The Myelin Regulator Factor (MYRF) is a master regulator governing myelin formation and maintenance in the central nervous system. The conservation of MYRF across metazoans and its broad tissue expression suggest it has functions extending beyond the well‐established role in myelination. Loss of MYRF results in developmental lethality in both invertebrates and vertebrates, andMYRFhaploinsufficiency in humans causesMYRF‐related Cardiac Urogenital Syndrome, underscoring its importance in animal development; however, these mechanisms are largely unexplored. MYRF, an unconventional transcription factor, begins embedded in the (...) membrane and undergoes intramolecular chaperone mediated trimerization, which triggers self‐cleavage, allowing its N‐terminal segment with an Ig‐fold DNA‐binding domain to enter the nucleus for transcriptional regulation. Recent research suggests developmental regulation of cleavage, yet the mechanisms remain enigmatic. While some parts of MYRF's structure have been elucidated, others remain obscure, leaving questions about how these motifs are linked to its intricate processing and function. (shrink)

The asymmetric distribution of lipids, maintained by flippases/floppases and scramblases, plays a pivotal role in various physiologic processes. Scramblases are proteins that move phospholipids between the leaflets of the lipid bilayer of the cellular membrane in an energy‐independent manner. Recent studies have indicated that viral infection is closely related to cellular lipid distribution. The level and distribution of phosphatidylserine (PtdSer) in cells have been demonstrated to be critical regulators of viral infections. Previous studies have supported that the infection of human (...) immunodeficiency virus (HIV), Zika virus, Ebola virus (EBOV), influenza virus, and dengue fever virus require the externalization of phospholipids mediated by scramblases, which are also involved in the pathogenicity of the pandemic severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). In this review, we review the relationship of scramblases with viruses and the potential viral effector proteins that might utilize host scramblases. (shrink)

Im Jahr 2002 wurde seitens der chinesischen Regierung die Forderung der Entfaltung der exzellenten nationalkulturellen Tradition aufgestellt. Nach einem Kultur-Gipfelforum mit dem Hauptthema "Globalisierung und die Chinesische Kultur" unter der Leitung von bedeutenden Wissenschaftlern wie Ren Jiyu, Ji Xianlin u. a. im Jahre 2004 stieg die Wertschätzung des Konfuzianismus als Kernbestandteil "exzellenter Nationalkultur". Folglich wächst heutzutage das Interesse an konfuzianischen Klassikern wieder, vorwiegend für Lunyu. Infolge des gestiegenen Interesses versuchten Autoren im neuen Zeitalter in China, diesen Klassiker neu auszulegen. Am (...) bekanntesten wurden die Bücher von Yu Dan. Einflussreich waren auch die Interpretationen von Li Ling und He Xin. Folglich werden diese neuen Interpretationen hier als Formen der Rekonstruktion der konfuzianischen Tradition behandelt und in drei Arten klassifiziert: volkstümlich, populärwissenschaftlich sowie akademisch. Die Theorie dieser Forschungsarbeit stützt sich auf dem Traditionsbegriff. Infolgedessen wird die Tradition aus der neologistischen Perspektive, im alltagssprachlichen Bezug, nach politischem Verständnis und im wissenschaftlichen Gebiet analysiert. Dann wird die Tradition als ein Konstrukt definiert, das aus über Generationen weitergegebenen Kulturelementen besteht. Daher wird der Konfuzianismus sowohl als ein bedeutsames Element der chinesischen Tradition als auch als eine konfuzianische Tradition betrachtet. Die Forschung wählt drei einflussreiche Interpretationen dieser Art aus, um einen kritischen Zugang zum Prozess der Neuschaffung von "Tradition" im gegenwärtigen China zu finden. Die Interpretationen scheinen die Nachfrage und Erwartungen von Gesellschaft und Politik gleichermassen zu befriedigen und können daher als Linsen dienen, mittels derer wichtige soziale und politische Anliegen und Entwicklungen Chinas seit der Jahrtausendwende in Augenschein genommen werden können. (shrink)

本书从唐君毅先生提出的“中国艺术精神”开始论述,分析了中国艺术精神的多层面向进而深入分析其阐释的意义;继而,本书对徐复观先生深入的研究进行了解读和探索,一直延续到今日学界的研究和探索,并对“中国艺术精 神”在世纪之交时发生的转向给出了结论.

As an enabler of environmental sustainability, Green information technology (IT) has become an emerging topic of interest in both academic and business communities. Despite its importance, confusions exist in the content and scope of Green IT practice. The purpose of this paper is to provide an overview of the current state of Green IT practice.,First 14 widely accepted Green IT practice topics were identified from prior research and a taxonomy was developed to categorize them. Using the content analysis method, these (...) topics were examined in the sustainability reports of 30 IT companies in 2014 Fortune 500. A quantity–quality portfolio framework was developed and applied to measure and assess the Green IT practices of the selected samples.,Currently, the Green IT practice is still in its infancy. Both research and practice attention are now focusing on IT’s direct impacts and enabling impacts, while overlooking the systemic impacts, on natural environment. The possible reasons for the current state and the recommendations for future research and practice are provided.,Theoretically, this paper identified 14 widely accepted Green IT practice topics and developed a taxonomy for categorizing them. The taxonomy and topics provide a theoretical basis for future examination on Green IT practice-related issues. Practically, the findings of this paper provide guidelines for Green IT practice and directions for both Green IT developers and adopters in their decision-making. (shrink)

本书评介了普列汉诺夫及其美学思想,尤其是从艺术的起源、艺术与社会心理等方面讨论了普列汉诺夫的观点,提出许多新的见解。.

Computational modeling and eye-tracking were used to investigate how phonological and semantic information interact to influence the time course of spoken word recognition. We extended our recent models to account for new evidence that competition among phonological neighbors influences activation of semantically related concepts during spoken word recognition . The model made a novel prediction: Semantic input modulates the effect of phonological neighbors on target word processing, producing an approximately inverted-U-shaped pattern with a high phonological density advantage at an intermediate (...) level of semantic input—in contrast to the typical disadvantage for high phonological density words in spoken word recognition. This prediction was confirmed with a new analysis of the Apfelbaum et al. data and in a visual world paradigm experiment with preview duration serving as a manipulation of strength of semantic input. These results are consistent with our previous claim that strongly active neighbors produce net inhibitory effects and weakly active neighbors produce net facilitative effects. (shrink)

Assuming the existence of a measurable cardinal, we define a hierarchy of Ramsey cardinals and a hierarchy of normal filters. We study some combinatorial properties of this hierarchy. We show that this hierarchy is absolute with respect to the Dodd-Jensen core model, extending a result of Mitchell which says that being Ramsey is absolute with respect to the core model.

Work procrastination is a retreat behavior associated with negative cognitive experience and it results in great losses to individual as well as organizational development. Understanding the antecedents of employees’ work procrastination behavior contributes to lower frequency of its occurrence. This research builds a dual-moderated mediation model from the perspective of cognitive appraisal theory and explored work procrastination behavior of employees subjected to abusive supervision. With 378 valid returned questionnaires, data collected from 32 companies in Beijing, Shanghai, Tianjin, and Chongqing supports (...) our hypotheses. This result has enriched the understanding of work procrastination behavior and provided practical implications to avoide its negative effects. (shrink)

本书以宽广的哲学视野,分析了法治与德治及其相互关系的历史演变,指出了两者之间存在着“合—分—合”的历史运动,社会主义社会中法治与德治之间是一个不可分割的“法治—人—德治”双向动互动关系链条,坚持“以人 为本”进行法治与德治建设是构建社会主义和谐社会的必然选择。.

Expect for formal contracts, there are informally unwritten psychological contracts in the relationship between buyer and supplier for construction projects. The PC can affect the construction project performance and even cause project failure, but its process and formation are complex and not comprehensive in existing researches. This paper analyzes the PC between buyer and supplier by using evolutionary game and repeated game to tackle this gap. The results show the following: the goodwill and interest have an important impact on PC (...) fulfillment. The PC is vulnerable; for example, once either one fails to perform PC, the other will also destroy PC, and then the construction project will enter a vicious circle. In the process of repeated game, the effect of goodwill will gradually disappear, and the interest will play a major role. If the project performance is only linked to one participant, it will lead to breach from another player. Some measures may help both sides to complete PC, such as making both sides profitable, increasing the emphasis on business reputation, and improving the relevance of construction projects performance. (shrink)

Philosophy; ancient civilizations; history.

In cells, microtubules (MTs) assemble from α/β‐tubulin subunits at nucleation sites containing the γ‐tubulin ring complex (γ‐TuRC). Within the γ‐TuRC, exposed γ‐tubulin molecules act as templates for MT assembly by interacting with α/β‐tubulin. The vertebrate γ‐TuRC is scaffolded by γ‐tubulin‐interacting proteins GCP2‐6 arranged in a specific order. Interestingly, the γ‐tubulin molecules in the γ‐TuRC deviate from the cylindrical geometry of MTs, raising the question of how the γ‐TuRC structure changes during MT nucleation. Recent studies on the structure of the vertebrate (...) γ‐TuRC attached to the end of MTs came to varying conclusions. In vitro assembly of MTs, facilitated by an α‐tubulin mutant, resulted in a closed, cylindrical γ‐TuRC showing canonical interactions between all γ‐tubulin molecules and α/β‐tubulin subunits. Conversely, native MTs formed in a frog extract were capped by a partially closed γ‐TuRC, with some γ‐tubulin molecules failing to align with α/β‐tubulin. This review discusses these outcomes, along with the broader implications. (shrink)

Examining the influence of trust in fostering knowledge sharing behavior in virtual teams is of great research value in the current complex, dynamic, and competitive era of a knowledge economy. This study investigated the relationship between trust in coworkers and KSB. Based on social information processing theory and social cognitive theory, we developed a multilevel moderated mediation model where the team members’ psychological safety was considered a mediator, while team virtuality and knowledge sharing self-efficacy acted as team and individual-level moderators, (...) respectively. On surveying 282 individuals in 37 virtual teams of three Chinese internet companies, we found that TC positively affected team members’ KSB and this relationship was fully mediated by team members’ PS. Our findings also demonstrated that the effect of TC on KSB depended on the degree of TV and employees’ KSSE. Specifically, when TV and KSSE were higher, the TC–PS and PS–KSB relationship and the mediating effects of PS in the TC–PS–KSB relationship were all stronger. Our study extends the trust-KSB literature by identifying the psychological mechanism and boundary conditions in the TC-KSB relationship. Moreover, our findings also offer valuable managerial implications for virtual team managers on facilitating team members’ PS and KSB. (shrink)

We show that a cardinal κ is a (strongly) Mahlo cardinal if and only if there exists a nontrivial κ-complete κ-normal ideal on κ. Also we show that if κ is Mahlo and λ ≥ κ and $\lambda^{ then there is a nontrivial κ-complete κ-normal fine ideal on P κ (λ). If κ is the successor of a cardinal, we consider weak κ-normality and prove that if κ = μ + and μ is a regular cardinal then (1) $\mu^{ if (...) and only if there is a nontrivial κ-complete weakly κ-normal ideal on κ, and (2) if $\mu^{ then there is a nontrivial κ-complete weakly κ-normal fine ideal on P κ (λ). (shrink)

A vehicle-commodity matching problem is presented for service providers to reduce the cost of the logistics system. The vehicle classification model is built as a Gaussian mixture model, and the expectation-maximization algorithm is designed to solve the parameter estimation of GMM. A nonlinear mixed-integer programming model is constructed to minimize the total cost of VCMP. The matching process between vehicle and commodity is realized by GMM-EM, as a preprocessing of the solution. The design of the vehicle-commodity matching platform for VCMP (...) is designed to reduce and eliminate the information asymmetry between supply and demand so that the order allocation can work at the right time and the right place and use the optimal solution of vehicle-commodity matching. Furthermore, the numerical experiment of an e-commerce supply chain proves that a hybrid evolutionary algorithm is superior to the traditional method, which provides a decision-making reference for e-commerce VCMP. (shrink)

Article aims to explore Augustine's "two cities" theory. First, a brief discussion of the "City of God" writing background and the main structure; Secondly, in both religious and secular aspects of life on the analysis of the "City of God" on the "two cities" of the main points; again, three perspectives of the "two cities" theory of history and ideological background. Although the "two cities" doctrine embodies a form with two points tend to think, but both different from the ontological (...) dualism and the dualism of body and soul, but also avoids the complex social reality for too absolute two points. The focus of this study is Augustine's doctrine of the "Two Cities." The first part treats the background and the structure of the City of God. In the second and the third part, the essay examines both the religious and the temporal aspect of this doctrine. Finally, the historical and intellectual background of the doctrine is discussed. The author argues that even though the doctrine of the "Two Cities" manifests a dualistic tendency in the thought of Augustine, it can hardly be labeled as a dualism. (shrink)