Combined non-invasive brain stimulation (NIBS) and rehabilitation interventions have the potential to improve function in children with unilateral cerebral palsy (UCP), however their effects on developing brain function are not well understood. In a proof-of-principle study, we used single-pulse transcranial magnetic stimulation (TMS) to measure changes in corticospinal excitability and relationships to motor performance following a randomized controlled trial consisting of 10 days of combined constraint-induced movement therapy (CIMT) and cathodal transcranial direct current stimulation (tDCS) applied to the contralesional motor (...) cortex. Twenty children and young adults (mean age = 12 years, 9 months, range = 7 years, 7 months, 21 years, 7 months) with UCP participated. TMS testing was performed before, after, and 6 months after the intervention to measure motor evoked potential (MEP) amplitude and cortical silent period (CSP) duration. The association between neurophysiologic and motor outcomes and differences in excitability between hemispheres were examined. Contralesional MEP amplitude decreased as hypothesized in five of five participants receiving active tDCS immediately after and 6 months after the intervention, however no statistically significant differences between intervention groups were noted for MEP amplitude [mean difference = −323.9 μV, 95% CI = (−989, 341), p = 0.34] or CSP duration [mean difference = 3.9 ms, 95% CI = (−7.7, 15.5), p = 0.51]. Changes in corticospinal excitability were not statistically associated with improvements in hand function after the intervention. Across all participants, MEP amplitudes measured in the more-affected hand from both contralesional (mean difference = −474.5 μV) and ipsilesional hemispheres (−624.5 μV) were smaller compared to the less-affected hand. Assessing neurophysiologic changes after tDCS in children with UCP provides an understanding of long-term effects on brain excitability to help determine its potential as a therapeutic intervention. Additional investigation into the neurophysiologic effects of tDCS in larger samples of children with UCP are needed to confirm these findings. (shrink)

The decision of the House of Lords in Gillick v West Norfolk Area Health Authority carved out a safe space for competent minors to confidentially access sexual and reproductive health care and advice in the UK. Ireland is one of the few common law jurisdictions that has not endorsed Gillick or a similar mature minor doctrine, nor has it securely legislated for the right to consent of those aged 16 and 17 years. The legal lacuna created by this (...) deficiency has left young persons in Ireland seeking sexual and reproductive healthcare, and the clinicians who provide this, in a challenging place. While this void has been partially filled with policy statements by bodies such as the Irish College of General Practitioners and the Health Service Executive, nonetheless the legal shortcomings leave both a sense of insecurity, and real world difficulties for adolescents seeking to access to sexual and reproductive healthcare. (shrink)

In this letter we demonstrate that the fermionic zero modes on a superconducting domain wall can be associated to an one dimensional \ supersymmetry that contains non-trivial topological charges. In addition, the system also possesses three distinct \ supersymmetries with non-trivial topological charges and we also study some duality transformations of the supersymmetric algebras.

In our recent past, at first glance, an ideologically monolithic society was a kind of "collective soul" that envisioned the internal subordination of the individual to the social, collective, existing system of ideologies, stereotypes that were perfected and skillfully introduced into public consciousness - and suddenly this ideological one-dimensionality society collapses and the person is alone with one another.

This problem is not a new one, but it is hardly likely that anyone will contend that it is not timely. It is all the more important because entirely too little attention has hitherto been given, in our schools and higher educational institutions, to visual and aesthetic education. Yet for the man of today visual culture is not the least bit less important than the culture of verbal communication, including that in written form, to which considerable attention is given throughout (...) one's school years. (shrink)

The purpose of this article is to reveal a number of socio-political ideas of medieval peasants. As material for the study, the report of Guillaume de Jumièges and the later story of Robert Wace about the uprising of the Norman peasants in 977 were taken. The author shows that the reconstructed political ideas of the peasantry largely diverged from the picture of the social world of the clergy.

Для широкого круга читателей (слушателей, аспирантов, преподавателей) интересующихся данной проблемой.

[kn. 1] Prostranstvo i vremi︠a︡ v nezhivoĭ i zhivoĭ prirode --kn. 2. Nauchnai︠a︡ myslʹ kak planetnoe i︠a︡vlenie.

ch. 1-2. Predystorii︠a︡, mif, religii︠a︡; Prosveshchenie, Kant, Gegelʹ -- ch. 3. Sovremennyǐ intellekt.

Articles on life and philosophy of Śaṅkarācārya.

A feature of the agro-industrial sphere is the high probability of distribution of production or research sites in areas far from each other for a considerable distance. Moreover, the center for collecting information and processing it, as a rule, is concentrated in one compact place. For research institutions, this feature often acquires a state of rather urgent problem, which requires the search for new innovative approaches. The paper proposes elements of the concept of construction and technological solutions for methods of (...) operational data transfer of field research from agricultural areas to a remote database for data storage with the possibility of feedback. As an example, the procedure of qualification examination of plant varieties with the definition of the criteria of "difference, homogeneity and stability" and "suitability for propagation of the variety in Ukraine" was chosen. (shrink)