High‐precision tumor targeting with conventional therapeutics is based on the concept of the ideal drug as a “magic bullet”; this became possible after techniques were developed for production of monoclonal antibodies (mAbs). Innovative DNA technologies have revolutionized this area and enhanced clinical efficiency of mAbs. The experience of applying small‐size recombinant antibodies (monovalent binding fragments and their derivatives) to cancer targeting showed that even high‐affinity monovalent interactions provide fast blood clearance but only modest retention time on the target antigen. Conversion (...) of recombinant antibodies into multivalent format increases their functional affinity, decreases dissociation rates for cell‐surface and optimizes biodistribution. In addition, it allows the creation of bispecific antibody molecules that can target two different antigens simultaneously and do not exist in nature. Different multimerization strategies used now in antibody engineering make it possible to optimize biodistribution and tumor targeting of recombinant antibody constructs for cancer diagnostics and therapy. BioEssays 30:904–918, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

This paper is dedicated to developing a formalism that takes rejection seriously. Bilateral notation of signed formulas with force indicators is adopted to define signed consequences which can be viewed as the bilateral counterpart of Tarskian consequence relations. Its relation to some other bilateral approaches is discussed. It is shown how David Nelson’s logic N4 can be characterized bilaterally and the corresponding completeness result is proved. Further, bilateral variants of three familiar notions are considered and investigated: that of a fragment, (...) of definitional equivalence, and of a conservative extension. (shrink)

We exploit properties of certain directed graphs, obtained from the families of sets with special effective enumeration properties, to generalize several results in computable model theory to higher levels of the hyperarithmetical hierarchy. Families of sets with such enumeration features were previously built by Selivanov, Goncharov, and Wehner. For a computable successor ordinal α, we transform a countable directed graph into a structure such that has a isomorphic copy if and only if has a computable isomorphic copy.A computable structure is (...) categorical if for all computable isomorphic copies of , there is an isomorphism from onto , which is . We prove that for every computable successor ordinal α, there is a computable, categorical structure, which is not relatively categorical. This generalizes the result of Goncharov that there is a computable, computably categorical structure, which is not relatively computably categorical.An additional relation R on the domain of a computable structure is intrinsically on if in all computable isomorphic copies of , the image of R is . We prove that for every computable successor ordinal α, there is an intrinsically relation on a computable structure, which not relatively intrinsically . This generalizes the result of Manasse that there is an intrinsically computably enumerable relation on a computable structure, which is not relatively intrinsically computably enumerable.The dimension of a structure is the number of computable isomorphic copies, up to isomorphisms. We prove that for every computable successor ordinal α and every n≥1, there is a computable structure with dimension n. This generalizes the result of Goncharov that there is a structure of computable dimension n for every n≥1.Finally, we prove that for every computable successor ordinal α, there is a countable structure with isomorphic copies in just the Turing degrees of sets X such that relative to X is not . In particular, for every finite n, there is a structure with isomorphic copies in exactly the non- Turing degrees. This generalizes the result obtained by Wehner, and independently by Slaman, that there is a structure with isomorphic copies in exactly the nonzero Turing degrees. (shrink)

We prove that a propositional Linear Temporal Logic with Until and Next has unitary unification. Moreover, for every unifiable in LTL formula A there is a most general projective unifier, corresponding to some projective formula B, such that A is derivable from B in LTL. On the other hand, it can be shown that not every open and unifiable in LTL formula is projective. We also present an algorithm for constructing a most general unifier.

We present novel proof systems for various FDE-based modal logics. Among the systems considered are a number of Belnapian modal logics introduced in Odintsov & Wansing and Odintsov & Wansing, as well as the modal logic KN4 with strong implication introduced in Goble. In particular, we provide a Hilbert-style axiom system for the logic $BK^{\square - } $ and characterize the logic BK as an axiomatic extension of the system $BK^{FS} $. For KN4 we provide both an FDE-style axiom system (...) and a decidable sequent calculus for which a contraction elimination and a cut elimination result are shown. (shrink)

Presented in the “Critique of Pure Reason” transcendental philosophy is the first theory of science,which seeks to identify and study the conditions of the possibility of cognition. Thus, Kant carries out a shift to the study of ‘mode of our cognition’ and TP is a method, where transcendental argumentation acts as its essential basis. The article is devoted to the analysis of the transcendental arguments. In § 2 the background of ТА — transcendental method of Antiquity and Leibniz’s Principle of (...) Sufficient Reason — are analyzed and their comparison with ТА is given. § 3 is devoted to the analysis of TA in the broad and narrow senses; a formal propositional and presupposition models are proposed. In § 4 I discuss the difference between TA and metaphysics’ modes of reasoning. It analyzes the Kant’s main limitations of the use TA shows its connection with the Modern Age and contemporary science. (shrink)

A significant increase in scientific discoveries, made possible, among other things, thanks to the computing power provided by modern information technologies, occurs against the background of the lack of theoretical and methodological resources necessary for their scientific conceptualization. The situation is similar to the one that took place at the turn of the 19th and 20th centuries and became the object of reflection on the part of philosophers called emergentists. This explains the revival in our time of interest in some (...) of their ideas, including the idea of ontological novelty, which emergent phenomena possess. Modern emergentism is positioned as a realistic teaching that aims to find access to reality in itself, before any knowledge about it, which implies overcoming the correlationism that has dominated philosophy since the time of Kant. One of the representatives of modern emergentism, Manuel DeLanda, tries to combine the position on the ontological novelty of emergent objects with the concept of individuation by Georges Kangilem, which reveals the mechanism of their occurrence and concretization in the form of individual singularities. This requires abandoning the ontology inherited from the ancient Greeks, based on the dialectic of the general and the singular, in favor of an ontology based on individual and universal singularities. The article analyzes the arguments of the supporters of the "new ontology" and concludes that, as in the case of classical emergence, modern discussions are caused by a crisis in physics, which is faced with the fact that the facts recorded during the study of the microcosm are inexplicable from the point of view of the existing theory, and therefore are really ontologically new. But it is possible that with the creation of the" new physics", these facts will cease to be emergent and will pass into the category of "others". (shrink)

Статтю присвячено розгляду телеіндустрії під філософським кутом зору. Зокрема, здійснено аналіз критичних теорій щодо економічних основ телеіндустрії, її функціонування як медіа та особливості означування у соціокультурному просторі. Розглянуто концепції масової культури Макса Горкгаймера і Теодора Адорно, дослідження інструментального характеру мас-медіа Гербертом Маркузе, суспільства спектаклю Гі Дебора, телематичного екрану Жана Бодріяра, неотрайбалізму Мішеля Маффесолі. Телеіндустрія постає як один з найбільш характерних проявів масової культури, а з іншого боку – як центральний елемент сучасної культурної індустрії. Розглянуто телесеріали як один з найбільш впливових (...) елементів телеіндустрії, який здійснює вагомий вплив на формування цінностей та світогляду сучасної людини. Свого часу телебачення швидко набуло соціальної домінантності і частково витіснило інші види впливу масової культури на людину. Телебачення дедалі більшою мірою адаптується до новітніх засобів масової комунікації, зокрема вторгається у царину мережі Інтернет. Телеіндустрія формує не лише смаки, а й домінантний у суспільстві дискурс, через який непомітно і владно формує життєві принципи і стратегію поведінки споживача телевізійного «продукту». (shrink)

The specificity of eukaryotic DNA organization into loops fixed to the nuclear matrix/chromosomal scaffold has been studied for more than fifteen years. The results and conclusions of different authors remain, however, controversial. Recently, we have elaborated a new approach to the study of chromosomal DNA loops. Instead of characterizing loop basements (nuclear matrix DNA), we have concentrated our efforts on the characterization of individual loops after their excision by DNA topoisomerase II‐mediated DNA cleavage at matrix attachment sites. In this review (...) the results of applying this mapping approach are compared with the results and conclusions from studies of nuclear matrix DNA. An attempt is also made to reconsider all data about the specificity of DNA interactions with the nuclear matrix and to suggest a model of spatial organization of the eukaryotic genome which resolves apparent contradictions between these data. (shrink)

At the present time, there are several interpretations and modes of Kant’s transcendental philosophy (TP). Which of these interpretations and modes of transcendentalism most adequately express the spirit of TP, i.e. can claim the title of the transcendental ones? For the explication of the ‘idea of transcendental philosophy’ [KrV, A1], here I distinguish two transcendental shifts: methodological and metaphysical ones, which in their totality predetermine the essence and set the specificity of Kant’s transcendental idealism. The methodological transcendental shift that Kant (...) postulates in his definitions of TP in the Critique of Pure Reason [KrV, A11; B25] represents a shift from studying of objects to the analysis and justification of our mode of cognition of objects. This shift sets a fairly wide range of a la Kantian a priori doctrines and predetermines the transcendental turn (Re–Transcendentalising) of modern philosophy. The metaphysical transcendental shift that can be correlated with “the altered method of our way of thinking [in metaphysics]” [KrV, BXVIII], is associated with the splitting of the “thing” into the actual object (or Kantian thing-in-itself) and object of experience (or Kantian appearance), and involves a transition from the study of thing-in-itself to the analysis of the appearance. More precisely, this shift finds its expression in the transcendental triad “object (thing-in-itself; Ding an sich) – appearance (Erscheinung) – representation (Vorstellung)”, which determines the ‘idea’ (essence) of transcendental idealism/metaphysics. (shrink)

This article deals with voice and bodily deixis as manifestations of performativity in written texts. A speech act of origin presents as both vocal and performative events. Ritual matrixes of culture contain performative complexes, as suggested by Austin. Such performative nuclei are neither true nor false, that is, their negation cannot be logically inferred from true premises. The term deixis describes the performative moment of the utterance, its active and transformative force. The first embodied deictic utterance in Western history would (...) be the biblical phrase “And the word made flesh.” It is the first mythopoetical performative denoting the bodily incarnation of logos. In the article, the term bodily deixis is considered against the background of experimental poetry of E.E. Cummings. (shrink)

This article considers how people judge the identity of objects (e.g., how people decide that a description of an object at one time, t₀, belongs to the same object as a description of it at another time, t₁). The authors propose a causal continuer model for these judgments, based on an earlier theory by Nozick (1981). According to this model, the 2 descriptions belong to the same object if (a) the object at t₁ is among those that are causally close (...) enough to be genuine continuers of the original and (b) it is the closest of these close-enough contenders. A quantitative version of the model makes accurate predictions about judgments of which a pair of objects is identical to an original (Experiments 1 and 2). The model makes correct qualitative predictions about identity across radical disassembly (Experiment 1) as well as more ordinary transformations (Experiments 2 and 3). (shrink)

What follows is a two-part review of Günther Witzany’s two-part book, The Logos of the Bios. The first part of the review is written by Sergey Chebanov, and it approaches the text as a source of ideas on biosemiotics and biohermeneutics. The second part is written by Anton Markoš, and it estimates the biological pithiness of the book and the correctness of the reflection of the included data of modern biology.

The article focuses the possibility of elaboration of a cross-disciplinary methodological approach to formation of the semiotics of power. Four possible forms of relation of semiotic research to the problem of power are revealed upon the basis of Drechsler’s typology. The approaches of Mandoki and Siefkes to formation of the methodological basis of the semiotics of power are analyzed and compared. The author designates the perspective directions of a further research and formulates methodological prerequisites for realization of the specified directions.

Recent years have witnessed an explosion of the single-cell biochemical toolbox including chromosome conformation capture -based methods that provide novel insights into chromatin spatial organization in individual cells. The observations made with these techniques revealed that topologically associating domains emerge from cell population averages and do not exist as static structures in individual cells. Stochastic nature of the genome folding is likely to be biologically relevant and may reflect the ability of chromatin fibers to adopt a number of alternative configurations, (...) some of which could be transiently stabilized and serve regulatory purposes. Single-cell Hi-C approaches provide an opportunity to analyze chromatin folding in rare cell types such as stem cells, tumor progenitors, oocytes, and totipotent cells, contributing to a deeper understanding of basic mechanisms in development and disease. Here, we review key findings of single-cell Hi-C and discuss possible biological reasons and consequences of the inferred dynamic chromatin spatial organization. Single-cell Hi-C expands the molecular biology toolbox for studies of chromatin structure in individual cells. This technique allows one to analyze cell-to-cell variability in TAD and loop structure, and to capture chromosome conformation in rare cell types such as oocytes, totipotent cells, and tumor progenitors. (shrink)

This article aims to demonstrate the unity of faith and reason as irrational and rational elements of the theoretical religious discourse on instances of Christian theoretical thought. This unity was represented as a dialectical contradiction, the violation of which led to the destruction of religious discourse. The contradictory unity of faith and reason was researched in European medieval philosophy and Russian religious philosophy in the first half of the 20th century and in the theoretical systems that were considered ways of (...) explaining the relationship between faith and reason in Christian thought. This article reveals two historical types of the dynamic unity of faith and reason as well as violations of this unity: when medieval authors attempted to find the most effective relationship between faith and reason for Christian theology; and when Russian philosophers attempted to transmit theological knowledge by means of philosophy in the secular age. The results of the dynamic unity violations in both traditions are investigated as the conceptions that had been denied by these traditions. The main conclusion of the article is that Christian theoretical thought maintained the contradictions between faith and reason as a search for its development. (shrink)

Abstract This article traces a historical shift, and in particular its erasure from memory on the intellectual map of the West, in concepts of subjectivity across practices of rabbinic thinking in late antiquity, medieval interpretations of the Talmud, and modern talmudic scholarship. I first introduce a comparative perspective that relies on a mutual hermeneutics of philosophical and talmudic traditions. I consequently engage with Alain de Libera's archaeological analysis of the birth of the thinking subject in medieval philosophy and theology. In (...) this light, I analyze the role of the notion of the thinking subject in construing the Talmud from Maimonides to contemporary Talmud criticism. Finally, I explore the implications of de Libera's program of a philosophical archaeology of the thinking subject for mapping the complex relationship of mutual presupposition and exclusion between philosophical, rhetorical, and talmudic traditions of thinking in antiquity, as manifested in the larger scope of these traditions. (shrink)

The work is concerned with the so called display property of display logic. The motivation behind it is discussed and challenged. It is shown using one display calculus for intuitionistic logic as an example that the display property can be abandoned without losing subformula, cut elimination and completeness properties in such a way that results in additional expressive power of the system. This is done by disentangling structural connectives so that they are no longer context-sensitive. A recipe for characterizing structural (...) extensions of display calculi is provided. (shrink)

The realities of the coronavirus crisis caused by the COVID-19 pandemic, in many cases, become decisive for adjusting the prospects for socio-economic development. The article presents the main results of studying the social aspect of the pandemic in the context of social heterogeneity and specific regional differences. The main points of the study are focused on analyzing the dynamics of the pandemic spreading in Russia’s regions, the specifics and effectiveness of social restrictions, and the transformation of social space. The analysis (...) of the pandemic dynamics was carried out taking into account the information from four large industrial regions in the center of Russia and the Urals. As part of the analysis, a number of problematic issues of the social constraints effectiveness are considered, among which there are the following ones: specificity of the pandemic dynamics by regions in the context of various options for self-isolation, factors of «Path Dependence» of the social space, the consequences of redundant restrictions, social «fatigue» and «erosion» of requirements for isolation. From the viewpoint of updating the transformation priorities - spatial transformations during a pandemic, the following aspects are considered: background for moving from isolation restrictions to spatial transformations, regional employment specificity, socio-economic priorities of spatial transformation, problem-oriented zoning of a heterogeneous socio-economic space. The study is aimed at developing an adequate authorities’ and society’s response to the problems of coronacrisis, forming a regionally adapted set of measures and strategies of socio-economic transformations during the pandemic, creating a basis for solving interdisciplinary issues in the subsequent situation of «normality 2020». (shrink)

Globalna świadomość jako pojęcie kulturowe i historyczne Artykuł stanowi analizę idei głoszonych przez przedstawicieli filozofii kosmicznej. Przedstawiony zostaje kulturowy, historyczny i cywilizacyjny charakter zjawiska świadomości globalnej. Dowodzi się w nim, że świadomość globalna jest częścią społecznego i kulturowego potencjału globalnych sieci informacyjnych oraz że może ona wskazywać perspektywę rozwoju obdarzonej rozumem ludzkości.

Of all global problems world population growth is the most significant. The growth of the number of people expresses the sum outcome of all economic, social and cultural activities that comprise human history. Demographic data in a concise and quantitative way describe this process in the past and present. By applying the concepts of nonlinear dynamics and synergetics, it is possible to work out a mathematical model for a phenomenological description of the global demographic process and project its trends into (...) the future. Assuming self-similarity as the dynamic principle of development, growth can be described over practically the whole of human history, with a growth rate proportional to the square of the number of people. This is due to a collective interaction, responsible for the growth of human numbers, as the result of the informational nature of development. The large parameter of the theory and the effective size of a coherent population group is of the order of 105. As the microscopic parameter of the phenomenology, the human life span is introduced into the theory. Estimates of the beginning of human development 4-5 million years ago and of the total number of people who have ever lived since then ≈ 100 billion are made. In the framework of the model, large scale cycles defined by history and anthropology are shown to follow an exponential pattern of growth, culminating in the demographic transition, a veritable revolution when population growth is to stabilize at 10 to 12 billion. (shrink)

The article provides a comparative analysis of the perception of time in Europe and China. Time is considered as one of the fundamentals of mentality. The author presents the specifics of mythological time, distinguishing sacred and profane times and analyzing the correlation between time, space, things, and their repetition. European logos time, which becomes mainstream in Modern Times, is examined. The article describes the postmodern period that took shape in the 20th and early 21st centuries. The formation and contemporary image (...) of time in China is traced in detail. This perception of time suddenly turns out to be the most relevant to today’s needs: in Chinese culture, time and space are closely connected, linearity is combined with cyclicality, involvement is combined with distancing, immovability and the ability to wait for the right moment – with an instant reaction. In Chinese culture, innovations are introduced under the guise of tradition, and activism, which has always been especially emphasized as the specificity of the modern Europe, as it turns out, is the most important characteristic of the Chinese. Under modern “network” conditions, the substantial understanding of things, which is characteristic of European culture, has given way to a networking perception, which is specific to the Chinese. This is a network in which interactions are carried out simultaneously and in different directions. By itself, a comparative analysis of mentalities yields important results and allows to draw far-reaching conclusions that are essential for understanding both the European and Chinese visions of the world. In conclusion, it becomes clearer what features of the Chinese mentality made possible not only the entry of China into the group of developed countries but also its transformation into one of the leaders among the world powers. (shrink)

From the end of the XX century academic community has been extensively discussing globalization issues affecting economy, politics and culture. First and foremost there grew anticipations of an ecological disaster on a global scale associated with environmental pollution. Solution of these problems on a global scale is based on a sustainable development strategy. The sustainable development is a balance between natural environment (biosphere) and artificial environment (technosphere). Russian thinkers of the early XX century introduced a notion of noosphere. One of (...) the landmarks of sustainable developmentmust become ecosophy. Asian civilization has been developing in the spirit of ecosophy. It shows that one can live in equilibrium with natural surroundings and scientific progress, preserving spiritual culture and maintaining high spiritual standard. Extending of culture dialogue became more essential in XXI century. (shrink)

The paper attempts to establish a methodological complementarity between Foucault’s and Deleuze’s accounts of the body on the basis of Nietzsche’s theory of active and reactive forces systematically elaborated in Deleuze’s Nietzsche et la philosophie. Deleuze’s reading of Nietzsche’s physics of forces opens up two prospective developments of Nietzsche’s legacy: the genealogical critique of the historical body produced by reactive forces on the one hand and the invention of a new unknown body produced by active forces on the other. The (...) paper shows how throughout their careers both Foucault and Deleuze pursue these two divergent yet mutually complementary scenarios respectively. Given the shared background of both thinkers, neither is complete without the other, especially when the question of resistance is at stake. Just as active force is necessarily presupposed by the existence of reactive force in the Nietzschean calculus, Foucault’s reactive body cannot exist without its own inverse, Deleuze’s active ‘body-without-organs’. (shrink)

El presente artículo versa sobre la estructura del tratado isidoriano llamado _Liber differentiarum _II. Hasta el momento, los trabajos acerca del contenido de la obra y su distribución han explicado su estructura según consideraciones que podríamos llamar “externas”, en tanto se basan en ideas generales en relación con el género o la lógica del texto. En contraste con ello, el objetivo de este estudio es ofrecer una explicación “interna” de tal estructura, una fundada en su contenido conceptual. Nuestra hipótesis sostiene, (...) pues, que la base para articular el texto entero es la definición de “hombre” que Isidoro desarrolla en _Diff. _II.13, así como su lugar en la escala de seres. En efecto, la posición especial del ser humano, que es considerado tanto por Isidoro como por sus fuentes como una creatura universal intermedia entre Dios y los seres materiales carentes de razón, es de capital importancia para la comprensión y consecuente estructuración de la obra. (shrink)

Nearly fifty years after the incorporation of the International Society for Knowledge Organization and the introduction of its formal scientific journal Knowledge Organization, a comprehensive encyclopedia of the domain appeared. The practice of domain analysis for knowledge organization, twenty years after its introduction as a core methodology, has created the largest corpus of theoretical knowledge in the domain analysis of knowledge organization itself. A substantial body of research data, therefore, is available in the corpus of articles and conference papers reporting (...) on the epistemological and ontological pillars of the science of knowledge organization. This paper is a report on the evolution of a formal taxonomy of knowledge organization, which is a product of an exhaustive meta-analysis of the KO domain. Our team compiled the corpus of twenty-nine formal published analyses together with key formative historical documents. We then analyzed the corpus thematically, bibliographically, and using co-word analysis to extract key concepts and the underlying faceted conceptual infrastructure. The taxonomy itself is faceted and is linked where possible to published definitions in the KO literature and as well as to the online ISKO Encyclopedia of Knowledge Organization. A dynamic project, the taxonomy will be maintained as linked open data and will grow as emergent research contributes new concepts or generates new facets. (shrink)

The logic with independent truth and falsehood operators TFL is proposed. In TFL(→) standard truth-conditions for the implication are adopted. Nevertheless the laws of classical logic are not valid. In this language more then 107 different binary connectives can be defined. So this logic can be treated as universal logic relatively to the class of sentential logics.

We develop a general theory of FDE-based modal logics. Our framework takes into account the four-valued nature of FDE by considering four partially defined modal operators corresponding to conditions for verifying and falsifying modal necessity and possibility operators. The theory comes with a uniform characterization for all obtained systems in terms of FDE-style formula-formula sequents. We also develop some correspondence theory and show how Hilbert-style axiom systems can be obtained in appropriate cases. Finally, we outline how different systems from the (...) literature can be expressed in our framework. (shrink)

Sequential transformative design of research :224–235, 2015; Groleau et al. in J Mental Health 16:731–741, 2007; Robson and McCartan in Real world research: a resource for users of social research methods in applied settings, Wiley, Chichester, 2016) allows testing a group of theoretical assumptions about the connections of artificial intelligence with culture and education. In the course of research, semiotics ensures the description of self-organizing systems of cultural signs and symbols in terms of artificial intelligence as a special set of (...) algorithms. This approach helps to consider the arguments proposed by Searle :417–457, 1980) against ‘strong’ artificial intelligence. Searle :417–457, 1980) believes that artificial or machine intelligence cannot fully emulate the processes of the human mind. Machine intelligence shows own inevitable weakness. This is non-autonomous tool for computations and data operating. In fact, this tool cannot provide insight into real cognitive conditions. After Lotman and Uspensky, authors expand the meaning of artificial intelligence. The authors identify a cultural type of ‘strong’ artificial intelligence or ‘self-increase of Logos’ in terms by Lotman and Uspensky. The interpretation of human intelligence as imitation of machine intelligence makes possible such immersion of artificial intelligence in culture. The authors reveal a case of self-organizing autonomous generation, encoding, decoding, reception, storage, and transmission of social information in the field of physical training. From the empirical studies it is clear that the organization of collective activities without external control ensures the development of positive emotions and social orientations. Interest in autonomous behavior provides the formation of educational and cognitive motives. As a special set of algorithms, these motives are the most promising and favorable for personal development. (shrink)

In the course of a close analysis of Kant’s essay in which he gives his original answer to the question, “What is Enlightenment?” I examine the causes and consequences of the theses about Enlightenment which makes a plea for emancipation from the shackles of guardianship, above all by getting rid of one’s own cowardice. In search of an answer to the question, “What is the real reason of self-incurred immaturity?” I consider the bifurcation: Is it all about unjust social institutions (...) established in the interests of the ruling social estates, as the best European brains contended throughout the Enlightenment era, thus anticipating and justifying revolutionary upheavals, or is it within ourselves who have refused to use our reason independently and regularly? — something which Kant unequivocally considers to be everyone’s special kind of guilt. Following Kant, I look for an answer to the question, “Which limits impede Enlightenment, and which limits, far from obstructing it, are bound to promote it?” and reveal the hidden paradox of the Kantian solution: maturity has to be preceded by the granting of freedoms; and the granting of freedoms in turn calls for a mature public. I also ask the question, “Whose yoke is heavier, one’s own or the guardian’s?” and offer my version of an answer. In conclusion, I assemble all parts of the complicated and original formula of the Kantian recipe of Enlightenment. Among other things, I reveal a special type of bonding within the social organism implied by Kant, and that is the requirement to obey those who are not above us in thinking and the right to speak out in public, which ultimately means not only personal maturity, but implies also the maturity of society’s functioning in accordance with the said maxim. (shrink)

The structure of G. V. Florovsky’s concept of neopatristic synthesis is analyzed and reassessed here in light of the current state of philosophy and theology. As a result, the concept receives a ne...

Personal branding has become an important concept in management literature in recent years. Yet, with more than 100 scholarly papers published on the concept to date, it has developed into a fragmented area of research with a diversity of definitions and conceptual boundaries. This paper posits that this heterogeneity of extant research impedes theoretical and empirical advancement. To strengthen the foundation for future work, we review the extant literature and offer an integrative model of personal branding. Through our systematic literature (...) review we identify the key attributes of the construct, establish its clarity by comparing it with similar concepts in its nomological network, and suggest the definitions of personal branding and personal brand based on the reviewed literature. Further, we propose a theoretical model of personal branding summarizing the findings from the reviewed papers. The proposed model outlines the trends conducive to personal branding, as well as its drivers, processes, and outcomes. Finally, we discuss ethical implications of personal branding for both scholarly work and practice. In conclusion, we outline a further research agenda for studying personal branding as a critical career and organizational behavior activity in contemporary working environment. (shrink)

We study connections between four types of modal operators – necessity, possibility, un-necessity and impossibility – over intuitionitstic logic in terms of compositions of these modal operators with intuitionistic negation. We investigate which basic compositions, i.e. compositions of the form ¬δ, δ¬ or ¬δ¬, yield modal operators of the same type over intuitionistic logic as over classical logic. We say that such compositions behave classically. We study which modal properties correspond to each basic compositions behaving classically over intuitionistic logic and (...) also prove that KC constitutes the smallest superintuitionistic logic over which all basic compositions behave classically. (shrink)

From descriptive interpretation of "understanding" to abstract-gnosiological understanding of mentality. The historical deconstruction of the existential understanding introduced as ontologic property of constantly becoming stable "Being-in-the-World" allows us to interpret this concept as mentality. Through theprism of existential philosophy in general and its interpreters such as Jacque Le Goff it allows us to make a conclusion that mentality is one of complete formations of public consciousness. But in the course of such interpretation of mentality it is important to avoid the (...) methodological situation in which Plato deadlocked, when he had decided to find out, what was beautiful itself. For the way out from this situation he had to introduce independently existing ideas and special space of ideas which define all the things and even gods. We, unfortunately, do not have such an opportunity which the history gave to Plato. Somehow to define structural and historical conditions for breaking out of mentality we shall be limited to the instruction that it is more complex, compound, but in the same time integrally complete formation historically actualized, unlike traditionally allocated kinds and forms of consciousness. Another important question is whether the concept "mentality" is acceptable for analysis of the current modern processes or it can only be used for the reconstruction of the completed formations. The mentality cannot be analyzed from inside. And we are inclined to consider that to operate the concept "mentality" in relation to a modern representative of civilization is inappropriate. (shrink)

With the help of syncretiсs as a new philosophical logic, the philosophy of carriers, the theory of similarity and the theory of Infinite Hierarchical Nesting of Matter, the problems of modern physics are analyzed. We consider the classical and relativistic mechanics, the special and general theories of relativity, the theory of electromagnetic and gravitational fields, of weak and strong interactions. The goal is axiomatization of these theories, building models of elementary particles and of their interactions with each other. The main (...) obtained results are: the model of bead lightning; an explanation of redshift of the spectra of galaxies; the derivation of the Newton law in the concept of gravitons; the calculation of nuclear forces and the structure of simplest nuclei with the help of the theory of strong gravitation; building the model of weak interactions of elementary particles; presentation of quarks as a particular type of quasiparticles; explanation of the electron spin. The book should be useful for students and researchers, as well as for those interested in physical and philosophical problems. Tables 20. Fig. 30. Ref. 155 titles. (shrink)