Some scholars attempt to explain sexual desire biologically by claiming that sex hormones play a necessary causal role in sexual desire. This can be claimed even if sexual desire is seen to be an experience. Yet the evidence for such biological essentialism is inadequate. With males the loss of sexual desire following hormonal changes can easily be explained in terms of social stigmas that are attached to the physiological situation. Concerning females, the relevance of sex hormones here is (...) even more unclear. Although some women seem to have fluctuations in sexual desire during hormonal changes, other women do not. Even where there are such fluctuations these can be explained by responses to other physiological changes or the meanings that are attached to the situation. Research with non-human primates supports this view of the non-essential relation of sex hormones to sexual desire. A phenomenology of sex hormones is given that shows a possible non-essential relation between sex hormones and sexual desire. Here hormone induced excitations in the genitals may or may not lead to sexual desire depending on the meaning they are given within awareness. This suggests that sexual desire has its origin in the meanings we give our biology and not in our biology itself. (shrink)

The emerging discipline of complexity science, applied to the social sciences, seeks to study the rise of human civilization as a part of a natural, evolving biological system that exploits energy resources to fuel its growth into a complex social system. In order to understand the whole system, the reductionist approach, typical to Western science, must be supplanted. The atomistic study of various scientific fields as separate mechanical parts of the system must be broadened, creating a more holistic view of (...) human culture as an integral part of larger universal process of evolution and creation. In this article I wish to integrate the various scientific fields, including physics, chronobiology, biology, evolutionary psychology, and the social sciences, to achieve a unified understanding of our cultural evolution. (shrink)

In my work I argue that sexual differences in the brain seem to shape the ideological gulf between the respective social groups each side represents. And most significantly, it is the male sex hormone testosterone that is the primary hormone affecting our sexual evolution. Not only does testosterone fuel the passion for reproduction and play a critical role in the length of human lives, it is an integral component to the mechanism of human civilization—its triumphs and its tragedies. In order (...) to understand the forces that drive the life cycles of human cultures and form the engine of history, it is important to look at the most fundamental building blocks of human neuroscience. Our hormones are the impetus for our history. Hormones regulate and control the way the human mind perceives the world and forms social organizations and political order accordingly. Hormones drive waves of social mood, shaping the evolution of our social life, the fluctuations of religious doctrines, cultural crusades, and sexual norms. (shrink)

Sex hormones today are seen as central to the production of biological sexual difference. This article examines the development of this scientific `fact', and asks how hormones came to be in this position. The article does not involve original historical research, however. Instead it uses existing histories of hormonal sexual difference to develop a theoretical argument about body histories. How can the history of scientific views of bodies be written and understood? What can these histories tell us about (...) the relation between scientific representations of bodies and the materiality of bodies? Combining and critiquing arguments from feminist histories of science, Bruno Latour's actor network theory, Michel Serres's theory of folded time, and Donna Haraway's notion of situated knowledges, this article argues for the centrality of embodiment and location to useful body histories. (shrink)

Spontaneous intrusive recollections are known to follow emotional events in clinical and non-clinical populations. Previous work in our lab has found that women report more SIRs than men after exposure to emotional films, and that this effect is driven entirely by women in the luteal phase of the menstrual cycle. To replicate and extend this finding, participants viewed emotional films, provided saliva samples for sex hormone concentration analysis, and estimated SIR frequency following film viewing. Women in the luteal phase reported (...) significantly more SIRs than did women in the follicular phase, and SIR frequency significantly correlated with salivary progesterone levels. The results are consistent with an emerging pattern in the literature suggesting that menstrual cycle position of female participants can potently influence findings in numerous cognitive domains. The potential implications of these results for disorders characterized by intrusions, such as post-traumatic stress disorder, are also discussed. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Feminist Studies 41, no. 3. © 2015 by Feminist Studies, Inc. 623 Jaye Cee Whitehead, Kath Bassett, Leia Franchini, and Michael Iacolucci “The Proof Is in the Pudding”: How Mental Health Practitioners View the Power of “Sex Hormones” in the Process of Transition In the United States today, popular discourse touts the power of “sex hormones” and hormone receptors in the brain to chemically produce gender expressions (...) (manifested in physical sex traits, behaviors, and attitudes) and identities (a sense of self as feminine or masculine). These accounts range from common assumptions that Western ideals of femininity (such as empathy understanding, cooperative orientation, nurturing behavior) and masculinity (rational/spatial understanding, competitive orientation, violent behavior) are produced by corresponding sex hormones, to studies that reduce complex gender identities and macrosocial economic phenomena to presocial, binary, hormonal processes.1 For sociologists, accounts that reduce complex identities to internal hormonal reactions are problematic for two primary reasons: first, they are inaccurate because they fail to examine how hormonal reactions are embedded in a complex cultural process of meaning and interpretation; second, they operate as bioreductive ideologies that obscure the social power inherent to the process of gender identity construction. In what follows, we extend both of these insights by examining mental health 1. For an example of a hybrid popular-scientific account of the power of sex hormones to destabilize economic structures, see Jon Coates and Joe Herbert, “Endogenous Steroids and Financial Risk Taking on a London Trading Floor,” Proceedings of the National Academy of Sciences 105, no. 16 (April 2008): 6167–72. 624 Whitehead, Bassett, Franchini, and Iacolucci practitioners’ divergent interpretations of the power of sex hormones in the process of gender transition.2 In doing so, we examine the cultural power of sex hormones in crafting gender identities without reproducing reductionist interpretations of trans embodiment. Perhaps what is most perplexing about the way we speak of sex hormones is that we know it is inaccurate to describe these hormones as sexed; scientists have acknowledged since the 1930s that they are neither sex specific in their function, nor in terms of their location in male or female bodies.3 In her extensive historicization of sex hormones, Anne Fausto-Sterling concludes that it is more accurate to call androgen- and estrogen-based hormones, “steroid hormones” as they have functions that are not confined to corresponding sexed bodies. In fact she urges scientists to “break out of the sex hormone straightjacket” and to look at steroids as just one of a number of components that are important to the creation of sex and gender, including environment and experience.4 Scholars also point to an inextricable link between the chemical operation of hormones and the social process of constructing meaning, both at the level of social interaction and macrocultural constructions of sex categories and gender ideologies.5 While brain organization/activation theory attributes sex and gender differences to hormonal interactions within the developing brain, Fausto-Sterling questions the distinction between activation and organization by pointing out how “the brain can respond to hormonal stimuli with anatomical changes…hormonal systems, after all, respond exquisitely to experience, be it in the form of nutrition, stress, or sexual activity (to name but a few possibilities ).”6 Drawing from Elizabeth Grosz, Fausto-Sterling argues that the power of hormones is best understood according to the model of the 2. “Gender transition” is a controversial phrase, as it implies that transgendered individuals who receive hormone therapy are changing identities. We are only using it for lack of clear alternative phrasing, not because we believe body modifications change gender identities. 3. See Anne Fausto-Sterling, Sexing the Body: Gender Politics and the Construction of Sexuality (New York: Basic Books, 2000); Rebecca Jordan-Young, Brainstorm: The Flaws in the Science of Sex Differences (Cambridge, MA: Harvard University Press, 2010); and Nelly Oudshoorn, Beyond the Natural Body: An Archeology of Sex Hormones (New York: Routledge, 1994). 4. Fausto-Sterling, Sexing the Body, 193–94. 5. Fausto-Sterling, Sexing the Body. 6. Ibid., 232. Whitehead, Bassett, Franchini, and Iacolucci 625 Möbius strip, wherein internal components of the self are always connected to and continuous with outer components such as culture and environment.7 In other... (shrink)

First Published in 2004. Routledge is an imprint of Taylor & Francis, an informa company.

Gender dysphoria in children has become a hot-button topic; however, clinical data still remain sparse on the effects of hormone therapy and transitional surgery on the physical and psychological well-being of those children. The American College of Pediatricians cites studies indicating that anywhere from 77 to 94 percent of boys and 73 to 88 percent of girls desist in GD; that is, following puberty the majority of children who experience GD will identify with their assigned biological sex. After reviewing the (...) clinical studies, this paper addresses the notion of gender from a Thomistic perspective, locating gender as a differentiation in the matter of the person flowing from the essence of the soul, resulting from the power of generation as opposed to other differences such as sight, which functions the same regardless of material differences. As a result, the paper concludes that hormone therapy cannot be morally licit for children. (shrink)

Studies of drug development have described the role of clinical trials in the selection of drug profiles. This article presents a case study of the development of hormonal drugs in the 1920s and 1930s to illustrate that clinical trials have a more extensive role than is assumed. Clinical trials are instrumental in mediating the relationships between the pharmaceutical industry, the laboratory, and the clinic, resulting in a network of actors collectively creating medical knowledge, drugs, and markets for these drugs.

Fitch & Denenberg have shown that manipulations of ovarian and testicular hormones early in development can influence the adult size of the corpus callosum in the rat. The human corpus callosum is highly variable in size and shape, but data are only now beginning to emerge on whether sex steroids influence callosal differentiation in humans. I describe recent data from our own laboratory and suggest avenues for future research.

Ethical concerns have been raised about routine practice in paediatric gender clinics. We discuss informed consent and the risk of iatrogenesis in the prescribing of gonadotropin-releasing hormone...

Recent brain imaging points to differences in brain structure that relate to intelligence, but how do we model their causal relationship within a coherent framework that circumvents classic dualist traps? A bottom-level nonlinear, dynamic, multifactor, multiplicative, multidimensional, molecular (ND4M) trait-covariance time-space model may accomplish this better than traditional approaches.

Les hormones sexuelles sont des objets hybrides et complexes à la frontière du sexe et du genre. Dès lors qu’elles sont synthétisées sous forme pharmaceutique, elles peuvent attribuer des caractéristiques sexuelles au corps de manière partiellement exogène à celui-ci. Il s’en suit que l’utilisation clinique qui en est faite est socialement réglementée. À travers une analyse de divers contextes d’utilisation des hormones observés à Bahia, au Brésil, cet article montre que le dualisme sexuel est le produit de pratiques (...) de régulation biomédicales qui visent à encadrer la circulation des hormones. Le sens du terme local « hormônio » n’est pas pleinement recoupé par celui d’hormone, qu’il excède. L’emploi commun qui est fait au Brésil du singulier procure au terme « hormônio » une qualité fluide et homogène. Dans ce contexte, les hormones sont comprises comme une sorte de substance qui peut circuler entre les corps. Cette conceptualisation des hormones comme une substance a des implications pour le statut ontologique des corps et révèle la relative plasticité de la relation sexe/genre. (shrink)

Drawing on feminist and queer epistemologies, this article is concerned with the post-feminist media’s construction of girls’ sexual subjecthood. Broadly defined as a biopolitical ideal, post-feminism is here related to a set of principles of the neoliberal art of government. It will be argued that these principles ethically sustain the exponential mainstreaming of a post-feminist hermeneutics of adolescence and its programme of governmentality. The article also links post-feminism to a particular methodology of subjectification, ultimately locating its hermeneutics of adolescence within (...) the pornographic and pharmacological imperatives of contemporary capitalism. On the empirical level, the analysis explores how techno-scientific discourses and bodily figurations (namely brains and hormones) enter the discursive apparatus of a Portuguese girls’ magazine, giving ideological ground to a distinctive production of adolescent body-subjects. Post-feminist media markets are finally discussed as a significant segment of the capitalist industrialisation of sexual difference that frames the general problematic of this study. (shrink)

Are there sex differences in pain? For experimentally delivered somatic stimuli, females have lower thresholds, greater ability to discriminate, higher pain ratings, and less tolerance of noxious stimuli than males. These differences, however, are small, exist only for certain forms of stimulation and are affected by many situational variables such as presence of disease, experimental setting, and even nutritive status. For endogenous pains, women report more multiple pains in more body regions than men. With no obvious underlying rationale, some painful (...) diseases are more prevalent among females, others among males and, for many diseases, symptoms differ between females and males. Sex differences in attitudes exist that affect not only reporting, coping, and responses to treatment, but also measurement and treatment. So many variables are operative, however, that the most striking feature of sex differences in reported pain experience is the apparent overall lack of them. On the other hand, deduction from known biological sex differences suggests that these are powerful sex differences in the operation of pain mechanisms. First, the vaginal canal provides an additional route in women for internal trauma and invasion by pathological agents that puts them at greater risk for developing hyperalgesia in multiple body regions. Second, sex differences in temporal patterns are likely to give rise to sex differences in how pain is and stimuli are interpreted, a situation that could lead to a greater variability and wider range of pains without obvious peripheral pathology among females. Third, sex differences in the actions of sex hormones suggest pain-relevant differences in the operation of many neuroactive agents, opiate and nonopiate systems, nerve growth factor, and the sympathetic system. Thus, while inductive analysis of existing data demonstrate more similarities than differences in pain experience between females and males, deductive analysis suggests important operational sex differences in its production. (shrink)

By integrating the entire body of research in human sexual dynamics, immune responses, and sociocultural behavior, we can conclude that the mass hysteria our society is currently experiencing originates in our evolved psychological adaptations to pandemic conditions [i]. A lack of hormonal balance [ii], due to a collapse in testosterone levels, may cause a disproportionate immune response that leads to the destruction of our cherished sociopolitical institutions—the very institutions that are design to protect human liberty and prosperity. What is playing (...) out at a societal level is similar to an excessive immune response that causes the body to attack itself: decreased testosterone causing the kind of auto-immune response that is more prevalent in females. [i] Barzilai, R.. Low Solar Activity, Winter Flu Conditions, Pandemics and Sex Wars: A Holistic View of Human Evolution. Science & Philosophy, 8. Doi: 10.23756/sp.v8i1.514 [ii] Barzilai, R.. Solar cycles, light, sex hormones and the life cycles of civilization: Toward integrated chronobiology. Science & Philosophy, 7. doi: 10.23756/sp.v7i2.483. (shrink)

The differentiation of male and female characteristics in vertebrates and insects has long been thought to proceed via different mechanisms. Traditionally, vertebrate sexual development was thought to occur in two phases: a primary and a secondary phase, the primary phase involving the differentiation of the gonads, and the secondary phase involving the differentiation of other sexual traits via the influence of sex hormones secreted by the gonads. In contrast, insect sexual development was thought to depend exclusively on cell‐autonomous expression (...) of sex‐specific genes. Recently, however, new evidence indicates that both vertebrates and insects rely on sex hormones as well as cell‐autonomous mechanisms to develop sexual traits. Collectively, these new data challenge the traditional vertebrate definitions of primary and secondary sexual development, call for a redefinition of these terms, and indicate the need for research aimed at explaining the relative dependence on cell‐autonomous versus hormonally guided sexual development in animals. (shrink)

In the context of transgender health, most people are not comfortable with allowing a twelve‐year‐old child with gender dysphoria to elect to undergo gender reassignment surgery. The likelihood is too high that the child would be unable to fully comprehend the scope of a decision that carries significant, permanent consequences, particularly because the decision to surgically change gender is based upon a conception of gender that can fluctuate during adolescent years. Conversely, however, most people would not contend that this fluidity (...) is reason to wholly deny certain medical care such as hormonal treatments to transgender youth, a demographic with extremely high rates of violent behavior, self‐harm, and suicide. This paper will explore ethical considerations to this emerging debate of what therapeutic options should be offered to transgender children and adolescents.Pediatric endocrinologists have been treating gender dysphoric adolescents with puberty‐suppressing drugs and, to a lesser extent, with cross‐sex hormone therapies for more than twenty years. Clinicians and thought leaders have mentioned ethical components of this emerging practice in the few cohort studies and clinical review articles about the subject. However, ethics have generally been a secondary consideration in the medical academic literature. In this paper, I will provide a brief overview of the practice, summarize the current research on hormone treatment for transgender minors, and provide an ethical analysis of the practice. (shrink)

Despite the controversial nature of studies of reproductive phenomena, a major center of reproductive biology emerged and coalesced in the Department of Zoology at the University of Chicago circa 1892–1940. Led by Frank R. Lillie, several small groups of researchers pioneered the study of sex determination and sex hormones, pursuing these via a Chicago approach to framing biological practice at both cellular and organismic levels. They worked in an interdisciplinary manner, however much in tandem, and drew strongly on local (...) resources—from the stockyards to local philanthropy. Most remarkably, Lillie redirected the mission of the major National Research Council Committee for Research Problems of Sex to address the biology of sex and then garnered about a fifth of its funds for Chicago. He thus guided Chicago biology into the fully modern era of external support for on-campus research and elaborate national scientific networks via promising biological solutions to social problems. (shrink)

The principles of sexual selection were used as an organizing framework for interpreting cross-national patterns of sex differences in mathematical abilities. Cross-national studies suggest that there are no sex differences in biologically primary mathematical abilities, that is, for those mathematical abilities that are found in all cultures as well as in nonhuman primates, and show moderate heritability estimates. Sex differences in several biologically secondary mathematical domains (i.e., those that emerge primarily in school) are found throughout the industrialized world. In particular, (...) males consistently outperform females in the solving of mathematical word problems and geometry. Sexual selection and any associated proximate mechanisms (e.g., sex hormones) influence these sex differences in mathematical performance indirectly. First, sexual selection resulted in greater elaboration in males than in females of the neurocognitive systems that support navigation in three-dimensional space. Knowledge implicit in these systems reflects an understanding of basic Euclidean geometry, and may thus be one source of the male advantage in geometry. Males also use more readily than females these spatial systems in problem-solving situations, which provides them with an advantage in solving word problems and geometry. In addition, sex differences in social styles and interests, which also appear to be related in part to sexual selection, result in sex differences in engagement iii mathematics-related activities, thus further increasing the male advantage in certain mathematical domains. A model that integrates these biological influences with sociocultural influences on the sex differences in mathematical performance is presented in this article. (shrink)

Several hundred thousand intellectually talented 12-to 13-year-olds have been tested nationwide over the past 16 years with the mathematics and verbal sections of the Scholastic Aptitude Test (SAT). Although no sex differences in verbal ability have been found, there have been consistent sex differences favoring males in mathematical reasoning ability, as measured by the mathematics section of the SAT (SAT-M). These differences are most pronounced at the highest levels of mathematical reasoning, they are stable over time, and they are observed (...) in other countries as well. The sex difference in mathematical reasoning ability can predict subsequent sex differences in achievement in mathematics and science and is therefore of practical importance. To date a primarily environmental explanation for the difference in ability has not received support from the numerous studies conducted over many years by the staff of Study of Mathematically Precocious Youth (SMPY) and others. We have studied some of the classical environmental hypotheses: attitudes toward mathematics, perceived usefulness of mathematics, confidence, expectations/ encouragement from parents and others, sex-typing, and differential course-taking. In addition, several physiological correlates of extremely high mathematical reasoning ability have been identified (left-handedness, allergies, myopia, and perhaps bilateral representation of cognitive functions and prenatal hormonal exposure). It is therefore proposed that the sex difference in SAT-M scores among intellectually talented students, which may be related to greater male variability, results from both environmental and biological factors. (shrink)

Sex differences in reproductive strategy and the sexual division of labor resulted in selection for and maintenance of sexual dimorphism across a wide range of characteristics, including body size, hormonal physiology, behavior, and perhaps spatial abilities. In laboratory tasks among undergraduates there is a general male advantage for navigational and mental-rotation tasks, whereas studies find female advantage for remembering item locations in complex arrays and the locations of plant foods. Adaptive explanations of sex differences in these spatial abilities have focused (...) on patterns of differential mate search and routine participation in distinct subsistence behaviors. The few studies to date of spatial ability in nonindustrial populations practicing subsistence lifestyles, or across a wider age range, find inconsistent results. Here we examine sex- and age-based variation in one kind of spatial ability related to navigation, dead-reckoning, among Tsimane forager horticulturalists living in lowland Bolivia. Seventy-three participants (38 male) aged 6–82 years pointed a handheld global positioning system (GPS) unit toward the two nearest communities and the more distant market town. We find no evidence of sex differences in dead reckoning (p = 0.47), nor do we find any evidence of age-related decline in dead-reckoning accuracy (p = 0.28). Participants were significantly more accurate at pointing toward the market town than toward the two nearest villages despite its being significantly farther away than the two nearest communities. Although Tsimane do show sexual dimorphism in foraging tasks, Tsimane women have extensive daily and lifetime travel, and the local environment lacks directional cues that typically enhance male navigation. This study raises the possibility that greater similarity in mobility patterns because of overlapping subsistence strategies and activities may result in convergence of some male and female navigation abilities. (shrink)

BackgroundWe review original papers on ovarian-hormone status in two areas of emotional processing: facial emotion recognition and emotional memory. Ovarian-hormone status is operationalized by the levels of the steroid sex hormones 17β-estradiol and progesterone, fluctuating over the natural menstrual cycle and suppressed under oral contraceptive use. We extend previous reviews addressing single areas of emotional processing. Moreover, we systematically examine the role of stimulus features such as emotion type or stimulus valence and aim at elucidating factors that reconcile the (...) inconsistent results.MethodsWe followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and included papers published until September 2020 indexed in PubMed and Web of Science databases. Search terms were MeSH terms AND AND with representing our separately searched areas, resulting in, and. To be included, articles had to be written and published in English, examine healthy, non-pregnant adult women in their reproductive age, and measure or at least estimate levels of E2 and P4. In PubMed, the search was limited to humans and to the search term present in the title or abstract.ResultsFeatures of the provided stimulus material constitute a relevant influence that interacts with E2- and P4-related ovarian-hormone status. For instance, recognition of basic emotions appears to be more related to P4- than E2-levels. Quite consistent, OC intake was accompanied by impaired recognition accuracy of basic and also complex emotions, although not in a recent large-sample study assessing complex emotions. Memory recall of negative content was mainly enhanced by P4, especially after having been stressed.Discussion and ConclusionWe document the methodological diversity in the field, presumably contributing to the heterogeneity of results. More studies explicitly contrasting the early follicular phase, mid-cycle phase, mid-luteal, and OC intake while standardizing tasks are needed. Research would take advantage of using within-subject designs and accounting for the recognition of complex emotions. (shrink)

This study investigated sex differences in interest in infants among children, adolescents, young adults, and older individuals. Interest in infants was assessed with responses to images depicting animal and human infants versus adults, and with verbal responses to questionnaires. Clear sex differences, irrespective of age, emerged in all visual and verbal tests, with females being more interested in infants than males. Male interest in infants remained fairly stable across the four age groups, whereas female interest in infants was highest in (...) childhood and adolescence and declined thereafter, particularly for the responses to visual stimuli. The observed developmental changes in female interest in infants are consistent with the hypothesis that they represent a biological adaptation for parenting. (shrink)

Displacing the physiological model that had held sway in 19th-century medical thinking, early 20th-century hormone research promoted an understanding of the body and sexual desires in which variations in sex characteristics and non-reproductive sexual behaviours such as homosexuality were attributed to anomalies in the internal secretions produced by the testes or the ovaries. Biotypology, a new brand of medical science conceived and led by the Italian endocrinologist Nicola Pende, employed hormone research to study human types and hormone treatments to normalise (...) individuals who did not conform to accepted medical norms. Latin American medical doctors, eugenicists, and sexologists took up biotypology with enthusiasm. This article considers the case studies of Italy, Argentina, and Brazil, and analyses the work of medical doctors who adopted a biotypological mode of reasoning and employed to various extents hormone therapies in their practice. By focusing on hormone therapies that aimed to normalise secondary sexual characteristics and the sexual instinct, the article suggests that while the existence of normality was contested to the point that a number of medical scientists argued that no such thing existed, the pursuit of normality was carried out in very practical terms through the new medical technologies hormone research had introduced. (shrink)

Sex is often thought of as a straightforwardly binary categorical variable. Yet there is considerable variation in would-be sex traits; from genitals and hormones to morphology, neurology and behaviour, there is rarely if ever a categorical binary. We introduce a strategy that researchers use to deal with this variation: Individualising Variation (IV). IV involves treating non-binary and gradual variation as idiosyncratic, as individual differences rather than sex-based differences. Using the contrasting cases of sex identification in field ornithology and the (...) debate about sex differences in neuroscience, we illustrate IV and investigate its epistemic and conceptual consequences. We argue that IV stabilises the ontological picture of sex as categorical and binary. While IV can be an epistemically benign research strategy in some cases, we argue that it can also be epistemically detrimental. This is because of its ability to mask evidence that would otherwise challenge related assumptions about the phenomenon of interest, such as what sexes are and what they look like. We also identify an alternative strategy, De- individualising Variation, which works against IV and helps life scientists recognise variation beyond categorical binaries. (shrink)

Current clinical guidelines for the treatment of individuals who experience gender dysphoria include the administration of testosterone to women who desire to appear as men and estrogen to men who desire to appear as women. Despite the rapid and widespread adoption of this practice, strikingly little scientific evidence supports this treatment approach as a safe and effective medical intervention to prevent associated depression and suicide. Although low-quality, short-term studies have demonstrated a reduction of dysphoria, emerging evidence reveals significant bodily harm (...) from this practice and a lack of long-term benefit in preventing depression and suicide. From an ethical perspective, this practice distorts a proper view of human nature and violates bodily integrity by directly inducing sterility. The use of exogenous cross-sex hormones reinforces rather than alleviates underlying psychiatric dysfunction while significantly increasing the risk of other medical morbidities. Despite the valid goal of alleviating suffering, this practice cannot be justified by the use of the principles of totality or double effect. (shrink)

1. Sexual Brains and Body Politics 2. Hormones and Hardwiring 3. Making Sense of Brain Organization Studies 4. Thirteen Ways of Looking at Brain Organization 5. Working Backward from “Distinct‘ Groups 6. Masculine and Feminine Sexuality 7. Sexual Orienteering 8. Sex-Typed Interests 9. Taking Context Seriously 10. Trading Essence for Potential.

Many decades after the publication of Genesis and development of a scientific fact, Fleck’s collective Denkstil remains a very important notion for analyzing the history of the biological and medical sciences. Following Fleck’s perspective this paper argues that the history of the sex hormones was critically shaped by our representation of the sexes, and our perceptions of the division of reproductive labor. Emerging at the boundary between physiological laboratories and consultation room, a molecular/endocrine style of thought stabilized during the (...) early decades of the twentieth century around the manipulation of sex hormones. This not only proved important in normalizing the sexual body, but also in defining sterility, menstrual disorders or menopause as pathological events to be treated ‘causally’.Analyzing the role played by industrial companies like the German firm Schering which produced these drugs, the paper suggests that the idea of a work style may be a convenient way to complement Fleck’s style of thought. First, the idea of work style is a reminder that science involves material action, which has strong links with industrial production. Second, it draws our attention to a deeply entrenched goal of the modern biosciences, the search for means to control the variability of the living, and standardize its uses. (shrink)

Historically, studies of the role of endogenous hormones in developmental differentiation of the sexes have suggested that mammalian sexual differentiation is mediated primarily by testicular androgens, and that exposure to androgens in early life leads to a male brain as defined by neuroanatomy and behavior. The female brain has been assumed to develop via a hormonal default mechanism, in the absence of androgen or other hormones. Ovarian hormones have significant effects on the development of a sexually dimorphic (...) cortical structure, the corpus callosum, which is larger in male than in female rats. In the females, removal of the ovaries as late as Day 16 increases the cross-sectional area of the adult corpus callosum. Treatment with low-dose estradiol starting on Day 25 inhibits this effect. Female callosa are also enlarged by a combination of daily postnatal handling and exogenous testosterone administered prior to Day 8. The effects of androgen treatment are expressed early in development, with males and testosterone-treated females having larger callosa than control females as early as Day 30. The effects of ovariectomy do not appear until after Day 55. These findings are more consistent with other evidence of a later sensitive period for ovarian feminization as compared to androgenic masculinization. (shrink)

At the turn of the twentieth century, biologists such as Oscar Riddle, Thomas Hunt Morgan, Frank Lillie, and Richard Goldschmidt all puzzled over the question of sexual difference, the distinction between male and female. They all offered competing explanations for the biological cause of this difference, and engaged in a fierce debate over the primacy of their respective theories. Riddle propounded a metabolic theory of sex dating from the late-nineteenth century suggesting that metabolism lay at the heart of sexual difference. (...) Thomas Hunt Morgan insisted on the priority of chromosomes, Frank Lillie emphasized the importance of hormones, while Richard Goldschmidt supported a mixed model involving both chromosomes and hormones. In this paper, I will illustrate how the older metabolic theory of sex was displaced when those who argued for the relatively newer theories of chromosomes and hormones gradually formed an alliance that accommodated each other and excluded the metabolic theory of sex. By doing so, proponents of chromosomes and hormones established their authority over the question of sexual difference as they laid the foundations for the new disciplines of genetics and endocrinology. Their debate raised urgent questions about what constituted sexual difference, and how scientists envisioned the plasticity and controllability of this difference. These theories also had immediate political and cultural consequences at the turn of the twentieth century, especially for the eugenic and feminist movements, both of which were heavily invested in knowledge of sex and its determination, ascertainment, and command. (shrink)

The development of hormonal contraception introduced a new era in medical practice, marked by the suppression of female fertility by interventions in the hormonal system. The interventions are very grave, as sex hormones are of existential importance both to preserve human life and to preserve the human species. This article conducts an ethical evaluation of the use of hormonal contraception through two ethical theories: natural law theory and virtue ethics. Based on philosophical reflection, the author examines what effects hormonal (...) contraception has on primary goods and whether its use is congruent with the cardinal virtues. National Catholic Bioethics Quarterly 14.3 : 491–524. (shrink)

Osteoporosis is characterized by reduced bone density and strength. Bone mass peaks between age 30 and 40 and then declines. This can be accelerated by factors including menopause and insufficient dietary calcium. Hormone replacement therapy (HRT) is currently the standard treatment for osteoporosis. However, growing concern over potential side effects of HRT has driven a search for alternative therapies. A recent report1 reveals a potential alternative to HRT: a gender‐neutral synthetic steroid that increases bone mass and strength without affecting reproductive (...) organs. This compound acts via a novel extranuclear sex steroid receptor signaling mechanism that has important implications for nuclear receptor biology and human health. BioEssays 25:195–199, 2003. © 2003 Wiley Periodicals, Inc. (shrink)