AbstractmiRNA‐mediated gene repression and ubiquitin‐dependent processes are among the oldest and most versatile mechanisms that control multiple molecular pathways, rather than just protein turnover. These systems were discovered decades ago and have become among the most studied. All systems within cells are interconnected, and these two are no exception: the plethora of studies have demonstrated that the activity of the miRNAs system depends on players of the ubiquitin‐centered universe of processes, and vice versa. This review focuses on recent progress that (...) highlights that very similar mechanisms of regulation of miRNAs by ubiquitin‐related processes are likely to be found in distantly related species, including animals, plants, and viruses. Most of them occur through the ubiquitination of Argonaute proteins, but some of the other miRNA system factors are also regulated. This suggests that their regulatory relationships are either ancient evolutionary acquisitions or have arisen independently in different kingdoms. (shrink)

We describe a general logical framework, Justification Logic, for reasoning about epistemic justification. Justification Logic is based on classical propositional logic augmented by justification assertions t: F that read t is a justification for F. Justification Logic absorbs basic principles originating from both mainstream epistemology and the mathematical theory of proofs. It contributes to the studies of the well-known Justified True Belief vs. Knowledge problem. We state a general Correspondence Theorem showing that behind each epistemic modal logic, there is a (...) robust system of justifications. This renders a new, evidence-based foundation for epistemic logic. As a case study, we offer a resolution of the GoldmanRed Barns in Justification Logic. Furthermore, we formalize the well-known Gettier example and reveal hidden assumptions and redundancies in Gettier’s reasoning. (shrink)

N4-lattices provide algebraic semantics for the logic N4, the paraconsistent variant of Nelson's logic with strong negation. We obtain the representation of N4-lattices showing that the structure of an arbitrary N4-lattice is completely determined by a suitable implicative lattice with distinguished filter and ideal. We introduce also special filters on N4-lattices and prove that special filters are exactly kernels of homomorphisms. Criteria of embeddability and to be a homomorphic image are obtained for N4-lattices in terms of the above mentioned representation. (...) Finally, subdirectly irreducible N4-lattices are described. (shrink)

This paper argues that unusual coincidences, particularly those involving historical events, can be viewed as design patterns, suggesting an intelligent influence over the course of events. A compelling case examined in detail using probability theory concerns the presidencies of Abraham Lincoln (1809–1865) and John F. Kennedy (1917–1963). This and other coincidences involving historical figures disfavor the materialistic perspective and point to the presence of an intelligent agent acting on a global scale, beyond the arrow of time, influencing human lives and (...) the course of history. (shrink)

We compare the logic HYPE recently suggested by H. Leitgeb as a basic propositional logic to deal with hyperintensional contexts and Heyting-Ockham logic introduced in the course of studying logical aspects of the well-founded semantics for logic programs with negation. The semantics of Heyting-Ockham logic makes use of the so-called Routley star negation. It is shown how the Routley star negation can be obtained from Dimiter Vakarelov’s theory of negation and that propositional HYPE coincides with the logic characterized by the (...) class of all involutive Routley star information frames. This result provides a much simplified semantics for HYPE and also a simplified axiomatization, which shows that HYPE is identical with the modal symmetric propositional calculus introduced by G. Moisil in 1942. Moreover, it is shown that HYPE can be faithfully embedded into a normal bi-modal logic based on classical logic. Against this background, we discuss the notion of hyperintensionality. (shrink)

Here is an account of recent investigations into the two main concepts of negation developed in the constructive logic: the negation as reduction to absurdity, and the strong negation. These concepts are studied in the setting of paraconsistent logic.

The relationships between various modal logics based on Belnap and Dunn’s paraconsistent four-valued logic FDE are investigated. It is shown that the paraconsistent modal logic \, which lacks a primitive possibility operator \, is definitionally equivalent with the logic \, which has both \ and \ as primitive modalities. Next, a tableau calculus for the paraconsistent modal logic KN4 introduced by L. Goble is defined and used to show that KN4 is definitionally equivalent with \ without the absurdity constant. Moreover, (...) a tableau calculus is defined for the modal bilattice logic MBL introduced and investigated by A. Jung, U. Rivieccio, and R. Jansana. MBL is a generalization of BK that in its Kripke semantics makes use of a four-valued accessibility relation. It is shown that MBL can be faithfully embedded into the bimodal logic \ over the non-modal vocabulary of MBL. On the way from \ to MBL, the Fischer Servi-style modal logic \ is defined as the set of all modal formulas valid under a modified standard translation into first-order FDE, and \ is shown to be characterized by the class of all models for \. Moreover, \ is axiomatized and this axiom system is proved to be strongly sound and complete with respect to the class of models for \. Moreover, the notion of definitional equivalence is suitably weakened, so as to show that \ and \ are weakly definitionally equivalent. (shrink)

Justification Logic provides an axiomatic description of justifications and delegates the question of their nature to semantics. In this note, we address the conceptual issue of the logical type of justifications: we argue that justifications in the logical setting are naturally interpreted as sets of formulas which leads to a class of epistemic models that we call modular models . We show that Fitting models for Justification Logic naturally encode modular models and can be regarded as convenient pre-models of the (...) former. (shrink)

We outline an intuitionistic view of knowledge which maintains the original Brouwer–Heyting–Kolmogorov semantics for intuitionism and is consistent with the well-known approach that intuitionistic knowledge be regarded as the result of verification. We argue that on this view coreflectionA→KAis valid and the factivity of knowledge holds in the formKA→ ¬¬A‘known propositions cannot be false’.We show that the traditional form of factivityKA→Ais a distinctly classical principle which, liketertium non datur A∨ ¬A, does not hold intuitionistically, but, along with the whole of (...) classical epistemic logic, is intuitionistically valid in its double negation form ¬¬(KA¬A).Within the intuitionistic epistemic framework the knowability paradox is resolved in a constructive manner. We argue that this paradox is the result of an unwarranted classical reading of constructive principles and as such does not have the consequences for constructive foundations traditionally attributed it. (shrink)

This article addresses the relationship between ontology and politics in Jean-Luc Nancy’s theory of democracy by probing the implications of his latest ontological innovation, the concept of struction. We argue that Nancy’s democracy is a mode of politics that makes the radical pluralism of struction legitimate, opening and guarding a political space for the coexistence of the incommensurable. From this perspective, and despite Nancy’s own skepticism about the concept of biopolitics, the notion of struction opens a pathway for theorizing democracy (...) in a biopolitical key as the regime of coexistence of radically incommensurable forms of life in the absence of any coordinating principle. We nonetheless take issue with Nancy’s prescription for democracy to remain devoid of any political affirmation of its own. Instead, we suggest that the prescriptive content of democracy consists in the affirmation of the contingency of all the forms of life that coexist in it, which implies their freedom, equality, and comm... (shrink)

Coronavirus disease 2019 (COVID-19) first appeared in China in late 2019 and since then it has become a pandemic. Various countries, in accordance with their cultures, have adopted different approaches to deal with the spread of this disease. The dimensions of this disease and its global spread are such that it will certainly have enormous effects on various aspects of human life for many years. One of these issues is examining the approach of religious countries in dealing with this crisis. (...) The issue of science and religion is one of the main issues in the philosophy of religion. A historical event that human society is struggling with today is the COVID-19 crisis. The issues of religion and science were intertwined during the COVID-19 outbreak, contrary to what some thought. This shows that the opposition between religion and science is not real but aims to attack religion without a valid reason. Given the importance of the subject, this article addresses two aspects of people’s exposure to religion during the COVID-19 period. On the one hand, the researchers’ field observations indicate that group of citizens has turned towards religious teachings since the beginning of the COVID-19 crisis. On the other hand, another group of citizens have distanced themselves from religiosity, raising the duality of science and religion.Contribution: This article describes the dual attitude of citizens towards religiosity due to the occurrence of COVID-19, which has not been previously considered in research. (shrink)

Tracing how the logic of inoperativity works in the domains of language, law, history and humanity, 'Agamben and Politics' systematically introduces the fundamental concepts of Agamben's political thought and a critically interprets his insights in the wider context of contemporary philosophy.

Let K be the least normal modal logic and BK its Belnapian version, which enriches K with ‘strong negation’. We carry out a systematic study of the lattice of logics containing BK based on: • introducing the classes of so-called explosive, complete and classical Belnapian modal logics; • assigning to every normal modal logic three special conservative extensions in these classes; • associating with every Belnapian modal logic its explosive, complete and classical counterparts. We investigate the relationships between special extensions (...) and counterparts, provide certain handy characterisations and suggest a useful decomposition of the lattice of logics containing BK. (shrink)

In 1933 Godel introduced a calculus of provability (also known as modal logic S4) and left open the question of its exact intended semantics. In this paper we give a solution to this problem. We find the logic LP of propositions and proofs and show that Godel's provability calculus is nothing but the forgetful projection of LP. This also achieves Godel's objective of defining intuitionistic propositional logic Int via classical proofs and provides a Brouwer-Heyting-Kolmogorov style provability semantics for Int which (...) resisted formalization since the early 1930s. LP may be regarded as a unified underlying structure for intuitionistic, modal logics, typed combinatory logic and λ-calculus. (shrink)

'Ontological Semantics' introduces a comprehensive approach to the treatment of text meaning by computer, arguing that being able to use meaning is crucial to the success of natural language processing applications.

We define a novel interpretation R of second order arithmetic into Explicit Mathematics. As a difference from standard D-interpretation, which was used before and was shown to interpret only subsystems proof-theoretically weaker than T 0 , our interpretation can reach the full strength of T 0 . The R-interpretation is an adaptation of Kleene's recursive realizability, and is applicable only to intuitionistic theories.

Neuroscience has established several brain pathways that process visual information. Distinct neural circuits analyze body appearance and movement providing information about the person’s cognitive and emotional states. The activity of the pathways depends on the salience of visual stimuli for the organism in the given circumstances. Since ballet performances are not among the crucial events for the viewer’s organism, not all viewers perceive and interpret bodily signs that express the mental state of the dancer. Treatment of the dancer as close (...) other activates the neural circuits that elaborate emotions, this enables the viewer to feel the internal state of the dancer and enrich the interpretation of the scenic action. (shrink)

In this paper the philosophical ideology of eclecticism of Modern times is considered, especially as it has been formulated byJ. Ch.Sturm, and assessment of its contribution to development of philosophical and scientific thought is given. The need of differentiation of eclecticism, syncretism and conciliatorics is proved. Eclecticism is characterized as a progressive for its time current. The decisive impact eclecticism on formation of new scientific outlook is emphasized.

The present paper is devoted to computational aspects of propositional inconsistency-adaptive logics. In particular, we prove (relativized versions of) some principal results on computational complexity of derivability in such logics, namely in cases of CLuN r and CLuN m , i.e., CLuN supplied with the reliability strategy and the minimal abnormality strategy, respectively.

Sergei Prozorov challenges the assumption that the biopolitical governance means the end of democracy, arguing for a positive synthesis of biopolitics and democracy. He develops a vision of democratic biopolitics where diverse forms of life can coexist on the basis of their reciprocal recognition as free, equal and in common.

Earlier algebraic semantics for Belnapian modal logics were defined in terms of twist-structures over modal algebras. In this paper we introduce the class of BK -lattices, show that this class coincides with the abstract closure of the class of twist-structures, and it forms a variety. We prove that the lattice of subvarieties of the variety of BK -lattices is dually isomorphic to the lattice of extensions of Belnapian modal logic BK . Finally, we describe invariants determining a twist-structure over a (...) modal algebra. (shrink)

Various features of the interpretation of these schools main positions, the reasons for their appearance and the consequences for the development of Mahayana Buddhism have been the subject of discussion in this research. Attention is drawn to the existence of various ideas of Buddhist authors about the interpretation of fundamental philosophical ideas of these schools. The influence of the peculiarities of translation into other languages for the adequate transmission of the author’s thought is discussed. It is noted that the possibility (...) of different interpretations was already established in the very methodology of the transmission of Buddhist doctrines, formed at the earliest stages of Buddhism. The opinions of a number of Tibetan authors are analyzed. The study presents the derivation of the existence of different interpretations of some categories central to Mahayana Buddhism due to the presence of different philosophical methodologies. A number of features were associated with the interpretation of the correlation of logical-critical knowledge, yogic methods and their priority in choosing ways to achieve an exit from the chain of rebirth. The factor of similarities in the positions of such authors as Nāgārjuna and Vasubandhu (traditionally attributed to different schools) makes it problematic to unambiguously interpret their philosophical positions; Some features of these schools were determined not only by theoretical backgrounds, but also by political struggle for a leading place in the Buddhist hierarchy of a certain country, as well as the desire to affect authorities. (shrink)

The article takes Giorgio Agamben’s declaration of his optimism with regard to the possibilities of global political transformation as a point of departure for the inquiry into the affirmative aspects of Agamben’s political thought, frequently overshadowed by his more famous critical claims. We reconstitute three principles grounding Agamben’s optimism that pertain respectively to the total crisis of the contemporary biopolitical apparatuses, the possibility of a radically different form-of-life on the basis of their residue and the minimalist character of this transformation (...) that consists entirely in the subtraction of existence from these apparatuses. While the first two principles are unproblematic in the wider context of Agamben’s work, the third principle introduces the problematic of will that remains highly ambiguous in his philosophy. In the remainder of the article we address this ambiguity in an analysis of Agamben’s reading of Melville’s ‘Bartleby the Scrivener’ and conclude that Agamben’s optimism ultimately consists in the affirmation of absolute contingency, beyond both will and necessity. (shrink)

This paper sheds light on the relationship between the logic of generalized truth values and the logic of bilattices. It suggests a definite solution to the problem of axiomatizing the truth and falsity consequence relations, \ and \ , considered in a language without implication and determined via the truth and falsity orderings on the trilattice SIXTEEN 3 . The solution is based on the fact that a certain algebra isomorphic to SIXTEEN 3 generates the variety of commutative and distributive (...) bilattices with conflation. (shrink)

In this paper individual proofs are integrated into provability logic. Systems of axioms for a logic with operators “A is provable” and “p is a proof of A” are introduced, provided with Kripke semantics and decision procedure. Completeness theorems with respect to the arithmetical interpretation are proved.

We define a realizability interpretation of Aczel's Constructive Set Theory CZF into Explicit Mathematics. The final results are that CZF extended by Mahlo principles is realizable in corresponding extensions of T 0 , thus providing relative lower bounds for the proof-theoretic strength of the latter.

This article examines a still contentious question: how conservative and liberal elements are combined in Boris N. Chicherin’s worldview and political doctrine. It considers several points of view...

Ivan Karamazov’s famous dictum ‘If there is no God, anything is permitted’ in fact appears as a central meta-theme in many of Dostoevsky’s works. Western philosophers and writers repeatedly reinterpreted this idea. The most recent versions belong to the contemporary psychoanalytic and Freudian–Marxist philosophy. E.g. Jacques Lacan famously said that “if there is a God, then anything is permitted”, and Slavoy Zizek attributed this to Dostoevsky himself. The paper demonstrates which versions of this saying are present in Dostoevsky’s novel The (...) Brothers Karamazov, what meaning this meta-theme has within the integral structure of these literary works, and which of them express the author’s own position. The paper also provides insight into those bright reinterpretations of Dostoevsky’s central meta-theme that were given by certain representatives of contemporary European psychoanalytic philosophy. These readings are regarded as the significant attempts to explain the present from the standpoint of European psychoanalytic philosophy, made on the basis of elements of Dostoevsky’s artistic thinking. (shrink)