Optogenetics is an invasive neuromodulation technology involving the use of light to control the activity of individual neurons. Even though optogenetics is a relatively new neuromodulation tool whose various implications have not yet been scrutinized, it has already been approved for its first clinical trials in humans. As optogenetics is being intensively investigated in animal models with the aim of developing novel brain stimulation treatments for various neurological and psychiatric disorders, it appears crucial to consider both the opportunities and dangers (...) such therapies may offer. In this review, we focus on the memory-modifying potential of optogenetics, investigating what it is capable of and how it differs from other memory modification technologies. We then outline the safety challenges that need to be addressed before optogenetics can be used in humans. Finally, we re-examine crucial neuroethical concerns expressed in regard to other MMTs in the light of optogenetics and address those that appear to be unique to the memory-modifying potential of optogenetic technology. (shrink)

In our article (Zawadzki and Adamczyk 2021), we analyzed threats that novel memory modifying interventions may pose in the future. More specifically, we discussed how optogenetics’ potential for reversible erasure/deactivation of memory “may impact authenticity by producing changes at different levels of personality.” Our article has received many thoughtful open peer commentaries for which we would like to express our great appreciation. We have identified two main threads of objections. They are related to the potential applicability of optogenetics as (...) a therapeutic memory modification technology (MMT) in humans—applicability thread, and the normative value of authenticity, that is, the assumption that preserving authenticity is valuable (either in general or in the particular approach we adopted)—normative thread. Both of these threads concern fundamental issues: The former deals with the scientific credibility of the case vignette on which our discussion is based, and the latter deals with the normative weight of our considerations. We think that addressing both of them can be instructive in a broader context as they reflect a more general disagreement among neuroethicists about the very purpose and method of our discipline. (shrink)

Boreal forests store a globally significant pool of carbon (C), mainly in tree biomass and soil organic matter (SOM). Although crucial for future climate change predictions, the mechanisms underlying C stabilization are not well understood. Here, recently discovered mechanisms behind SOM stabilization, their level of understanding, interrelations, and future directions in the field are provided. A recently unraveled mechanism behind C stabilization via interaction of root‐derived tannins with fungal necromass emphasizing fungal necromass chemistry is brought forth. The long‐lasting dogma of (...) the stability of SOM on minerals is challenged and the newest insights from the field of soil fauna and their influence on SOM stabilization are provided. In conclusion, mechanisms unraveled during the last decade are crucial steps forward to draw a holistic view of the main drivers of SOM stabilization. (shrink)

Filozoficko-antropologické dědictví Viktora E. Frankla zůstává dosud nedoceněnou oblastí v jeho široké tvůrčí činnosti, která zahrnuje také neurologické, psychiatrické, psychoterapeutické a axiologicko-etické bádání. Franklovým dílem však prolíná svébytná multidimenzionální koncepce člověka, která je v následujícím příspěvku úzce spojena s Franklovou primární profesní orientací - péčí o zdraví a snahou o uzdravení nemocných - a s jednou z dominant Franklovy tragické triády - utrpením.

This article provides Catholic authorities with a useful framework for forming prudent and just policies to minimize clerical child sexual abuse, exploiting the 2011 John Jay College report Causes and Context while not ignoring its shortcomings. The framework is St. Thomas Aquinas’s treatment of prudence, and a “profile” of the clerical perpetrators is developed that uses their narcissism as a middle term to explain why these men behaved the way they did. The author concludes by recommending a deterrent policy similar (...) to the policy advocated by St. Paul, which does not unrealistically aim at an angelic clergy but aims to deter those who would enter the priesthood for its benefits. National Catholic Bioethics Quarterly 13.2 (Summer 2013): 299–311. (shrink)

In the _Phaedrus_, Plato provides an intriguing dramatic detail immediately before Socrates's first speech. "I shall veil myself to speak," Socrates declares, "so that I may run through the speech as quickly as possible and may not be at a complete loss from a sense of shame as I look towards you." In this essay, I argue that Socrates's veiling illustrates how authors of dialogic literature about philosophical topics subtly use dramatic and literary details to suggest preferred philosophical takeaways.

La filosofía cristiana de Stein surgió en el campo de tensión marcado por la fenomenología de Edmund Husserl y la enseñanza de Tomás de Aquino. El primero la fascinó por su ética de pensamiento riguroso y honesto, y el segundo por su clara concepción del campo de trabajo común para la razón y la fe. De este modo, Stein, a su vez, ideó la confrontación entre Husserl y Tomás, con la esperanza de que la filosofía se acercara así a su (...) ideal. Pues la filosofía siempre ha querido ser una teoría del ser cerrada y posiblemente coherente, cuyos enunciados estén definitivamente demostrados. Sin embargo, según Stein, sólo puede ser una teoría de este tipo si tiene en cuenta lo que dice la teología sobre el ser y, más concretamente, sobre su causa. En la filosofía de Stein en el estado cristiano, se pueden ver constantemente influencias tanto de Husserl como de Tomás. Al mismo tiempo, Stein propone su propia concepción de la filosofía y, por tanto, estas influencias se elevan muy por encima de ella. El artículo pretende describir el camino intelectual de Stein hacia esta filosofía, las influencias de Husserl y Tomás en su enfoque teórico de la filosofía cristiana, así como en sus investigaciones prácticas en el marco de la filosofía cristiana, y especialmente la peculiaridad de la filosofía de Stein. (shrink)

The Decalogue is the ten commandments which are a covenant between God and His people. Written on two tablets of stone, this Decalogue is apodictive (unconditional command and prohibition). It expresses the love between God and His people and between members of the people. This article shows that in the Pentateuch there are two versions of the Decalogue (Ex. 20:1-17 and Deut. 5:6-21) with some differences between them. Deuteronomy 5:6-21 contains additions to Exodus 20:1-17. Ex. 20:1-17 was spoken by God (...) himself to the Israelites at Mount Sinai; Deut. 5:6-21 by Moses in the plains of Moab when quoting Ex. 20:1-17. The commandment to keep the Sabbath day holy in Ex. 20:8-11 is motivated by God’s rest on the seventh day of creation; in Deut. 5:12-15 it is motivated by Israel’s liberation from slavery in the land of Egypt. Ex. 20:13-17 contains fi ve social commandments in no apparent order; Deut. 5:17-21 contains six social commandments inparallel arrangement. The Decalogue, as a law does not guarantee its implementation. And the Israelites repeatedly violated or disobeyed the law. Therefore, God Himself takes the initiative and intervenes toensure its implementation. After the destruction of the city of Jerusalem as an outward sign of the end of the Old Covenant, the prophet Jeremiah prophesied the New Covenant at the initiative of God to bewritten in the hearts, so that previously impossible loyalty would now become a reality (Jer. 31:31-34). Thus, the New Covenant is not different from the Sinai Covenant, but rather a renewal of YHWH’s faithfulnesswhich is rebuilt and deepened continuously so that it becomes a “covenant without end” (Lam. 3:22-23). Abstrak Dekalog adalah sepuluh fi rman yang merupakan pernjanjian antara Allah dengan umat-Nya, tertulis dalam dua loh batu. Dekalog yang bersifat apodiktif (perintah dan larangan tanpa syarat) mengungkapkankasih antara Allah dengan umat-Nya dan antarumat Allah. Artikel ini menunjukkan bahwa dalam Pentateukh terdapat dua versi Dekalog (Kel. 20:1-17 dan Ul. 5:6-21) dengan beberapa perbedaan. Ul. 5:6-21 memuat beberapa tambahan yang tidak terdapat dalam Kel. 20:1-17. Kel. 20:1-17 diucapkan sendiri oleh YHWH kepada bangsa Israel di gunung Sinai; Ul. 5:6-21 diucapkan oleh Musa di dataran Moab dengan mengutip isi Kel. 20:1-17. Perintah kuduskanlah hari Sabat dalam Kel. 20:8-11 bermotifkan istirahat Allah pada hari ketujuh saat penciptaan; dalam Ul. 5:12-15 bermotifkan pembebasan bangsa Israel dari perbudakan di tanah Mesir. Kel. 20:13-17 memuat lima perintah sosial tanpa urutan yang jelas; Ul. 5:17-21 memuat enam perintah sosial yang disusun paralel. Dekalog sebagai undang-undang tidak menjamin pelaksanaannya. Berulangkali bangsa Israel telah melanggar atau tidak setia pada penjanjian tersebut. Maka, Allah sendiri yang berinisiatif dan campur tangan demi terjaminnya pelaksanaan perjanjian-Nya. Sesudah penghancuran kota Yerusalem sebagai tanda lahiriah berakhirnya Perjanjian Lama, Nabi Yeremia menubuatkan Perjanjian Yang Baru atas prakarsa Allah yang akan ditulis dalam hati manusia, sehingga kesetiaan yang tadinya mustahil akan menjadi kenyataan (Yer. 31:31-34). Dengan demikian Perjanjian Yang Baru itu tidak berbeda dengan Perjanjian Sinai, tetapi lebih berupa pembaruan kesetiaan YHWH yang dibangun kembali dan diperdalam terus-menerus sehingga menjadi “perjanjian yang tak berkesudahan” (Rat. 3:22-23). (shrink)

The author describes a team taught (philosophy/agriculture) professional ethics in agriculture course at Cal Poly, San Luis Obispo. He shows how the teaching, student selection (half agriculture, half non-agriculture), topic selection and class projects (mock public forums on critical issues aimed at achieving a public consensus) were chosen to achieve one main goal, a professional ethics aimed at public service. A second goal, public awareness of the legitimate needs of agriculture, is pursued simultaneously.The public-good orientation of this model of professional (...) ethics is distinguished from the frequent professional-defensive role found in other fields. The author indicates that agriculture's need for publicly effective and credible leadership makes the older defensive models useless today as well as wrong, given the common-good goals of ethics.A short list of goals of agriculture is proposed: sufficient, sustainable and healthy food/fiber supplies by means which respect the dignity of all participants. From these goals it is claimed that consensus “first principles” of agricultural ethics can be constructed. More fundamental first principles, such as the golden rule, are given their appropriate role.From these some simple criteria for the problem solving efforts of the students are suggested: broad consideration of technical and human impacts (no dismissal of impacts as “externalities”), awareness of the need for technical information, consideration of risk-reducing alternative tools or policies, and fair, humane and consistent risk/benefit analysis.The author concludes with a description of the impact on students, the importance of the role model of agriculture teachers in the course with the resultant importance of the team-taught format, and the need for special administrative support to attain the goals of the course. (shrink)

Zeno's paradox as it appears in Aristotle's Physics, Book VI, chapter 9. 239b 15-30.

There has been a growing interest in research concerning memory modification technologies (MMTs) in recent years. Neuroscientists and psychologists are beginning to explore the prospect of controllable and intentional modification of human memory. One of the technologies with the greatest potential to this end is optogenetics—an invasive neuromodulation technique involving the use of light to control the activity of individual brain cells. It has recently shown the potential to modify specific long-term memories in animal models in ways not yet possible (...) with other MMTs. As the therapeutic potential of optogenetics has already prompted approval of the first human trials, it is especially important and timely to consider the opportunities and dangers this technology may entail. In this article, we focus on possible consequences of optogenetics as an MMT by analyzing fundamental threats potentially associated with memory modifications: the potential disruption of personality and authenticity. (shrink)

In their article, Sankary et al. (2022) interviewed participants who underwent implantation (n = 16) and subsequent explantation (n = 9) of brain stimulation devices associated with their recent (n...

Stosunki polsko-węgierskie pozostają czymś niezwykłym na skalę europejską. Choć w świadomości społeczeństw obu narodów dominuje pozytywne postrzeganie wzajemnych relacji, nie było to zjawisko stale występujące w historii. Najintensywniej zachodziło, gdy oba kraje opierały się dominacji pierwiastka germańskiego. Węgry jako pierwsze utraciły niepodległość, ulegając naciskom ze Wschodu. Również Polska podzieliła los Węgier, ulegając presji zarówno ze Wschodu, jak i Zachodu. Doświadczenia historyczne obu krajów pokazały konieczność współdziałania wobec zagrożeń płynących z obu kierunków. Warunki po 1886 roku nie sprzyjały realizacji tego założenia, (...) choć w XIX i XX wieku Polacy i Węgrzy snuli wizje geopolityczne określające skalę możliwych przemian w Europie Środkowej. Zmiana nastąpiła po zakończeniu II wojny światowej. Niezależnie od naturalnie występujących rozbieżności w postrzeganiu własnego otoczenia, w XXI wieku trudno wskazać polską koncepcję geopolityczną, która nie uwzględnia regionalnej roli Węgier, czy też węgierską, ignorującą Rzeczpospolitą Polską. (shrink)