The first aim of simulation in virtual environment is to help biologists to have a better understanding of the simulated system. The cost of such simulation is significantly reduced compared to that of in vivo simulation. However, the inherent complexity of biological system makes it hard to simulate these systems on non-parallel architectures: models might be made of sub-models and take several scales into account; the number of simulated entities may be quite large. Today, graphics cards are used for general (...) purpose computing which has been made easier thanks to frameworks like CUDA or OpenCL. Parallelization of models may however not be easy: parallel computer programing skills are often required; several hardware architectures may be used to execute models. In this paper, we present the software architecture we built in order to implement various models able to simulate multi-cellular system. This architecture is modular and it implements data structures adapted for graphics processing units architectures. It allows efficient simulation of biological mechanisms. (shrink)

Much of cognitive science is committed to the modular approach to the study of cognition. The core of this approach consists of a pair of assumptions - the anatomical and the functional modularity assumptions - which motivate two kinds of inference: the anatomical and the functional modularity inferences. The legitimacy of both of these inferences has been strongly challenged, a situation that has had surprisingly little impact on most theorizing in the field. Following the introduction of an important, yet rarely (...) made, distinction between two functional concepts - the distinction between cognitive working and cognitive role - this paper analyses these kinds of inference, and refocuses the attention on new aspects of their main limitations. It is argued that both the anatomical and functional modularity inferences can, and do, operate in three distinct modes in contemporary cognitive science, and that seeing this is essential to understanding both the power and the limitations of these methodological tools. (shrink)

Der Denkstil der Chemiker. Der Aufsatz diskutiert die Tragfähigkeit des Begriffes “Denkstil”, wie er von Alistair Crombie eingeführt und Ian Hacking aufgegriffen wurde, für das Verständnis dessen, wie das Fach Chemie historisch seine Identität ausgeprägt hat. Obwohl weder Crombie noch Hacking den Begriff “Denkstil” in Bezug auf einzelne Disziplinen verwendet haben, erscheint im Fall der Chemie seine Anwendung besonders vielversprechend, weil er hier hilft, ein zentrales Problem zu thematisieren – nämlich die Frage, wie es Chemikern trotz wechselnder Gegenstandsbereiche und theoretischer (...) Umbrüche gelang, eine eigenständige und stabile Identität auszubilden. Nach einer Einführung in den Begriff “Denkstil”, argumentiert der Aufsatz, dass die Beständigkeit der Chemie als eines Faches wesentlich in ihren Laborpraktiken gründet, die ihrerseits wiederum die spezifische Art der Fragen bestimmten, die Chemiker in ihren Forschungen stellten bzw. die Form der Antworten, nach denen sie suchten. Folgende Merkmale kennzeichnen diesen “chemischen Denkstil” (1) eine spezifische, im Herstellen begründete Form des Wissens, (2) die Befassung mit einzelnen Stoffen und Materialien statt mit Materie im Allgemeinen und (3) eine Beobachtung von Natur besonders im Hinblick auf Transformationsprozesse.The Chemists' Style of Thinking. This paper discusses the relevance of the notion of “styles of scientific thinking” introduced by Alistair Crombie and revisited by Ian Hacking, for understanding how chemistry shaped its identity. Although neither Crombie nor Hacking applied this notion to individual disciplines, it seems appropriate to use it in the case of chemistry because it helps to address a puzzling issue: how did chemists manage to shape an identity of their own, despite shifting territories and theoretical transformations? Following a presentation of the notion of style, I will argue that the stable identity of chemistry is rooted in laboratory practices, which determined the specific questions that chemists put to nature as well as the answers to their questions. The “chemical style of thinking” is characterized by i) a specific way of knowing through making, ii) the concern with individual materials rather than matter in general and iii) a specific commitment to nature. (shrink)

At first glance twentieth-century philosophy of science seems virtually to ignore chemistry. However this paper argues that a focus on chemistry helped shape the French philosophical reflections about the aims and foundations of scientific methods. Despite patent philosophical disagreements between Duhem, Meyerson, Metzger and Bachelard it is possible to identify the continuity of a tradition that is rooted in their common interest for chemistry. Two distinctive features of the French tradition originated in the attention to what was going on in (...) chemistry.French philosophers of science, in stark contrast with analytic philosophers, considered history of science as the necessary basis for understanding how the human intellect or the scientific spirit tries to grasp the world. This constant reference to historical data was prompted by a fierce controversy about the chemical revolution, which brought the issue of the nature of scientific changes centre stage.A second striking—albeit largely unnoticed—feature of the French tradition is that matter theories are a favourite subject with which to characterize the ways of science. Duhem, Meyerson, Metzger and Bachelard developed most of their views about the methods and aims of science through a discussion of matter theories. Just as the concern with history was prompted by a controversy between chemists, the focus on matter was triggered by a scientific controversy about atomism in the late nineteenth-century.Keywords: France; Epistemology; Chemistry; Revolution; Atomism; Realism. (shrink)

La chimie est délaissée des philosophes et historiens des sciences. Cette discipline ne serait-elle pas bonne à penser? Qu’est-ce que ce silence, ce mépris ou cette méconnaissance nous enseignent sur le régime du savoir en chimie? Inversement, la chimie méprisée, méconnue ou simplement ignorée ne signalerait-elle pas les travers des philosophes et les limites de leur pouvoir de conceptualiser et de penser? Cet ouvrage donne un aperçu de la complexité de ces questions en adoptant un point de vue symétrique où (...) se croisent les regards des chimistes et des philosophes. En abordant les problématiques posées par les théories de la matière et en étudiant la question du corps du chimiste et de son statut social, ce volume s’interroge aussi sur l’image de la chimie et sur le rejet du « chimique » au profit du « naturel » très en vogue aujourd’hui. (shrink)

The strong opposition of nineteenth-century French chemists to atomism is usually described as a national attitude due to the overarching influence of positivism in France. The explanation sounds plausible, at first glance. However, the idea that a philosophy of science acted as an obstacle to the advancement of science needs further investigation. What is meant exactly by a philosophical influence on a scientific community? In analysing the alleged influence of positivism on the chemists' community it is argued that the common (...) connection established between philosophical views and scientific attitudes leads to a misunderstanding of both philosophy and scientific activity. This paper first stresses the misreading of Auguste Comte's works; then the misunderstanding of scientific debates about atomism in chemistry. Finally it suggests an alternative view: that the atomic debates generated a variety of positivisms. (shrink)

Scientists and engineers who extensively use the term “nanomachine” are not always aware of the philosophical implications of this term. The purpose of this paper is to clarify the concept of nanomachine through a distinction between three major paradigms of machine. After a brief presentation of two well-known paradigms - Cartesian mechanistic machines and Von Neumann's complex and uncontrolled machines – we will argue that Drexler's model was mainly Cartesian. But what about the model of his critics? We propose a (...) third model - Gilbert Simondon's notion of concrete machines – which seems more appropriate to understand nanomachines than the notion of “soft machines”. Finally we review a few strategies currently used to design nanomachines, in an effort to determine which paradigm they belong to. (shrink)

In 1900 David Hilbert announced his famous list of then-opened mathematical problems; the problem number 6 in this list is axiomatization of physical theories. Since then a lot of systematic efforts have been invested into solving this problem. However the results of these efforts turned to be less successful than the early enthusiasts of axiomatic method expected. The existing axiomatizations of physical and biological theories provide a valuable logical analysis of these theories but they do not constitute anything like their (...) standard presentation,which can be used for transmission, evaluation, and justification of physical and biological knowledge. This state of theart in the axiomatization of physics is strong evidence that the standard notion of axiomatic theory stemming from Hilbert and Tarski is not appropriate for thet ask. However in the recent years in mathematics there emerged a new axiomatic approach best represented by the Homotopy Type theory (HoTT). We argue that the constructive axiomatic architecture used in HoTT has better chances to be successfully applied in physics as well as in computer science and engineering. (shrink)

Este artículo es un acercamiento a la temática, construcción y recursos humorísticos de la obra Las miserables (2016) de la compañía Las Reinas Chulas, con el objeto de reconocer al cabaret y el humor como recursos de un artivismo que puede incidir en cambios culturales, políticos o sociales. Esta compañía es un referente obligado para comprender y valorar al teatro-cabaret contemporáneo mexicano que se ha caracterizado, desde sus orígenes en los años 80, por su crítica creativa y compromiso con los (...) feminismos y la comunidad LGTB+. Teniendo como telón de fondo la Revolución Francesa, la obra se refiere a los derechos de las mujeres, la diversidad sexual y la violencia de género. Su oportuno estreno en 2016, coincidió con las discusiones para la redacción de la actual Constitución de la Ciudad de México. (shrink)

General theories are reductionist explications of apparently independent facts. Here, in reviewing the literature, I develop a GT to simplify the cluttered landscape of cancer therapy targets by revealing they cluster parsimoniously according to only a few underlying principles. The first principle is that targets can be only exploited by either or both of two fundamentally different approaches: causality-inhibition, and ‘acausal’ recognition of some marker or signature. Nonetheless, each approach must achieve both of two separate goals, efficacy and selectivity ; (...) if the mechanisms are known, this provides a definition of rational treatment. The second principle is target fragmentation, whereby the target may perform up to three categoric functions, potentially mediated by physically different target molecules, even on different cell types, or circulating freely. This GT remains incomplete until the minimal requirements for cure, or alternatively, proof that cure is impossible, become predictable. A reductionist General Theory of Cancer Targets is presented, proposing that all good targets are based either on causality-inhibition, or recognition; essential tasks emerge differently in each case. Sophisticated hybrids may provide additional benefit. General theory analysis, including target fragmentation concepts, provides deeper insights into therapeutic mechanisms. (shrink)

The present work explores interspecies intersubjectivity, including its content and limitations, through the paradigmatic instances of such relationships that are present among companion species. I aim to defend the claim that meaningful relationships are possible and do in fact occur between humans and nonhuman animals by appealing to both philosophical and empirical literature. I will also begin to delineate the content and limitations of these interspecies relationships.

Espace d'expression et de discussion, les forums médiatiques font se rencontrer des individus aux opinions et appartenances variées. Il s'agit d'observer le rôle du dispositif communicationnel et la manière dont ses membres en usent: privilégient-ils la dimension conversationnelle ou publicitaire? quelle est la nature de cet espace public et des échanges qui s'y déroulent? L'analyse statistique et de contenu des courriels révèle un espace interactionnel de groupe où la publicité l'emporte sur la sociabilité, ainsi qu'une parole publique dégradée marquée par (...) l'incommunication et une dérive ethniciste.Space for expression and discussion forums are media meet individuals with varied opinions and affiliations. It is to observe the role of communicative device and how its members wear: they prefer the conversational dimension or advertising? What is the nature of public space and exchanges that take place? Statistical analysis and content of emails reveals a group interactional space where advertising outweighs sociability, and a degraded public speech marked by miscommunication and a drift ethnocentric. (shrink)

What did God mean to F.H. Bradley? Bradley’s style and subtle philosophical approach makes it difficult to ascertain precisely what his settled thoughts were on this issue. He does say, for example, quite a lot as to what God is not. This essay will initially follow out this negative reading. This latter enterprise entails comparisons, first, with philosophy, or more appropriately the ‘metaphysical impulse’, second, with morality, and third, with history. Having followed out the more negative arguments, the essay turns (...) to what religion is for Bradley. This is intrinsically more difficult. The discussion elicits here some help from the other idealist thinkers who were close readers of Bradley. Almost surprisingly, Bradley does comment substantively, if briefly, on issues of faith, miracle, atonement, prayer, church going, and clerics. The most significant theological point to arise in both Bradley is the significance of St. Paul’s writings. The Pauline ‘justification by faith’ becomes a repeated motif. However, there still remains an ambiguous relation of God and religion to ‘social life’ or ‘sociality’, which is explored more carefully at the conclusion of the essay. The essay finally argues that Bradley’s highly nuanced response to religion and God embodies paradoxical and unresolved elements which encapsulate, unwittingly, a dilemma at the heart of the Idealist conception of religion. (shrink)

Chemistry deserves more philosophical attention not so much to do justice to a long-neglected science or to enhance its cultural prestige, but to undermine a number of taken-for-granted assumptions about scientific rationality and more importantly to diversify our metaphysical views of nature and reality. In brief, this paper does not make the case for a philosophy of chemistry. It rather urges philosophers of science to listen to chemists and discuss what they learn from them. Because over the course of many (...) centuries chemists have developed a special access to nature and a special way of investigating and dealing with material substances, they have confronted a number of epistemological and ontological issues that are worth discussing. Following critical remarks about the disciplinary partition of philosophy, a historical section presents the contributions to philosophy of a few French twentieth-century chemists-turned philosophers to emphasize how they have challenged the dominant philosophical categories. The final section develops one of the lessons that philosophers can learn from chemists: to pay attention to things, to their materiality and activity in order to develop new ontological perspectives. (shrink)

Esta reseña invita a la lectura del ensayo de Dorte Katrin Jansen, dramaturga e investigadora teatral, quien presenta una cartografía de las dramaturgas mexicanas de mediados del siglo pasado hasta su fecha de publicación en 2018. Toma como punto de partida el trabajo de Elena Garro, Luisa Josefina Hernández y Sabina Berman para continuar con los procesos de más de ciento cincuenta dramaturgas. El esfuerzo de la autora por distinguir a las creadoras de acuerdo con su lugar de enunciación, así (...) como, la diferenciación entre escritura de las mujeres, femenina y feminista son tan solo algunos de los aportes que subrayo como relevantes en esta reseña. Con este trabajo la autora obtuvo el Premio Internacional de Ensayo Teatral. (shrink)

The paper is premised on the well-recorded fact that R.B. Haldane, throughout his working life, remained fascinated with German idealist philosophy. The paper unravels Haldane’s own perception of the relation between his philosophical interests and his diverse policy-orientated work at the beginning of the twentieth century. Many commentators have noted this relation but often pass over it as a curious detail of his biography. The most basic tool his philosophy gave him was a way of analysing problems. This philosophical stance (...) was not an ex post facto rationalisation but conversely was always his first thought on encountering a problem. To solve a policy problem one has to identify the leading ideas of that particular mode of human experience. Haldane believed that finding such rational principles underlying all forms of experience was the first duty of a politician, lawyer or civil servant. He contended that this painstaking ideational analysis would ultimately lead to the most effective policy solutions. The paper focuses first on Haldane’s initial encounter with German philosophical culture in both Edinburgh and Göttingen, second, it unpacks the key philosophical themes which characterize his approach, derived largely from his reading of Hegel’s Science of Logic. Thirdly, it turns - in the light of his philosophical beliefs - to his overt commitments to policy developments in the Edwardian new liberalism, military reform, administrative and civil service policy reorganisation, and finally his extensive work in education policy, particularly in the university sector. (shrink)

That literary scholarship is experiencing an "ethical turn" has become something of a commonplace, and seminal to this "turn" is the use of literary works as examples in moral-philosophical arguments. So far, however, ethical criticism has dealt almost exclusively with narrative texts—little work has been done on poetry. I argue that considering poetry in this context not only expands the corpus of exemplary works but also reveals methodological caveats applicable to ethical critics of poetry and fiction alike. Poetic examples raise (...) new doubts about the moral authority of literature—doubts elided in the narrative-based discussions that currently prevail. (shrink)

Thomas Szasz has wrestled with the following question: Does mental illness even exist? Here, I sketch two provocative papers by Szasz and detail his reasons for criticizing the concept ‘mental illness.’ I will proceed to highlight where I think Szasz’s writing is philosophically dubious, despite its role in forcing us to think critically about ‘mental illness.’ I will conclude that his argument is best left behind as an antiquated take on neurodivergence. Finally, I will propose what I think is a (...) more promising alternative to Szasz’s view that there is a myth around mental illness. There is a myth indeed, and it involves what is often meant by ‘mental.’ With new developments in embodied cognition, I will ask us to revisit the concept of ‘mental illness,’ to correctly diagnose the problematic myth that must be confronted by the psychiatric community, and to explore what the myth of the mental means for neurodivergence. (shrink)

Scientists and engineers who extensively use the term “nanomachine” are not always aware of the philosophical implications of this term. The purpose of this paper is to clarify the concept of nanomachine through a distinction between three major paradigms of machine. After a brief presentation of two well-known paradigms - Cartesian mechanistic machines and Von Neumann’s complex and uncontrolled machines – we will argue that Drexler’s model was mainly Cartesian. But what about the model of his critics? We propose a (...) third model - Gilbert Simondon’s notion of concrete machines – which seems more appropriate to understand nanomachines than the notion of “soft machines”. Finally we review a few strategies currently used to design nanomachines, in an effort to determine which paradigm they belong to. (shrink)

ABSTRACTEven though Émile Meyerson is rightly seen as an opponent of Comte's positivism, analyzing passages of his works with the help of his correspondence shows the ambiguity of his relation to Comte's philosophy. Drawing on Meyerson's remarks about his relation to Comte's philosophy, this article offers a new perspective on the notion of influence, which is too often perceived as passive or unassimilated reception of a stream of ideas. I argue that Meyerson treated Comte's ideas as a sort of raw (...) matter he transformed into a finished product. (shrink)