Here we present and develop the hypothesis that the derepression of endogenous retrotransposable elements (RTEs) – “genomic parasites” – is an important and hitherto under‐unexplored molecular aging process that can potentially occur in most tissues. We further envision that the activation and continued presence of retrotransposition contribute to age‐associated tissue degeneration and pathology. Chromatin is a complex and dynamic structure that needs to be maintained in a functional state throughout our lifetime. Studies of diverse species have revealed that chromatin undergoes (...) extensive rearrangements during aging. Cellular senescence, an important component of mammalian aging, has recently been associated with decreased heterochromatinization of normally silenced regions of the genome. These changes lead to the expression of RTEs, culminating in their transposition. RTEs are common in all kingdoms of life, and comprise close to 50% of mammalian genomes. They are tightly controlled, as their activity is highly destabilizing and mutagenic to their resident genomes. (shrink)

This volume presents the first unabridged translation of Ito Jinsai's (1627-1705) masterwork, the Gomo jigi (Philosophical Lexicography of the Analects and ...

Kripke-completeness of every classical modal logic with Sahlqvist formulas is one of the basic general results on completeness of classical modal logics. This paper shows a Sahlqvist theorem for modal logic over the relevant logic Bin terms of Routley- Meyer semantics. It is shown that usual Sahlqvist theorem for classical modal logics can be obtained as a special case of our theorem.

To investigate how bereaved families felt about the explanation received before and after forensic autopsies, the authors conducted a cross-sectional survey of the bereaved families whose next of kin underwent a forensic autopsy at the two Departments of Forensic Medicine and a few bereaved families of crime victims. Of 403 questionnaires sent, 126 families responded. Among 81.5% of the respondents who received an explanation from policemen before the autopsy, 78.8% felt that the quality of the explanation was poor or improper. (...) In Japan, the law has restricted disclosure of information from a forensic autopsy. Despite legal restrictions, 82% wanted to hear from the person who conducted the autopsy. However, police explained the results of autopsy to 65.2% of respondents. Among the families whose frustration and anger increased after autopsy, 86.4% had not been satisfied with the explanation before the autopsy. Additionally, 57.7% had not been informed on the autopsy findings at the time of the questionnaire when more than 2 years had passed after the autopsy. These results reminded us of the importance of an explanation before and shortly after a forensic autopsy for a better understanding and acceptance by bereaved families. (shrink)

Die neuere Naturwissenschaft trat im 17. Jahrhundert zuerst als “Physik” auf. Man soll sich an die Gründung der modernen Dynamik von Galileo und Newton erinnern.Die methodisch-allgemeine Grundlegung dieser neuen Wissenschaft wird in der Cartesischen Philosophie am klarsten ausgedrückt.

Recently, several funding agencies have introduced the distribution of funds by a lottery system; however, its effects on the productivity of the research community are unclear. Simulation studies in philosophy of science have argued that a combination of peer review and lottery is an optimal method. However, these models overlook several important aspects of research activities, such as baseline funding through block grants. In this study, I constructed a general theoretical model that incorporates these aspects and argue that the conventional (...) combination of peer review and baseline funding outperforms the combination of peer review and lottery in many situations. (shrink)

Halldén completeness closely resembles the relevance property. To prove Halldén completeness in terms of Kripke-style semantics, the van Benthem–Humberstone theorem is often used. In relevant modal logics, the Halldén completeness of Meyer–Fuhrmann logics has been obtained using the van Benthem–Humberstone theorem. However, there remain a number of Halldén-incomplete relevant modal logics. This paper discusses the Halldén completeness of a wider class of relevant modal logics, namely, those with some Sahlqvist axioms.

In lieu of an abstract, here is a brief excerpt of the content:Guest Editor’s IntroductionNakajima Takahiro 「東京学派」とは聞きなれない名称であろう。日本研究において「京都学派」は大変よく知られている。たとえ「京都学派」が、「無の論理は論理ではない」と述べた上で、戸坂潤が発明した批判的な概念であったとしても 、現在ではそれは西田幾多郎や田辺元を中心とした一大哲学運動として世界的に認知されている。ところが、西田にしても田辺にしてももともとは東京帝国大学で学んだ学生であった。また、戦前においては、井上哲次郎か ら桑木厳翼へと続く東京帝国大学哲学科の流れは、当時の社会状況と相互に影響しあって、一定の意義を示していたのである。また、大森荘蔵、廣松渉、坂部恵といった戦後の東京大学の哲学者たちは、「京都学派」の問題 系を乗り越えることを重視していた。 この特別号では、発見的概念として「東京学派」を用いて、戦前・戦後におけるその意義と広がりを探究することにした。それは東京大学もしくは東京帝国大学に限定されたものではなく、それ以外の東京圏の大学との相互 交流も含まれるものである。「京都学派」に対しては、政治との距離をどう測るかがしばしば議論されてきたが、「東京学派」は政治により密着したものである。日本の近代の哲学の有している政治性そして倫理性を考える のであれば、やはり「東京学派」の議論は避けて通る ことのできないものである。 無論、「学派」というほどのまとまりを「東京学派」が有しているわけではないことも確かである。西田幾多郎が「京都学派」で果たした中心性は、「東京学派」にはない。そこで、トマス・カスリスが示唆するように、「 学派」の代わりに「サークル」や「スタイル」という言葉を使った方がより正確かもしれない。それでも、あえて「東京学派」と呼ぶのは、「京都学派」に比べて関心を持たれることの少ない、しかし当時は圧倒的な影響力 を有し、戦後決定的に忘却されていった東京の哲学者たちに光をあて、近代日本の哲学の総体を明らかにしたいからである。「東京学派」の研究は緒についたばかりである。今後、国際的な研究の高まりを期待しながら擱筆 する。The “Tokyo School” may be an unfamiliar term to readers. The Kyoto School is very well known in Japanese studies. Even if the Kyoto School is a critical concept invented by Tosaka Jun, who stated [End Page 2] that “the logic of nothingness is not logic,” it is now recognized worldwide as a major philosophical movement led by Nishida Kitarō and (...) Tanabe Hajime. However, both Nishida and Tanabe were originally students at Tokyo Imperial University. In addition, before the war, the output of the Department of Philosophy at Tokyo Imperial University, from Inoue Tetsujirō to Kuwaki Gen’yoku, had a certain significance because it interacted with the social conditions of the time. In addition, postwar philosophers at the University of Tokyo, such as Ōmori Shōzō, Hiromatsu Wataru, and Sakabe Megumi emphasized overcoming the problematics of the Kyoto School.In this special issue, we use the Tokyo School as a heuristic concept to explore its significance and spread in the prewar and postwar periods. It is not limited to the University of Tokyo or Tokyo Imperial University but includes interactions with other universities in the Tokyo area. While the Kyoto School has often been discussed in terms of how to measure its distance from politics, the Tokyo School is more closely connected to politics. If we consider the political and ethical dimensions of modern Japanese philosophy, we cannot avoid discussing the Tokyo School.Of course, it is true that the Tokyo School is not as coherent as a “school.” The central role that Nishida fulfilled in the Kyoto School is perhaps lacking in the Tokyo School. Therefore, as Thomas P. Kasulis suggests, it might be more accurate to use the term “circle” or “style” instead of “school.” Nevertheless, I dare to call it the Tokyo School because I would like to shed light on the Tokyo philosophers who were less popular than those of the Kyoto School but whose influence was overwhelming at the time and who were definitively forgotten after the war, so as to clarify the totality of philosophy in modern Japan.Research on the Tokyo School has only just begun. I am writing this introductory note in anticipation of further international research on the Tokyo School. [End Page 3]Copyright © 2023 State University of New York Press... (shrink)

Antonio Gramsci rigorously analysed the modern transformation of the Catholic Church and its strategy to spread its worldview to the Italian masses through secular means. His critique of the Church largely drew on his examination of the grounds that ensured Croce’s critique was doomed to failure. Despite its harshness, Croce’s critique failed because he did not grasp that the main target of the Church’s strategy was the common sense of the masses, while Croce pursued his critique in a highly idealist (...) manner, appealing only to his fellow intellectuals. He thereby, according to Gramsci, helped to reinforce the Church’s strategy by endorsing the rigid separation between the intellectuals and the masses. In contrast, unlike Croce and orthodox Marxism, Gramsci did not dismiss religion as a mere absurdity, recognising it as a source of people’s common sense that, albeit confusing in nature, informed their worldview. Gramsci considered that even the common sense of the masses constituted an appropriate grasp of the world, or ‘good sense’. In this sense, Gramsci’s critique of religion echoed his preoccupation with the longstanding division of Italian society between the intellectuals and the masses, which prevented mass participation in politics. (shrink)

帝国主義全盛の時代に武断的侵略的帝国主義に対し「倫理的帝国主義」を高唱。評価が分かれる稀代の自由主義思想家の実像に肉薄。.

Reinforcement learning has recently received much attention as a learning method for complicated systems, e.g., robot systems. It does not need prior knowledge and has higher capability of reactive and adaptive behaviors. However increase in dimensionality of the action-state space makes it diffcult to accomplish learning. The applicability of the existing reinforcement learning algorithms are effective for simple tasks with relatively small action-state space. In this paper, we propose a new reinforcement learning algorithm: “Q-learning with Dynamic Structuring of Exploration Space (...) Based on Genetic Algorithm ”. The algorithm is applicable to systems with high dimensional action and interior state spaces, for example a robot with many redundant degrees of freedom. To demonstrate the effectiveness of the proposed algorithm simulations of obstacle avoidance by a 50 links manipulator have been carried out. It is shown that effective behavior can be learned by using the proposed algorithm. (shrink)

Previous studies have confirmed that the temporal attentional control created by the repetition of stimulus-response compatibility (SRC) tasks was transferred to shooting skills in lacrosse players. In the current study, we investigated whether combining motor imagery training with SRC tasks could enhance the scoring ability of lacrosse players. We grouped 33 male lacrosse players into three groups: an SRC task and motor imagery group (referred as to SRC+Image), an SRC task group, and a control group. Players in the first two (...) groups underwent five sessions of 200 SRC task trials. In addition, the SRC+Image group completed five sessions of motor imagery training. The control group underwent no training interventions. All three groups performed a lacrosse shooting test and a Simon task before and after training sessions to assess the magnitude of the interference effects of the various types of training they underwent. The results of the Simon task showed that repetition of 1,000 trials was enough to create a short-term representation with the incompatible special mapping being transferred to a dynamic activity like lacrosse shooting. Moreover, combination of a computer-based Type 2 task and motor-imagery training could effectively increase players’ scoring ability in a field of large spatial conflict. (shrink)

Interaction systems with gesture-based touchless inputs are becoming more common. Nevertheless, perceptual properties of the visual feedback used in the system have not been well documented. We investigated whether the speed of motion shown in visual feedback used in gesture-based touchless inputs could be a cue for the heaviness sensation of an object even when other incidental cues, such as changes in object size and spatial consistencies in direction between gestures and feedback, were eliminated from the stimuli. Participants were asked (...) to make a gesture to grasp and raise/lower disks shown on a horizontal display. The disk’s diameter changed in accordance with the vertical position of the participant’s hand. The results showed that the rate of change in diameter determined the heaviness sensation. When the disks were replaced with concentric gratings having sinusoidal radial intensity and thus the cue of size change was eliminated from the stimuli, the heaviness sensation was dependent on the speed of phase shift in the grating. It was also found that spatial consistency between the direction of gestures and phase shift was not a critical condition for the heaviness sensation. Finally, the speed of motion served as a critical determinant of the heaviness sensation even when another visual feature was modulated in a single session, which indicates that the effect of the speed of motion on the heaviness sensation was unlikely due to demanded characteristics. The results indicate that the heaviness sensation for visual feedback of gesture-based touchless inputs is based purely on the speed of the visual feedback motion. (shrink)

荘子、朱子学、魯迅、ポーコック、アーレント、レヴィナス...言語と政治をめぐる古今の思考に分け入り、他者の声の響きに耳をすます。中国哲学を脱構築する企て。.

This thesis describes a method to control rare events in non-equilibrium systems by applying physical forces to those systems but without relying on numerical simulation techniques, such as copying rare events. In order to study this method, the book draws on the mathematical structure of equilibrium statistical mechanics, which connects large deviation functions with experimentally measureable thermodynamic functions. Referring to this specific structure as the "phenomenological structure for the large deviation principle", the author subsequently extends it to time-series statistics that (...) can be used to describe non-equilibrium physics. The book features pedagogical explanations and also shows many open problems to which the proposed method can be applied only to a limited extent. Beyond highlighting these challenging problems as a point of departure, it especially offers an effective means of description for rare events, which could become the next paradigm of non-equilibrium statistical mechanics. (shrink)

The English discourse marker after all and the Japanese discourse marker datte have been commonly claimed to give a reason or justification to the preceding utterance, and therefore, these two expressions are regarded as the equivalent translation counterparts to each other. This paper first attempts to propose that such an equated account is motivated by these two discourse markers constructing a similar inferential schema involved in the interpretation of the utterance including them. In fact, datte and after all make manifest (...) similar polyfunctions according to the syntactic position although they encode different lexical information. This is because these two discourse markers are indicators that contribute to the inferential phase of communication by various degrees of modulation of a cognitive gap between two different assumptions. Another aim of this paper is to differentiate a procedural constraint these two indicators encode on the interpretation of the utterance. (shrink)

A virtual dialogue interface for soft interaction between a system and a user is proposed. It enables the information acquisition as a sub task without hindering the user main task during the main task execution. A virtual dialogue is performed with suitable timing between the two characters used in this interface: the user avatar with a model obtained by observing the interaction of the user and the environment, and an agent having the knowledge about the environment. The user is usually (...) an indirect participant performing ``soft interaction'' as an onlooker of the system behavior (dialogue between the user avatar and the agent), and only when required he can participate through a direct interaction instead of his avatar. A car navigation interface was used to examine the applicability of the proposed technique. A task of memorizing information about one's profile while performing an operation task was given and the rate of main task execution and rate of related information memory were used as evaluation criteria. Our proposed method showed outstanding results comparing to the conventional direct interactive interface. Moreover, the degree of favorable impression for the proposed interface was higher than the conventional one and the subjectivity evaluation clearly showed that it was considered as a sociable interface. (shrink)

The purpose of the present study was two-fold. First we examined whether visible motion appearance was altered by the spatial interaction between invisible and visible motion. We addressed this issue by means of simultaneous motion contrast, in which a horizontal test grating with a counterphase luminance modulation was seen to have the opposite motion direction to a peripheral inducer grating with unidirectional upward or downward motion. Using a mirror stereoscope, observers viewed the inducer and test gratings with one eye, and (...) continuous flashes of colorful squares forming an annulus shape with the other eye. The continuous flashes rendered the inducer subjectively invisible. The observers’ task was to report whether the test grating moved upward or downward. Consequently, simultaneous motion contrast was observed even when the inducer was invisible . Second, we examined whether the observers could correctly respond to the direction of invisible motion: It was impossible. (shrink)

Experiment with public deployment of the semantic service matchmaker to a UDDI registry for a year is described in this paper. UDDI is a standard registry for Web Services, but, its search functionality has been limited to a keyword search. Therefore, we propose an enhancement of UDDI, called Matchmaker, that supports semantic service capability discovery. Since September 2003, we have deployed the Matchmaker in one of four official UDDI registries operated by NTT-Communications. In this paper, we first introduce the Matchmaker, (...) and illustrate client tools which lower the threshold of use of semantics. Then, we evaluate this experiment by benchmarks in terms of its performance and functionality. Finally, we discuss user requirements obtained by two ways: questionnaire and observation of search behavior. (shrink)

General frames are often used in classical modal logic. Since they are duals of modal algebras, completeness follows automatically as with algebras but the intuitiveness of Kripke frames is also retained. This paper develops basics of general frames for relevant modal logics by showing that they share many important properties with general frames for classical modal logic.

Crispin Wright in his 1982 paper argues for strict finitism, a constructive standpoint that is more restrictive than intuitionism. In its appendix, he proposes models of strict finitistic arithmetic. They are tree-like structures, formed in his strict finitistic metatheory, of equations between numerals on which concrete arithmetical sentences are evaluated. As a first step towards classical formalisation of strict finitism, we propose their counterparts in the classical metatheory with one additional assumption, and then extract the propositional part of ‘strict finitistic (...) logic’ from it and investigate. We will provide a sound and complete pair of a Kripke-style semantics and a sequent calculus, and compare with other logics. The logic lacks the law of excluded middle and Modus Ponens and is weaker than classical logic, but stronger than any proper intermediate logics in terms of theoremhood. In fact, all the other well-known classical theorems are found to be theorems. Finally, we will make an observation that models of this semantics can be seen as nodes of an intuitionistic model. (shrink)

Background: Chief nurses are most likely to take the lead in discussing and working to resolve ethical dilemmas, creating an ethical culture within their organization that results in effective ethics training. As the first step in this process, there is a need to define the kinds of ethical dilemmas that chief nurses grapple with on a regular basis as a target for future study. Research design: Anonymous written questionnaires and semi-structured interviews. Ethical considerations: All research procedures were approved by the (...) Chubu University Ethics Review Board, the research institution to which the authors belong (authorization no. 250016). Findings and discussion: Responses from four chief nurses indicated that ethical dilemmas could be categorized as either those related to patient dignity or those related to management (unique to their roles as administrators). It was also learned that chief nurses struggle with the fact that although they consult with their superiors and others, these efforts do not lead to resolution. The expectation is that going forward, chief nurses will play a central role in acting as coordinators with physicians to promote better communication as well as lead group discussions aimed at providing care that respects patient dignity. (shrink)

A logic is called metacomplete if formulas that are true in a certain preferred interpretation of that logic are theorems in its metalogic. In the area of relevant logics, metacompleteness is used to prove primeness, consistency, the admissibility of γ and so on. This paper discusses metacompleteness and its applications to a wider class of modal logics based on contractionless relevant logics and their neighbours using Slaney’s metavaluational technique.

The?-admissibility is one of the most important problems in the realm of relevant logics. To prove the 7-admissibility, either the method of normal models or the method using metavaluations may be employed. The?-admissibility of a wide class of relevant modal logics has been discussed in Part I based on a former method, but the?-admissibility based on metavaluations has not hitherto been fully considered. Sahlqvist axioms are well known as a means of expressing generalized forms of formulas with modal operators. This (...) paper shows that? is admissible for relevant modal logics with restricted Sahlqvist axioms in terms of the method using metavaluations. (shrink)

A classical reconstruction of Wright’s first-order logic of strict finitism is presented. Strict finitism is a constructive standpoint of mathematics that is more restrictive than intuitionism. Wright sketched the semantics of said logic in Wright (Realism, Meaning and Truth, chap 4, 2nd edition in 1993. Blackwell Publishers, Oxford, Cambridge, pp.107–75, 1982), in his strict finitistic metatheory. Yamada (J Philos Log. https://doi.org/10.1007/s10992-022-09698-w, 2023) proposed, as its classical reconstruction, a propositional logic of strict finitism under an auxiliary condition that makes the logic (...) correspond with intuitionistic propositional logic. In this paper, we extend the propositional logic to a first-order logic that does not assume the condition. We will provide a sound and complete pair of a Kripke-style semantics and a natural deduction system, and show that if the condition is imposed, then the logic exhibits natural extensions of Yamada (2023)’s results. (shrink)

Haptic sensation of a material can be modulated by its visual appearance. A technique that utilizes this visual-haptic interaction is called as pseudo-haptic feedback. Conventional studies have investigated pseudo-haptic feedback in situations, wherein a user manipulated a virtual object using a computer mouse, a force-feedback device, etc. The present study investigated whether and how it was possible to offer pseudo-haptic feedback to a user who manipulated a virtual object using keystrokes. Participants moved a cursor toward a destination by pressing a (...) key. While the cursor was moving, the cursor was temporarily slowed down on a square area of the screen. The participants’ task was to report, on a five-point scale, how much resistance they felt to the cursor’s movement. In addition to the basic speed of the cursor, the ratio of the basic speed to the speed within the square area was varied. In Experiment 1, we found that these two factors interacted significantly with each other, but further analysis showed that the cursor speed within the square area was the most important determinant of perceived resistance. In Experiment 2, consistent with the results of the previous experiment, it was found that the cursor movement outside of the square area was not required to generate the sense of resistance. Counterintuitively, in Experiment 3, the sense of resistance was apparent even without user’s keystrokes. We discuss how the sense of resistance for a cursor moved by keystrokes can be triggered visually, but interpreted by the brain as a haptic impression. (shrink)

Face recognition is impaired in patients with prosopagnosia, which may occur as a side effect of neurosurgical procedures. Face selective regions on the ventral temporal cortex have been localized with electrical cortical stimulation, electrocorticography, and functional magnetic resonance imagining. This is the first group study using within-patient comparisons to validate face selective regions mapping, utilizing the aforementioned modalities. Five patients underwent surgical treatment of intractable epilepsy and joined the study. Subdural grid electrodes were implanted on their ventral temporal cortices to (...) localize seizure foci and face selective regions as part of the functional mapping protocol. Face selective regions were identified in all patients with fMRI, four patients with ECoG, and two patients with ECS. From 177 tested electrode locations in the region of interest, which is defined by the fusiform gyrus and the inferior temporal gyrus, 54 face locations were identified by at least one modality in all patients. fMRI mapping showed the highest detection rate, revealing 70.4% for face selective locations, whereas ECoG and ECS identified 64.8 and 31.5%, respectively. Thus, 28 face locations were co-localized by at least two modalities, with detection rates of 89.3% for fMRI, 85.7% for ECoG and 53.6 % for ECS. All five patients had no face recognition deficits after surgery, even though five of the face selective locations, one obtained by ECoG and the other four by fMRI, were within 10 mm to the resected volumes. Moreover, fMRI included a quite large volume artifact on the ventral temporal cortex in the ROI from the anatomical structures of the temporal base. In conclusion, ECS was not sensitive in several patients, whereas ECoG and fMRI even showed activation within 10 mm to the resected volumes. Considering the potential signal drop-out in fMRI makes ECoG the most reliable tool to identify face selective locations in this study. A multimodal approach can improve the specificity of ECoG and fMRI, while simultaneously minimizing the number of required ECS sessions. Hence, all modalities should be considered in a clinical mapping protocol entailing combined results of co-localized face selective locations. (shrink)

This study investigated the circumstances and problems that departments of forensic medicine encounter with bereaved families regarding samples obtained from medico-legal autopsies. A questionnaire was posted to all 76 departments of forensic medicine performing medico-legal autopsies in Japan, and responses were received from 48 . Of the respondents, 12.8% had approached and communicated with bereaved families about collecting samples from the deceased person during an autopsy and the storage of the samples. In addition, 23.4% of these had informed families that (...) samples might be used in research. Eighteen departments had received enquiries and requests from families about the samples, with most requests concerning their return. The response to such requests varied according to the department. Few departments interacted with the bereaved families regarding the procedure for obtaining autopsy samples, and their methods for handling family concerns differed depending on the person within the department authorised to contact the family. Moreover, the procedures for engaging in such communication have long been unclear, and no legal or ethical consensus or agreement with the general public has been established. It is important for researchers to further discuss the correct way for forensic medicine departments to communicate with bereaved families. (shrink)

The sense of agency refers to an experience in which one’s own action causes a change in environment. It is strongly modulated by both the contingency between action and its outcome and the consistency between predicted and actual action outcomes. Recent studies have suggested that the action outcome can retrospectively modulate action awareness. We suspect that the sense of agency can also be retrospectively modulated. This study examined whether the quantity of action outcome could influence the sense of agency. The (...) participants’ task was to trigger dot motion in a display and rate the extent to which they could control the initiation of dot motion. Independently of both the temporal contiguity between action and its outcome and the consistency between predicted and actual action outcomes, the speed of dot motion as an action’s outcome strongly influenced the sense of agency rating. The present study suggests that the sense of agency stems partly from the inference of action efficiency based on the quantitative aspect of action outcome. (shrink)

The admissibility of Ackermann's rule γ is one of the most important problems in relevant logics. The admissibility of γ was first proved by an algebraic method. However, the development of Routley-Meyer semantics and metavaluational techniques makes it possible to prove the admissibility of γ using the method of normal models or the method using metavaluations, and the use of such methods is preferred. This paper discusses an algebraic proof of the admissibility of γ in relevant modal logics based on (...) modern algebraic models. (shrink)

Gramsci’s concept of the “ethical state” has been interpreted as a synonym for the “regulated society”—a future society in which everybody participates in governance following the rationalization o...