"Deep Words contains translations of "Honso, the "Core Text" of "Gengo, by Miura Baien, 1723-1789 - a widely renowned Japanese teacher and writer of his time; ...

Alternative cleavage and polyadenylation (APA) can diversify coding and non‐coding regions, but has particular impact on increasing 3′ UTR diversity. Through the gain or loss of regulatory elements such as RNA binding protein and microRNA sites, APA can influence transcript stability, localization, and translational efficiency. Strikingly, the central nervous systems of invertebrate and vertebrate species express a broad range of transcript isoforms bearing extended 3′ UTRs. The molecular mechanism that permits proximal 3′ end bypass in neurons is mysterious, and only (...) beginning to be elucidated. This landscape of neural 3′ UTR extensions, many reaching unprecedented lengths, may help service the unique post‐transcriptional regulatory needs of neurons. A combination of approaches, including transcriptome‐wide profiling, genetic screening to identify APA factors, biochemical dissection of alternative 3′ end formation, and manipulation of individual neural APA targets, will be necessary to gain fuller perspectives on the mechanism and biology of neural‐specific 3′ UTR lengthening. (shrink)

Since the 1990s, the relation between liberalism and colonialism has been one of the most important issues in Locke studies and also in the field of modern political thought. This present work is a unique contribution to discussion of this issue in that it elucidates Lockeâ (TM)s concept of the law of nature and his view of war. Lockeâ (TM)s law of nature includes, despite its ostensible universal validity, some particular rules which favour the rights of a European form of (...) political society and individualistic land-acquisition at the sacrifice of native traditional land-rights and subsistence. Concerning wars between settlers and the natives, Lockeâ (TM)s concept of â oepunishmentâ in state of nature allows the militarily superior side to make a war with the inferior in disregard for the latterâ (TM)s claim and nevertheless, after winning victory, proclaim its own just cause of war. By putting Lockeâ (TM)s discourse on colonization and war in the context of contemporary relations between English colonists and the natives, this book makes clear that the expansive element of his theory of property actually overbalanced his rule of limitation of property according to equitableness and that it, after all, undermines the general principles of freedom and equality of all in his law of nature. (shrink)

Biological forms are very complex, and mechanisms of pattern formation are not well understood. Although developmental biology deals with the mechanistic explanation of patterns, currently we do not know how to understand the mechanisms of pattern formation from huge amounts of molecular information. In this article, I present one useful tool, mathematical modeling, to obtain a mechanistic understanding of biological pattern formation, and show an actual example in lung branching morphogenesis. In this example, mathematical modeling plays an indispensable role in (...) understanding the biological phenomena. The model successfully reproduces the basic features of morphogenesis in vitro, but mechanism in vivo still remains to be elucidated. (shrink)

Les trois modèles d'intégration politique au sein de l'espace francophone sont analysés d'un point de vue japonais. Le premier est « le modèle républicain » de tolérance ou le modèle français de « nation citoyenne ». Le second est le modèle nord-américain de « multiculturalisme » respectueux de la différence et de l'Autre. Et le troisième est le modèle antillais d'identité créole, identité multiple et composite forgée par un processus ininterrompu de rencontres et de métissages culturels. Ces modèles sont confrontés (...) les uns aux autres du point de vue de la gestion des sociétés pluriculturelles.Three models of political integration are compared in the francophone space. The French Republican model is compared with the North America’s multicultural model and with the Creole model born in the Caribbean. Whereas the second model seems to take into account ethnicity differentiation, it doe not propose, like the first one, any values to develop cultural diversity and solidarity. The Creole model is said to be very useful theoretically but does not offer a political alternative. (shrink)

In motion-induced blindness , a target within rotating random dots is occasionally hidden from observers’ consciousness during observation. In the present study, a red ring-like cue was centered on a target and presented immediately after observers reported subjective disappearance of the target in MIB . The radius of the cue was systematically modulated. Observers quickly regained awareness of the disappeared object only after they were provided with a pinpoint cue of its location. We also found that a flickering cue at (...) 1 Hz hindered MIB when the radius of the cue was critically small . Furthermore, abrupt onset of a small square was enough to regain awareness of the target . Successful revival of the target with a small cue indicates that critical spatial distribution of visual attention determines what in the visual scene is included in visual awareness. (shrink)

This research was conducted to examine the psychological profiles of people who publish their weblogs on the Internet and the characteristics of their community. Weblogs can be defined as online sites, not owned by major corporations, which are frequently updated by one or more people. Weblogs provide an opportunity to develop communication through information sharing with other Internet users. Our particular focus is on authors of “informative” weblogs, who have a powerful desire to provide information and share their knowledge, rather (...) than other weblog forms, such as “diary-like” weblogs, in which the authors have a more powerful need for self-disclosure and the resulting interactions. The results of online author surveys suggested that the system of weblog have many benefits for supporting knowledge community and the weblog authors were oriented to reciprocal information interchange and perceive much psychological benefits from it. (shrink)

ABSTRACTWe tested the response dynamics of the evaluative priming effect using a mouse tracking procedure that records hand movements during the execution of categorisation tasks. In Experiment 1, when participants performed the evaluative categorisation task but not the non-evaluative semantic categorisation task, their mouse trajectories for evaluatively incongruent trials curved more toward the opposite response than those for evaluatively congruent trials, indicating the emergence of evaluative priming effects based on response competition. In Experiment 2, implementing a task-switching procedure in which (...) evaluative and non-evaluative categorisation tasks were intermixed, we obtained reliable evaluative priming effects in the non-evaluative semantic categorisation task as well as in the evaluative categorisation task when participants assigned attention to the evaluative stimulus dime... (shrink)

The “Human Genome Project” was completed in 2003, shifting the focus to proteome and transcriptome research. One approach to proteomics involves the comprehensive visualization of the localization of proteins in all tissues and organs. We discuss in situ phospho‐protein atlases, which are systematized representations of the localization of proteins. Protein atlases provide important information about the identity and presence of proteins in specific organs, tissues and cells under physiological and pathological conditions. Antibody‐based immunohistochemical analysis is a powerful method for generating (...) a protein atlas. However, it is difficult to localize phosphorylated proteins under in vivo physiological conditions, even with immunohistochemistry, because these proteins tend to be dephosphorylated or phosphorylated due to the experimental manipulations. We also discuss an improved immunohistochemical method for precisely detecting phosphorylated protein, using the detection of phosphorylated ERK1/2 as an example. We consider that it is possible and useful to generate a phospho‐protein atlas. (shrink)