Epigenetic and transcriptional variability contribute to the vast diversity of cellular and organismal phenotypes and are key in human health and disease. In this review, we describe different types, sources, and determinants of epigenetic and transcriptional variability, enabling cells and organisms to adapt and evolve to a changing environment. We highlight the latest research and hypotheses on how chromatin structure and the epigenome influence gene expression variability. Further, we provide an overview of challenges in the analysis of biological variability. An (...) improved understanding of the molecular mechanisms underlying epigenetic and transcriptional variability, at both the intra- and inter-individual level, provides great opportunity for disease prevention, better therapeutic approaches, and personalized medicine. Epigenetic and transcriptional variability mediate phenotypic plasticity, enabling adaptation to changing environments. In this review, we describe the sources of inter- and intra-individual variability and discuss epigenetic regulators of gene expression variability, including DNA methylation and chromatin structure. Understanding these molecular mechanisms will improve therapeutic approaches and personalized medicine. (shrink)

Album photographique consacré au philosophe et écrivain français. Au total, 181 documents en noir et blanc assortis de commentaires assez brefs, répartis dans un ordre thématique (le professeur, l'écrivain, etc.) et en partie chronologique.

While discourse and deliberation cannot replace voting, bargaining, or compromise, Chambers argues, it is important to maintain a background moral conversation in which to anchor other activities.

Emerging from thought-provoking discussions and correspondence Simone Weil had with the Reverend Father Perrin, this classic collection of essays contains her most profound meditations on the relationship of human life to the realm of the transcendant.An enlightening introduction by Leslie Fiedler examines Weil's extraordinary roles as a philosophy teacher turned mystic. "One of the most neglected resources of our century ", Waiting for God will continue to influence spiritual and political thought for centuries to come.

"What is required if men and women are to feel at home in society and are to recover their vitality? Into wrestling with that question, Simone Weil put the very substance of her mind and temperament. The apparently solid edifices of our prepossessions fall down before her onslaught like ninepins, and she is as fertile and forthright in her positive suggestions . . . she can be relied upon to toss aside the superficial and to come to grips with (...) the essential and the profound." -- Time Literary Supplement. (shrink)

Constitutional reform has been an important means to push populist authoritarian agendas in Hungary, Poland, Turkey and Venezuela. The embrace of constitutional means and rhetoric in pursuit of these agendas has led to the growing recognition of ‘populist constitutionalism’ as a contemporary political phenomenon. In all four examples mentioned above, democracy, popular sovereignty and direct plebiscitary appeal to the people is the rhetorical and justificatory framework for constitutional reform. This, I worry, gives democracy a bad name and reinforces the widespread (...) suspicion that citizens should not be directly involved in constitutional reform as popular participation can lead to dangerous majoritarianism and is easily manipulated by elite actors seeking to weaken constitutional checks and balances. But the problem, I argue, is not inherent in citizen’s participation in constitutional reform. In contrast to populist constitutionalism, I develop an idea of deliberative constitutionalism in which citizens can participate in constitution-making and reform without hijacking constitutionalism for majoritarian, nationalist or anti-pluralist ends. Deliberative constitutionalism as I understand it has four features: a Habermasian co-originality thesis that articulates the interdependence of democracy and liberalism mediated by a conception of discourse; a proceduralized idea of popular sovereignty that reduces the tension between appeal to the people and respect for pluralism; the centrality of the public sphere over the voting booth as the cradle of democracy; institutional innovations intended to include citizens in constitutional reform (including through referendums) but avoid majoritarian and populist pathologies. (shrink)

In the reported, experiment participants hit a ball to aim at the vertex of a Müller–Lyer configuration. This configuration either remained stable, changed its shaft length or the orientation of the tails during movement execution. A significant illusion bias was observed in all perturbation conditions, but not in the stationary condition. The illusion bias emerged for perturbations shortly after movement onset and for perturbations during execution, the latter of which allowed only a minimum of time for making adjustments . These (...) findings indicate that allocentric information is exploited for online control when people make rapid adjustments in response to a sudden change in the environment and not when people guide their limb movements to interact with a stable environment. (shrink)

The main goal of the paper is to investigate the relation between indicative conditionals and rationality. We wil l do this by consider- ing several interpretations of a very wel l-known example of reasoning involving conditionals, that is the Wason selection task, and showing how those interpretations have different bearings on the notion of ra- tionality. In particular, in the first part of the paper, after having briefly presented the selection task, we wil l take a look at two prag- (...) matic responses to the chal lenge posed by the task, through Wason ’s notion of confirmation bias and Grice’s theory of conversational im- plicature. The second part wil l introduce Adams’ probabilistic view of indicative conditionals and wil l give reasons for preferring his account to those aforementioned. The conclusion wil l evaluate the question of human rationality in the light of the new standpoint acquired. -/-. (shrink)

The techno-moral scenarios approach has been developed to explore the interplay between technology, society and morality. Focused on new and emerging sciences and technologies, techno-moral scenarios can be used to inform and enhance public deliberation on the desirability of socio-technical trajectories. The article presents an attempt to hybridise this scenario tool, complementing the focus on ethics with an explicit acknowledgement of the multiple meanings of responsibility and of the plurality of its regimes, i.e. the institutional arrangements presiding over the assumption (...) and assignment of responsibilities. We call this integrated technique ‘rTMS’ to stress the continuity with the original technique and, at the same time, to highlight the additional element we aim to develop: responsibility. The article describes this approach and illustrates a loosely standardised procedure that can be used to organise and conduct public engagement workshops based on rTMS. (shrink)

In this article we discuss what are the implications for improving the design of corporate ethics programs, if we focus on the moral motivation accounts offered by main ethical theories. Virtue ethics, deontological ethics and utilitarianism offer different criteria of judgment to face moral dilemmas: Aristotle's virtues of character, Kant's categorical imperative, and Mill's greatest happiness principle are, respectively, their criteria to answer the question "What is the right thing to do?" We look at ethical theories from a different perspective: (...) the question we ask is "Why should I do the right thing?" In other words, we deal with the problem of moral motivation, and we examine the different rationale the main ethical theories provide. We then point out the relation between moral motivation and the concept of rationality in the different approaches - is acting morally seen as an expression of rational behavior? Our analysis of moral motivation provides a useful framework to improve the understanding of the relationships between formal and informal elements of corporate ethics programs, emphasizing the importance of the latter, often overlooked in compliance-focused programs. We conclude by suggesting that the concept of moral imagination can provide a unifying approach to enhance the effectiveness of corporate ethics programs, by providing an intangible asset that supports the implementation of their formal components into management decision making. (shrink)

ABSTRACT Diana Mutz's individual-level data show that participation and deliberation are often inversely related. This, according to Mutz, undermines many claims made by deliberative-democratic theory. However, a systemic approach to deliberative democracy challenges the significance of this finding. Although it is true that some citizens are political activists not open to hearing the other side and other citizens are less active but more open minded, both types of citizens make equally important and positive contributions to deliberative politics when it is (...) viewed as a system that deploys a division of labor. (shrink)

This introduces a series of articles in a themed section entitled City of Potentialities: Race, Violence and Invention. The section concerns how we might think more specifically about how to act in domains where complexity is both a resource for the imagination and an impediment to action. What kinds of dilemmas do residents face and what kinds of practices do they engage in in order to continuously gather up the tools and possibilities to endure in volatile urban conditions, where volatility (...) seems a critical force in the simultaneous undoing and remaking of life, as well as in providing assets and opportunities to inhabitants? How does violence obscure the various manoeuvres and practices that keep things together or apart? (shrink)

When people inhabit a city, they situate themselves and are situated through the intersections of infrastructure and technical systems, and the particular domains and modalities of occupation – settlement and work – that are configured by them. At the same time, people are also inhabited by the city, as a kind of possession, endowment, and series of conundrums. People figure themselves out through figuring arrangements of materials, of designing what is available to them in formats and positions that enable them (...) particular vantage points and ways of doing things. What it is possible for people to do with each other is largely a question of what it is that exists between them, and how this ‘between’ can be shaped as active points of reference, connection and anchorage. Infrastructure exerts a force – not simply in the materials and energies it avails, but also the way it attracts people, draws them in, coalesces and expends their capacities. If territory is a bundle of political technologies for measuring, administering and regulating the scope of what it is possible to do in the city, then other inventive political technologies are also at work in the making of urban life. (shrink)

In Intimations of Christianity Among the Ancient Greeks , Simone Weil discusses precursors to Christian religious ideas which can be found in ancient Greek mythology, literature and philosophy. She looks at evidence of "Christian" feelings in Greek literature, notably in Electra, Orestes, and Antigone , and in the Iliad , going on to examine God in Plato, and divine love in creation, as seen by the ancient Greeks.

Introducing the Selected Works of Simone Weil Some of Simone Weil's most important thinking was done through the medium of her notebooks. She used them in several inter-related ways. First, she used them to note things she had read and was researching. Far more often, they were workbooks where she worked through her ideas. Many of the ideas in her completed essays can first be found in her notebooks, and thus the notebooks are invaluable for adding context and (...) nuance along with a sense of development to the reading of those later essays. Finally, her notebooks simply contain Weil's aphoristic writing at its best in its most striking presentation. For that reason alone, the last two notebooks, which she wrote while in New York and London in 1942-43, published in French as "La Connaissance surnaturel" have been read as books of great wisdom. This volume also includes her first notebook from the year 1934, not long after her time in the factory and its subject matter reflects this period in her life. (shrink)

The term “lean in” was popularized by Sheryl Sandberg, Facebook COO, via her #1 Best Seller encouraging women to defy their fears and dare to be leaders in their fields. She received criticism because although admitting to external barriers contributing to the gender gap in leadership, the scope of her book focused on the internal shortcomings of women. She asserted that women are hindered by barriers that exist within themselves, and provided practical tips, backed by research, to equip women with (...) strategies to proactively progress in the workplace instead of shying away. Sandberg is not the first to raise concern about gender inequality. Other women in history like Susan B. Anthony and Maggie Lena Walker also challenged lopsided gender roles through their words and actions. Using the critical biography methodology, this paper explores these women’s experiences, philosophies and contributions, reflects on Sandberg’s insight, and develops a framework, based on the theory of planned behavior as well as the ethical principles of utilitarianism and corporate social responsibility, that links internal factors, organizational external factors, and societal external factors to intentions to lean in and leaning in behavior. Thus, via critical biography, this paper examines both internal and external factors, showing how they are linked, and how they may impact leaning in intentions and behavior. The paper also discusses how leaning in may influence both individual and gender mobility for women, and ultimately, increased gender equality. (shrink)

The problem of free will lies at the heart of modern scientific studies of consciousness. Some authors propose that actions are unconsciously initiated and awareness of intention is referred retrospectively to the action after it has been performed [e.g. Aarts, H., Custers, R., & Wegner, D. M. . On the inference of personal authorship: Enhancing experienced agency by priming effect information. Consciousness & Cognition, 14, 439–458]. This contrasts with the common impression that our intentions cause those actions. By combining a (...) stop signal paradigm and an intentional action paradigm we show that participants sometimes indicate to have intentionally initiated an action while reaction time data strongly suggest that they in fact failed to stop the action. In a second experiment we demonstrate that the number of trials in which participants misattributed their awareness of intention varied with the intentional involvement during action planning. Our data support the retrospective account of intentional action. Furthermore, we introduce an experimental approach that objectifies introspective judgments of awareness of intention. (shrink)

This book describes a novel methodology for studying algorithmic skills, intended as cognitive activities related to rule-based symbolic transformation, and argues that some human computational abilities may be interpreted and analyzed as genuine examples of extended cognition. It shows that the performance of these abilities relies not only on innate neurocognitive systems or language-related skills, but also on external tools and general agent–environment interactions. Further, it asserts that a low-level analysis, based on a set of core neurocognitive systems linking numbers (...) and language, is not sufficient to explain some specific forms of high-level numerical skills, like those involved in algorithm execution. To this end, it reports on the design of a cognitive architecture for modeling all the relevant features involved in the execution of algorithmic strategies, including external tools, such as paper and pencils. The first part of the book discusses the philosophical premises for endorsing and justifying a position in philosophy of mind that links a modified form of computationalism with some recent theoretical and scientific developments, like those introduced by the so-called dynamical approach to cognition. The second part is dedicated to the description of a Turing-machine-inspired cognitive architecture, expressly designed to formalize all kinds of algorithmic strategies. (shrink)

This book disentangles the complex meanings of responsibility in nanotechnology development by focusing on its theoretical and empirical dimensions. The notion of responsibility is extremely diversified in the public discourse of nanoscale technologies. Addressed are major disciplinary perspectives working on nanotechnology, e.g. philosophy, sociology, and political science, as well as the major multidisciplinary areas relevant to the innovation process, e.g. technology assessment and ethics. Furthermore, the interplay between such expertises, disciplines, and research programmes in providing a multidisciplinary understanding of responsibility (...) is emphasized. (shrink)

Making better choices about future technologies that are being researched or developed is an important motivator behind lay ethics interventions. However, in practice, they do not always succeed to serve that goal. Especially authors who have noted that lay ethicists sometimes take recourse to well-known themes which stem from old, even ‘archetypical’ stories, have been criticized for making too little room for agency and decision-making in their approach. This paper aims to contribute to a reflection on how lay ethics can (...) acquire more practical relevance. It will use resources in narrative ethics to suggest that in order to be relevant for action, facilitators of lay ethics interventions need to invite participants to engage in a narrative quest. As part of a quest, lay ethicists should be asked to reflect on a specific question or choice, use diverse input which is informative about the heterogeneity of viewpoints that are defended in society and argue for their standpoints. (shrink)

In this paper, I argue that the asymmetrical mediated communication of the broad democratic public sphere can profitably be understood through the lens of deliberative democracy only if we adopt a system approach to deliberation. A system approach, however, often introduces a division of labor between ordinary citizens and experts. Although this division of labor is unavoidable and I believe compatible with a deliberative principle of legitimacy, it flirts with elitist theories of democracy: epistemic elites come up with the agendas, (...) ideas, and policy positions and democratic publics ratify or repudiate the agendas but do not generate or really engage with them. This I argue would violate an essential defining feature of deliberative democracy, namely that epistemic quality and equal participation are tightly linked. I turn to Habermas and his idea of a feedback loop as a possible solution to this dilemma. (shrink)

Simone Weil's Leçons de Philosophie are derived from a course she taught at the lyce;e for girls at Roanne in 1933-4. Anne Reynaud-Gue;rithault was a pupil in the class; her notes are not a verbatim record but are a very full and, as far as one can judge, faithful rendering, often catching the unmistakable tone of Simone Weil's voice as well as the force and the directness of her thought. The lectures form a good general introduction to philosophy, (...) ranging widely over problems about perception, mind, language, reasoning and problems in moral and political philosophy too. Her method of presentation is a characteristic combination of abstract argument, personal experience and literary or historical reference. Peter Winch points out in his introduction to the book some of the more systematic connections in her philosophical work (and between this philosophical work and her other concerns), and makes a number of suggestive comparisons between Simone Weil and Wittgenstein. The translation is by Hugh Price from the Plon edition of 1959. Dr Price has added some notes to explain references in the text that might be unfamiliar to English speaking students beginning philosophy. (shrink)

This text considers how a host of ethical traditions define civil society.

Although developmental dyslexia (DD) is frequently associate to a phonological deficit, the underlying neurobiological cause remain undetermined. One prominent hypothesis suggests a specific deficit in magnocellular-dorsal (M-D) pathway. Here we investigated the visual M-D and parvocellular-ventral (P-V) pathway in dyslexic and in chronological age and IQ-matched normally reading children by measuring dynamic (frequency doubling illusion) and static stimuli sensibility, respectively. A specific deficit in M-D task was found. Importantly, the M-D deficit was selectively shown in poor phonological decoders. M-D deficit (...) appears to be frequent because 75% of poor pseudo-word readers were at least 1 SD below the mean of the controls. Finally, a replication study by using a new group of poor phonological decoders and reading level controls suggests a possible role of M-D deficit in DD. These results showed that a M-D deficit might impair the sub-lexical mechanisms that are critical for reading development. The possible link between these findings and the oscillatory “temporal sampling” framework is discussed. (shrink)