Background Sharing of genomic data aims to make efficient use of limited resources, which may be particularly valuable in rare disease research. Adult research participants and parents of pediatric research participants have shown support for data sharing with protections, but little is known about adolescent attitudes on genomic privacy and data sharing.Methods In-depth interviews were conducted with 10 adolescents and 18 parents of children enrolled in a pediatric genomic research repository. Interview transcripts were analyzed for themes on attitudes toward genomic (...) privacy, restricted-access data sharing, and open-access data sharing. Findings in adolescent and parent participants were compared and contrasted.Results No adolescents endorsed privacy concerns for restricted-access data sharing. Both adolescents and parents saw value in data sharing for reaching the goals of research and discussed trust in institutions and researchers to protect their data and use it as intended. Adolescents were more likely than parents to accept open-access data sharing, including after risks were discussed.Conclusions In this exploratory study, adolescents and parents enrolled in a genomic research repository shared many attitudes about genomic data sharing, but adolescents were less concerned about privacy and more agreeable toward open-access data sharing. Future research is needed to investigate this hypothesis in expanded populations and settings, and to clarify whether adolescent attitudes change with age and experiences. (shrink)

In 1999, Neale Donald Walsch wrote three little books, each focusing on different areas of life: Neale Donald Walsch on Relationships, Neale Donald Walsch on Holistic Living, and Neale Donald Walsch on Abundance and Right Livelihood. In 2010, these three books were published in a single volume as Neale Donald Walsch's Little Book of Life. Walsch describes this book as a thousand pages of dialogue in the Conversations with God series reduced down to a few salient points and a few (...) very direct observations about how to render them functional. Readers can think of this book as either Conversations with God in a Nutshell or the Essential Conversations with God. Here are the basic principles for: Satisfying personal relationships; Living a joyful, harmonious life; Discovering authentic prosperity. Walsch's words provide hope and help for readers living in particularly challenging times. This is indeed Walsch's essential life guide for twenty-first century readers."--Back cover. (shrink)

Participation in experimental studies can be conceptualized as Goffmanian frames, i.e. a set of rules which include the fact the experimenter will be observing participant behavior through (the recording of) the experiment. This study is focused on frame breaches in 16 video- and audio-recorded dyadic conversations taking place in an experimental setting. Our main conclusion is that the experimental frame is conceptualized by participants as including constraints that go beyond non-experimental interactions, and in particular the need to mitigate frame breaches, (...) which are seen as face-threatening. Analyses revealed that participants only broke the research frame after they completed the task they were assigned by the researcher, and that breaches did not necessarily correspond to changes in key. Insights gained in relation to face and mitigation are discussed, as well as the participants’ need to determine their next steps once the research purpose has been perceived complete. (shrink)

Why do American ghettos persist? Decades after Moynihan’s report on the black family and the Kerner Commission’s investigations of urban disorders, deeply disadvantaged black communities remain a disturbing reality. Scholars and commentators today often identify some factor―such as single motherhood, joblessness, or violent street crime―as the key to solving the problem and recommend policies accordingly. But, Tommie Shelby argues, these attempts to “fix” ghettos or “help” their poor inhabitants ignore fundamental questions of justice and fail to see the urban (...) poor as moral agents responding to injustice. (shrink)

The dialogue focuses on the major issues of the contemporary theoretical debate on judicial review and the Supreme Court's role in American constitutional democracy. The discussion begins with the US Supreme Court's case Hamdan v. Rumsfeld, successfully argued by Prof. Katyal last year, and covers important issues such as the separation and balance of powers after 9/11, the legitimacy of the laws of terror, the relation between US constitutional law and foreign law, the counter‐majoritarian difficulties posed by the exercise of (...) judicial review, and the legal academy's influence on legal practice. (shrink)

In this study, we test the interactive effect on ethical decision-making of (1) personal characteristics, and (2) personal expectanciesbased on perceptions of organizational rewards and punishments. Personal characteristics studied were cognitive moral developmentand belief in a just world. Using an in-basket simulation, we found that exposure to reward system information influenced managers’ outcome expectancies. Further, outcome expectancies and belief in a just world interacted with managers’ cognitive moral development to influence managers’ ethical decision-making. In particular, low-cognitive moral development managers who (...) expected that their organization condoned unethical behavior made less ethical decisions while high cognitive moral development managers became more ethical in this environment. Low cognitive moral development managers also behaved less ethically when their belief in a just world was high. (shrink)

ABSTRACTIn Therapeutic Nations, Dian Million highlights the complicated role that neoliberal arenas like the Truth and Reconciliation Commission and international dialogues concerning human rights play in the marginalization of Indigenous communities. Neoliberal arenas are empowered by sociopolitical imaginaries, or a metaphorical moral fabric of a given community, that consist in discursive content and affective, felt knowledge. According to Million, the sociopolitical imaginaries that give weight and context to negative stereotypes about Indigenous peoples are the same sociopolitical imaginaries that empower neoliberal (...) arenas. In a sense, the proposed solutions are ‘cut from the same cloth’ as the causes of settler colonial violence. Million does not directly apply her argument to Indigenous language reclamation, but Million’s conceptions of sociopolitical imaginaries and paradoxically imposed neoliberal arenas are useful for framing a discussion of the potential harms in some Indigenous language reclamation projects, specifically, revitalization programming described by UNESCO and those pursued by U.S. research universities. I aim to show that some of these proposed solutions to Indigenous language loss are cut from the very same cloth, justified by the same sociopolitical imaginaries, as attempted linguicide itself. (shrink)

Much evidence suggests that, from a young age, humans are able to generalize information learned about a subset of a category to the category itself. Here, we propose that—beyond simply being able to perform such generalizations—people are biased to generalize to categories, such that they routinely make spontaneous, implicit category generalizations from information that licenses such generalizations. To demonstrate the existence of this bias, we asked participants to perform a task in which category generalizations would distract from the main goal (...) of the task, leading to a characteristic pattern of errors. Specifically, participants were asked to memorize two types of novel facts: quantified facts about sets of kind members and generic facts about entire kinds. Moreover, half of the facts concerned properties that are typically generalizable to an animal kind, and half concerned properties that are typically more idiosyncratic. We predicted that—because of the hypothesized bias—participants would spontaneously generalize the quantified facts to the corresponding kinds, and would do so more frequently for the facts about generalizable properties. In turn, these generalizations would lead to a higher rate of quantified-to-generic memory errors for the generalizable properties. The results of four experiments supported this prediction. Moreover, the same generalizable-versus-idiosyncratic difference in memory errors occurred even under cognitive load, which suggests that the hypothesized bias operates unnoticed in the background, requiring few cognitive resources. In sum, this evidence suggests the presence of a powerful bias to draw generalizations about kinds. (shrink)

State violence against disabled people and Indigenous people as well as disabled Indigenous people has long been endemic in the US. Recent scholarship in philosophy of disability and disability studies rarely addresses the underlying issue that causes such state violence: settler-colonial conceptions of land. The aim of this article is to begin filling this gap in the literature. We detail settler colonial epistemologies and argue that the property relation underwrites operative concepts of accessibility dominant across disability theory. We show how (...) such concepts of accessibility are Lockean and thereby defined terms of the project of settler colonialism. We instead offer an Indigenized account of access, which we term deep access, that does not rely on the notion of Lockean property and that provides a coalitional path for Indigenous futures and disability justice. On our account, decolonization is and must be a deep access measure. (shrink)

An incisive and sympathetic examination of the case for ending the practice of imprisonment Despite its omnipresence and long history, imprisonment is a deeply troubling practice. In the United States and elsewhere, prison conditions are inhumane, prisoners are treated without dignity, and sentences are extremely harsh. Mass incarceration and its devastating impact on black communities have been widely condemned as neoslavery or “the new Jim Crow.” Can the practice of imprisonment be reformed, or does justice require it to be ended (...) altogether? In The Idea of Prison Abolition, Tommie Shelby examines the abolitionist case against prisons and its formidable challenge to would-be prison reformers. Philosophers have long theorized punishment and its justifications, but they haven’t paid enough attention to incarceration or its related problems in societies structured by racial and economic injustice. Taking up this urgent topic, Shelby argues that prisons, once reformed and under the right circumstances, can be legitimate and effective tools of crime control. Yet he draws on insights from black radicals and leading prison abolitionists, especially Angela Davis, to argue that we should dramatically decrease imprisonment and think beyond bars when responding to the problem of crime. While a world without prisons might be utopian, The Idea of Prison Abolition makes the case that we can make meaningful progress toward this ideal by abolishing the structural injustices that too often lead to crime and its harmful consequences. (shrink)

Considerable evidence from preclinical and clinical investigations implicates disturbances of brain dopamine (DA) function in the pathophysiology of several psychiatric and neurologic disorders. We describe a neural model that may help organize theseindependent experimental observations. Cortical regions classically associated with the limbic system interact with infracortical structures, including the nucleus accumbens, ventral pallidum, and dorsomedial nucleus of the thalamus. In our model, overactivity in forebrain DA systems results in the loss of lateral inhibitory interactions in the nucleus accumbens, causing disinhibition (...) of pallidothalamic efferents; this in turn causes rapid changes and a loss of focused corticothalamic activity in cortical regions controlling cognitive and emotional processes. These effects might be manifested clinically by some symptoms of psychoses. Underactivity of forebrain DA results in excess lateral inhibition in the nucleus accumbens, causing tonic inhibition of pallidothalamic efferents; this perpetuates tonic corticothalamic activity and prevents the initiation of new activity in other critical cortical regions. These effects might be manifested clinically by some symptoms of depression. This model parallels existing explanations for the etiology of several movement disorders, and may lead to testable inferences regarding the neural substrates of specific psychopathologies. (shrink)

Despite a long period of neglect, research on emotion in organizational behavior has developed into a major field over the past 15 years, and is now seen to be part of an affective revolution in the organization sciences. In this article, we review current research on emotion in the organizational behavior field based on five levels of analysis: within person, between persons, dyadic interactions, leadership and teams, and organization-wide. Specific topics we cover include affective events theory, state and trait affect (...) and mood, emotional intelligence, emotional labor, emotional contagion, emotions and leadership, and building a healthy emotional climate. We conclude with suggestions for future research. (shrink)

Marxists often make claims about the content, causes, and social functions of ideologies. Perhaps the most iconoclastic of these is the thesis that mortality is ideological . But given certain other commitments of Marxism, it is difficult to make sense of this thesis, let alone assess its truth. For while clearly the moral ideology thesis is meant as a severe criticism of morality, one that seems to preclude Marxism from consistently offering a moral critique of class societies, Marxists seem to (...) be employing a form of moral critique when they claim that class societies are exploitative. This is, of course, one version of the familiar "paradox" of Marxism's attitude toward morality. ;There are roughly three ways to dissolve this "paradox" within Marxism: Reject, or weaken, the moral ideology thesis so that Marxism can consistently offer a moral critique of class-structured societies; accept the moral ideology thesis and treat Marxism as a non-evaluative "science," rejecting the critical enterprise of Marxism altogether; or accept the moral ideology thesis, along with its implication that the moral critique of class societies is incompatible with certain basic commitments of Marxism, but show that this does not undermine the Marxist critical project. In this dissertation, I defend the moral ideology thesis in accordance with strategy . ;I argue that ideologies are illusory forms of social consciousness that function to stabilized relations of domination and exploitation and that tend to be accepted by agents because of the unconscious influence of their class interests or class position on their beliefs. I defend the moral ideology thesis by showing that morality exhibits these ideological characteristics. To resolve the tension between the moral ideology thesis, the thesis that class societies are exploitative, and the Marxist critique of class society, I explain how the Marxist theory of exploitation forms the basis of a nonmoral critique of class societies. And I argue that the critique of moral ideology in fact supports, rather than undermines, the thesis that class societies are exploitative. (shrink)

Despite the fact that the reductio ad absurdum argument is a valid deductive form, while the slippery slope argument is most often presented as a fallacious form of inductive argument, the two argument types bear some striking similarities. Investigation of these similarities reveals some more universal difficulties in the teaching of informal logic, and, in particular the difference between strong informal arguments and fallacious ones.

When philosophers talk about descriptions, usually they have in mind singular definite descriptions such as ‘the finest Greek poet’ or ‘the positive square root of nine’, phrases formed with the definite article ‘the’. English also contains indefinite descriptions such as ‘a fine Greek poet’ or ‘a square root of nine’, phrases formed with the indefinite article ‘a’ (or ‘an’); and demonstrative descriptions (also known as complex demonstratives) such as ‘this Greek poet’ and ‘that tall woman’, formed with the demonstrative articles (...) ‘this’ and ‘that’. Following the custom in philosophy, in this chapter often we use ‘description’ as short for ‘definite description’; and following the custom in linguistics, often we use ‘definite’, ‘indefinite’, and ‘demonstrative’ as shorthand nouns. For the most part we focus on definite and indefinites, although a few words about demonstratives are called for. At the centre of debates about descriptions is the matter of whether they are devices of reference or of predication (simple or higher-order), and much discussion focuses on how various proposals are to be incorporated into broader theories of the semantics of natural language. But philosophical interest goes beyond the confines of linguistics, logic, and the philosophy of language because choices made about the semantics of descriptions have repercussions elsewhere, particularly in epistemology and metaphysics. A simple match of form and meaning appears to fail.1 First, many occurrences of expressions of both forms ‘the φ’ and ‘a φ’ appear to be used to talk about particular individuals. Consider (1). (shrink)

It is commonly assumed that we currently face a climate crisis insofar as the climatological effects of excessive carbon emissions risk destabilizing advanced civilization and jeopardize cherished modern institutions. The threat posed by climate change is treated as unprecedented, demanding urgent action to avert apocalyptic conditions that will limit or even erase the future of all humankind. In this essay, we argue that this framework—the default climate crisis motif—perpetuates a discursive infrastructure that commits its proponents, if unwittingly, to logics that (...) ultimately reinforce the dynamics driving climate change and its attending injustices. By centering Indigenous feminist environmental discourses, which privilege the role of richly interweaving networks of responsibilities composing extended more-than-human kinship arrangements, we contend that climate crisis is instead primarily a manifestation of devastating multidimensional relational disruptions of Indigenous lands and lives. More pointedly, it is a rebound effect of centuries of accumulating colonial injustices against responsible lifeways that are critical for socioecological adaptability and responsiveness. Framing climate crisis as relational crisis hereby creates discursive space for much needed transformational Indigenous feminist visions for justly and effectively addressing climate change. (shrink)

In this close examination of the social and political thought of Marcus Tullius Cicero, Neal Wood focuses on Cicero's conceptions of state and government, showing that he is the father of constitutionalism, the archetype of the politically conservative mind, and the first to reflect extensively on politics as an activity.

Despite the frequent interpretation of any Early-Christian-era art that contains both Christian and pagan imagery as being solely Christian in meaning, this paper argues that the identification of these images as being Christian in nature, with the pagan imagery only present as borrowed ideas to support a Christian message, is problematic. By assessing some of the existing scholarship surrounding this topic, I attempt to problematize the assumptions made that lead to these widely-accepted interpretations.

Scholars in language and social interaction have long been concerned with the role of texts in institutional settings, studying, for example, how interview schedules actively shape conversational dynamics between participants. While texts have been acknowledged as active in this way, their generative capacity remains largely overlooked. This article argues that like human subjects, texts in interaction enact agency. One text in particular, a screening form used to diagnose the learning disability attention deficit/hyperactivity disorder, is analyzed to claim that this text (...) brings about the very condition it is designed to measure: a learning disability. Drawing from work in discursive psychology, I show how the measurement requires the client to adopt certain speaking positions, which then enables the text to speak for the client. I also demonstrate how the text constructs otherwise normal behavior as pathological through punctuation and nominalization. Finally, I illustrate how the spatial organization of the text constrains clients’ choices for interacting with it. This article claims that texts produce, rather than reflect, cognitive phenomena, and it moreover encourages that the notion of text as agent be taken seriously, especially when it presents the capacity to disable. (shrink)

Game, Sports, and Play: Philosophical EssaysHURKATHOMAS oup. 2019. pp. 256. £50.00.

Jurors’ emotions, both integral and incidental, can affect their attributions of legal responsibility and blame in several, sometimes complexly interrelated ways. The article reviews the experimental research, outlining the multiple paths of emotional influence, and explains why identifying them is worthwhile. It then discusses why the modest to moderate effect sizes found in the research may understate emotions’ actual influence in some cases yet overstate it in others, and discounts moral intuitionism as a reason for believing that emotional influences in (...) real cases are stronger than the experimental data indicates. The article concludes with recommendations for further research. (shrink)

We used optical neuroimaging to explore the extent of functional overlap between working memory (WM) networks involved in language and Early Stone Age toolmaking behaviors. Oldowan tool production activates two verbal WM areas, but the functions of these areas are indistinguishable from general auditory WM, suggesting that the first hominin toolmakers relied on early precursors of verbal WM to make simple flake tools. Early Acheulian toolmaking elicits activity in a region bordering on Broca’s area that is involved in both visual (...) and verbal WM tasks. The sensorimotor and mirror neurons in this area, along with enhancement of general WM capabilities around 1.8 million years ago, may have provided the scaffolding upon which a WM network dedicated to processing exclusively linguistic information could evolve. In the road map going forward, neuro-archaeologists should investigate the trajectory of WM over the course of human evolution to better understand its contribution to language origins. (shrink)

Clinical trials for acute conditions such as myocardial infarction and stroke pose challenges related to informed consent due to time limitations, stress, and severe illness. Consent processes shou...

Recent years have seen a resurgence of interest in the doctrine of purgatory among Christian philosophers. Some of these philosophers argue for the existence of purgatory from principles consistent with historic Protestant theology and then attempt, on the basis of those principles, to formulate a distinctively Protestant view of purgatory—i.e., one that differs essentially from the Catholic doctrine as regards purgatory’s raison d’etre. Here I aim to show that Protestant models of purgatory which are grounded in the necessity of becoming (...) fully sanctified before entering heaven (Sanctification Models) fail to contrast materially with the Catholic model of purgatory, which has historically been formulated in terms of the necessity of making satisfaction for sins already forgiven (The Satisfaction Model). Indeed, I shall argue that contrary to widespread assumption, the Sanctification Model and the Satisfaction Modelare equivalent when the latter is properly understood. (shrink)

In public health research, tracking folk racial categories (in disease risk, etc.) is a double-edged tool. On the one hand, tracking folk racial categories is dangerous because it reinforces a problematic but fairly common belief in biological race essentialism. On the other hand, ignoring racial categories also runs the risk of ignoring very real biological phenomena in which marginalized communities, likely in virtue of their marginalization, are sicker and in need of improved resources. Much of the conversation among epidemiologists and (...) philosophers of medicine concerning the issue of tracking folk racial categories in public health research springs forth from largely black/white binarized health inequities. While health inequities between black and white Americans are certainly a very important topic, I am interested in investigating the complications to this conversation about the potential harms of tracking folk racial categories in public health research generated by the consideration of Indigenous identities in the US—groups whose health inequities are typically tracked based on the folk racial category of “Native American” or “American Indian,” but whose unique identity categories and community membership problematize the current spectrum of approaches to tracking folk racial categories in epidemiologic research. This paper will draw on scholarship by and about Indigenous people in the US context to address an undertheorized facet of the conversations concerning the potential harms of tracking folk racial categories in public health research, including the potential undermining of American Indian sovereignty and Indigenous epistemologies. I will end on some methodological considerations inspired by the inclusion of Indigenous identities in the US in the conversation about tracking folk racial categories in epidemiologic research. (shrink)

In this encyclopedia entry I sketch the way contemporary theorists understand moral responsibility -- its varieties, its requirements, and its puzzles.

Although the character of the “lady detective”is a staple of the cozy mystery genre, we contend that there are no great lady detectives to rival Holmes or Poirot. This is not because there are no clever or interesting lady detective characters, but ratherbecause the concept of greatness is sociallyconstructed and, like coolness, depends on public acclaim and perception. We explore the mechanics of genre formation, arguing that the very structure of cozy mysteries precludes female greatness. To create a “great”character,theauthor cannot (...) just endowher with certain attributes; she must actively work to overcome her audience’s tendency to import structures of oppression into the story, and she must wrestle against the conventions of the genre. In doing so, however, authors risk setting their stories in a wholly different genre. (shrink)

Cancer and its treatment pose challenges that affect not only patients but also their significant others, including intimate partners. Accumulating evidence suggests that couples’ ability to communicate effectively plays a major role in the psychological adjustment of both individuals and the quality of their relationship. Two key conceptual models have been proposed to account for how couple communication impacts psychological and relationship adjustment: the social-cognitive processing (SCP) model and the relationship intimacy (RI) model. These models posit different mechanisms and outcomes, (...) and thus have different implications for intervention. The purpose of this project is to test and compare the utility of these models using comprehensive and methodologically rigorous methods. Aims are: (1) to examine the overall fit of the SCP and RI models in explaining patient and partner psychological and relationship adjustment as they occur on a day-to-day basis and over the course of 1 year; (2) to examine the fit of the models for different subgroups (males vs. females, and patients vs. partners); and (3) to examine the utility of various methods of assessing communication by examining the degree to which baseline indices from different measurement strategies predict self-reported adjustment at 1-year follow up. The study employs a longitudinal, multi-method approach to examining communication processes including: standard self-report questionnaires assessing process and outcome variables collected quarterly over the course of 1 year; smartphone-based ecological momentary assessments to sample participant reports in real time; and laboratory-based couple conversations from which we derive observational measures of communicative behavior and affective expression, as well as vocal indices of emotional arousal. Participants are patients with stage II-IV breast, colon, rectal, or lung cancer and their spouses/partners, recruited from two NCI-designated comprehensive cancer centers. Results will be published in scientific journals, presented at scientific conferences, and conveyed to a larger audience through infographics and social media outlets. Findings will inform theory, measurement, and the design and implementation of efficacious interventions aimed at optimizing both patient and partner well-being. (shrink)

Telomerase is a cellular reverse transcriptase responsible for telomere maintenance in most organisms. It does so by adding telomere repeats onto pre‐existing ends using an integral RNA component as template. Compared to “prototypical” reverse transcriptases, telomerase is unique in being able to repetitively copy a short templating RNA segment, thus adding multiple copies of the repeat to the DNA substrate following a single binding event. This uniquely processive property hints at the intricate conformational alterations that the enzyme must choreograph during (...) its reaction cycles. Recent studies have identified distinct structural elements within both the RNA and protein components of telomerase that modulate enzyme processivity. Pharmacological and genetic analysis suggest that telomerase processivity is a significant determinant of telomere length. Because telomere maintenance and the lack thereof have been linked to tumor progression and aging, further investigation of telomerase processivity may lead to novel medical intervention strategies. BioEssays 26:955–962, 2004. © 2004 Wiley Periodicals, Inc. (shrink)