Large-scale sequencing tests, including whole-exome and whole-genome sequencing, are rapidly moving into clinical use. Sequencing is already being used clinically to identify therapeutic opportunities for cancer patients who have run out of conventional treatment options, to help diagnose children with puzzling neurodevelopmental conditions, and to clarify appropriate drug choices and dosing in individuals. To evaluate and support clinical applications of these technologies, the National Human Genome Research Institute and National Cancer Institute have funded studies on clinical and research sequencing under (...) the Clinical Sequencing Exploratory Research program as well as studies on return of results. Most of these studies use sequencing in real-world clinical settings and collect data on both the application of sequencing and the impact of receiving genomic findings on study participants. They are occurring in the context of controversy over how to obtain consent for exome and genome sequencing. (shrink)

Richard Rorty’s neopragmatism is more similar to the self-described pragmatisms of his contemporaries Jürgen Habermas and Hilary Putnam than it is dissimilar from them. Indeed, the only significant difference between Rorty’s views and those of his interlocutors, and what forms the basis of their many public exchanges, is their respective stances toward the status of epistemic norms. Rorty’s arguments against Habermas’s endorsement of transcendental conditions that ground successful communication, and against Putnam’s contention that there exists a limit conception of truth (...) upon which the possibility for critique depends speak to the very heart of his philosophical differences from the Kantian pragmatisms of Habermas and Putnam. -/- This paper engages in a detailed exploration of the debates between Rorty and Habermas and between Rorty and Putnam over these matters. These debates provide us with a direct route to understanding Rorty’s own views on epistemic norms. That is, the comparison between his own position and those of his fellow neopragmatists throws into sharp relief Rorty’s belief in the radical contingency of epistemic norms. -/- This exploration profits from engaging a feminist lens because feminist critiques, specifically of Habermas’s work, draw attention to the inadequacies of his views that Rorty seeks to correct, inadequacies that can be easily translated to Putnam’s case as well. By approaching this issue from a feminist angle, the paper highlights the dissimilarities in the theoretical positions between Rorty and his contemporaries, and shows why this difference is more significant than it might seem at first blush. The paper concludes with the suggestion that Rorty’s emphasis on the radical contingency of epistemic norms can provide a basis for the kind of revolutionary social, political, and cultural change that is central to much recent feminist theory. (shrink)

Given that one of the major goals of the practice of Philosophy for Children (P4C) is the development of critical thinking skills (Sharp 1987/2018, pp. 4 6), an urgent question that emerged for one of the authors, who is of Chinese Heritage and a novice practitioner at a P4C summer camp was whether this emphasis on critical thinking might make this practice incompatible with the fabric of Chinese culture. Filial piety (孝), which requires respect for one’s parents, elders, and ancestors (...) is considered an important virtue in Asian culture, as is the preservation of harmony. But if one of the goals of P4C is to teach youngsters to courageously pursue reasoned dialogue, does this not set-up young Asians for serious conflict when they come face-to-face with positions that are articulated by elders, but which are ones to which they are diametrically opposed; a racist grandmother, for instance, or an uncle who insists that those at the Tiananmen Square uprising were nothing but hooligan’s. It is this question that we will explore in this presentation. In the process, we will come to the conclusion that, when positions seem irreconcilable, rather than continuing to pursue rigorous critical interchange that may do little other than escalate insult, the facilitator, rather, ought to move toward creating a deeper understanding of each position juxtaposed against its opposing view (a process that we refer to as ‘collaborative caring’), so as to produce side-by-side understanding, knowing that communal bonds have been maintained and, hence, that the opportunity for genuine reasoned collaborative inquiry on other issues and at future times remains open. (shrink)

This paper explores Spinoza’s relationship to poetry by considering two prominent allusions to classical literature in Spinoza’s political treatises. Susan James illuminates Spinoza’s worries about the dangers of poetic address. At the same time, Spinoza relies on poetic language and citation to press some central claims. References to Seneca and Tacitus, I suggest, aim to transform the popular imagination with respect to the relationship between government, violence, and domination. Poetic language reinforces his challenge to false solutions to the problems (...) of violence, rebellion, and the precarity of political authority, which preoccupied early-modern political thinkers. (shrink)

William of Ockham (d. 1347) is well known for his commitment to parsimony and for his so-called ‘razor’ principle. But little is known about attempts among his own contemporaries to deflect his use of the razor. In this paper, I explore one such attempt. In particular, I consider a clever challenge that Ockham’s younger contemporary, Walter Chatton (d. 1343) deploys against the razor. The challenge involves a kind of dilemma for Ockham. Depending on how Ockham responds to this dilemma, his (...) razor will, Chatton argues, either prove unacceptably dull when it comes to determining ontological commitment or prove unacceptably sharp when it comes to determining commitments entailed by certain theological doctrines. While Chatton’s objection is subtle and interesting in its own right, the broader significance of the debate between these thinkers lies in the light it sheds on medieval approaches to issues surrounding metaphysical methodology. (shrink)

Susan Stebbing’s paper “Logical Positivism and Analysis” (March 1933) was unusually critical of Wittgenstein. It put up a sharp opposition between Cambridge analytic philosophy of Moore and Russell and the positivist philosophy of the Vienna Circle to which she included Wittgenstein from 1929–32. Above all, positivists were interested in analyzing language, analytic philosophers in analyzing facts. Moreover, whereas analytic philosophers were engaged in directional analysis which seeks to illuminate the multiplicity of the analyzed facts, positivists aimed at final analysis (...) which “proves” that there are simples. Stebbing’s paper urged Wittgenstein to recast his philosophy and 1933 abandon those components of it that linked him to the Vienna Circle. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Callimachus in Context: From Plato to the Augustan Poets by Benjamin Acosta-Hughes, Susan A. StephensIvana PetrovicBenjamin Acosta-Hughes and Susan A. Stephens. Callimachus in Context: From Plato to the Augustan Poets. Cambridge: Cambridge University Press 2012. xvi + 328 pp. 4 maps. Cloth, $99.Callimachus is a scholar’s poet, not just because his poetry is difficult and challenging, but also because we tend to see a reflection of (...) ourselves in him: self-assured to the point of arrogance, delighting in recondite words and fun facts, a target of unfair criticism from malevolent and envious colleagues. Callimachus was for decades perceived as antiquarian, bookish, a scholar whose poetry was divorced from the performative setting, not championing civic values, but rather l’art pour l’art avant la lettre. The main focus of scholarship used to be Callimachus’ relationship with the Greek poetic tradition, and virtuoso studies in intertextuality demonstrated just how rich and wide-ranging the tapestry of his allusions is, from poetry to technical writings in prose. However, in the last couple of decades, this image of Callimachus as the ivory-tower scholar-poet began to change. In his ground-breaking monograph Callimachus and His Critics (Princeton 1995), Alan Cameron argued that Callimachus was a prominent and active figure at the Alexandrian court, and far from an armchair intellectual.In recent years, numerous scholars have looked into the way Callimachus was indeed a child of his own time. Brill’s 2011 Companion to Callimachus (edited by the authors of the present book and Luigi Lehnus) is a good illustration of the current state of affairs in Callimachus scholarship: six out of twenty-seven papers discuss Callimachus’ relationship with the royal family and explore his status as a court-poet, his attitude to contemporary religion, and the geopoetics of his poetry and its political implications.This book is a successful union of the two aforementioned approaches to the poet. First, the authors set out to “contextualize Callimachus within his intellectual traditions and within his physical and social environments”; second, they pose five questions: “Why do there appear to be so many Platonic tangents in Callimachus? Why, in a poet considered the model of the ‘bookish’ author, are there so many indications of poetic performance? What is the rapport between the Ptolemies and their political interests and a remarkably diffuse body of work of one court poet? Why is Callimachus an ongoing feature of Roman poetic culture, and in such a particular way?” (viii). They provide an answer to each of these questions in separate chapters, carefully and meticulously negotiating between the study of intertexts and Callimachus’ social contexts.The introduction is fast-paced and fact-based. It provides an overview of Callimachus’ career and the political and cultural history of his native city, Cyrene, and his adopted home, Alexandria. It is the choice of facts and the sharp eye for detail that sets this section apart from a mere collection of data: by discussing the poetic production of the lesser-known Cyrenaean epic poet Eugamon, the authors provide “a glimpse into regional poetics and how it operated within the broader Panhellenic context” (6); careful reading of inscriptions and an assessment of the archaeological remains allows them to offer an interesting suggestion regarding [End Page 365] the dramatic performances of dithyrambic choruses in connection with the festival of the Carneia, which Callimachus memorably described in his Hymn to Apollo.A succinct discussion of Cyrenaean cults brings together results of decades of archaeological study and allows material culture to inform and enrich our view of Callimachus’ poetry: there was a bronze Delian palm in the Cyrenaean sanctuary of Leto (cf. H. Ap. 1–2); the local temple of Zeus Olympius had a cult statue that replicated Phidias’ (cf. Iambus 6); Thesmophoria were probably celebrated in the Cyrenaen sanctuary of Demeter and Kore (cf. H. Dem.); a number of local statue-groups and reliefs coincide with figures in Callimachus’ poetry. By juxtaposing the old and venerable city Cyrene with the newly founded cosmopolitan Alexandria in Egypt, the authors emphasize the cultural contrast between Callimachus’ native city and his chosen home. Since Callimachus was a poet active in a city... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Spirit Stones of China: The Ian and Susan Wilson Collection of Chinese Stones, Paintings, and Related Scholars' ObjectsGraham ParkesSpirit Stones of China: The Ian and Susan Wilson Collection of Chinese Stones, Paintings, and Related Scholars' Objects. Edited by Stephen Little. Chicago: The Art Institute of Chicago in association with University of California Press, 1999. Pp. 112.Let me introduce Spirit Stones of China: The Ian and (...) class='Hi'>Susan Wilson Collection of Chinese Stones, Paintings, and Related Scholars' Objects (edited by Stephen Little) with this quotation:The purest essence of the energy of the heaven-earth world coalesces into rock. It emerges, bearing the soil. Its formations are wonderful and fantastic. Some with cavernous cliffs, revealing their interior; some with peaks and summits in sharp-edged layers.... Within the size of a fist can be assembled the beauty of a thousand cliffs. Rocks large enough to be set up in great courtyards, small enough to be set upon a stand. Like gazing upon the peaks of Song Shan, or facing the entire range of the Meng mountains; sitting quietly, your imagination purified.... The Sage [Confucius] once said, "the humane man loves mountains," and the love of stones has the same meaning. Thus, longevity through quietude is achieved through this love.This passage articulates the very different understanding of stone—as "essential energy" rather than mere matter—that underlies the traditional Chinese passion for rock collecting and appreciating, for which even the terms "petromania" and "litholatry" seem too weak. It comes from the preface to the earliest surviving Chinese manual on the topic, Du Wan's Stone Compendium of Cloudy Forest, compiled in the early twelfth century, and is quoted by Stephen Little in his erudite and informative introduction to this magnificent catalog for a unique collection of "spirit" or "strange stones" (guai shi) and other scholars' articles. This essay nicely complements and amplifies ideas set forth some fifteen years ago by John Hay, in his now classic introduction to the catalog Kernels of Energy, Bones of Earth: The Rock in Chinese Art (New York: China House Gallery, China Institute in America, 1985).Most cultures appear to begin with a natural reverence for stone in its natural state—one thinks of the Druids, the Indian tradition, the Polynesians, Native Americans, and Australian aboriginal culture—and many seem to retain that reverence as they develop. Indeed, when seen in a global perspective, the general lack of interest in (or respect for) rock in its unhewn state that characterizes the European and Anglo-American traditions seems idiosyncratic. But Chinese culture definitely has the longest and most enthusiastic tradition of collecting stones and arranging rocks in gardens: "strange stones" figure among articles of tribute offered to the mythical emperor Yu (mid-second millennium B.C.E.), and the emperor Wu Di (second century B.C.E.) is recorded as having had rocks arranged in the gardens of his palace. [End Page 306]Stephen Little's essay gives an eloquent account of the development of the practice of stone collecting in China, delineating its relationships with poetry and painting and other arts and practices, and containing numerous translations of passages from primary sources otherwise inaccessible to the non-reader of Chinese. Most of the rocks in the catalog are of the well-known Lingbi (sonorous) and Ying types, but other kinds are represented, too. The editor also supplies a context for appreciating the paintings, scrolls, and other articles from scholars' desks that are in the catalog: brush rests, inkstones, brush holders, and so forth. The sixty-six items from the collection are represented in excellent black-and-white photographs.The book is beautifully designed and produced—and is indeed a work of art in itself with its handsome, dark blue Chinese-style case. All in all, this a stylish and informative contribution to the growing literature on a philosophically fascinating topic. [End Page 307]Graham Parkes University of Hawai'iCopyright © 2001 University of Hawai'i Press... (shrink)

This book is a collection of specifically commissioned articles on the key continental European philosophical movements since 1914. It shows how each of these bodies of thought has been shaped by their responses to the horrors set in train by World War I, and considers whether we are yet ‘post-post-war’. The outbreak of World War I in August 1914,set in chain a series of crises and re-configurations, which have continued to shape the world for a century: industrialized slaughter, the end (...) of colonialism and European empires, the rise of the USA, economic crises, fascism, Soviet Marxism, the gulags and the Shoah. Nearly all of the major movements in European thinking were forged in, or shaped by, attempts to come to terms with the global trauma of the World Wars. This is the first book to describe the development of these movements after World War I, and as such promises to be of interest to philosophers and historians of philosophy around the world. (shrink)

The terms "appropriate" and "necessary" are crucial determinants in decisions regarding the use and reimbursement of medical treatments. This paper encourages greater awareness of the political, economic, and normative assumptions that give meaning to these concepts.

Much of the sustained attention on pandemic preparedness has focused on the ethical justification for plans for the “crisis” phase of a surge when, despite augmentation efforts, the demand for life...

After September 11, Sullivan wrote that while he wasn’t worried about the heartland, “decadent coastal liberals may well mount a fifth column.†This in response, as is well known, to a thoughtful New Yorker essay by Susan Sontag. Sullivan, who Eric Alterman—not usually a sharp wordsmith—memorably calls “Young Roy Cohn†later issued “Sontag awards.†His attitude and his popularization of a sort of Lynne Cheneyist position on what “Views†are improper and thus should not be publicly aired, probably did (...) far more damage to civil liberties than Joe McCarthy’s pal Roy, who at the very least didn’t take himself seriously. (shrink)

In the 11th chapter of the second book of Samuel, we read how King David saw Bathsheba in the evening: ‘v.2. And it came to pass in an eveningtide, that David arose from off his bed, and walked upon the roof of the king's house: and from the roof he saw a woman washing herself; and the woman was very beautiful to look upon.’.

Propositions are items that play certain theoretical roles: (among other things) they serve as objects of belief, fundamental bearers of truth-value, and the semantic contents of sentences. In this paper, I examine the key role Ockham played in the development of later medieval debates about propositions. Unlike contemporary philosophers, who typically assume that propositions are abstract entities of some sort, Ockham holds a nominalist view of propositions according to which token entities—namely, token mental representations—play the proposition role. While Ockham's view (...) generates a great deal of controversy and discussion I argue that it isn't his nominalism about propositions per se that proves objectionable. Indeed, insofar as few medieval philosophers countenance abstract objects, the view that token mental representations function as fundamental bearers of truth and as the semantic content of sentences is fairly standard. What does prove controversial, I claim, is Ockham's contention that token mental states—what he refers to as ‘mental sentences’—serve as objects for propositional attitudes. My discussion in the paper explores both (i) the reasons why Ockham’s attempt to treat mental representations as objects for belief and knowledge proved controversial and (ii) what alternative positions emerged in the subsequent debate about propositional attitudes. -/- . (shrink)

Freud seems to have been torn between a literary and a scientific model for his enterprises. On the one hand he stresses the scientific nature of his researches to an extent which makes the suspicious reader wonder whether he protests too much. On the other hand it is well known that he regarded many writers, though predominantly Shakespeare, as anticipating his findings on the unconscious. In one famous passage in the Introductory Lectures on Psycho-analysis he places his discovery of the (...) unconscious on a par with the discoveries of Darwin and Copernicus in their effect upon man's picture of himself. He is justified, of course, and if we add Marx to this triumvirate we add a figure even closer to Freud in claiming a scientific status for his work, a scientific status which is, to the uncommitted, dubious. Theodore Mischel argues that Freud increasingly construes neurotic behaviour upon the model of ordinary intentional behaviour and, though he continued to show interest in the view that the unconscious impulses which are repressed are physiological in nature, this ideal of a reduction of the psychological to the physiological became a less active ingredient in his published work as his collaboration with Fliess receded into the past. So although he may have paid lip service to some form of psycho-physical identity, believing that mental phenomena are ultimately no more or less than physical happenings in the neurones of the brain, in mature Freud this seems to have been an idly spinning wheel. Roy Schafer has recently pointed out that many of Freud's followers use the concepts of natural science , whilst simultaneously retaining traces of anthropomorphism in their metapsychology. For instance Heinz Hartmann emphasizes the concept of a ‘higher organizing function’ which resists formulation in the mechanistic metapsychology he favours. Similar difficulties obtrude in the work of Waelder and Kohut. The significance of these conflicts leads Schafer to frame basic Freudian insights in terms of the theory of action, stressing the manner in which an action may be described in differing ways and thus allowing us to present the fact that a patient's behaviour may both tell and not tell us of his deepest anxieties. Yet curiously Schafer denies that freedom plays any part in his account whereas we would have expected a concept so central to agency to have an equally central role in any recasting of psycho-analysis in terms of the theory of action. (shrink)

In this note I have presented the essentials of a view of how laws are falsified, a view which has been held by some notable philosophers but which is radically opposed to that of Professor Popper. I have not scrupled to ?improve? upon it, so the view of no one philosopher is presented. I try to show that an interesting and convincing account of scientific simplicity is implicit in the theory and I conclude by suggesting how we can bring the (...) argument to bear on the problem of the logical status of laws of nature, showing that through their manner of falsifiability, laws share some characteristics with necessary statements as well as with empirical generalizations. (shrink)

The ethical ideologies of psychologists and physicians were compared using the Ethics Position Questionnaire. The findings reveal that psychologists tend to be less relativistic than physicians. Further, we explored the degree to which physicians and psychologists report being influenced by a variety of factors in their ethical decision making. Psychologists were more influenced by their code of ethics and less influenced by family views, religious background, and peer attitudes than were physicians. We argue that these differences reflect the varied professional (...) cultures in which practitioners are trained and socialized. (shrink)

This detailed 1990 book describes the light and dark adaptation of receptoral and post-receptoral mechanisms from a number of perspectives. The authors emphasise the importance of the study of achromatopsia, a rare congenital condition in which the visual mechanisms that mediate day vision are absent whilst those that mediate night vision remain intact.

Many bilingual speakers believe they engage in different forms of thinking when they shift languages. This experience of entering different thought worlds can be explained with the hypothesis that languages induce different forms of `thinking-for-speaking'-- thinking generated, as Slobin (1987) says, because of the requirements of a linguistic code. "`Thinking for speaking' involves picking those characteristics that (a) fit some conceptualization of the event, and (b) are readily encodable in the language"[2] (p. 435). That languages differ in their thinking-for-speaking demands (...) is a version of the linguistic relativity hypothesis, the proposition that language influences thought and that different languages influence thought in different ways. (shrink)

This book explores the relevance of David Bowie's life and music for contemporary legal theory. Focusing on the artist and artworks of David Bowie, this book brings to life, in essay form, particular theoretical ideas, creative methodologies and ethical debates that have contemporary relevance within the fields of law, social theory, ethics and art. What unites the essays presented here is that they all point to a beyond law: to the fact that law is not enough, or to be more (...) precise, too much, too much to bear. For those who, like Bowie, see art, creativity and love as what ought to be the central organising principles of life, law will not do. In the face of its certainties, its rigidities, and its conceits, these essays, through Bowie, call forth the monster who laughs at the law, celebrate inauthenticity as a deeper truth, explore the ethical limits of art, cut-up the laws of writing, and embrace that which is most antithetical to law, love. This original engagement with the limits of law will appeal to those working in legal theory, ethics, and law and popular culture, as well as in art and cultural studies. (shrink)