In this chapter we explore the process of extrapolating causal claims from model organisms to humans in pharmacology. We describe and compare four strategies of extrapolation: enumerative induction, comparative process tracing, phylogenetic reasoning, and robustness reasoning. We argue that evidence of mechanisms plays a crucial role in several strategies for extrapolation and in the underlying logic of extrapolation: the more directly a strategy establishes mechanistic similarities between a model and humans, the more reliable the extrapolation. We present case studies from (...) the research on atherosclerosis and the development of statins, that illustrate these strategies and the role of mechanistic evidence in extrapolation. (shrink)

This paper analyses the similarities and connections between philosophy of science and causal layered analysis. The paper points out that philosophy of science can be understood as a kind of causal layered analysis of science. These similarities and connections mean that the insights in philosophy of science can be used to investigate the important but neglected topic of possible futures of science. The connections make it possible (i) to open up the present and past to create alternative futures of science, (...) and (ii) to reveal deep worldview commitments behind surface phenomena in science-related discourses. (shrink)

The use of evidence in medicine is something we should continuously seek to improve. This book seeks to develop our understanding of evidence of mechanism in evaluating evidence in medicine, public health, and social care; and also offers tools to help implement improved assessment of evidence of mechanism in practice. In this way, the book offers a bridge between more theoretical and conceptual insights and worries about evidence of mechanism and practical means to fit the results into evidence assessment procedures.

The topic of epistemic decolonisation is currently the locus of lively debate both in academia and in everyday life. The aim of this piece is to isolate a few main strands in the philosophical literature on the topic, and draw some new connections amongst them through the lens of epistemic injustice. I first sketch what I take to be the core features of epistemic decolonisation. I then philosophically situate the topic. Finally, I map it in relation to key epistemic-injustice concepts (...) and to the contributions in this special issue. (shrink)

Believable Evidence argues that evidence consists of true beliefs. This claim opens up an entirely overlooked space on the ontology of evidence map, between purely factualist positions and purely psychologist ones. Veli Mitova provides a compelling three-level defence of this view in the first contemporary monograph entirely devoted to the ontology of evidence. First, once we see the evidence as a good reason, metaethical considerations show that the evidence must be psychological and veridical. Second, true belief in particular allows (...) epistemologists to have everything they want from the concept of evidence. Finally, the view helps us locate the source of the normative authority of evidence. The book challenges a broad range of current views on the ontology of reasons and their normative authority, making it a must-read for scholars and advanced students in metaethics and epistemology. (shrink)

What sorts of things can be evidence for belief? Five answers have been defended in the recent literature on the ontology of evidence: propositions, facts, psychological states, factive psychological states, all of the above. Each of the first three views privileges a single role that the evidence plays in our doxastic lives, at the cost of occluding other important roles. The fifth view, pluralism, is a natural response to such dubious favouritism. If we want to be monists about evidence and (...) accommodate all roles for the concept, we need to think of evidence as propositional, psychological and factive. Our only present option along these lines is the fourth view, which holds that evidence consists of all and only known propositions. But the view comes with some fairly radical commitments. This paper proposes a more modest view—‘truthy psychologism’. According to this view, evidence is also propositional, psychological and factive; but we don’t need the stronger claim that only knowledge can fill this role; true beliefs are enough. I first argue for truthy psychologism by appeal to some standard metaethical considerations. I then show that the view can accommodate all of the roles epistemologists have envisaged for the concept of evidence. Truthy psychologism thus gives us everything we want from the evidence, without forcing us to go either pluralist or radical. (shrink)

The call to decolonise knowledge is gaining increasing popularity in African philosophy. But as scholarly attention to the topic intensifies, so do doubts about the usefulness of theorising it, especially in spaces – like Africa – that are riddled with deeper problems such as mass poverty and social disempowerment. I focus on three challenges that Bernard Matolino has recently issued. If these challenges are on the right track, they threaten to derail the whole project of epistemic decolonisation worldwide, since many (...) of the aspects of Africa that Matolino thinks make decolonial theorising unhelpful are shared by the rest of the Global South. In this paper, I develop a conception of epistemic decolonisation that is geared to withstanding such doubts in the contemporary African context, and can hopefully serve others in the Global South who share some of Africa’s problems. (shrink)

In this paper, I argue that certain social-identity groups—ones that involve systematic relations of power and oppression—have distinctive epistemic reasons in virtue of constituting this group. This claim, I argue further, would potentially benefit at least three bodies of scholarship—on the epistemology of groups, on collective moral responsibility, and on epistemic injustice.

Inconsistencies between scientific theories have been studied, by and large, from the perspective of paraconsistent logic. This approach considered the formal properties of theories and the structure of inferences one can legitimately draw from theories. However, inconsistencies can be also analysed from the perspective of modelling practices, in particular how modelling practices may lead scientists to form opinions and attitudes that are different, but not necessarily inconsistent. In such cases, it is preferable to talk about disagreement, rather than inconsistency. Disagreement (...) may originate in, or concern, a number of epistemic, socio-political or psychological factors. In this paper, we offer an account of the ‘loci and reasons’ for disagreement at different stages of the scientific process. We then present a controversial episode in the health sciences: the studies on hypercholesterolemia. The causes and effects of high levels of cholesterol in blood have been long and hotly debated, to the point of deserving the name of ‘cholesterol wars’; the debate, to be sure, isn’t settled yet. In this contribution, we focus on some selected loci and reasons for disagreement that occurred between 1920 and 1994 in the studies on hypercholesterolemia. We hope that our analysis of ‘loci and reasons’ for disagreement may shed light on the cholesterol wars, and possibly on other episodes of scientific disagreement. (shrink)

When you believe something for a good reason, your belief is in a position to be justified, rational, responsible, or to count as knowledge. But what is the nature of this thing that can make such a difference? Traditionally, epistemologists thought of epistemic normative notions, such as reasons, in terms of the believer's psychological perspective. Recently, however, many have started thinking of them as factive: good reasons for belief are either facts, veridical experiences, or known propositions. This ground breaking volume (...) reflects major recent developments in thinking about this 'Factive Turn', and advances the lively debate around it in relation to core epistemological themes including perception, evidence, justification, knowledge, scepticism, rationality, and action. With clear and comprehensive chapters written by leading figures in the field, this book will be essential for students and scholars looking to engage with the state of the art in epistemology. (shrink)

Many influential philosophers have claimed that truth is valuable, indeed so valuable as to be the ultimate standard of correctness for intellectual activity. Yet most philosophers also think that truth is only instrumentally valuable. These commitments make for a strange pair. One would have thought that an ultimate standard would enjoy more than just instrumental value. This paper develops a new argument for the non-instrumental value of truth: (1) inquiry is non-instrumentally valuable; and (2) truth inherits some of its value (...) from the value of inquiry. This makes truth finally but extrinsically valuable, a thesis that to my knowledge has not been directly defended in the literature. I support (1) by appeal to the notion of epistemic injustice, and (2) through the surprising claim that some goals get their value from the pursuit that aims at them. (shrink)

The paper argues that some tools from the epistemic injustice literature can be fruitfully applied to the debate on epistemic decolonisation. The first step for such a project is to defuse recent misgivings about the liberatory potential of epistemic injustice scholarship. I group these misgivings under the slogan ‘Epistemic injustice is white-people stuff’, or ‘the WPS challenge’, for short, and use them to set desiderata for good theorising with epistemic injustice tools. I then look at three such tools – epistemic (...) oppression, white ignorance, and contributory injustice – and argue that they advance theorising epistemic decolonisation while meeting the three desiderata. If the argument works, its implications for the topic of this special issue are that we don’t need to decolonise epistemic injustice; we can instead use the tools of the epistemic injustice literature to advance the decolonisation project. (shrink)

When we examine the history of astronomy up to the end of the seventeenth century by considering the relation between mathematical astronomy and natural philosophy, it has been argued that there were two groups of philosophers and astronomers: instrumentalists and realists. However, this classification is deficient when we consider attitudes toward the explanatory power of mathematics in determining astronomical theories. I offer the solution of dividing realists into two subcategories—mathematical realists and physical realists. Mathematical realists include those who thought mathematics (...) could provide the real motions of celestial bodies. The physical realists, who include Ibn Rushd (Averroës), believed mathematics could not provide us with the real structure of the heavens. To avoid contradictions between the physical and mathematical models, the physical realists held that a mathematical model of the heavens should be designed by considering physics. I argue, in this article, that Francis Bacon can be considered a physical realist. (shrink)

What is going on when we explain someone’s belief by appeal to stereotypes associated with her gender, sexuality, race, or class? In this paper I try to motivate two claims. First, such explanations involve an overlooked form of epistemic injustice, which I call ‘explanatory injustice’. Second, the language of reasons helps us shed light on the ways in which such injustice wrongs the victim qua epistemic agent. In particular, explanatory injustice is best understood as occurring in explanations of belief through (...) a so-called reason-why when the correct explanation in fact features a motivating reason. I reach this conclusion by arguing that such explanations are a kind of normative inversion of confabulation. Thinking in these terms helps us see both how certain reason-ascriptions empower while others disempower, and (consequently) how through them believers are robbed of agency over their beliefs. (shrink)

This article compares the epistemic roles of theoretical models and model organisms in science, and specifically the role of non-human animal models in biomedicine. Much of the previous literature on this topic shares an assumption that animal models and theoretical models have a broadly similar epistemic role—that of indirect representation of a target through the study of a surrogate system. Recently, Levy and Currie have argued that model organism research and theoretical modelling differ in the justification of model-to-target inferences, such (...) that a unified account based on the widely accepted idea of modelling as indirect representation does not similarly apply to both. I defend a similar conclusion, but argue that the distinction between animal models and theoretical models does not always track a difference in the justification of model-to-target inferences. Case studies of the use of animal models in biomedicine are presented to illustrate this. However, Levy and Currie’s point can be argued for in a different way. I argue for the following distinction. Model organisms function as surrogate sources of evidence, from which results are transferred to their targets by empirical extrapolation. By contrast, theoretical modelling does not involve such an inductive step. Rather, theoretical models are used for drawing conclusions from what is already known or assumed about the target system. Codifying assumptions about the causal structure of the target in external representational media allows one to apply explicit inferential rules to reach conclusions that could not be reached with unaided cognition alone. (shrink)

According to moral encroachers, the moral stakes of a belief partly determine how much evidence we need for the belief to count as knowledge. This view concerns the beliefs of individual believers. In this paper, I argue for a social group version of moral encroachment: dominant groups, such as white people or men, need to have more evidence than the marginalised in order for some of their beliefs to constitute knowledge. I argue for this claim in three steps. First, I (...) spell out the group moral stakes involved – the harms dominant knowers cause the marginalised and the knowledge economy. Second, I show off the theoretical benefits of having the notion of social group moral encroachment at our disposal: it can be an invaluable tool for decolonial and feminist epistemologists if they want to avoid the relativistic ring to their views (a ring that tends to put off many well-wishers). Finally, I start on a positive account of social group moral encroachment by addressing a potential puzzle and responding to objections. (shrink)

In this paper, the epistemological and conceptual limits of our ability to conceive and reason about future possibilities are analyzed. It is argued that more attention should be paid in futures studies on these epistemological and conceptual limits. Drawing on three cases from philosophy of science, the paper argues that there are deep epistemological and conceptual limits in our ability to conceive and reason about alternatives to the current world. The nature and existence of these limits are far from obvious (...) and become visible only through careful investigation. The cases establish that we often are unable to conceive relevant alternatives; that historical and counterfactual considerations are more limited than has been suggested; and that the present state of affairs reinforces its hegemony through multiple conceptual and epistemological mechanisms. The paper discusses the reasons behind the limits of the conceivability and the consequences that follow from the considerations that make the limits visible. The paper suggests that the epistemological and conceptual limits in our ability to conceive and reason about possible futures should be mapped systematically. The mapping would provide a better understanding of the creative and critical bite of futures studies. (shrink)

In this paper, I offer an explication of the notion of local explanation. In the literature, local explanations are considered as metaphysically and methodologically satisfactory: local explanations reveal the contingency of science and provide a methodologically sound historiography of science. However, the lack of explication of the notion of local explanation makes these claims difficult to assess. The explication provided in this paper connects the degree of locality of an explanans to the degree of contingency of the explanandum. Moreover, the (...) explication is shown to be compatible with the methodological need for a general consideration in the historiography of science. In this way, the explication satisfies the need to explicate an important notion, connects local explanations and contingency, and enables us to see how local explanations and general considerations can be connected. However, the explication also sheds critical light on many claims and expectations that are associated with local explanations and their satisfactoriness. (shrink)

There are many narrations about the Stories of the Prophets in basic hadith, tafsir and historical sources. In addition to the Qur'an, some information about the stories of the prophets is contained in the Torah and the Bible. The stories of the Prophet were known to Jews and Christians before the advent of Islam. Even the Arabs of the jahiliyyah period had some knowledge about the parables. When the revelation about the stories of the Prophet was revealed, the polytheists were (...) extremely disturbed by it and "esâtîru'l-evvelîn" was used to describe these stories as the tales of the past tribes. Apart from the verses in the Qur'an about the stories of the Prophet, both the hadiths in the hadith sources and the narrations in the historical sources, some of this information was authentic information, while some of it consisted of fabricated information. Among these narrations, there are weak narrations such as Isrâiliyyât, as well as sound ones. It is important how the authors who wrote the works of Kasasu'l-Enbiyâ were affected by the hadiths in the main sources and whether they included these narrations in their works. Therefore, in this study, some hadiths related to the Stories of the Prophets in the Kitâbu'l-Anbiyâ section of Sahîhu'l-Bukhârî, which is one of the most important hadith works and accepted as the most reliable book after the Qur'an, were tried to be examined. In particular, some narrations that the authors of Kasasu'l-Enbiyâ's works were not included in their works, although they were mentioned in Sahîhu'l-Bukhârî, were discussed. In fact, there are many hadiths related to the subject in Sahihu'l-Bukhari. However, in this study, six narrations that were not mentioned by the authors of history, tafsir and Kasasu'l-Anbiya were mentioned. While referring to the aforementioned narrations, no analysis of the hadiths was made in order not to go beyond the scope of the subject and not to exceed the limits of the study. The reasons why these narrations are not references in the Kasasu'l-Anbiya literature are emphasized. Thus, these narrations, which are not mentioned in Kasasu'l-Enbiya's works but are mentioned in the Kitabu'l-Anbiyâ section of Sahîhu'l-Bukhârî, are examined and their source status for the stories of the Prophet is examined. (shrink)

Interventionism is a theory of causation with a pragmatic goal: to define causal concepts that are useful for reasoning about how things could, in principle, be purposely manipulated. In its original presentation, Woodward’s interventionist definition of causation is relativized to an analyzed variable set. In Woodward, Woodward changes the definition of the most general interventionist notion of cause, contributing cause, so that it is no longer relativized to a variable set. This derelativization of interventionism has not gathered much attention, presumably (...) because it is seen as an unproblematic way to save the intuition that causal relations are objective features of the world. This paper first argues that this move has problematic consequences. Derelativization entails two concepts of unmediated causal relation that are not coextensional, but which nonetheless do not entail different conclusions about manipulability relations within any given variable set. This is in conflict with the pragmatic orientation at the core of interventionism. The paper then considers various approaches for resolving this tension but finds them all wanting. It is concluded that interventionist causation should not be derelativized in the first place. Various considerations are offered rendering that conclusion acceptable. (shrink)

In this article, the authors present several topics related to the nascent development of a merit-based hiring system in North Macedonia. This paper employs a normative approach. We advocate for a merit-based hiring system, similar to the American model. First, we explore the pressure exerted by the European Commission to adopt a merit-based system at all levels of government as a condition for entry into the European Union. Second, we delve into the patronage system in North Macedonia. Third, we provide (...) a short history of patronage in the United States and the difficulty that nation had in curbing its entrenched patronage system. Fourth, we discuss the advantages of a merit-based hiring system, namely the creation of good governance, the improvement of employee morale, the development of more public confidence in government, the reduction of the influence of ethnic politics and the furtherance of the rule of law. Finally, we present an example drawn from the American federal government about the basic procedures of a merit-based hiring process. (shrink)

Abstract I defend the following three-part hypothesis: (1) the sense that one is running out of time diminishes one's capacity to reauthor oneself; (2) this capacity is constitutive of agency par excellence; so, (3) the sense of running out of time attenuates agency. (2) is shown to enjoy both intuitive and abductive plausibility. (1) and (3) are confirmed by existing reflections on old age, as well as by empirical research.

Artikkeli on väitöstilaisuudessa esitetty lectio praecursoria. Väitöskirjani käsittelee kysymystä, miten tiedettä voidaan ymmärtää tarkastelemalla sen historiaa. Lectiossa tuon esiin neljä väitöskirjani keskeistä teemaa. Ensinnäkin tieteen historia on osoittautunut monimutkaiseksi prosessiksi. Tämän vuoksi tieteenhistorian on tutkittava monenlaisten syiden yhteisvaikutusta tieteen kehitykseen. Mikään yksittäinen syiden luokka ei auta selittämään kokonaisuutta. Toiseksi esitän, ettei tieteen historiaa voida lähestyä määritelmien tai kategorioiden avulla. Puolustan nykyhetkikeskeistä lähestymistä tieteenhistoriaan, jonka mukaan tieteen historia on se prosessi, joka johti nykyiseen tieteeseen. Se, mikä on osa tieteen historiaa, ei (...) riipu siitä, mitä pidämme tieteenä vaan siitä, millainen historian kausaalikudelma on. Kolmanneksi tuon esiin, että kontrafaktuaalisten skenaarioiden tarkastelu on välttämätöntä historian ymmärtämiselle. Väitän, että vain hallittu jossittelu voi tarjota meille ymmärrystä siitä, miksi historia kehittyi tietyllä tavalla. Neljänneksi argumentoin, ettei tieteen historiaa voida selittää käyttämättä nykyistä tieteellistä, vaikka tällaista jakoa onkin joskus esitetty historiografiseksi hyveeksi. Kaiken kaikkeaan esitän, että tieteen historiaa tarkastelemalla voimme nähdä oman paikkamme osana todellisuuden valtavaa kausaalikudelmaa. (shrink)

Epistemic risk is of central importance to epistemology nowadays: one common way in which a belief can fail to be knowledge is by being formed in an epistemically risky way, that is, a way that makes it true by luck. Recently, epistemologists have been expanding this rather narrow conception of risk in every direction, except arguably the most obvious one—to enable it to accommodate the increasingly commonplace thought that knowledge has an irreducibly social dimension. This paper fills this lacuna by (...) bringing issues of epistemic injustice to bear on epistemic risk. In particular, it draws on the phenomenon of white ignorance, to sketch a more social notion of epistemic risk, on which the interests of one's epistemic community partly determine whether a belief‐forming procedure is epistemically risky. (shrink)

In this paper, I investigate the issue of the contingency and inevitability of science. First, I point out valuable insights from the existing discussion about the issue. I then formulate a general framework, built on the notion of contrastive explanation and counterfactuals, that can be used to approach questions of contingency of science. I argue, with an example from the existing historiography of science, that this framework could be useful to historians of science. Finally, I argue that this framework shows (...) the existing views on historical contingency and counterfactuals in a new light. The framework also shows the value of existing historiography in philosophical debates. (shrink)

Understanding nature of science is widely considered an important educational objective and views of NOS are closely linked to science teaching and learning. Thus there is a lively discussion about what understanding NOS means and how it is reached. As a result of analyses in educational, philosophical, sociological and historical research, a worldwide consensus about the content of NOS teaching is said to be reached. This consensus content is listed as a general statement of science, which students are supposed to (...) understand during their education. Unfortunately, decades of research has demonstrated that teachers and students alike do not possess an appropriate understanding of NOS, at least as far as it is defined at the general level. One reason for such failure might be that formal statements about the NOS and scientific knowledge can really be understood after having been contextualized in the actual cases. Typically NOS is studied as contextualized in the reconstructed historical case stories. When the objective is to educate scientifically and technologically literate citizens, as well as scientists of the near future, studying NOS in the contexts of contemporary science is encouraged. Such contextualizations call for revision of the characterization of NOS and the goals of teaching about NOS. As a consequence, this article gives two examples for studying NOS in the contexts of scientific practices with practicing scientists: an interview study with nanomodellers considering NOS in the context of their actual practices and a course on nature of scientific modelling for science teachers employing the same interview method as a studying method. Such scrutinization opens rarely discussed areas and viewpoints to NOS as well as aspects that practising scientists consider as important. (shrink)

In this paper, I defend causal presentism in the historiography of science. In causal presentism, historiography of science studies events, processes and practices that were causally relevant to the development of present science. I argue that causal presentism has three main virtues: First, causal presentism avoids the conceptual problems the historiography of science has recognized in its core. Secondly, causal presentism provides a clear account of what counts as historical explanatory understanding about science. Thirdly, causal presentism enables novel ways to (...) address several conceptual and methodological problems in the historiography of science. The conclusion is that causal presentism is distinctively strong position with respect to the historiography of science. (shrink)

In this paper, I analyze how frameworks shape historiographical explanations. I argue that, in order to identify a sequence of events as relevant to a historical outcome, assumptions about the workings of the relevant domain have to be made. By extending Lakatosian considerations, I argue that these assumptions are provided by a framework that contains a set of factors and intertwined principles that (supposedly) govern how a historical phenomenon works. I connect frameworks with a counterfactual account of historical explanation. Frameworks (...) enable us to explain the past by providing a backbone of explanatory patterns of counterfactual dependency. I conclude by noting that both counterfactual scenarios and scenarios of the future require frameworks and, therefore, historiographical explanation generates a set of possible futures. Analyzing these possible futures enables us to reveal the theoretical commitments of historiography. (shrink)

In this paper, I explicate desiderata for accounts of explanation in historiography. I argue that a fully developed account of explanation in historiography must explicate many explanation-related notions in order to be satisfactory. In particular, it is not enough that an account defines the basic structure of explanation. In addition, the account of explanation must be able to explicate notions such as minimal explanation, complete explanation, historiographical explanation, explanatory depth, explanatory competition, and explanatory goal. Moreover, the account should also tell (...) how explananda can be chosen in a motivated way. Furthermore, the account should be able to clarify notions that are closely connected with explanation such as historical contingency. Finally, it is important that the account is able to recognize when explanation-related notions and issues are so closely intertwined that we are in danger of not seeing the differences between them. In other words, I argue that a satisfactory account of explanation in historiography must have the power to explicate central explanation-related notions and to clarify discussions where the differences between the notions are obscure. In order to explicate these desiderata, I formulate a counterfactual account of explanation and show how that account is able to explicate explanation-related notions and clarify issues that are connected with historiographical explanations. The success of the counterfactual account suggests that historiographical explanations do not differ fundamentally from explanations in many other fields. (shrink)

By looking at videogame production through a two-vector model of design – a practice determined by the interplay between economic and technological evolution – we argue that shared screen play, as both collaboration and competition, originally functioned as a desirable pattern in videogame design, but has since become problematic due to industry transformations. This is introduced as an example of what we call design vestigiality: momentary loss of a design pattern’s contextual function due to techno-economical evolution.

In this article, I analyze historical counterfactuals. Historical counterfactuals are conditional statements in which the antecedent refers to some change in the past. We ask what would have happened, had that change occurred. I discuss the nature of such counterfactuals. I then identify important functions that historical counterfactuals have. I point out that they are at the heart of explanations and, therefore, reveal issues related to contingency and actual history. I then discuss counterfactual reasoning in historiography. I argue that the (...) problem of suitable antecedent conditions has been exaggerated, and more serious issues concern the tracking of counterfactual scenarios. Throughout the paper, I argue that the interventionist way of thinking about historical counterfactuals clarifies both historical explanations and the nature of historical counterfactuals and should be adopted as the standard. I conclude by noting that historical counterfactuals may not fundamentally differ from more familiar forms of historiography. (shrink)

The precise and proper territorial boundaries of skepticism, relativism, and pluralism have been perennial topics of debate in philosophy. Very few philosophers endorse these positions in an unqual...