Microfluidic technology – the manipulation of fluids at micrometer scales – has revolutionized many areas of synthetic biology. The bottom‐up synthesis of “minimal” cell models has traditionally suffered from poor control of assembly conditions. Giant unilamellar vesicles (GUVs) are good models of living cells on account of their size and unilamellar membrane structure. In recent years, a number of microfluidic approaches for constructing GUVs has emerged. These provide control over traditionally elusive parameters of vesicular structure, such as size, lamellarity, membrane (...) composition, and internal contents. They also address sophisticated cellular functions such as division and protein synthesis. Microfluidic techniques for GUV synthesis can broadly be categorized as continuous‐flow based approaches and droplet‐based approaches. This review presents the state‐of‐the‐art of microfluidic technology, a robust platform for recapitulating complex cellular structure and function in synthetic models of biological cells. (shrink)

Resumen En este texto se intenta mostrar que la radicalización de la tesis expresada por Platón en el libro X de la República no permite "apreciar" el valor que el filósofo ateniense sabe que posee la poesía, pues ella podría ser un medio para el ejercicio reflexivo si se sirve de la sobriedad que la filosofía propone. Para realizar esta tarea es menester trazar tres puntos sobre los cuales gira este texto: primero, se ubica al lector en la discusión entre (...) poesía y filosofía para comprender el contexto de la crisis entre estos dos factores de la educación en la antigüedad griega; segundo, se aborda la crítica establecida en el libro X sobre la falta de rigor que muestran los poetas en la búsqueda del conocimiento; finalmente se vislumbra o abre una posibilidad interpretativa acerca del interés que puede tener la proposición de una "poesía filosófica" en la obra de Platón.The following text will try to show that radicalization of the thesis expressed by Plato in the book X does not allow "to "estímate" the value that the Athenian philo-sopher knows that poetry possesses, since poetry might be a means for the reflexive exercise if it takes advantage of the sobriety that philosophy proposes. To carry out this task it is necessary to define three points on which this paper will be about: first, the author will inform the reader about the old discussion among poetry and philosophy to understand the context of the crisis between these two forms of teaching; Second, criticism established in the book X on the lack of rigor in the search of knowledge that poets have will be addressed. Finally, the paper glimpses or opens an interpretive possibility about the interest that the proposition of a "philosophical poetry" can have in Plato's work. (shrink)

This paper investigates the link between the consumer perception that a company is socially oriented and the consumer intention to buy products marketed by that company. We suggest that this link exists when at least two conditions prevail: (1) the products sold by that company comply with ethical and social requirements; (2) the company has an acknowledged commitment to protect consumer rights and interests. To test these hypotheses, we conducted a survey among the clients of retail chains offering Fair Trade (...) products. The results show that socially oriented companies can successfully leverage their reputation to market products with high symbolic values. (shrink)

We largely agree with Grimwade et al ’s1 conclusion that challenge trial participants may ethically be paid, including for risk. Here, we add further arguments, clarify some points from the perspective of economics and indicate areas where economists can support the development of a framework for ethically justifiable payment. Our arguments apply to carefully constructed and monitored controlled human infection model trials that have been appropriately reviewed and approved. Participants in medical studies perform a service. Outside the domain of research (...) participation, there is nearly universal agreement that workers providing a service should be compensated fairly, and that work involving more discomfort and risk should be compensated more generously. Accordingly, labour regulations impose floors, not caps on compensation. Caps, even if intended to protect against undue inducement, also raise concerns about illegal price-fixing that disadvantages workers. Such limits on payment for egg donors have successfully been challenged in court.i Moreover, caps on compensation may harm everyone at risk of infection, not just potential participants. Insufficient compensation may impede the recruitment of enough suitable subjects, for example, when representativeness of the subject sample is required. Delays in vaccine development not only prolong disruption of social, educational and economic activity but also lead to excess infections and deaths. Unlike paid CHIM participants, individuals exposed to such infection do not accept it voluntarily, are not compensated for it, and are unlikely to receive the level of medical supervision afforded to closely monitored CHIM participants. Payment caps can lead to attempts to circumvent the regulation. For example, many countries …. (shrink)

Scholarly research largely converges on the argument that trust is of paramount importance to drive economic agents toward mutually satisfactory, fair, and ethically compliant behaviors. There is, however, little agreement on the meaning of trust, whose conceptualizations differ with respect to actors, relationships, behaviors, and contexts. At present, we know much better what trust does than what trust is. In this article, we present an extensive review and analysis of the most prominent articles on trust in market relationships. Using computer-aided (...) content analysis and network analysis methods, we identify key, recurring dimensions that guided the conceptualization of trust in past research, and show how trust can be developed as a multifaceted and layered construct. Our results are an important contribution to a convergence of research toward a shared and common view of the meaning of trust. This process is important to ensure the body of trust research’s internal theoretical consistency, and to provide reliable and common principles for the management of business relationships – a context in which opportunism and imperfect information may induce economic actors to cheat and stray from fair and ethically compliant behaviors. (shrink)

This article argues that a manuscript dated to the summer of 1927 by the editors of Bohr’s Collected Works was written a year earlier. The re-dating allows the conclusion that Bohr was well on his way to complementarity before his famous fight with Heisenberg over the uncertainty principle early in 1927. The literature that assumes that complementarity was Bohr’s response to Heisenberg is therefore in error. The editors of the Collected Works assigned the document the date of 1927 because it (...) refers to electron-diffraction experiments by Davisson and Germer, which were published in 1927. But as the article points out, Bohr and other leading physicists such as Max Born met Davisson in Britain in 1926 and discussed the experiments with him then. That demolished the basis of the earlier dating. Finally, the article argues that when the document takes its place between the Bohr–Kramers–Slater theory (1924) and the 1927 drafts of complementarity, everything falls neatly into place. (shrink)

In the context of propositional logics, we apply semantics modulo satisfiability—a restricted semantics which comprehends only valuations that satisfy some specific set of formulas—with the aim to efficiently solve some computational tasks. Three possible such applications are developed.We begin by studying the possibility of implicitly representing rational McNaughton functions in Łukasiewicz Infinitely-valued Logic through semantics modulo satisfiability. We theoretically investigate some approaches to such representation concept, called representation modulo satisfiability, and describe a polynomial algorithm that builds representations in the newly (...) introduced system. An implementation of the algorithm, test results and ways to randomly generate rational McNaughton functions for testing are presented. Moreover, we propose an application of such representations to the formal verification of properties of neural networks by means of the reasoning framework of Łukasiewicz Infinitely-valued Logic.Then, we move to the investigation of the satisfiability of joint probabilistic assignments to formulas of Łukasiewicz Infinitely-valued Logic, which is known to be an NP-complete problem. We provide an exact decision algorithm derived from the combination of linear algebraic methods with semantics modulo satisfiability. Also, we provide an implementation for such algorithm for which the phenomenon of phase transition is empirically detected.Lastly, we study the game theory situation of observable games, which are games that are known to reach a Nash equilibrium, however, an external observer does not know what is the exact profile of actions that occur in a specific instance; thus, such observer assigns subjective probabilities to players actions. We study the decision problem of determining if a set of these probabilistic constraints is coherent by reducing it to the problems of satisfiability of probabilistic assignments to logical formulas both in Classical Propositional Logic and Łukasiewicz Infinitely-valued Logic depending on whether only pure equilibria or also mixed equilibria are allowed. Such reductions rely upon the properties of semantics modulo satisfiability. We provide complexity and algorithmic discussion for the coherence problem and, also, for the problem of computing maximal and minimal probabilistic constraints on actions that preserves coherence.prepared by Sandro Márcio da Silva Preto.E-mail: [email protected]:https://doi.org/10.11606/T.45.2021.tde-17062021-163257. (shrink)

In this paper, we suggest a strategy for modelling cognitive context within a truth‐conditional semantics, using Asher's model of predication. This allows us to introduce the notion of type presupposition intended as a lexical constraint to the composition of the truth‐conditional content. More specifically, we suggest that this model of predication produces a notion of truth‐conditional meaning where the cognitive context fixes a set of lexical restrictions and forced modifications. We conclude that this model might offer an intermediate position between (...) Minimalism and Contextualism: an account that provides intuitive truth conditions within a formal semantic theory. (shrink)

Normal 0 21 false false false MicrosoftInternetExplorer4 Apresento aqui algumas das teses que Levinas ergue a partir da ideia do infinito em Descartes. Como tônica o texto apresenta uma breve consideraçáo a respeito da alteridade, do desejo e da ética como conceitos, a ponto de desembocar no sentido maior do humano como hospitalidade.

Åsa Burman has recently introduced the important notion of telic power and differentiated it from deontic power in an attempt to build a bridge between ideal and non-ideal social ontology. We find Burman’s project promising but we argue that more is to be done to make it entirely successful. First, there is a palpable tension between Burman’s claim that telic power can be ontologically independent of deontic power and her examples, which suggests that these forms of power share the same (...) basis. Second, it is not completely clear how telic power specifically helps non-ideal social ontologists explain oppression. We offer solutions to both problems. First, we argue that Burman’s arguments for the conclusion that telic power can exist without deontic power are unsuccessful. Burman contends that this is possible because some social roles involving telic power can exist independently of institutions as sets of constitutive rules, which are––in her opinion––the source of deontic power. Burman’s arguments are not persuasive because she disregards the plausible view that all social roles involve deontic power, whether or not they are institutional. Second, we argue that while the exercise of deontic power requires a collective recognition of the social roles of the interacting agents and, therefore, a recognition of the associated norms, the exercise of telic power does not require recognition of the relevant norms. This is why invoking telic power is particularly useful in explaining how oppression and injustice can arise. Lastly, we suggest that the relation between teleological normativity and the forms of telic power has not been fully clarified by Burman and requires a deeper analysis. (shrink)

The 3sg pronouns “he” and “she” impose descriptive gender conditions (being male/female) on their referents. These conditions are standardly analysed as presuppositions (Cooper in Quantification and syntactic theory, Reidel, Dordrecht, 1983; Heim and Kratzer in Semantics in generative grammar, Blackwell, Oxford, 1998). Cooper argues that, when 3sg pronouns occur free, they have indexical presuppositions: the gender condition must be satisfied by the pronoun’s referent in the actual world. In this paper, we consider the behaviour of free 3sg pronouns in conditionals (...) and focus on cases in which the pronouns’ gender presuppositions no longer seem to be indexical and project locally instead. We compare these cases to previously reported shifty readings of indexicals in so-called “epistemic conditionals” (Santorio in Philos Rev 121(3):359–406, 2012) and propose a unified account of locally projected gender presuppositions and shifty indexicals based on the idea that indicative conditionals are Kaplanian monsters. (shrink)

I discuss two competing theories of the progressive: the theory proposed in Parsons (1980, 1985, 1989, 1990) and the theory proposed in Landman (1992). These theories differ in more than one way. Landman regards the progressive as an intentional operator, while Parsons doesn't. Moreover, Landman and Parsons disagree on what uninflected predicates denote. For Landman, cross the street has in its denotation complete events of crossing the street; the aspectual contribution of English simple past (perfective aspect) is the identity function. (...) For Parsons, both complete and incomplete events of crossing the street can be in the denotation of the base VP; perfective aspect restricts its denotation to the events that culminate. I present a version of ParsonÕs theory that avoids the problems raised by Landman, in particular the problem posed for Parsons by creation verbs. The repaired version and Landman's theory still differ in the way they analyze uninflected verbs. The repaired version and Landman's theory still differ in the way they analyze uninflected predicates. I present evidence from Slavic languages that both theories are needed. Finally, I discuss some evidence that may favor one or the other approach to the semantics of the English progressive. (shrink)

The aim of this article is to interpret the naturalist epistemological project of W. Quine from a problematic nucleus that we can identify in I. Kant, especially in the Critique of Pure Reason, which is expressed in the categories of explanation-justification, experimental psychology and transcendental philosophy. The hypothesis of our work is that the naturalization of epistemology in a psychology by Quine is possible due to a dissolution of the limits of the concepts of explanation and justification, which have in (...) Quine a translation in the notions of concept and doctrine. To account for this, (i) we will propose, in a general way, the Kantian problematic nucleus about the distinction between explanation and justification and its relationship with the experimental psychology of the 18 th century; ii) we will analyze some important texts of W. Quine where he bases the project of a naturalization of epistemology. Our focus will be to establish the relationship between concept and doctrine as translations of Quine of the concepts of explanation and justification; (iii) finally; we will describe the psychology as a new epistemology and observational statements as an expression of this epistemological turn of Quine. (shrink)

The article show that the purpose of the final elaboration of Merleau-Ponty is thus to find a new idea of philosophy in which both Hegelian and Husserlian phenomenology can converge. But this tension in no way constitutes an element of rupture in the theoretical continuity of the Merleau-Pontian philosophy.

O artigo apresenta o livro O fogo e o relato. Ensaios sobre criação, escrita, arte e livros, do filósofo italiano Giorgio Agamben, discutindo alguns dos limiares poéticos do seu pensamento político. Parte-se de alguns dos debates subentendidos de Agamben com Jacques Derrida sobre linguagem e literatura, passa-se pelo ato poético como ato de resistência, define-se a potência inoperante presente em gestos de interrupção discursiva e chega-se à discussão sobre vida e obra em contexto biopolítico. Seguindo a ordem dos capítulos, mas (...) sem pretender esgotá-los, o pressuposto do artigo é de que o italiano, que tem a poesia e a literatura geralmente vinculada a uma espécie de “primeira fase” de sua obra, também na série biopolítica nomeada Homo Sacer lançou mão da poesia e da literatura como forte estratégia de resistência e abertura de limiares ante a lógica que se desenha do poder soberano. Se, por um lado, o livro pode ser lido como formando um círculo hermenêutico, os capítulos, por outro lado, permitem ao leitor perceber as principais linhas em que filosofia, literatura, poesia e política se entrecruzam para o pensador italiano. Por isso, também, recorreu-se à relação direta de alguns argumentos expostos em O fogo e o relato tanto com noções e argumentos presentes em outros livros de Agamben, quanto pontualmente com outros interlocutores. (shrink)

Il dibattito bioetico sulla regolamentazione delle decisioni di fine vita ri­ce­ve per lo più impulso da casi individuali che vengono portati all’attenzione del­l’opinione pubblica. Il ruolo che hanno avuto per gli Stati Uniti le vi­cende biografiche di Nancy Cruzan e di Terry Schiavo è sta­to svolto in Ita­lia da Piergiorgio Welby ed Eluana Englaro. Le vicende giudiziarie hanno tro­­vato difficoltà a essere decise perché la legge si è rivelata inadeguata ad at­tribuire significati univoci a concetti come ‘accanimento terapeutico’ e ‘trat­tamenti (...) futili’. Il dibattito è stato ul­te­riormente complicato dall’uso di im­magini e da emozioni. La ricerca di una legge condivisa ha trovato in Ita­lia un ostacolo nella contrapposizione di atteggiamenti irriducibili. Il con­di­zio­­namento più negativo sembra essere l’intento di fare una legge ‘contro’ una delle posizioni ideo­logiche in gioco.The bioethical debate concerning regulations of end-of-life decisions has star­ted mainly from the analysis of individual cases, since these cases usually draw public attention. In the United States the life-stories of Nancy Cru­zan and Terry Schiavo have played an important role, whereas in Italy we have been focusing on the cases of Piergiorgio Welby and Eluana En­glaro. In all these cases the laws of the country have proved inadequate to de­fine the meaning of ‘futile medical care’. The debate has become even mo­re complicated because of intellectual and emotional implications. In Ita­ly the pursuit of an agreement from the legal point of view has found ma­ny obstacles and has basically displayed strongly conflicting views. The main problem in the Italian case seems to be the pursuit of an impartial law, nei­ther favouring nor contrasting one of the views at stake. (shrink)

What are words? How should words be individuated? Such questions set the agenda for the metaphysics of words. Unfortunately, misunderstandings are piling up in this field. Although the discussion between Kaplan, Cappelen, Hawthorne, Lepore and others has given rise to interesting insights into many aspects of words, I contend that the debate is highly compromised by a lack of clarity about the questions in the first place. The purpose of this article is to partially clarify the debate on the metaphysics (...) of words by examining the very nature of the questions to be addressed. I shall differentiate three inquiries about words and shall provide explanations of why misunderstandings can and do arise. I claim that, in so doing, we may put the debate back on solid footing in order to rethink the real nature of words. (shrink)

Collapse models predict the spontaneous collapse of the wave function, in order to avoid the emergence of macroscopic superpositions. In their mass-dependent formulation, they claim that the collapse of any system’s wave function depends on its mass. Neutral K, D, B mesons are oscillating systems that are given by Nature as superposition of two distinct mass eigenstates. Thus they are unique laboratory for testing collapse models that are sensitive to the mass. In this paper we derive—for the single mesons and (...) bipartite entangled mesons—the effect of the mass-proportional CSL (Continuous Spontaneous Localization) collapse model on the dynamics on neutral mesons. We compare the theoretical prediction with experimental data from different accelerator facilities. (shrink)

This article addresses the modern concept of sovereignty as a multivocal and conflictual semantic field, arguing for the necessity to trace its genealogy based on the structural tensions that haunt its logical framework – as well as its representations – rather than on a linear historiographic reconstruction. In particular, the scrutiny I propose aims to examine a series of exchanges that have been characterizing this concept since the beginning: the global and the European, the maritime and the territorial, the colony (...) and the state, the imperial and the proprietary. The problematic balance between ‘imperium’ and ‘dominium’ is indeed assumed here as the turning point of the rise of a sovereign power that appears to be originally rooted in the very production and governance of the global space, thus giving up all possible Eurocentric narratives of modernity. To illustrate my argument, I focus on the frontispieces to three of Thomas Hobbes’s most important books, that is, his translation of Thucydides’ Peloponnesian Wars, De Cive and Leviathan. A thorough analysis of these images enables us to understand how these lines of force traverse the very heart of modern European political concepts, along with the mirroring effects that constantly bounce their normative construction of subjectivity back and forth from the periphery to the centre and, ultimately, from the market to the state. (shrink)

When communicating, people adapt their linguistic representations to those of their interlocutors. Previous studies have shown that this also occurs at the semantic level for vague and context-dependent terms such as quantifiers and uncertainty expressions. However, work to date has mostly focused on passive exposure to a given speaker's interpretation, without considering the possible role of active linguistic interaction. In this study, we focus on gradable adjectives big and small and develop a novel experimental paradigm that allows participants to ask (...) clarification questions to figure out their interlocutor's interpretation. We find that, when in doubt, speakers do resort to this strategy, despite its inherent cognitive cost, and that doing so results in higher semantic alignment measured in terms of communicative success. While not all question–answer pairs are equally informative, we show that speakers become better questioners as the interaction progresses. Yet, the higher semantic alignment observed when speakers are able to ask questions does not increase over time. This suggests that conversational interaction's key advantage may be to boost coordination without committing to long-term semantic updates. Our findings shed new light on the mechanisms used by speakers to achieve semantic alignment and on how language is shaped by communication. (shrink)

Traditionally, medical professionals have taken a paternalistic stance towards their patients and have relied on a traditional approach to medical ethics. In recent years, in Britain, however, a new ‘managerialism’ has developed in the National Health Service (the NHS). This stresses consumerism and greater patient choice and is changing the relationship between doctors and patients. This paper draws out the implications for patients. It describes the ethical characteristics of the two conflicting approaches and argues the need to stress again the (...) view of the patient as an individual person. (shrink)

Åsa Burman has written an illuminating monograph in the flourishing field of analytical social ontology. The book is both a reconstruction of recent development.