourgeois white women. Instead, it was perpetrated and enabled by one. There is no sisterhood to be found here. A critique of this framework is now common sense in most feminist circles, and yet the loudest feminist intervention in recent years trades in exactly the “bourgeois notion about a ‘battle of the sexes.’” Some seventy years after “An End to the Neglect’s” publication, the #MeToo movement has brought broad international attention to 4. For an overview of the case and its legal legacy, see Risa L. Goluboff, The Lost Promise of Civil Rights (Cambridge, MA: Harvard University Press, 2010), 162–5. 5. Erik S. McDuffie, Sojourning for Freedom: Black Women, American Communism, and the Making of Black Left Feminism (Durham, NC: Duke University Press, 2011), 9. 6. Jones, “An End to the Neglect of the Problems of the Negro Woman!” 13. 7. Ibid. Heather Berg 261 the problem of workplace sexual violence. In 2006, civil rights activist Tarana Burke founded an anti-violence movement based... (shrink)

I. Pragmatismus und Neukantianismus Marc Rölli: Die Durchquerung des Absoluten. Zur Hegel-Rezeption John Deweys Wolfgang Bonsiepen: Hegel und der Neukantianismus Matthias Wunsch: Phänomenologie des Symbolischen? Die Hegelrezeption Ernst Cassirers II. Phänomenologie - Ontologie - Lebensphilosophie Annette Sell: Das Geheimnis des Anfangs. Die Aufnahme des Hegelschen Anfangsbegriffs in der Philosophie Martin Heideggers Hans-Ulrich Lessing: Hegel und Helmuth Plessner: Die verpaßte Rezeption Walter Jaeschke: Der Geist und sein Sein. Nicolai Hartmann auf Hegelschen Wegen Holger Glinka: Aus Phänomenologie mach Dialektik. Jean-Paul Sartres (...) Anverwandlung Hegels III. Marxistische Tradition und kritische Theorie Andreas Arndt: Lenin liest Hegel Daniel Althof: Das "Geklapper der Triplizität" - Adornos Hegelrezeption Christoph J. Bauer: Mit Hegel gegen den 'Positivismus' - mit Hegel zum 'Wesen des Menschen'. Herbert Marcuses Interpretation der Hegelschen Urteilslehre IV. Postmoderne und Gegenwart Karin de Boer: Differenz: zwischen Hegel und Derrida Robert B. Pippin: Brandoms Hegel. (shrink)

Margaret Cavendish is known for her personal allegiance to monarchy in England. This is reflected in her writings; as Hobbes did, she tended to criticize severely any attempt at rebellion and did not think England could become a republic. Yet it seems that Cavendish did have sympathy with some republican values, in particular, as Lisa Walters has argued, with the republican concept of freedom as nondomination. How can we explain this apparent inconsistency? I believe that the answer lies in a (...) lack of fit between the republican theories that were available to her and the values she accepted and according to which she was expected to live her life. (shrink)

Albert Einstein's bold assertion of the form-invariance of the equation of a spherical light wave with respect to inertial frames of reference became, in the space of six years, the preferred foundation of his theory of relativity. Early on, however, Einstein's universal light-sphere invariance was challenged on epistemological grounds by Henri Poincaré, who promoted an alternative demonstration of the foundations of relativity theory based on the notion of a light-ellipsoid. Drawing in part on archival sources, this paper shows how an (...) informal, international group of physicists, mathematicians, and engineers, including Einstein, Paul Langevin, Poincaré, Hermann Minkowski, Ebenezer Cunningham, Harry Bateman, Otto Berg, Max Planck, Max Laue, A. A. Robb, and Ludwig Silberstein, employed figures of light during the formative years of relativity theory in their discovery of the salient features of the relativistic worldview. (shrink)

La identidad de la expresión lingüistica argentina ha sido estudiada a fondo por numerosos críticos literarios y lingüistas que demostraron la estrecha relación que existe entre lengua, ideología y contexto socio-histórico, especialmente al incorporarse al discurso narrativo el concepto de oralidad y “coloquialidad”. En este ensayo nos basaremos en estudios de autores tales como Beatriz Sarlo, Walter Bruno Berg, Wolf Oesterreicher, María Zulema Kulikowski, entre otros, para situar a dos escritores argentinos, Jorge Luis Borges y Manuel Puig, dentro (...) de su época y revelar cómo sus ansiedades personales y sociales impactaron la percepción de su obra como representativa de lo que se considera el lenguaje argentino. (shrink)

The idea that consciousness and complexity are closely related has been a major driver of the popularity of integrated information theory of consciousness, despite its major formal, phenomenological, and neuroscientific shortcomings. Here, I argue that we can recover this intuition by replacing its biologically neutral notion of complexity with an evolutionary one that I shall dub “pathological complexity.”.

In this essay the visual arts of the machine age morph into literature and theory and then back again to images, gestures, and thought.

Recent advances in human genetics suggest that it may become possible to genetically manipulate telomerase and embryonic stem cells to alter the mechanisms of aging and extend the human life span. But a life span significantly longer than the present norm would be undesirable because it would severely weaken the connections between past‐ and future‐oriented mental states and in turn the psychological grounds for personal identity and prudential concern for our future selves. In addition, the collective effects of longer lives (...) might lower the quality of life for all people. These two problems provide reasons against genetic manipulation of cells to alter the length of the human life span. (shrink)

Many believe that it is morally wrong to give lower priority for a liver transplant to alcoholics with end-stage liver disease than to patients whose disease is not alcohol-related. Presumably, alcoholism is a disease that results from factors beyond one's control and therefore one cannot be causally or morally responsible for alcoholism or the liver failure that results from it. Moreover, giving lower priority to alcoholics unfairly singles them out for the moral vice of heavy drinking. I argue that the (...) etiology of alcoholism may involve enough control for the alcoholic to be responsible for his condition and accordingly have a weaker claim to receive a new liver than someone who acquires the disease through no fault of his own. In addition, I show why it is more plausible to reframe the question of priority in terms of control and responsibility rather than virtue and vice. Given that medical resources like livers are scarce, some people may justifiably be given lower priority than others in receiving these resources. (shrink)

There are many connections among artificial intelligence, learning, reasoning and ontologies. The Ontology Summit 2017 explored, identified and articulated the relationships among these areas. As p...

This article explores possibilities for establishing dialogues between feminism and constructivism in the field of technology studies. Based on an overview of Norwegian feminist debates about technology, it indicates several points where feminism and constructivism meet and can mutually benefit from each other. The article critically examines feminist studies questioning the problems of technological determinism, social deternacnism, and essentialism. It criticizes constructivism for a lack of concern for gender and politics but holds that it is still possible to use theoretical (...) tools from constructivism in feminist analyses. Fruitful dialogues require the application of the principle of symmetry to the dcalogues and sharing some common ground and mutual recognation of each other's strengths and weaknesses. (shrink)

The world was changing at a blistering speed in Bagehot's day. New scientific ideas were reshaping the world, and every field of human inquiry was affected by this new interest in giving a full explanation for the history of everything in existence. In this work, first published in 1872, Bagehot applies scientific ideas, like survival of the fittest, to the development of nations and government. He further discusses the effect of scientific and technological advancements, like the invention of stronger and (...) more deadly weapons, on politics. British journalist WALTER BAGEHOT (1826-1877) was an early editor of The Economist and was among the first economists to discuss the concept of the business cycle. He is also the author of The English Constitution (1873) and The Postulates of English Political Economy (1885). (shrink)

The author nationally recognized for the quality and depth of his teaching in religious studies has written the first full-scale introduction to the history and methods of the study of religion.

Meta-learning offers a promising framework to make sense of some parts of decision-making that have eluded satisfactory explanation. Here, we connect this research to work in animal behaviour and cognition in order to shed light on how and whether meta-learning could help us to understand the evolution of cognition.

In The Human Career, Walter Goldschmidt presents a challenge to conventional views of human social behaviour. He argues that change rather than equilibrium is the natural condition of society, that humans must be seen as motivated actors rather than as passive recipients of cultural roles and that emotions, rather than intellect, are the crucial element in the formulation of culture. These three elements, combined with established theory form a dynamic model of human sociality.

This new collection by Walter Laqueur, one of the most distinguished historians and political commentators of the twentieth and twenty-first centuries, vividly brings to life his perspective on fifty years of political life. The essays in this volume deal with events ranging from more than seventy years ago to some that have not yet happened, but may in years to come. Laqueur divides his writings into five main areas: optimism in politics, the topic that unites this volume; Europe; the (...) Arab Spring; Israel and Jewish affairs; and recollections of the past. This volume addresses an increasingly important question: How much optimism do we need in politics? Some neuroscientists believe that many of our assessments rest on an excess of optimism amounting to a dangerous bias. Another school of cognitive scientists sees the main danger in being influenced too much by negative conclusions. Although these competing perspectives have been only rarely investigated, Laqueur argues that such psychological factors play a decisive role in the assessment of political trends, and they should. Laqueur also reminds readers that there is a connection between writing history and commenting on current affairs, but it is not remotely as close and simple as often thought. The idea that the historian is somehow better qualified than others to interpret the present, let alone predict the future, is certainly not borne out by the evidence. Some great historians have been good and reliable political commentators, others have been miserable failures. Laqueur definitely falls in the former camp, as these reflections attest. (shrink)

Valuable insights into eukaryotic regulatory circuits can emerge from studying interactions of bacterial pathogens such as Helicobacter pylori with host tissues. H. pylori uses a type IV secretion system (T4SS) to deliver its CagA virulence protein to epithelial cells, where much of it becomes phosphorylated. CagA's phosphorylated and non‐phosphorylated forms each interact with host regulatory proteins to alter cell structure and cell fate. Kwok and colleagues1 showed that CagA destined for phosphorylation is delivered using host integrin as receptor and H. (...) pylori's CagL protein as an integrin‐specific adhesin, and that CagL–integrin‐binding activates the kinase cascade responsible for CagA phosphorylation. This research contributes to understanding infectious disease and the control of cell fates. BioEssays 30:515–520, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Virtues are standardly understood as (1) essentially dispositions to perform certain actions and (2) having only instrumental value as motives to fulfill moral duties which can be fulfilled by persons lacking the virtue because the duties mandate only certain act-types. The argument of this article is that the duties of beneficence, gratitude and self-respect cannot be stated in terms of obligatory act-types because they cannot be fulfilled (except in deficient form) by persons lacking the appropriate virtue; they are, rather, duties (...) to cultivate specific virtues which therefore cannot themselves be defined in terms of obligatory actions. (shrink)

The American Journal of Bioethics, Volume 11, Issue 8, Page 48-49, August 2011.